17beta-Estradiol increases the number of effector memory CD8+ lymphocytes in mice with contact hypersensitivity and among cultured splenocytes.

Abstract:

:To determine how estrogen exacerbates allergies, the effects of 17beta-estradiol (E2) on lymphocyte proliferation were investigated. BALB/c mice were ovariectomized, administered 3.2 microg E2, and sensitized with 50 microL 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one. After 7 days, their spleens were excised and flow cytometrically analyzed. The CD8(+)CD45RA(-)CCR7(-) cell-to-CD8(+) cell ratio in the spleen was greater in the E2-administered mice than in the controls. Splenocytes were cultured under concanavalin A stimulation, with or without E2. After 4 days, the above ratio was greater in the case of E2-treated splenocytes. E2 increases the number of effector memory CD8(+) lymphocytes during sensitization in contact hypersensitivity.

authors

Sakazaki F,Ueno H,Nakamuro K

doi

10.3109/08923970903229053

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

246-50

issue

2

eissn

0892-3973

issn

1532-2513

journal_volume

32

pub_type

杂志文章
  • HP-NAP ameliorates OXA-induced atopic dermatitis symptoms in mice.

    abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic skin inflammatory disease characterized by disequilibrium between Th1/Th2 lymphocytes. Helicobacter pylori neutrophil-activating protein (HP-NAP) has been reported that it has the potential immunomodulatory effect able to regulate the Th1/Th2 balance. OBJECTIVE:This study...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923973.2020.1806869

    authors: Guo X,Ding C,Lu J,Zhou T,Liang T,Ji Z,Xie P,Liu X,Kang Q

    更新日期:2020-10-01 00:00:00

  • Sensitive detection of two IgG Fc receptors of mouse macrophages by chemiluminescence analysis.

    abstract::Luminol-enhanced chemiluminescence assay was used to detect the surface expression and the consequent activation of receptors (FcRI and FcRII) of murine macrophages (M phi s). When murine IgG2a was used for the specific detection of FcRI and IgG2b for FcRII, a newly established procedure enabled us to detect the activ...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923978909005371

    authors: Majima T,Itoh K,Yatsu J,Yoshie O,Ishida N

    更新日期:1989-01-01 00:00:00

  • Enhancement of lymphocyte proliferation and IL-2 receptor expression by a processed form (GM-1/P) of monosialoganglioside GM-1.

    abstract::In this study we investigated the ability of GM-1/P, a calcium mediated processed form of monosialoganglioside GM-1, of in vivo augmenting mouse T and B-lymphocyte blastogenesis induced by mitogens. We have also determined its effect on IL-2 responsiveness by analyzing the induction of the expression of IL-2 receptor ...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979009019677

    authors: Giuffrida A,Morrone S,Gismondi A,Santoni G,Punturieri A,Velotti F,Cavallo G,Tubaro E,Piccoli M,Frati L

    更新日期:1990-01-01 00:00:00

  • Anti-allergic effects of Sanguisorba officinalis on animal models of allergic reactions.

    abstract::We investigated the effect of aqueous extract of Sanguisorba officinalis L.(Rosaceae) root (SOAE) on the immediate-type allergic reactions in vivo and in vitro. SOAE (0.01 to 1 g/kg) inhibited systemic allergic reaction induced by compound 48/80. When SOAE was employed in a systemic allergic reaction test, the plasma ...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1081/iph-120014729

    authors: Shin TY,Lee KB,Kim SH

    更新日期:2002-08-01 00:00:00

  • Hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity in rats.

    abstract::Objectives: Several studies demonstrated the antioxidant and anti-inflammatory role of melatonin and celecoxib. This study is designed to explore the underlying mechanism of hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity by morphological, and biochemical approaches.Materials...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923973.2020.1746802

    authors: Ullah U,Badshah H,Malik Z,Uddin Z,Alam M,Sarwar S,Aman A,Khan AU,Shah FA

    更新日期:2020-06-01 00:00:00

  • Influence of arecoline on immune system: II. Suppression of thymus-dependent immune responses and parameter of non-specific resistance after short-term exposure.

    abstract::Arecoline, a major alkaloid of arecanut was screened to explore its modulatory influence on cell-mediated immune response in a murine model system. The in vivo and in vitro effects were evaluated at subtoxic concentrations of arecoline. Delayed type hypersensitivity (DTH) reactions to sheep red blood cells (SRBC) were...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979109019706

    authors: Selvan RS,Selvakumaran M,Rao AR

    更新日期:1991-01-01 00:00:00

  • Enhancement of natural killer cell activity and interferon production by manganese in young mice.

