Ex vivo triggering of T-cell-mediated immune responses by autologous tumor cell vaccine in oral cancer patients.

abstract：:To determine how estrogen exacerbates allergies, the effects of 17beta-estradiol (E2) on lymphocyte proliferation were investigated. BALB/c mice were ovariectomized, administered 3.2 microg E2, and sensitized with 50 microL 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one. After 7 days, their spleens were excised and flow ...

journal_title：Immunopharmacology and immunotoxicology

authors： Sakazaki F,Ueno H,Nakamuro K

更新日期：2010-06-01 00:00:00

abstract：:A competitive enzyme-linked immunosorbent assay (ELISA) with generated mouse anti-consensus interferon (CIFN) antibody was developed for quantitative determination of pegylated consensus interferon (PEG-CIFN) in rhesus monkey serum. The operational concentrations of the original assay were determined using the chessbo...

journal_title：Immunopharmacology and immunotoxicology

authors： Cao J,Du Y,Tian H,Gao XD,Yao WB

更新日期：2009-01-01 00:00:00

abstract：:Ethanol has been recognized as an immunosuppressive agent for many years. Effects of high levels of ethanol consumption on immune functions have been extensively studied, but little is known about the effects of low levels (scuh as 5% ethanol) of ethanol consumption. Herein we report that exposure of mice to 5% ethano...

journal_title：Immunopharmacology and immunotoxicology

authors： Guo TL,Zhang LX,Chen JP,Nguyen VA,White KL Jr,Gao B

更新日期：2002-02-01 00:00:00

abstract：:Many flavonoids were demonstrated to possess the antiallergic effect. Here we detected whether apigenin, a flavonoid, can attenuate allergen-induced airway inflammation and what is the possible mechanism in a murine model of asthma. Apigenin decreased the degree of the inflammatory cell infiltration, airway hyperrespo...

journal_title：Immunopharmacology and immunotoxicology

authors： Li RR,Pang LL,Du Q,Shi Y,Dai WJ,Yin KS

更新日期：2010-09-01 00:00:00

abstract：:We previously showed that formation of pulmonary granulomas in mice in response to a mycobacterial glycolipid, trehalose 6,6'-dimycolate (TDM) is due to the action of TNF-α and not of IFN-γ. However, the mechanisms of formation and maintenance of pulmonary granulomas are not yet clear. The purpose of the present study...

journal_title：Immunopharmacology and immunotoxicology

authors： Saitoh T,Yano I,Kumazawa Y,Takimoto H

更新日期：2012-10-01 00:00:00

abstract：:The induction of T-cell responses involves the recognition of extrinsic antigens in association with antigens of the major histocompatibility complex (MHC). The present results demonstrate that the lateralized control exerted by the brain neocortex on T-cell activities extends to the expression of MHC antigens, yet di...

journal_title：Immunopharmacology and immunotoxicology

authors： Renoux G,Renoux M,Bizière K

更新日期：1988-01-01 00:00:00

abstract：:Vasoactive intestinal polypeptide (VIP) has been shown to stimulate adenylate cyclase in a human lymphoblast cell line (MOLT 4). In the present study, we monitored fluorescence in cell suspensions and in single fura-2 loaded MOLT 4 lymphoblasts to determine if VIP modulates intracellular calcium concentrations ([Ca2+]...

journal_title：Immunopharmacology and immunotoxicology

authors： Anton PA,Shanahan F,Sun XP,Diehl D,Kodner A,Mayer EA

更新日期：1993-08-01 00:00:00

abstract：:Accumulating evidence has suggested that hydrogen sulfide (H(2)S) is endogenously generated in many types of mammalian cells. Since H(2)S plays an important role in cardiovascular, central nervous and gastrointestinal systems, it is currently considered to be the third gaseous mediator. Recently, more and more attenti...

journal_title：Immunopharmacology and immunotoxicology

authors： Zhang H,Bhatia M

更新日期：2008-01-01 00:00:00

abstract：:A substantial body of research exists to support the production of growth hormone by cells of the immune system. However, the function and mechanism of action of lymphocyte-derived growth hormone remain largely unelucidated. Since, it has been found that exogenous growth hormone (GH) primes neutrophils for the product...

journal_title：Immunopharmacology and immunotoxicology

authors： Arnold RE,Weigent DA

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Capsaicin is a chili pepper extract with multiple therapeutic properties including anti-liver fibrosis. However, the paucity of its underlying mechanisms limited its widely clinical application. METHODS:In the present study, carbon tetrachloride (CCl4) was used to induce liver fibrosis in mice, and transfor...

journal_title：Immunopharmacology and immunotoxicology

authors： Sheng J,Zhang B,Chen Y,Yu F

更新日期：2020-12-01 00:00:00

abstract：:The aim of the present study was to investigate putative mechanisms implicated in the impaired phagocytic response of spontaneously hypertensive rats (SHR)1. The effect of in vitro treatment with isoproterenol (ISO), a beta-adrenergic drug, on phagocytosis and respiratory burst by splenic macrophages (SpMø) from normo...

