From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs.

abstract：:Powerful advances in neuroimaging techniques have added to and refined classical descriptions of the neurobiology of language in adults. Recent studies have employed these methodologies to study the nature and extent of plasticity of language-relevant aspects of cerebral organization in adults, in early and late bilin...

journal_title：Current opinion in neurobiology

authors： Neville HJ,Bavelier D

更新日期：1998-04-01 00:00:00

abstract：:Computational models of reinforcement learning (RL) strive to produce behavior that maximises reward, and thus allow software or robots to behave adaptively [1]. At the core of RL models is a learned mapping between 'states'-situations or contexts that an agent might encounter in the world-and actions. A wealth of phy...

journal_title：Current opinion in neurobiology

authors： Lau B,Monteiro T,Paton JJ

更新日期：2017-10-01 00:00:00

abstract：:Neurons utilize mRNA transport and local translation as a means to influence development and plasticity. The molecular mechanisms for this mRNA sorting involve the recognition of cis-acting sequences by distinct mRNA binding proteins that have a dual role, acting in both mRNA transport and translational regulation. Ot...

journal_title：Current opinion in neurobiology

authors： Bassell GJ,Kelic S

更新日期：2004-10-01 00:00:00

abstract：:The ability to make accurate predictions of future stimuli and consequences of one's actions are crucial for the survival and appropriate decision-making. These predictions are constantly being made at different levels of the nervous system. This is evidenced by adaptation to stimulus parameters in sensory coding, and...

journal_title：Current opinion in neurobiology

authors： Sharpee TO,Calhoun AJ,Chalasani SH

更新日期：2014-04-01 00:00:00

abstract：:Recent results have shown the possibility of both reconstructing connectomes of small but biologically interesting circuits and extracting from these connectomes insights into their function. However, these reconstructions were heroic proof-of-concept experiments, requiring person-months of effort per neuron reconstru...

journal_title：Current opinion in neurobiology

authors： Plaza SM,Scheffer LK,Chklovskii DB

更新日期：2014-04-01 00:00:00

abstract：:The precise causal factors for obsessive-compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive-repetitive behaviors. Recent progress in...

journal_title：Current opinion in neurobiology

authors： Ting JT,Feng G

更新日期：2011-12-01 00:00:00

abstract：:Metabotropic L-glutamate receptors are involved in various forms of synaptic plasticity in the hippocampus. The use of a new antagonist (LY341495) that blocks all known metabotropic L-glutamate receptors in the brain, together with subtype-selective antagonists, has identified multiple roles both for cloned and novel ...

journal_title：Current opinion in neurobiology

authors： Bortolotto ZA,Fitzjohn SM,Collingridge GL

更新日期：1999-06-01 00:00:00

abstract：:The gastrointestinal tract is innervated by its own enteric nervous system and by extrinsic neurons that connect it with the central nervous system. Innervation allows the gastrointestinal tract to sense and respond to diverse stimuli, adjusting motility and secretion, but also affecting our physiology, behaviour and ...

journal_title：Current opinion in neurobiology

authors： Ameku T,Beckwith H,Blackie L,Miguel-Aliaga I

更新日期：2020-06-01 00:00:00

abstract：:Databases of consistent, directed- and weighted inter-areal connectivity for mouse, macaque and marmoset monkeys have recently become available and begun to be used to build structural and dynamical models. A structural hierarchy can be defined based by laminar patterns of cortical connections. A large-scale dynamical...

journal_title：Current opinion in neurobiology

authors： Wang XJ,Pereira U,Rosa MG,Kennedy H

更新日期：2020-12-01 00:00:00

abstract：:Molecular mechanisms involved in the various stages of transmitter secretion have been studied by perturbing the composition of secretory cells using pharmacological and biochemical agents. An emerging approach is to reconstitute individual steps or the entire sequence of secretion mechanisms in non-secretory cells by...

