Abstract:
OBJECTIVE:Two methods of quantitating cerebral blood flow (CBF) with iodine-123-labeled N-isopropyl-p-iodoamphetamine (I-123 IMP) and a two-compartment model had been proposed; one is the table look-up (TLU) method and the other is the autoradiographic (ARG) method. The TLU method provides values of the cerebral blood flow (CBF) values and distribution volume of I-123 IMP (Vd) independently. In the ARG method, a fixed Vd is applied for the entire brain to calculate CBF. Our purpose was to evaluate regional differences in Vd in the human brain, or possible effects of regional differences in Vd on CBF calculated by the ARG method. METHODS:In the present study, two SPECT scans were acquired from each of eight normal subjects (aged 44.0 +/- 16.7) at 40 min and 180 min of mid-scan-time after intravenous 1 min infusion of 111 MBq IMP. A single arterial blood sampling was performed 10 min after the IMP infusion. All images were anatomically normalized and analyzed with SPM99 and Matlab. We generated CBF and Vd images for each subject by the TLU method and evaluated differences in Vd among brain structures. We subsequently generated another set of CBF images by the ARG method and examined differences between CBF calculated by the TLU method and that by the ARG method. RESULTS:Significant main effects of subject and brain structure in Vd were observed (two-way ANOVA). Vd values were higher in the deep gray matter than in the cerebral cortical regions. Among the cerebral cortical regions, no significant difference in Vd was observed. In spite of the significant differences in Vd among the brain structures, the voxel-by-voxel analyses as well as the ROI analyses revealed no statistically significant difference between CBF calculated by the TLU method and that by the ARG method. CONCLUSIONS:Although regional differences in Vd were observed, the present results support the assumption that a fixed Vd does not cause significant error in the calculation of CBF by the ARG method.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Inoue K,Ito H,Nakagawa M,Goto R,Yamazaki T,Fukuda Hdoi
10.1007/BF02988615subject
Has Abstractpub_date
2002-07-01 00:00:00pages
311-6issue
5eissn
0914-7187issn
1864-6433journal_volume
16pub_type
临床试验,杂志文章abstract:OBJECTIVE:Image segmentation is an essential step in quantifying the extent of reduced or absent lung function. The aim of this study is to develop and validate a new tool for automatic segmentation of lungs in ventilation and perfusion SPECT images and compare automatic and manual SPECT lung segmentations with referen...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1223-y
更新日期:2018-02-01 00:00:00
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journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-007-0112-1
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abstract:OBJECTIVES:Nowadays, the number of primary studies on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has been increasing rapidly. Thus, we updated meta-analysis to evaluate the test performance of FDG PET/CT for nodal staging in non-small cell lung cancer (NSCLC) including the most r...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,meta分析
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journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-1015-1
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abstract:OBJECTIVE:While high-energy gamma and beta probes have gained considerable attention due to their ability to detect cancerous lesions using (18)F-FDG in humans intraoperatively, it is unknown whether the sensitivity of such probes would allow the detection of remaining tumor tissue in the resection bed after removal of...
journal_title:Annals of nuclear medicine
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doi:10.1007/s12149-011-0492-0
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abstract:OBJECTIVES:Breast cancer is the most common malignancy for females worldwide. This study was to evaluate the application of dual-phase breast-specific gamma imaging (BSGI) in detecting primary breast cancer. METHODS:Seventy-six patients with indeterminate breast lesions that underwent dual-phase BSGI enrolled in this ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0776-7
更新日期:2014-01-01 00:00:00
abstract::Nerve growth factor (NGF) exerts various actions on neuronal and non-neuronal tissues and has potential therapeutic utility, but difficulties in using the whole protein have stimulated interest in small NGF fragments. We radioiodinated a small cyclic peptide derived from NGF using the Bolton-Hunter method [125I-C(92-9...
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s12149-020-01551-x
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journal_title:Annals of nuclear medicine
pub_type: 杂志文章
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journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
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journal_title:Annals of nuclear medicine
pub_type: 杂志文章
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更新日期:1991-03-01 00:00:00
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journal_title:Annals of nuclear medicine
pub_type: 杂志文章
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更新日期:1996-08-01 00:00:00
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journal_title:Annals of nuclear medicine
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pub_type: 杂志文章,评审
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journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02984657
更新日期:2006-11-01 00:00:00
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journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-007-0064-5
更新日期:2007-12-01 00:00:00
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journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
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journal_title:Annals of nuclear medicine
pub_type: 杂志文章
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更新日期:1997-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s12149-007-0096-x
更新日期:2008-04-01 00:00:00
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更新日期:2008-11-01 00:00:00