Norepinephrine-induced myeloid-derived suppressor cells block T-cell responses via generation of reactive oxygen species.

abstract：:The effect of Cordyceps militaris culture broth (CMB) on melanogenesis in B16F0 melanoma cells was evaluated by measurement of the melanin concentration after 3 days of incubation. The B16F0 melanoma cells were treated with various concentrations of CMB 10-100 μg/mL and arbutin of 200 μM. Phenolic content and antioxid...

journal_title：Immunopharmacology and immunotoxicology

authors： Cha JY,Yang HJ,Park MY,Choi ST,Moon HI,Cho YS

更新日期：2011-10-13 00:00:00

abstract：:Carpal tunnel syndrome (CTS) is a neurological impairment caused by compression of the median nerve throughout the carpal tunnel, which consequently induces ischemia and mechanical disruption, dysfunctional axonal transport, and epidural blood flow. Most common symptoms include numbness, rather than pain, with a typic...

journal_title：Immunopharmacology and immunotoxicology

authors： Foti C,Romita P,Vestita M

更新日期：2011-12-01 00:00:00

abstract：:Association between Crohn's disease (CD) and lupus nephritis is very rare and, to the best of our knowledge, it has been described only once. We report here a clinical case of CD occurred in a young woman 8 years after a diagnosis of lupus nephritis according to clinical, laboratory and histological criteria. CD was u...

journal_title：Immunopharmacology and immunotoxicology

authors： Principi M,Di Leo A,Ingrosso M,Pisani A,Marangi S,Amoruso A,Panella C,Francavilla A,Ierardi E

更新日期：2004-05-01 00:00:00

abstract：:Inflammatory bowel diseases are characterized by disabilities in gastrointestinal system and defects in mucosal immune system. Statins are 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitor and are used to treat hypercholesterolemia in patients with coronary artery and atherosclerotic diseases. Recent studies ...

journal_title：Immunopharmacology and immunotoxicology

authors： Aktunc E,Kayhan B,Arasli M,Gun BD,Barut F

更新日期：2011-12-01 00:00:00

abstract：:The effect of aqueous extract of Stachys riederi var. japonica Miq. (Labiatae) (SRAE) on the mast cell-mediated allergic and inflammatory reactions were investigated. SRAE inhibited systemic allergic reaction induced by compound 48/80. SRAE dose-dependently inhibited passive cutaneous anaphylaxis (PCA) activated by an...

journal_title：Immunopharmacology and immunotoxicology

authors： Shin TY

更新日期：2004-01-01 00:00:00

abstract：:The effects of Bulnesia sarmienti (BS) aqueous extract on the cell growth of A549 cell lines were investigated. BS has strong cytotoxic activity on the A549 cell lines (IC(50); less than 100 microg/mL) in MTT assay. HPLC confirmed that BS contains catechins as major compound. Cell cycle analysis by flow cytometry indi...

journal_title：Immunopharmacology and immunotoxicology

authors： Mollah ML,Kim JO,Lee GD,Park CH,Hong JH,Kim HY,Kim KS

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND AIM:To probe into the effects of different doses of FK506 on endocrine function of pancreatic islets in Wistar rats. METHODS:Wistar rats were randomly divide into control group A (0mg/kg/d) and experimental group B (1mg/kg/d), C (3mg/kg/d), D (10mg/kg/d) treated with FK506. In an intraperitoneal glucose...

journal_title：Immunopharmacology and immunotoxicology

authors： Li F,Li Q

更新日期：2010-06-01 00:00:00

abstract：:Lymphocyte proliferation assays are commonly used to quantify the effects of immunosuppressive drugs in animal models, but the influence of anesthetic agents on those assays is not well understood. We used a whole blood proliferation assay to compare lymphocyte proliferation in blood drawn from normal male Lewis rats ...

journal_title：Immunopharmacology and immunotoxicology

authors： Gummert JF,Otto G,Barten MJ,Morris RE

更新日期：1999-05-01 00:00:00

abstract：:We previously showed that formation of pulmonary granulomas in mice in response to a mycobacterial glycolipid, trehalose 6,6'-dimycolate (TDM) is due to the action of TNF-α and not of IFN-γ. However, the mechanisms of formation and maintenance of pulmonary granulomas are not yet clear. The purpose of the present study...

journal_title：Immunopharmacology and immunotoxicology

authors： Saitoh T,Yano I,Kumazawa Y,Takimoto H

更新日期：2012-10-01 00:00:00

abstract：:Various cells are associated with the integrated stress response (ISR) that leads to translation arrest via phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Pathogenic insults or nutritional imbalance in the mucosal tissues including the intestinal, airway, and genitourinary epitheli...

journal_title：Immunopharmacology and immunotoxicology

authors： Park SH,Moon Y

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION AND AIMS:N-Acetyl-β-D-glucosaminidase (NAG), a marker of renal tubular dysfunction, is increased in patients with lupus nephritis. In addition to the toxic effects of proteinuria, patients with lupus nephritis may exhibit other factors that contribute to tubular dysfunction, such as pathogenic antitubular ...