journal_title：Immunopharmacology and immunotoxicology

authors： Serio M,Potenza MA,Montagnani M,Mansi G,Mitolo-Chieppa D,Jirillo E

更新日期：1996-05-01 00:00:00

abstract：:Modulation of immune response to alleviate diseases has long since been of interest. Plant extracts have been widely investigated for their possible immunomodulatory properties. We have evaluated the immunomodulatory activity of aqueous extract of Rhodiola rhizome in human peripheral blood mononuclear cells (PBMCs) an...

journal_title：Immunopharmacology and immunotoxicology

authors： Mishra KP,Padwad YS,Jain M,Karan D,Ganju L,Sawhney RC

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To establish the clearance of cervical human papillomavirus (HPV) infection following postoperative immunotherapy with inosine pranobex in women receiving surgical treatment of established high-grade squamous intraepithelial lesion (HSIL) of the uterine cervix. MATERIALS AND METHODS:Over the six-year study p...

journal_title：Immunopharmacology and immunotoxicology

authors： Kovachev SM

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:To explore the effect and mechanism of artesunate on γδ T cell-mediated antitumor immune responses against hepatoma carcinoma cells (HepG2) in vitro. METHODS:Human γδ T cells or HepG2 were respectively treated with artesunate, subjected to co-culture as appropriate, and the following assays were subsequently...

journal_title：Immunopharmacology and immunotoxicology

authors： Qian P,Zhang YW,Zhou ZH,Liu JQ,Yue SY,Guo XL,Sun LQ,Lv XT,Chen JQ

更新日期：2018-04-01 00:00:00

abstract：:We reported recently that a novel immunomodulator, 7-thia-8-oxoguanosine (7T8OG)2 inhibited formation of pulmonary melanoma metastases (1), prevented against viral infection in mice (2) and potentiated the efficacy of a weakly immunogenic leukemia vaccine (3). Since certain tumor metastases and virus infected cells ar...

journal_title：Immunopharmacology and immunotoxicology

authors： Sharma BS,Mhaskar S,Balazs L,Siaw M

更新日期：1992-01-01 00:00:00

abstract：:Objective: Apigenin is a natural flavonoid compound extracted from Matricaria chamomilla. We evaluated the anti-inflammatory effects of apigenin in this study using the Lipopolysaccharide (LPS)-stimulated BV2 microglia.Methods: BV2 cells were treated with apigenin for 1 h and then treated with LPS. The inflammatory cy...

journal_title：Immunopharmacology and immunotoxicology

authors： Chen P,Huo X,Liu W,Li K,Sun Z,Tian J

更新日期：2020-02-01 00:00:00

abstract：:We studied the effect of pyridoxine deficiency state on the responses of human lymphocytes to certain mitogenic factors. Deoxypyridoxine (DB6), a potent pyridoxine antagonist, considerably inhibited Bromodeoxyuridine (BrdU) incorporation into the newly synthesized DNA of lymphocytes cultured with Phytohemagglutinin (P...

journal_title：Immunopharmacology and immunotoxicology

authors： Scountzou J,Malisiovas N,Antoniadis A,Trakatellis A

更新日期：1989-01-01 00:00:00

abstract：:Objective: The present study aimed to investigate whether recombinant human erythropoietin (rHuEPO) plays an immunomodulatory function by regulating the TLR4/NF-κB signaling pathway.Materials and methods: C57BL/6 mice were intraperitoneally injected with rHuEPO and, half an hour later, with 50% glycerol at the dose of...

journal_title：Immunopharmacology and immunotoxicology

authors： Zhou J,Bai Y,Jiang Y,Tarun P,Feng Y,Huang R,Fu P

更新日期：2020-02-01 00:00:00

abstract：:Protective effect of a Japanese traditional herbal medicine, Juzen-taiho-to (TJ-48), which was recently reported to augment host-mediated antifungal actions, in Candida albicans-infected mice was further studied. TJ-48, given orally once daily for 5 consecutive days in a dose of 2 g/kg after intravenous infection of C...

journal_title：Immunopharmacology and immunotoxicology

authors： Akagawa G,Abe S,Tansho S,Uchida K,Yamaguchi H

更新日期：1996-02-01 00:00:00

abstract：:Spleen and thymus weight, delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC), contact hypersensitivity to picryl chloride, anti-sheep red blood cell hemagglutinin titers and plaque-forming cells (PFC), resistance against experimental toxoplasmosis as well as serum total and intestinal specific IgA wer...

journal_title：Immunopharmacology and immunotoxicology

authors： Brouland JP,Perriat A,Revillard JP,Descotes J

更新日期：1989-01-01 00:00:00

abstract：:Identifying the regulatory T cells (Tregs) and Th17 cells led to breaking the dichotomy of Th1/Th2 cells axis in immune responses involved in several autoimmune diseases. It is now well known that Tregs and Th17 cells are main orchestra leaders in pathogenesis symphony of autoimmunity. While Tregs are protective cells...

