Abstract:
BACKGROUND:The use of intravenous immunoglobulin (IVIG) is well established as an initial therapy for Kawasaki disease (KD), but treatment for IVIG-resistant KD remains uncertain AIM:To analyse the effects of intravenous methylprednisolone (IVMP) pulse therapy compared with additional IVIG in IVIG-resistant patients. METHODS:IVMP was administered to patients with KD who had persistent or recurrent fever after a single dose of IVIG, at Juntendo University Hospital and affiliated medical institutions between May 2003 and March 2006. The effectiveness of the treatment and the incidence of coronary lesions in patients who received IVMP and those who received additional IVIG were retrospectively analysed and compared by chart review. RESULTS:411 patients with KD were treated with a single dose of IVIG. Of the 63 IVIG-resistant patients, 44 were then given IVMP and 19 were given additional IVIG. Treatment was successful in 34 (77%) of the patients who received IVMP and 12 (63%) who received additional IVIG. Five of the 10 patients who did not respond to IVMP and two of the seven who did not respond to additional IVIG developed coronary artery aneurysms. Although fever initially resolved faster in the IVMP-resistant group, there was a delay in fever recurrence, which ultimately delayed the final resolution of fever. CONCLUSIONS:The findings suggest that IVMP is an effective additional treatment for IVIG-resistant KD. However, there was a tendency for fever to recur later in IVMP-resistant patients, which could potentially delay the therapeutic decision-making process.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Furukawa T,Kishiro M,Akimoto K,Nagata S,Shimizu T,Yamashiro Ydoi
10.1136/adc.2007.126144subject
Has Abstractpub_date
2008-02-01 00:00:00pages
142-6issue
2eissn
0003-9888issn
1468-2044pii
adc.2007.126144journal_volume
93pub_type
杂志文章abstract:OBJECTIVE:To determine how many children are admitted to paediatric intensive care unit (PICU) with life-limiting conditions (LLCs) and their outcomes. DESIGN:National cohort, data-linkage study. SETTING:PICUs in England. PATIENTS:Children admitted to a UK PICU (1 January 2004 and 31 March 2015) were identified in t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-312638
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Children with type 1 diabetes should be encouraged to participate in physical activity because exercise can benefit insulin sensitivity and improve known risk factors for atherosclerosis. METHODS:Physical activity patterns of 127 children and adolescents with stable type 1 diabetes were investigated by 24 h...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.075283
更新日期:2005-12-01 00:00:00
abstract:AIMS:To pilot a novel approach to providing pharmaceutical care to paediatric inpatients using structured referral and assessment tools. Using standardised referral criteria to ensure patients are assessed by appropriately skilled pharmacists. METHOD:Three wards of varying acuity and specialism were selected in a tert...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-311535.4
更新日期:2016-09-01 00:00:00
abstract:AIMS:To investigate the differences in perception of quality of life between parents of chronically ill children and paediatricians at diagnosis and follow up. Quality of life was assessed using the (HUI3). METHODS:Longitudinal study (July 1999-January 2002) of 37 paediatricians and 181 parents of patients (children a...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.051722
更新日期:2005-05-01 00:00:00
abstract::Concerns have been expressed in recent years about the decline in children's clinical and biomedical research in the UK, and in the paediatric academic workforce. Here I consider the extent to which these concerns are justified, the sweeping changes that have taken place in research funding, governance and organisatio...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.178160
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To determine current use of vitamin K (VK) prophylaxis in newborns and review the efficacy and effectiveness of regimens used. DESIGN:Efficacy and effectiveness calculated using current practice details, data from Southern Ireland and two previous surveys, together with contemporaneous studies of vitamin K d...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2006.105304
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Studies have shown a correlation between increased accident rates and levels of deprivation in the community. School accident reporting is one area where an association might be expected. AIMS:To investigate differences in primary school accident rates in deprived and more affluent wards, in an area managed...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.86.2.91
更新日期:2002-02-01 00:00:00
