Carvacrol ameliorates the progression of liver fibrosis through targeting of Hippo and TGF-β signaling pathways in carbon tetrachloride (CCl4)-induced liver fibrosis in rats.

abstract：:Arecoline, a major alkaloid of arecanut was screened to explore its modulatory influence on cell-mediated immune response in a murine model system. The in vivo and in vitro effects were evaluated at subtoxic concentrations of arecoline. Delayed type hypersensitivity (DTH) reactions to sheep red blood cells (SRBC) were...

journal_title：Immunopharmacology and immunotoxicology

authors： Selvan RS,Selvakumaran M,Rao AR

更新日期：1991-01-01 00:00:00

abstract：:N-nitrozodimethyloamine (NDMA) is a carcinogenic compound that can be formed in vivo. NDMA is synthesized from precursors-amines and nitrosating agents. Nitrosating agents are formed through the reaction of oxide, reactive oxygen species and nitric oxide (NO). Human neutrophils (PMN) are an important source of the mos...

journal_title：Immunopharmacology and immunotoxicology

authors： Jabłoński J,Jabłońska E,Iwanowska J,Marcińczyk M,Moniuszko-Jakoniuk J

更新日期：2006-01-01 00:00:00

abstract：AIM:To determine the steady state concentration and the pharmacokinetics of Cyclosporine A (CsA) in heart transplant recipients. METHODS:A single dose of 100 mg CsA capsules twice daily was given to five heart transplant recipients of steady state. The concentrations of CsA in plasma were determined by streptavidin pe...

journal_title：Immunopharmacology and immunotoxicology

authors： Jin R,Duan H,Zhao C,Wang Z,Qu F

更新日期：2012-06-01 00:00:00

abstract：:Chronic administration of oxytetracycline (OXT) (incorporated at a level of 0.05 g per kg of feed for 50 days) to pigeons, significantly decreased total leukocyte and lymphocyte counts, increased heterophil:lymphocyte ratio and lysosomal enzyme activity, and decreased reticuloendothelial system function compared with ...

journal_title：Immunopharmacology and immunotoxicology

authors： Al-Ankari AS

更新日期：2005-01-01 00:00:00

abstract：:The aim pf the present study was to characterize the time course of the synthesis of mRNA encoding interleukin-2 (IL-2) by peripheral blood mononuclear cells (PBMCs) isolated from nickel-allergic women and subsequently exposed to nickel sulphate in vitro. The level of this mRNA (determined by employing real-time polym...

journal_title：Immunopharmacology and immunotoxicology

authors： Falsafi-Amin H,Holst M,Lundeberg L

更新日期：2008-01-01 00:00:00

abstract：:The Scrophularia buergeriana (SB) has long been used to treat various diseases an account of its antimicrobial and anti-virus activity. However, it is unclear how SB regulates the immune responses. This study investigated the effect of SB on the production of cytokines in a human T-cell line, MOLT-4 cells, and mouse p...

journal_title：Immunopharmacology and immunotoxicology

authors： Kim SJ,Park JS,Myung NY,Moon PD,Choi IY,An HJ,Kim NH,Na HJ,Kim DH,Kim MC,An NH,Kim IK,Lee JY,Jeong HJ,Um JY,Kim HM,Hong SH

更新日期：2009-06-01 00:00:00

abstract：:The rate of collagen deposition in implanted polytetrafluoroethylene (PTFE) tubing in non-diabetic and streptozotocin-induced (STZ) diabetic mice was measured during 14 days post-wounding. At the time of implantation, test groups received injections of either Quadrol [N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine...

journal_title：Immunopharmacology and immunotoxicology

authors： Bhide MV,Dunphy MJ,Mirkopulos N,Smith DJ

更新日期：1988-01-01 00:00:00

abstract：:We reported recently that a novel immunomodulator, 7-thia-8-oxoguanosine (7T8OG)2 inhibited formation of pulmonary melanoma metastases (1), prevented against viral infection in mice (2) and potentiated the efficacy of a weakly immunogenic leukemia vaccine (3). Since certain tumor metastases and virus infected cells ar...

journal_title：Immunopharmacology and immunotoxicology

authors： Sharma BS,Mhaskar S,Balazs L,Siaw M

更新日期：1992-01-01 00:00:00

abstract：:The immune effects of acebutolol, a beta-blocker, are investigated in various strains of mice. In 6-12 weeks old C57Bl/6 female mice, an increase in the number of immunoglobulin secreting cells is observed only at the age of 9 weeks. At that age, such an effect is seen neither in C57Bl/6 male mice nor in female mice f...

journal_title：Immunopharmacology and immunotoxicology

authors： In S,Lulé J,Fournié GJ

更新日期：1990-01-01 00:00:00

abstract：:Association between Crohn's disease (CD) and lupus nephritis is very rare and, to the best of our knowledge, it has been described only once. We report here a clinical case of CD occurred in a young woman 8 years after a diagnosis of lupus nephritis according to clinical, laboratory and histological criteria. CD was u...