journal_title：Immunopharmacology and immunotoxicology

authors： Jadidi-Niaragh F,Mirshafiey A

更新日期：2012-10-01 00:00:00

abstract：:The effects of anti-thyroid drug, methimazole (MMI), on haematopoiesis in inbred C57BL/6 mice were studied. The in vitro proliferative response of bone marrow (BM) cells to interleukin-3 (IL-3) was significantly increased when mice were provided with 0.1% MMI in water (w/v) ad librium for 4 to 6 weeks. Using soft agar...

journal_title：Immunopharmacology and immunotoxicology

authors： Mak NK,Lai WH,Liu WK,Leung KN,Fung MC

更新日期：1995-11-01 00:00:00

abstract：:Apigenin is a plant flavonoid and a pharmacologically active agent that has been isolated from several plant species. However, the molecular mechanism of apigenin-mediated immune modulation has not been fully understood. One of the possible mechanisms of its protective effects is the down-regulation of inflammatory re...

journal_title：Immunopharmacology and immunotoxicology

authors： Kang OH,Lee JH,Kwon DY

更新日期：2011-09-01 00:00:00

abstract：:Chief part of hemopoietic stromal cells in mediating hemopoiesis-stimulating effects of adamantylamide dipeptide (AdDP), a synthetic immunomodulatory compound, has been determined in a series of combined in vivo/in vitro studies. Indirect stimulatory effect of AdDP on proliferation of hemopoietic progenitor cells for ...

journal_title：Immunopharmacology and immunotoxicology

authors： Vacek A,Hofer M,Weiterová L,Hoferová Z,Pipalová I,Masek K

更新日期：2001-11-01 00:00:00

abstract：:Temporary henna-based tattoos, particularly popular among western tourists holidaying in exotic places, can expose to the risk to develop allergic reactions. Although hypersensitivity to henna is extremely rare, para-phenylenediamine, which is sometimes added to henna to obtain a dark, blackish color, is a frequent co...

journal_title：Immunopharmacology and immunotoxicology

authors： Calogiuri G,Foti C,Bonamonte D,Nettis E,Muratore L,Angelini G

更新日期：2010-12-01 00:00:00

abstract：:The effect that MnCl2 has on murine splenic natural killer (NK) cell activity was investigated in infant (10 days old), pre-weanling (18 days old) and weanling (24 days old) C57BL/6J mice. A single intraperitoneal injection of 10, 20 or 40 micrograms MnCl2/g body weight caused a significant enhancement in NK activity,...

journal_title：Immunopharmacology and immunotoxicology

authors： Smialowicz RJ,Riddle MM,Rogers RR,Luebke RW,Burleson GR

更新日期：1988-01-01 00:00:00

abstract：:The Scrophularia buergeriana (SB) has long been used to treat various diseases an account of its antimicrobial and anti-virus activity. However, it is unclear how SB regulates the immune responses. This study investigated the effect of SB on the production of cytokines in a human T-cell line, MOLT-4 cells, and mouse p...

journal_title：Immunopharmacology and immunotoxicology

authors： Kim SJ,Park JS,Myung NY,Moon PD,Choi IY,An HJ,Kim NH,Na HJ,Kim DH,Kim MC,An NH,Kim IK,Lee JY,Jeong HJ,Um JY,Kim HM,Hong SH

更新日期：2009-06-01 00:00:00

abstract：AIM:To determine the steady state concentration and the pharmacokinetics of Cyclosporine A (CsA) in heart transplant recipients. METHODS:A single dose of 100 mg CsA capsules twice daily was given to five heart transplant recipients of steady state. The concentrations of CsA in plasma were determined by streptavidin pe...

journal_title：Immunopharmacology and immunotoxicology

authors： Jin R,Duan H,Zhao C,Wang Z,Qu F

更新日期：2012-06-01 00:00:00

abstract：:We conducted a comparative study of NK1.1+ cells in spleen and bone marrow and the effects of administration of M-CSF on them. Administration of M-CSF to mice increased the number of NK1.1+ cells in spleen but not in bone marrow. The NK1.1+ cells in spleen (Spl-NK1.1) and bone marrow (BM-NK1.1) were purified by magnet...

journal_title：Immunopharmacology and immunotoxicology

authors： Sakurai T,Misawa E,Yamada M,Hayasawa H,Motoyoshi K

更新日期：2002-11-01 00:00:00

abstract：:Naloxone at concentrations 10(-6) M to 10(-10) M modulated endogenous NK-activity in 11 of 14 samples of human peripheral blood lymphocytes after 18-hour incubation. The dose response usually showed two peaks, which varied with the donor. Enhancement was obtained in 6, suppression in 4, and both effects (depending on ...

journal_title：Immunopharmacology and immunotoxicology

authors： Martin-Kleiner I,Gabrilovac J

更新日期：1993-03-01 00:00:00