Abstract:
:The effect of aqueous extract of Stachys riederi var. japonica Miq. (Labiatae) (SRAE) on the mast cell-mediated allergic and inflammatory reactions were investigated. SRAE inhibited systemic allergic reaction induced by compound 48/80. SRAE dose-dependently inhibited passive cutaneous anaphylaxis (PCA) activated by anti-dinitrophenyl (DNP) IgE. SRAE also dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. Moreover, SRAE inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells (HMC-1 cells). These results provide evidences that SRAE may be beneficial in the treatment of acute and chronic allergic diseases.
journal_name
Immunopharmacol Immunotoxicoljournal_title
Immunopharmacology and immunotoxicologyauthors
Shin TYdoi
10.1081/iph-200042365subject
Has Abstractpub_date
2004-01-01 00:00:00pages
621-30issue
4eissn
0892-3973issn
1532-2513journal_volume
26pub_type
杂志文章abstract::The recruitment of eosinophils from the circulation into the airway is a prominent feature of allergic asthma. Persistent inflammatory responses may arise from inefficient mechanisms for resolution of inflammation, including delayed apoptosis. Several studies suggest that eosinophil apoptosis is delayed in asthma. Sia...
journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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