    abstract::The effect that MnCl2 has on murine splenic natural killer (NK) cell activity was investigated in infant (10 days old), pre-weanling (18 days old) and weanling (24 days old) C57BL/6J mice. A single intraperitoneal injection of 10, 20 or 40 micrograms MnCl2/g body weight caused a significant enhancement in NK activity,...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923978809014404

    authors: Smialowicz RJ,Riddle MM,Rogers RR,Luebke RW,Burleson GR

    更新日期:1988-01-01 00:00:00

  • VIP modulates intracellular calcium oscillations in human lymphoblasts.

    abstract::Vasoactive intestinal polypeptide (VIP) has been shown to stimulate adenylate cyclase in a human lymphoblast cell line (MOLT 4). In the present study, we monitored fluorescence in cell suspensions and in single fura-2 loaded MOLT 4 lymphoblasts to determine if VIP modulates intracellular calcium concentrations ([Ca2+]...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979309035238

    authors: Anton PA,Shanahan F,Sun XP,Diehl D,Kodner A,Mayer EA

    更新日期:1993-08-01 00:00:00

  • Modulating effects on CD25 and CD71 antigen expression by lectin-stimulated T lymphocytes in the elderly.

    abstract::During the last few years, several observations outline that the impaired T lymphocyte proliferative capacity in the elderly is due to a reduced interleukin 2 (IL-2) release. To further investigate the activation process during lectin stimulation, aged peripheral blood mononuclear cells (PBMC) were stimulated with phy...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979109019693

    authors: Antonaci S,Tortorella C,Polignano A,Ottolenghi A,Jirillo E,Bonomo L

    更新日期:1991-01-01 00:00:00

  • Allergic contact dermatitis to condoms: description of a clinical case and analytical review of current literature.

    abstract::We describe the case of a 42-years-old non-atopic man who developed a severe eczematous reaction in the genital area some hours after the use of a condom (Settebello-Hatù Durex) containing a retarding cream. Patch test revealed a strong allergic reaction to the retarding cream and to benzocaine and paraben mix contain...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1081/iph-200026918

    authors: Foti C,Bonamonte D,Antelmi A,Conserva A,Angelini G

    更新日期:2004-08-01 00:00:00

  • The induction of cytokine gene expression in murine peritoneal macrophages by Pseudostellaria heterophylla.

    abstract::We have previously shown that a mitogenic fraction (PH-I) separated from Pseudostellaria heterophylla (P. heterophylla) could act as a priming agent for the release of tumor necrosis factor-alpha (TNF-alpha) in mice. In the present study, PH-I was further purified by gel filtration chromatography and the resulting thr...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979409007098

    authors: Wong CK,Leung KN,Fung MC,Fung KP,Choy YM

    更新日期:1994-08-01 00:00:00

  • Feasibility study of personalized peptide vaccination for recurrent ovarian cancer patients.

    abstract:CONTEXT:To develop a personalized peptide vaccine (PPV) for recurrent ovarian cancer patients and evaluate its efficacy from the point of view of overall survival (OS), Phase II study of PPV was performed. PATIENTS AND METHODS:Forty-two patients, 17 with platinum-sensitive and 25 with platinum-resistant recurrent ovar...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2014.913617

    authors: Kawano K,Tsuda N,Matsueda S,Sasada T,Watanabe N,Ushijima K,Yamaguchi T,Yokomine M,Itoh K,Yamada A,Kamura T

    更新日期:2014-06-01 00:00:00

  • Comparative study and effects of macrophage colony-stimulating factor (M-CSF) administration on NK1.1+ cells in mouse spleen and bone marrow.

    abstract::We conducted a comparative study of NK1.1+ cells in spleen and bone marrow and the effects of administration of M-CSF on them. Administration of M-CSF to mice increased the number of NK1.1+ cells in spleen but not in bone marrow. The NK1.1+ cells in spleen (Spl-NK1.1) and bone marrow (BM-NK1.1) were purified by magnet...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1081/iph-120016035

    authors: Sakurai T,Misawa E,Yamada M,Hayasawa H,Motoyoshi K

    更新日期:2002-11-01 00:00:00

  • The anti-ophidian properties of Anacardium occidentale bark extract.

    abstract::Snakebites in rural areas of tropical and subtropical regions are commonly treated with medicinal plants. In this report, we have studied the ability of Anacardium occidentale bark extract to neutralize enzymatic as well as pharmacological effects induced by Vipera russelii venom. The extract neutralized the viper ven...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923970902911909

    authors: Ushanandini S,Nagaraju S,Nayaka SC,Kumar KH,Kemparaju K,Girish KS

    更新日期:2009-01-01 00:00:00

  • Thymostimulin administration modulates polymorph metabolic pathway in patients with chronic obstructive pulmonary disease.