abstract::Altogether 38 postpubertal children with coeliac disease were rebiopsied. Mucosal abnormality in nine (24%) of them indicated poor adherence to the diet. Gluten challenge with a diet containing a normal amount of gluten was performed in those 29 patients with a normal mucosa. During challenge, rebiopsy was done when r...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.11.1604
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine the glycaemic profile of patients with cystic fibrosis using a continuous glucose monitoring system (CGMS), and to evaluate the associations of glycaemic abnormalities with sex, age, pubertal stage, CFTR gene mutations, nutritional status, lung function, oral glucose tolerance te...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-314250
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:Moderately preterm children (gestational age 32-36+6 weeks) are at risk of cognitive and behaviour problems at school age. The aim of this study was to investigate if these problems are already present at the age of 2 years. STUDY DESIGN:Developmental outcome was assessed at 24-months (corrected age) with th...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2014-307016
更新日期:2015-06-01 00:00:00
abstract::In a prospective follow up of 116 high risk infants, a 24 hour behavioural chart on seven consecutive days was analysed at seven and 12 weeks of age. Of children who manifested atopic disease at 2 years, 44/116 (38%), had shown significantly more fussing during the seventh, and colic type cry during the twelfth week t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.84.4.349
更新日期:2001-04-01 00:00:00
abstract::The communication development in 11 children with Angelman's syndrome is described. The clinical observation that these children appear to have a greater ability with receptive rather than expressive language is investigated and these skills assessed using published communication schedules. In addition the understandi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.1.148
更新日期:1993-07-01 00:00:00
abstract:AIM:In paediatrics drugs are prescribed as mg/kg doses to facilitate accurate dosing. Anecdotally, some drugs are prescribed in such a way that the volume to be given is difficult to measure which may lead to inaccuracies and potential for error. Locally, errors have been reported where there has been a misunderstandin...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-311535.21
更新日期:2016-09-01 00:00:00
abstract:AIMS:To test the hypothesis that oxygen free radicals are mediators of excessive protein permeability in steroid responsive nephrotic syndrome. DESIGN:Case control study. SUBJECTS: PATIENTS:20 children with steroid responsive nephrotic syndrome; controls: 20 children admitted for elective surgery. SETTING:The paedi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.82.1.76
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:Poor condition at birth may impact on IQ, although its effect on other measures of neurodevelopment is unclear. The authors' aim was to determine whether infants receiving resuscitation after birth have reduced scores in measures of attention, memory and language skills or the need for educational support at ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2009.176065
更新日期:2011-01-01 00:00:00
abstract::A standard acid resistant microsphere pancreatic enzyme preparation was compared with identical capsules half filled with mini-tablets of a new high lipase preparation in a randomised double blind crossover study in children with cystic fibrosis. Each patient received his/her usual number of capsules and the same dose...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.68.2.227
更新日期:1993-02-01 00:00:00
abstract::The management of neonatal jaundice can be made much easier using simple methods that increase the radiant energy in the range 420 to 480 nm. Two groups of infants being treated for physiological jaundice during a period of 6 months were compared. The first group received treatment from two unmodified phototherapy uni...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.6.406
更新日期:1983-06-01 00:00:00
abstract:OBJECTIVE:To investigate possible renal toxicity of long-term gentamicin inhalation in patients with cystic fibrosis. METHODS:Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity was measured during routine respiratory clinic visits. Outpatient records were reviewed for data on long-term gentamicin inhalation, and p...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.6.540
更新日期:1998-06-01 00:00:00
abstract::A presenting sample of 127 consecutive referrals to a community based enuresis clinic were evaluated after treatment with baseline behavioural recording and the enuresis alarm. Almost one in five became dry after baseline recording only while 81 of 96 (84%) enuretics who used the alarm achieved the initial dryness cri...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.65.10.1158
