Suppression of IgE antibody response in mice by a polysaccharide, AZ9, produced by Klebsiella oxytoca strain TNM3.

Abstract:

:A soil bacterium, Klebsiella oxytoca TNM3 was found to produce a polysaccharide named AZ9 that shows suppressive effects on IgE antibody response in mice. When mice were administered with 50 to approximately 100 mg/kg AZ9 subcutaneousely for 4 consecutive days after immunization with trinitrophenyl (TNP)-keyhole limpet hemocyanin, anti-TNP IgE production was significantly suppressed, while the level of anti-TNP IgM was affected marginally. In AZ9-administered mice, IL-4 secretion from splenic cells was reduced to approximately 30% of the untreated control. Thus, AZ9 suppression of IgE production may be due to attenuating effects on the Th2-type response. Although oral administration of AZ9 alone had no effects on IgE production, ovalbumin (OVA)-induced oral tolerance of anti-TNP IgE response to TNP-OVA was markedly augmented when a suboptimal dose of OVA was administered orally in combination with AZ9. Collectively, our data suggest that AZ9 has beneficial suppressive effects on IgE-dependent allergic responses.

authors

Sugihara R,Matsumoto Y,Ohmori H

doi

10.1081/iph-120003754

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

245-54

issue

2

eissn

0892-3973

issn

1532-2513

journal_volume

24

pub_type

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