journal_title：Immunopharmacology and immunotoxicology

authors： Principi M,Di Leo A,Ingrosso M,Pisani A,Marangi S,Amoruso A,Panella C,Francavilla A,Ierardi E

更新日期：2004-05-01 00:00:00

abstract：:Multiple Drug Allergy Syndrome (MDAS) is a frequent clinical condition characterized by reactions to more than one different class of antibiotics. Even if some studies have previously reported an increased rate of allergic reactions to drugs in patients with a history of antimicrobials and NSAIDs allergy, risk factors...

journal_title：Immunopharmacology and immunotoxicology

authors： Nettis E,Colanardi MC,Paola RD,Ferrannini A,Tursi A

更新日期：2001-11-01 00:00:00

abstract：:Two dideoxynucleosides, 2',3'-dideoxy-beta-L-cytidine and 2',3'-dideoxy-beta-L-5-flurocytidine, containing unnatural L-configuration in their sugar moieties, were synthesized and assayed for antiviral activities. Both compounds were shown to possess potent anti-human immunodeficiency virus type 1 and antihepatitis B v...

journal_title：Immunopharmacology and immunotoxicology

authors： Gagnon L,Nordstrom PA,Duchaine J,Jutras D,Hamel M,Barbeau D,Hooker E,Ashman C,Cammack N,Tse A

更新日期：1995-02-01 00:00:00

abstract：:Myasthenia gravis is an autoimmune disease in which antibodies are produced against one's acetylcholine receptors, resulting in complement-mediated membrane destruction and internalization of antibody-receptor complexes. Symptoms range from weakening of extraocular muscles to severe impairment of movement and breathin...

journal_title：Immunopharmacology and immunotoxicology

authors： Hinman CL,Stevens-Truss R

更新日期：1998-05-01 00:00:00

abstract：:Sera obtained from a group of pigs (n = 5) fed a diet amended with fumonisin containing Fusarium moniliforme culture material was used to determine the levels of Tumor Necrosis Factor-Alpha (TNF) activity by a functional bioassay utilizing the TNF sensitive WEHI 140 mouse fibrosarcoma cell line. Two pigs developed sig...

journal_title：Immunopharmacology and immunotoxicology

authors： Guzman RE,Bailey K,Casteel SW,Turk J,Rottinghaus G

更新日期：1997-05-01 00:00:00

abstract：:T-2 toxin, a fungal metabolite shown previously to exert potent immunosuppressive effects, was examined for its effects on activation and interleukin 2 (IL 2) production by murine and rat splenocytes. Splenocytes (1 X 10(6) cells/well) were incubated with 1 microgram Concanavalin A (Con A) for 48 h at which time cellu...

journal_title：Immunopharmacology and immunotoxicology

authors： Holt PS,Corrier DE,DeLoach JR

更新日期：1988-01-01 00:00:00

abstract：:Enhanced glucose utilization was observed in continuous cultures of macrophages in medium containing 4mM Quadrol, [N,N,N',N',Tetrakis(2-hydroxypropyl)ethylenediamine]. This enhancement was both time and concentration dependent. Radiolabeled 4mM Quadrol, after incubation with macrophages for 60 minutes, was shown to be...

journal_title：Immunopharmacology and immunotoxicology

authors： Bhide MV,Smith DJ

更新日期：1987-01-01 00:00:00

abstract：:Myricetin, a common dietary flavonoid, is widely distributed in fruits and vegetables. It is known to be a food supplement contributing to human health because of its immune modulatory function, and its antioxidation, antitumor, and anti-inflammatory properties. In the present study, myricetin was shown to directly in...

journal_title：Immunopharmacology and immunotoxicology

authors： Yuan X,Liu Y,Hua X,Deng X,Sun P,Yu C,Chen L,Yu S,Liu S,Pang H

更新日期：2015-01-01 00:00:00

abstract：:The guidelines for the management of urticaria in adults and children have been published in outstanding position papers. By contrast, the onset of urticaria in the elderly has not yet had a clear definition. In order to approach diagnosis and treatment in a population of elderly patients, we have performed an epidemi...

journal_title：Immunopharmacology and immunotoxicology

authors： Ventura MT,Napolitano S,Buquicchio R,Cecere R,Arsieni A

更新日期：2012-06-01 00:00:00

abstract：:Vasoactive intestinal polypeptide (VIP) has been shown to stimulate adenylate cyclase in a human lymphoblast cell line (MOLT 4). In the present study, we monitored fluorescence in cell suspensions and in single fura-2 loaded MOLT 4 lymphoblasts to determine if VIP modulates intracellular calcium concentrations ([Ca2+]...

journal_title：Immunopharmacology and immunotoxicology

authors： Anton PA,Shanahan F,Sun XP,Diehl D,Kodner A,Mayer EA

更新日期：1993-08-01 00:00:00

abstract：:The aim of this study was to investigate the anti-endotoxin effects of sinomenine, fangchinoline, stachydrine, chuanxionggzine, oxymartrine and evodiamine alkaloids commonly found in Chinese herbal medicines. Porcine endothelial cells were challenged with 1 μg LPS/ml for 3 h and then treated with one of the six alkalo...

