Abstract:
:Myasthenia gravis is an autoimmune disease in which antibodies are produced against one's acetylcholine receptors, resulting in complement-mediated membrane destruction and internalization of antibody-receptor complexes. Symptoms range from weakening of extraocular muscles to severe impairment of movement and breathing. Prior to administering a therapeutic agent to eliminate antibody-producing lymphocytes, it will be necessary to remove specific antibody from the circulation. This process was investigated in an animal model of ex vivo specific immunoadsorption using awake, conscious rabbits. Following arterial blood separation, plasma was pumped upward through an affinity column containing covalently-bound acetylcholine receptor. Treated plasma was returned to the rabbit. Within a one-hour ex vivo procedure, specific antibody levels could be lowered from 16.2 ng/ml to less than 0.6 ng/ml, a reduction of more than 95%. By washing the column, at least four exchanges could be performed before specific antibody removal significantly diminished. The effects of specific antibody removal upon muscle function varied among individual rabbits, but if symptoms were not severe following passive transfer of purified monoclonal antibody to induce myasthenia, removal of 60% of the total specific antibody resulted in clinical improvement, as monitored by an animal's response to gallamine triethiodide.
journal_name
Immunopharmacol Immunotoxicoljournal_title
Immunopharmacology and immunotoxicologyauthors
Hinman CL,Stevens-Truss Rdoi
10.3109/08923979809038542subject
Has Abstractpub_date
1998-05-01 00:00:00pages
233-49issue
2eissn
0892-3973issn
1532-2513journal_volume
20pub_type
杂志文章abstract::Sera obtained from a group of pigs (n = 5) fed a diet amended with fumonisin containing Fusarium moniliforme culture material was used to determine the levels of Tumor Necrosis Factor-Alpha (TNF) activity by a functional bioassay utilizing the TNF sensitive WEHI 140 mouse fibrosarcoma cell line. Two pigs developed sig...
journal_title:Immunopharmacology and immunotoxicology
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doi:10.3109/08923979709007663
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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doi:10.1081/iph-100108607
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
pub_type: 杂志文章,收录出版
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更新日期:2004-08-01 00:00:00
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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