journal_title：Current opinion in neurobiology

authors： Alder J,Poo MM

更新日期：1993-06-01 00:00:00

abstract：:Recent studies have provided new insights into the role of presynaptic ligand-gated ion channels in modifying synaptic transmission. Along with a growing list of different types of presynaptic ionotropic receptors and the cell types that express them, there have been advances in characterizing the molecular components...

journal_title：Current opinion in neurobiology

authors： McGehee DS,Role LW

更新日期：1996-06-01 00:00:00

abstract：:The fruit fly, Drosophila melanogaster, is equipped with a sophisticated olfactory sensory system that permits it to recognize and discriminate hundreds of discrete odorants. The perception of these odorants is essential for the animal to identify relevant food sources and suitable sites for egg-laying. Advances in th...

journal_title：Current opinion in neurobiology

authors： Vosshall LB

更新日期：2000-08-01 00:00:00

abstract：:Tight control of developmental timing is pivotal to many major processes in developmental biology, such as patterning, fate specification, cell cycle dynamics, cell migration and connectivity. Temporal change in these ontogenetic sequences is known as heterochrony, a major force in the evolution of body plans and orga...

journal_title：Current opinion in neurobiology

authors： Bielen H,Pal S,Tole S,Houart C

更新日期：2017-02-01 00:00:00

abstract：:Neurons have a multiplicity of ionic conductance mechanisms, the interactions of which determine in part the response of a neuron to chemical and electrical synaptic interactions, firing patterns, excitability, membrane potential and action-potential waveform. Several papers published in the past year have provided im...

journal_title：Current opinion in neurobiology

authors： Baxter DA,Byrne JH

更新日期：1991-06-01 00:00:00

abstract：:Recent progress in our understanding of the trafficking of potassium channels can be seen in particular when considering the Kv-type channels. To date, we have discovered that folding of the Kv1.3 T1 domain begins in the ribosomal exit tunnel, and that the cell surface expression of Kv4 channels is enhanced by the pre...

journal_title：Current opinion in neurobiology

authors： Heusser K,Schwappach B

更新日期：2005-06-01 00:00:00

abstract：:Depression, conceptualized as major depressive disorder (MDD), is a complex psychiatric disorder with multiple behavioral changes and alterations in various brain regions. Biochemically, serotonin and others substances like GABA, glutamate, norepinephrin, adrenaline/noradrenaline play an essential role in the pathogen...

journal_title：Current opinion in neurobiology

authors： Northoff G

更新日期：2013-02-01 00:00:00

abstract：:Schizophrenia remains a daunting challenge for efforts aimed at identifying fundamental pathophysiological processes and to develop evidence-based effective treatments and interventions. One reason for the lack of progress lies in the fact that the pathophysiology of schizophrenia has been predominantly conceived in t...

journal_title：Current opinion in neurobiology

authors： Uhlhaas PJ

更新日期：2013-04-01 00:00:00

abstract：:Neocortex expansion in development and evolution reflects an increased and prolonged activity of neural progenitor cells. Insight into key aspects of the underlying cell biology has recently been obtained. First, the restriction of apical progenitors to undergo mitosis at the ventricular surface is overcome by generat...

journal_title：Current opinion in neurobiology

authors： Wilsch-Bräuninger M,Florio M,Huttner WB

更新日期：2016-08-01 00:00:00

abstract：:For most neurons to function properly, they need to develop synaptic specificity. This requires finding specific partner neurons, building the correct types of synapses, and fine-tuning these synapses in response to neural activity. Synaptic specificity is common at both a neuron's input and output synapses, whereby u...

journal_title：Current opinion in neurobiology

authors： Rawson RL,Martin EA,Williams ME

更新日期：2017-08-01 00:00:00

abstract：:Schizophrenia is a disorder of cognitive neurodevelopment. At least some of the core cognitive deficits of the illness appear to be the product of impaired gamma frequency oscillations which depend, in part, on the inhibitory actions of a subpopulation of cortical GABA neurons that express the calcium binding protein ...