journal_title：Immunopharmacology and immunotoxicology

authors： Gluhovschi C,Velciov S,Kaycsa A,Gluhovschi G,Petrica L,Marian R,Bozdog G,Gadalean F,Bob F,Cioca D,Vernic C

更新日期：2012-02-01 00:00:00

abstract：:Formyl peptides released by some bacteria are powerful chemoattractants and activators of mammalian granulocytes and monocytes, acting through 7-transmembrane specific formyl peptide receptors (FPRs). Three distinct segments of the formyl peptide receptor 1 (FPR1) mRNA of Man share probabilistically significant homolo...

journal_title：Immunopharmacology and immunotoxicology

authors： Panaro MA,Acquafredda A,Sisto M,Lisi S,Calvello R,Saccia M,Maffione AB,Mitolo V

更新日期：2005-01-01 00:00:00

abstract：:Objectives: Several studies demonstrated the antioxidant and anti-inflammatory role of melatonin and celecoxib. This study is designed to explore the underlying mechanism of hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity by morphological, and biochemical approaches.Materials...

journal_title：Immunopharmacology and immunotoxicology

authors： Ullah U,Badshah H,Malik Z,Uddin Z,Alam M,Sarwar S,Aman A,Khan AU,Shah FA

更新日期：2020-06-01 00:00:00

abstract：:CD69, also known as activation inducer molecule, very early activation antigen, MLR-3 and Leu-23, is a member of the natural killer (NK) cell gene complex family of signal transducing receptors. CD69 is as a type II transmembrane glycoprotein with a C-type lectin binding domain in the extracellular portion of the mole...

journal_title：Immunopharmacology and immunotoxicology

authors： Marzio R,Mauël J,Betz-Corradin S

更新日期：1999-08-01 00:00:00

abstract：:Langerhans cells (LC) are immature dendritic cells (DC) present in the skin epithelium. To understand the molecular and cellular mechanisms governing the inflammatory reaction in atopic dermatitis (AD), the expression of the LC specific marker CD1a, a member of major histocompatibility (MHC)-like glycoproteins, and th...

journal_title：Immunopharmacology and immunotoxicology

authors： Fesenkova VI,Kurchenko AI,Castellani ML,Conti P,Anogeianaki A,Caraffa A,Kalogeromitros D

更新日期：2007-01-01 00:00:00

abstract：:Several abnormalities of the immune system have been reported in association with clinical and experimental iron overload. To dissect further such abnormalities, changes in lymphocyte subsets were evaluated in iron-loaded male Sprague-Dawley rats. The iron-loading protocol consisted of a total dose of irondextran (1.5...

journal_title：Immunopharmacology and immunotoxicology

authors： Cardier JE,Romano E,Soyano A

更新日期：1997-02-01 00:00:00

abstract：:The effect that MnCl2 has on murine splenic natural killer (NK) cell activity was investigated in infant (10 days old), pre-weanling (18 days old) and weanling (24 days old) C57BL/6J mice. A single intraperitoneal injection of 10, 20 or 40 micrograms MnCl2/g body weight caused a significant enhancement in NK activity,...

journal_title：Immunopharmacology and immunotoxicology

authors： Smialowicz RJ,Riddle MM,Rogers RR,Luebke RW,Burleson GR

更新日期：1988-01-01 00:00:00

abstract：:Temporary henna-based tattoos, particularly popular among western tourists holidaying in exotic places, can expose to the risk to develop allergic reactions. Although hypersensitivity to henna is extremely rare, para-phenylenediamine, which is sometimes added to henna to obtain a dark, blackish color, is a frequent co...

journal_title：Immunopharmacology and immunotoxicology

authors： Calogiuri G,Foti C,Bonamonte D,Nettis E,Muratore L,Angelini G

更新日期：2010-12-01 00:00:00

abstract：:We examined the effects of interferon (IFN)beta-1a on interleukin (IL)-12p70 and IL-10 secretion in 27 Relapsing Remitting Multiple Sclerosis (RRMS) patients, divided in responders and non-responders. In responders, IFNbeta-1a does not change the IL-12p70 concentrations, but it leads to a remarkable increase in the IL...

journal_title：Immunopharmacology and immunotoxicology

authors： Carrieri PB,Ladogana P,Di Spigna G,de Leva MF,Petracca M,Montella S,Buonavolontà L,Florio C,Postiglione L

更新日期：2008-01-01 00:00:00

abstract：:Apigenin is a plant flavonoid and a pharmacologically active agent that has been isolated from several plant species. However, the molecular mechanism of apigenin-mediated immune modulation has not been fully understood. One of the possible mechanisms of its protective effects is the down-regulation of inflammatory re...

journal_title：Immunopharmacology and immunotoxicology

authors： Kang OH,Lee JH,Kwon DY

更新日期：2011-09-01 00:00:00

abstract：:A soil bacterium, Klebsiella oxytoca TNM3 was found to produce a polysaccharide named AZ9 that shows suppressive effects on IgE antibody response in mice. When mice were administered with 50 to approximately 100 mg/kg AZ9 subcutaneousely for 4 consecutive days after immunization with trinitrophenyl (TNP)-keyhole limpe...