    abstract::Several studies outline the imbalance of phagocyte functions in chronic obstructive pulmonary disease (COPD). In this regard, here, we have assessed either monocyte- and polymorphonuclear cell (PMN)-mediated chemotactic, phagocytic and killing capacities or PMN-triggered metabolic pathway in a group of COPD patients b...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979209005402

    authors: Tortorella C,Ottolenghi A,Moretti AM,Jirillo E,Antonaci S

    更新日期:1992-01-01 00:00:00

  • Anti-inflammatory and antioxidant effects of coumarins isolated from Foeniculum vulgare in lipopolysaccharide-stimulated macrophages and 12-O-tetradecanoylphorbol-13-acetate-stimulated mice.

    abstract:CONTEXT:Foeniculum vulgare (F. vulgare) is traditionally used to treat inflammatory diseases. Recently, anti-inflammatory and antioxidant activities of methanol extract of the fruits of F. vulgare were reported. To identify biologically active compounds responsible for the anti-inflammatory activity, we isolated four c...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2015.1038751

    authors: Yang IJ,Lee DU,Shin HM

    更新日期:2015-06-01 00:00:00

  • Functional and histopathologic effects of rapamycin on mouse kidney.

    abstract::The effect of rapamycin (RAPA) on kidney function and histopathology was assessed in two strains of mice. Male C3H/HeJ mice were treated with RAPA for 4 days at doses of 25, 50, 75, and 100 mg/kg, ip and male C3H/HeJ or female Balb/cJ mice were both treated for 7 days at doses of 75, 150 and 200 mg/kg. Cyclosporine (C...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979309066932

    authors: Di Joseph JF,Sehgal SN

    更新日期:1993-01-01 00:00:00

  • Hydrogen sulfide: a novel mediator of leukocyte activation.

    abstract::Accumulating evidence has suggested that hydrogen sulfide (H(2)S) is endogenously generated in many types of mammalian cells. Since H(2)S plays an important role in cardiovascular, central nervous and gastrointestinal systems, it is currently considered to be the third gaseous mediator. Recently, more and more attenti...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章,评审

    doi:10.1080/08923970802278045

    authors: Zhang H,Bhatia M

    更新日期:2008-01-01 00:00:00

  • Effect of short-term cocaine administration on the immune system of young and old C57BL/6 female mice.

    abstract::It has been shown that either cocaine or aging alone can alter the immune system. Our objective was to study if the immune system of aging mice was more susceptible to the effect of cocaine than the immune system of young mice. We used a short term (20 days) cocaine daily administration protocol. Cocaine only decrease...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979909007140

    authors: Colombo LL,López MC,Chen GJ,Watson RR

    更新日期:1999-11-01 00:00:00

  • The effects of methimazole on haematopoiesis in mice.

    abstract::The effects of anti-thyroid drug, methimazole (MMI), on haematopoiesis in inbred C57BL/6 mice were studied. The in vitro proliferative response of bone marrow (BM) cells to interleukin-3 (IL-3) was significantly increased when mice were provided with 0.1% MMI in water (w/v) ad librium for 4 to 6 weeks. Using soft agar...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979509037193

    authors: Mak NK,Lai WH,Liu WK,Leung KN,Fung MC

    更新日期:1995-11-01 00:00:00

  • Effect of fluoride exposure on different immune parameters in humans.

    abstract:CONTEXT:T regulatory (Treg) cells play an important role in the modulation of the immune response, and are implicated in the pathogenesis of autoimmune diseases. Many people is exposed to fluoride (F), mainly through drinking water. OBJECTIVE:The aim of this work was to assess the possible effect of F exposure on diff...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2010.491081

    authors: Hernández-Castro B,Vigna-Pérez M,Doníz-Padilla L,Ortiz-Pérez MD,Jiménez-Capdeville E,González-Amaro R,Baranda L

    更新日期:2011-03-01 00:00:00

  • The effect of two glucan carboxymethyl derivatives with various substitution degrees on cyclophosphamide immunosuppression in mice.

    abstract::Carboxymethylglucan (CMG) in two different degrees of substitution of carboxymethyl groups (0.56 and 0.89) was administered to cyclophosphamide (CY) treated (200 mg/kg) C57B1/6 mice in three doses (10, 50, and 100 mg/kg) 24 h after CY. The influence of CMG administration on the cell suppression caused by CY was observ...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979309025996

    authors: Wagnerová J,Lísková A,Navarová J,Kristofová A,Trnovec T,Ferencík M

    更新日期:1993-03-01 00:00:00

  • Clerodendron glandulosum.Coleb leaf extract attenuates in vitro macrophage differentiation and expression of VCAM-1 and P-selectin in thoracic aorta of atherogenic diet fed rats.

