Emergence of increasing linezolid-resistance in enterococci in a post-outbreak situation with vancomycin-resistant Enterococcus faecium.

Abstract:

:During 2004 and at the start of 2005 a university hospital in Southwest Germany was affected by an extensive outbreak of vancomycin-resistant Enterococcus faecium (VRE). Although the outbreak was contained, linezolid-resistant enterococci emerged during and after the outbreak as the usage of linezolid became more common. Linezolid resistance was no longer limited to VRE. Nosocomial spread of linezolid-resistant but vancomycin-susceptible E. faecium was detected and these strains also emerged in patients without prior drug exposure. Linezolid should therefore be used with caution and the susceptibility of isolates monitored over time. Isolation precautions and screening of contacts should be considered to avoid spread of resistant isolates.

journal_name

Epidemiol Infect

authors

Schulte B,Heininger A,Autenrieth IB,Wolz C

doi

10.1017/S0950268807009508

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

1131-3

issue

8

eissn

0950-2688

issn

1469-4409

pii

S0950268807009508

journal_volume

136

pub_type

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