journal_title：Immunopharmacology and immunotoxicology

authors： Sugihara R,Matsumoto Y,Ohmori H

更新日期：2002-05-01 00:00:00

abstract：:The effects of anti-thyroid drug, methimazole (MMI), on haematopoiesis in inbred C57BL/6 mice were studied. The in vitro proliferative response of bone marrow (BM) cells to interleukin-3 (IL-3) was significantly increased when mice were provided with 0.1% MMI in water (w/v) ad librium for 4 to 6 weeks. Using soft agar...

journal_title：Immunopharmacology and immunotoxicology

authors： Mak NK,Lai WH,Liu WK,Leung KN,Fung MC

更新日期：1995-11-01 00:00:00

abstract：:A human THP-1 monocyte cell line culture system has been utilized to observe the effect of granulocyte macrophage colony stimulating factor (GM-CSF) supplementation with lipopolysaccharide (LPS) of oral microorganisms to stimulate monocyte/macrophage functional activity. LPS of oral microorganisms, Fusobacterium nucle...

journal_title：Immunopharmacology and immunotoxicology

authors： Baqui AA,Meiller TF,Turng BF,Kelley JI,Falkler WA Jr

更新日期：1998-11-01 00:00:00

abstract：CONTEXT:The pentapeptide YGSRS is originated from coffee bean, while its pharmacological features have little been examined. OBJECTIVES:We investigated the effects of YGSRS on proliferation, cytokine production and CD4+ CD25+ Foxp3+ regulatory T (Treg) cell frequency of human peripheral blood mononuclear cells (PBMCs)...

journal_title：Immunopharmacology and immunotoxicology

authors： Nakamura Y,Hayakawa A,Ishizawa H,Kamei Y,Tanaka S,Onda K,Sugiyama K,Hirano T

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Sorafenib is an orally active multikinase inhibitor licensed for the treatment of patients with unresectable hepatocellular carcinoma (HCC). PATIENTS AND METHODS:The web-based registry, used for appraisal on new drugs, allows developing the observational prospective analysis of innovative drug therapies. To...

journal_title：Immunopharmacology and immunotoxicology

authors： Trojniak MP,Palozzo AC,Mazurek M,Jirillo A

更新日期：2012-06-01 00:00:00

abstract：:N-nitrozodimethyloamine (NDMA) is a carcinogenic compound that can be formed in vivo. NDMA is synthesized from precursors-amines and nitrosating agents. Nitrosating agents are formed through the reaction of oxide, reactive oxygen species and nitric oxide (NO). Human neutrophils (PMN) are an important source of the mos...

journal_title：Immunopharmacology and immunotoxicology

authors： Jabłoński J,Jabłońska E,Iwanowska J,Marcińczyk M,Moniuszko-Jakoniuk J

更新日期：2006-01-01 00:00:00

abstract：:The effects of cimetidine upon suppressor cell effector function in a well-studied murine model of contact hypersensitivity were examined. Intravenous inoculation of BALB/c mice with DNP-coupled syngeneic spleen cells induced the production of DNP-specific suppressor cells which was demonstrated by a reduction in ear ...

journal_title：Immunopharmacology and immunotoxicology

authors： Kumar A,Cleveland RP

更新日期：1988-01-01 00:00:00

abstract：:A human hepatoma cell line, Hep G2 cells are reliable for the study of alcohol-induced hepatotoxicity. In this study, we investigated the effect of an aqueous extract of Polygala tenuifolia WILLDENOW (Polygalaceae) roots (PTAE) on ethanol (EtOH)-induced cytotoxicity in Hep G2 cells. PTAE (0.01-1 microg/ml) dose-depend...

journal_title：Immunopharmacology and immunotoxicology

authors： Koo HN,Jeong HJ,Kim KR,Kim JC,Kim KS,Kang BK,Kim HM,Kim JJ

更新日期：2000-08-01 00:00:00

abstract：:To probe into the mechanism of immunosuppression of FTY720, the authors study the cell cycle arrest effects of large-dose FTY720 on lymphocytes in mouse skin transplantation models and the expression of cell cycle-related factors in cell cycle regulation system in mouse skin allograft models using flow cytometry, Immu...

journal_title：Immunopharmacology and immunotoxicology

authors： Li QY,Chi YY,Liu SQ

更新日期：2008-01-01 00:00:00

abstract：:Serum tumor necrosis factor (TNF) levels in 33 patients with inflammatory bowel disease (IBD) were measured by using a sensitive enzyme immunoassay. Four of five Crohn's diseases (CD) and nine of twenty eight ulcerative colitis (UC) had elevated levels of serum TNF. In active CD or UC, a greater fraction of patients s...

journal_title：Immunopharmacology and immunotoxicology

authors： Maeda M,Watanabe N,Neda H,Yamauchi N,Okamoto T,Sasaki H,Tsuji Y,Akiyama S,Tsuji N,Niitsu Y

更新日期：1992-01-01 00:00:00