A longitudinal household study of Streptococcus pneumoniae nasopharyngeal carriage in a UK setting.

Abstract:

:A 10-month longitudinal household study of pre-school children and their families was undertaken with monthly visits collecting epidemiological data and nasopharyngeal swabs in Hertfordshire, England from 2001 to 2002. Pneumococcal culture was with standard methods. In total, 121 families (489 individuals) took part. Mean prevalence of carriage ranged from 52% for age groups 0-2 years, 45% for 3-4 years, 21% for 5-17 years and 8% for >or=18 years. Carriage occurred more than once in 86% of children aged 0-2 years compared to 36% of those aged >or=18 years. The most prevalent serotypes in the 0-2 years age group were 6B followed by 19F, 23F, 6A and 14. Young children were responsible for the majority of introductions of new serotypes into a household. Erythromycin resistance (alone or in combination) occurred in 10% of samples and penicillin non-susceptibility in 3.7%. Overall the recently licensed 7-valent conjugate vaccine (PCV) would protect against 64% of serotypes with no intra-serogroup cross protection and 82% with such protection. Nasopharyngeal carriage of S. pneumoniae is common in a UK setting in the pre-conjugate vaccine era. PCV would protect against a large proportion of carriage isolates. However, the impact of vaccination on non-vaccine serotypes will need to be monitored.

journal_name

Epidemiol Infect

authors

Hussain M,Melegaro A,Pebody RG,George R,Edmunds WJ,Talukdar R,Martin SA,Efstratiou A,Miller E

doi

10.1017/S0950268805004012

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

891-8

issue

5

eissn

0950-2688

issn

1469-4409

pii

S0950268805004012

journal_volume

133

pub_type

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