    abstract::Present inventory evaluates the anti-atherogenic potential of C. glandulosum.Coleb leaf extract (CG) using in vivo and in vitro experimental models. Serum markers of low density lipoprotein (LDL-C) oxidation, cholesterol, triglycerides, lipoproteins, auto-antibody titer, ex vivo LDL-C oxidation, LDL-C aggregation, aor...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2011.618136

    authors: Jadeja RN,Thounaojam MC,Jain M,Devkar RV,Ramachandran AV

    更新日期:2012-06-01 00:00:00

  • Effect of Bifidobacterium bifidum and Lactobacillus acidophilus on gut mucosa and peripheral blood B lymphocytes.

    abstract::In 15 elderly individuals lyophilized Bifidobacterium bifidum (BB) and Lactobacillus acidophilus (LA) (Infloran) were administered in capsules (two capsules 4 times per day) for 28 days, while in 10 elderly controls placebo were given the same posology and for an equal period of time. The effects of this treatment on ...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 临床试验,杂志文章

    doi:10.3109/08923979209009228

    authors: De Simone C,Ciardi A,Grassi A,Lambert Gardini S,Tzantzoglou S,Trinchieri V,Moretti S,Jirillo E

    更新日期:1992-01-01 00:00:00

  • Phenolic composition and antioxidant effect of aqueous extract of Arisaema cum Bile, the Oriental Herb Medicine, in human fibroblast cells.

    abstract::Phenolic composition and antioxidant activities of the aqueous extract of Arisaema cum Bile, which is widely used as a folk medicine in Korea, were determined. Phenolic composition profile revealed that the aqueous extract is rich in sinapic acid (13.14 mg/100 g extract), catechin (9.88 mg/100 g extract), neohesperidi...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2011.649289

    authors: Ahn CB,Shin TS,Seo HK,Je JY

    更新日期:2012-08-01 00:00:00

  • Melanogenesis effect of Cordyceps militaris culture broth on the melanin formation of B16F0 melanoma cells.

    abstract::The effect of Cordyceps militaris culture broth (CMB) on melanogenesis in B16F0 melanoma cells was evaluated by measurement of the melanin concentration after 3 days of incubation. The B16F0 melanoma cells were treated with various concentrations of CMB 10-100 μg/mL and arbutin of 200 μM. Phenolic content and antioxid...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2011.611810

    authors: Cha JY,Yang HJ,Park MY,Choi ST,Moon HI,Cho YS

    更新日期:2011-10-13 00:00:00

  • Immunological effects following administration of interferon-alpha in patients with chronic hepatitis C virus (cHCV) infection.

    abstract::The immunological effects of interferon (IFN)-alpha administration were evaluated in 15 patients with cHCV infection. Individuals were treated with 6 MU of lymphoblastoid IFN-alpha three times a week for 6 months and with 3 MU three times a week for an additional 6 months. Patients were divided into responders (12 sub...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979609052741

    authors: Jirillo E,Greco B,Caradonna L,Satalino R,Amati L,Cozzolongo R,Cuppone R,Manghisi OG

    更新日期:1996-08-01 00:00:00

  • An approach to urticaria in the elderly patients.

    abstract::The guidelines for the management of urticaria in adults and children have been published in outstanding position papers. By contrast, the onset of urticaria in the elderly has not yet had a clear definition. In order to approach diagnosis and treatment in a population of elderly patients, we have performed an epidemi...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2011.631549

    authors: Ventura MT,Napolitano S,Buquicchio R,Cecere R,Arsieni A

    更新日期:2012-06-01 00:00:00

  • Beta-adrenoceptor responsiveness of splenic macrophages in normotensive and hypertensive rats.

    abstract::The aim of the present study was to investigate putative mechanisms implicated in the impaired phagocytic response of spontaneously hypertensive rats (SHR)1. The effect of in vitro treatment with isoproterenol (ISO), a beta-adrenergic drug, on phagocytosis and respiratory burst by splenic macrophages (SpMø) from normo...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979609052735

    authors: Serio M,Potenza MA,Montagnani M,Mansi G,Mitolo-Chieppa D,Jirillo E

    更新日期:1996-05-01 00:00:00

  • Stachys riederi inhibits mast cell-mediated acute and chronic allergic reactions.

    abstract::The effect of aqueous extract of Stachys riederi var. japonica Miq. (Labiatae) (SRAE) on the mast cell-mediated allergic and inflammatory reactions were investigated. SRAE inhibited systemic allergic reaction induced by compound 48/80. SRAE dose-dependently inhibited passive cutaneous anaphylaxis (PCA) activated by an...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1081/iph-200042365

    authors: Shin TY

    更新日期:2004-01-01 00:00:00