更新日期:1990-10-01 00:00:00
abstract::Two neonates with spontaneous rupture of the bladder and an otherwise normal genitourinary tract are described. Conservative management resulted in complete resolution of the lesion in one but the other child died from a coliform septicaemia. Necropsy showed a discrete ischaemic lesion in the fundus of the bladder. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.7.676
更新日期:1985-07-01 00:00:00
abstract::Two patients with raised intracranial pressure responding to ventriculoperitoneal shunting are described in whom ultrasound failed to show dilated ventricles. The importance of not equating absence of ventricular dilatation with normal pressure and ventricular dilatation with high pressure is emphasised. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.6.581
更新日期:1985-06-01 00:00:00
abstract::Thirty seven healthy infants (18 born at full term and 19 preterm) were studied serially with cross sectional and Doppler echocardiography to compare their postnatal circulatory adaptation. Pulmonary artery pressure was assessed by its inverse relationship with the ratio of pulmonary artery time to peak velocity and r...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.1_spec_no.24
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:Risk of childhood asthma is increased in children with recurrent otitis media. This may be associated with recurrent respiratory tract infections in these children, but the role of adenoidectomy, a frequent operation during childhood, is unknown. Therefore, the role of adenoidectomy in the development of atop...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,随机对照试验
doi:10.1136/adc.2008.145664
更新日期:2009-05-01 00:00:00
abstract::Samples of saliva and nasal secretions were collected sequentially from 15 breast fed and 15 bottle fed infants on five occasions between 6 days and 9 months of age. Total immunoglobulin concentrations of G, M, and A classes, and class specific antibodies to tetanus toxoid and a pool of commensal strains of Escherichi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.3.263
更新日期:1986-03-01 00:00:00
abstract:AIMS:To document gastroenteritis hospitalisations of the 1995-96 cohort of infants born in Western Australia to mid-2002, and to assess factors associated with their hospitalisations and readmissions. METHODS:Retrospective analysis of the State's hospitalisation data, Midwives' Notification of Births data, the Austral...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2003.037531
更新日期:2004-08-01 00:00:00
abstract::Metabolites of vitamin D were measured in plasma from 83 patients with idiopathic infantile hypercalcaemia syndrome who were mentally handicapped but had normal calcium values at the time of the study. No significant difference was detected in the mean plasma concentrations of 25-hydroxyvitamin D2, 1,25-dihydroxyvitam...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.12.1140
更新日期:1985-12-01 00:00:00
abstract::Plasma testosterone was estimated by radioimmunoassay in 60 children with disorders of sexual development before and after stimulation with human chorionic gonadotrophin (HCG). In 21 children the testosterone levels after 3 and 5 daily injections of 1000 units HCG were compared and good correlation was found between t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.8.596
更新日期:1976-08-01 00:00:00
abstract:INTRODUCTION:Despite immunisation, antibiotics and intensive care management, infection with Streptococcus pneumoniae remains a major cause of morbidity and mortality in children. The WHO currently recommends vaccinating infants with either a 3+0 schedule (6 weeks, 3-4 and 4-6 months of age) or 2+1 schedule (2 doses be...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,随机对照试验
doi:10.1136/archdischild-2018-316254
更新日期:2019-07-01 00:00:00
abstract:AIMS:To determine the prevalence of hypovitaminosis D among healthy adolescent schoolgirls attending an inner city multiethnic girls' school. METHODS:Fifty one (28%) of 182 girls (14 white, 37 non-white; median age 15.3 years, range 14.7-16.6) took part in the study. Biochemical parameters, dietary vitamin D intake, m...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.077974
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:There are no objective ambulatory studies on the temporal relationship between reflux and cough in children. Commercial pHmetry loggers have slow capture rates (0.25 Hz) that limit objective quantification of reflux and cough. The authors aimed to evaluate if there is a temporal association between cough and ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.177733
更新日期:2011-05-01 00:00:00