journal_title：Immunopharmacology and immunotoxicology

authors： Hu Y,He K,Zhu H

更新日期：2015-06-01 00:00:00

abstract：:Several abnormalities of the immune system have been reported in association with clinical and experimental iron overload. To dissect further such abnormalities, changes in lymphocyte subsets were evaluated in iron-loaded male Sprague-Dawley rats. The iron-loading protocol consisted of a total dose of irondextran (1.5...

journal_title：Immunopharmacology and immunotoxicology

authors： Cardier JE,Romano E,Soyano A

更新日期：1997-02-01 00:00:00

abstract：:Although investigations to date have demonstrated the ability of the monocyte/macrophage to synthesize complement components, only a limited number of studies on complement synthesis by nonhepatic tissue cells have been reported. To begin to fill this gap in our knowledge we have recently evaluated the ability of lung...

journal_title：Immunopharmacology and immunotoxicology

authors： Rothman BL,Contrino J,Merrow M,Despins A,Kennedy T,Kreutzer DL

更新日期：1994-11-01 00:00:00

abstract：:We conducted a comparative study of NK1.1+ cells in spleen and bone marrow and the effects of administration of M-CSF on them. Administration of M-CSF to mice increased the number of NK1.1+ cells in spleen but not in bone marrow. The NK1.1+ cells in spleen (Spl-NK1.1) and bone marrow (BM-NK1.1) were purified by magnet...

journal_title：Immunopharmacology and immunotoxicology

authors： Sakurai T,Misawa E,Yamada M,Hayasawa H,Motoyoshi K

更新日期：2002-11-01 00:00:00

abstract：INTRODUCTION:Parsley (Petroselinum crispum) has been traditionally used for the treatment of allergy, autoimmune and chronic inflammatory disorders. The present study aims to investigate the suppressive effects of parsley essential oil on mouse splenocytes and macrophages cells. METHODS AND MATERIALS:Parsley essential...

journal_title：Immunopharmacology and immunotoxicology

authors： Yousofi A,Daneshmandi S,Soleimani N,Bagheri K,Karimi MH

更新日期：2012-04-01 00:00:00

abstract：:To investigate the role of CD4(+) T cells in neurotrophin production following toluene exposure, male C3H mice were exposed to filtered air (control) or 9 ppm of toluene in a nose-only exposure chamber for 30 min on 3 consecutive days followed by weekly sessions for 4 weeks. All the mice were immunized with ovalbumin ...

journal_title：Immunopharmacology and immunotoxicology

authors： Fujimaki H,Win-Shwe TT,Yamamoto S,Nakajima D,Goto S

更新日期：2009-01-01 00:00:00

abstract：:Natural killer (NK) activity plays an important role in host defense against tumors, especially once augmented by immunomodulators. It is likely that the modulation of NK cells is a reflection of the environment in which they reside. The current study was undertaken to characterize the response profile of lung interst...

journal_title：Immunopharmacology and immunotoxicology

authors： Lauzon W,Lemaire I

更新日期：1991-01-01 00:00:00

abstract：:The aim of the present investigation was to evaluate the efficacy of Withania somnifera on tricarboxylic acid (TCA) cycle enzymes and electron transport chain in azoxymethane-induced experimental colon cancer in mice. Azoxymethane at the dose of 15 mg/kg body weight was induced intraperitoneally once in a week for 28 ...

journal_title：Immunopharmacology and immunotoxicology

authors： Muralikrishnan G,Amanullah S,Basha MI,Dinda AK,Shakeel F

更新日期：2010-09-01 00:00:00

abstract：:Paraquat (methyl viologen, PQ) is highly toxic to humans. Pulmonary fibrosis is the most common cause of death after PQ poisoning. However, no effective therapy is available. The current treatment dilemma and pathology suggest that we should reconsider how to treat the poisoning using other methods, such as immunizati...

journal_title：Immunopharmacology and immunotoxicology

authors： Wu Q,Xu Q,Jian X,Wang H,He X,Gao B,Wang K,Kan B

更新日期：2018-08-01 00:00:00

abstract：:Physalin E is a naturally occurring seco-steroid isolated from the stems and aerial parts of Physalis angulata L. (Solanaceae). This study was aimed to explore the anti-inflammatory effects of physalin E on RAW 264.7 mouse macrophages stimulated by lipopolysaccharide (LPS) and the potential underlying mechanisms. The ...

journal_title：Immunopharmacology and immunotoxicology

authors： Yang YJ,Yi L,Wang Q,Xie BB,Dong Y,Sha CW

更新日期：2017-04-01 00:00:00

abstract：:Various cells are associated with the integrated stress response (ISR) that leads to translation arrest via phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Pathogenic insults or nutritional imbalance in the mucosal tissues including the intestinal, airway, and genitourinary epitheli...

journal_title：Immunopharmacology and immunotoxicology

authors： Park SH,Moon Y

更新日期：2013-04-01 00:00:00