journal_title：Current opinion in neurobiology

authors： Lewis DA

更新日期：2014-06-01 00:00:00

abstract：:'Auditory scenes' often contain contributions from multiple acoustic sources. These are usually heard as separate auditory 'streams', which can be selectively followed over time. How and where these auditory streams are formed in the auditory system is one of the most fascinating questions facing auditory scientists t...

journal_title：Current opinion in neurobiology

authors： Shamma SA,Micheyl C

更新日期：2010-06-01 00:00:00

abstract：:Most high-level sensory neurons have complex, nonlinear response properties; a comprehensive characterization of these properties remains a formidable challenge. Recent studies using complex sensory stimuli combined with linear and nonlinear analyses have provided new insights into the neuronal response properties in ...

journal_title：Current opinion in neurobiology

authors： Touryan J,Dan Y

更新日期：2001-08-01 00:00:00

abstract：:Discoveries in modern human neuroscience are increasingly driven by quantitative understanding of complex data. Data-intensive approaches to modeling have promise to dramatically advance our understanding of the brain and critically enable neuroengineering capabilities. In this review, we provide an accessible primer ...

journal_title：Current opinion in neurobiology

authors： Brunton BW,Beyeler M

更新日期：2019-10-01 00:00:00

abstract：:Human children benefit from a possibly unique set of adaptations facilitating the acquisition of knowledge about material culture. They represent artifacts (human-made objects) as tools with specific functions and seek for functional information about novel objects. Even young infants pay attention to functionally rel...

journal_title：Current opinion in neurobiology

authors： Hernik M,Csibra G

更新日期：2009-02-01 00:00:00

abstract：:Plasma membrane Cl- channels perform a variety of functions, including control of excitability in neurons and muscle, cell volume regulation and transepithelial transport. Structurally, three classes of Cl- channels have been identified: ligand-gated, postsynaptic Cl- channels (e.g. GABA and glycine receptors); the cy...

journal_title：Current opinion in neurobiology

authors： Jentsch TJ

更新日期：1996-06-01 00:00:00

abstract：:Of the few animal groups that learn their vocalizations, songbirds are uniquely amenable to molecular, physiological, and behavioral analyses of the neural features responsible for vocal learning. In order to communicate effectively as an adult, a young songbird recognizes and memorizes a model of his species-specific...

journal_title：Current opinion in neurobiology

authors： White SA

更新日期：2001-08-01 00:00:00

abstract：:GABAergic interneurons in the hippocampus coordinate neuronal activity that gives rise to network oscillations. In this article we present advances in our understanding of how different classes of hippocampal interneurons contribute to distinct hippocampal network oscillations. We focus on two main experimental approa...

journal_title：Current opinion in neurobiology

authors： Allen K,Monyer H

更新日期：2015-04-01 00:00:00

abstract：:Growth cones, the highly motile tips of growing axons, guide axons to their targets by responding to molecular cues. Growth cone behaviors such as advancing, retracting, turning and branching are driven by the dynamics and reorganization of the actin and microtubule cytoskeleton through signaling pathways linked to gu...

journal_title：Current opinion in neurobiology

authors： Kalil K,Dent EW

更新日期：2005-10-01 00:00:00

abstract：:Selective transport of transmembrane proteins to different intracellular compartments often involves the recognition of sorting signals in the cytosolic domains of the proteins by components of membrane coats. Some of these coats have as their key components a family of heterotetrameric adaptor protein (AP) complexes ...

journal_title：Current opinion in neurobiology

authors： Guardia CM,De Pace R,Mattera R,Bonifacino JS

更新日期：2018-08-01 00:00:00

abstract：:Recent experiments on the retina have examined the effectiveness of various factors (e.g. growth factors, neurotrophins and cytokines) for enhancing survival and reducing injury of retinal neurons, such as photoreceptors and ganglion cells, whose death leads to blindness in degenerative retinal diseases. It has also b...

journal_title：Current opinion in neurobiology

authors： Steinberg RH

更新日期：1994-08-01 00:00:00