Alpha- and gamma-mangostins exhibit anti-acne activities via multiple mechanisms.

Abstract:

:Objective: Acne is a chronic skin disease that involves four key pathogenic factors: excess sebum production, ductal epidermal hyperproliferation, Propionibacterium acnes (P. acnes) colonization, and skin inflammation. Mangostins are well-known for their anti-bacterial and anti-inflammatory effects, suggesting that mangostins may have therapeutic potential for acne. The present study aimed to explore the anti-acne effects of mangostins from the perspective of multiple pathogenic mechanisms of acne. Methods: The effects of α- and γ-mangostins on the growth of P. acnes and lipase activity were analyzed. Their effects on P. acnes-induced keratinocyte proliferation were examined by CCK-8. The expression of inflammatory genes and activation of NF-κB and MAPK signaling pathways were detected by quantitative real-time PCR and western blotting, respectively. Results: Alpha- and γ-mangostins not only inhibited the growth of P. acnes, but also reduced the proliferation of keratinocytes induced by heat-killed P. acnes. Furthermore, α- and γ-mangostins were able to suppress P. acnes-induced expression of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 in keratinocytes by inhibiting the activation of NF-κB and MAPK signaling pathways. Discussion and conclusions: Mangostins appeared to possess multiple anti-acne activities, including the inhibition of P. acnes growth, regulation of keratinocytes proliferation, and attenuation of skin inflammatory reaction. Hence, mangostins might be developed into a potential therapeutic agent for the treatment of acne.

authors

Xu N,Deng W,He G,Gan X,Gao S,Chen Y,Gao Y,Xu K,Qi J,Lin H,Shen L,Li X,Hu Z

doi

10.1080/08923973.2018.1519831

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

415-422

issue

5

eissn

0892-3973

issn

1532-2513

journal_volume

40

pub_type

杂志文章
  • The anti-ophidian properties of Anacardium occidentale bark extract.

    abstract::Snakebites in rural areas of tropical and subtropical regions are commonly treated with medicinal plants. In this report, we have studied the ability of Anacardium occidentale bark extract to neutralize enzymatic as well as pharmacological effects induced by Vipera russelii venom. The extract neutralized the viper ven...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923970902911909

    authors: Ushanandini S,Nagaraju S,Nayaka SC,Kumar KH,Kemparaju K,Girish KS

    更新日期:2009-01-01 00:00:00

  • Role of tumour necrosis factor in the enhanced sensitivity of mice to endotoxin after exposure to lead.

    abstract::Heavy metals administered to animals, at doses which appear relatively innoxious by themselves, enhance susceptibility to endotoxin. The mechanisms which underly this phenomenon are not yet fully understood. In this study we investigated the role of the cytokine Tumour Necrosis Factor (TNF), an important mediator of t...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923978909005373

    authors: Dentener MA,Greve JW,Maessen JG,Buurman WA

    更新日期:1989-01-01 00:00:00

  • Effect of fluoride exposure on different immune parameters in humans.

    abstract:CONTEXT:T regulatory (Treg) cells play an important role in the modulation of the immune response, and are implicated in the pathogenesis of autoimmune diseases. Many people is exposed to fluoride (F), mainly through drinking water. OBJECTIVE:The aim of this work was to assess the possible effect of F exposure on diff...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2010.491081

    authors: Hernández-Castro B,Vigna-Pérez M,Doníz-Padilla L,Ortiz-Pérez MD,Jiménez-Capdeville E,González-Amaro R,Baranda L

    更新日期:2011-03-01 00:00:00

  • Role of CD4(+) T cells in the modulation of neurotrophin production in mice exposed to low-level toluene.

    abstract::To investigate the role of CD4(+) T cells in neurotrophin production following toluene exposure, male C3H mice were exposed to filtered air (control) or 9 ppm of toluene in a nose-only exposure chamber for 30 min on 3 consecutive days followed by weekly sessions for 4 weeks. All the mice were immunized with ovalbumin ...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923970802504762

    authors: Fujimaki H,Win-Shwe TT,Yamamoto S,Nakajima D,Goto S

    更新日期:2009-01-01 00:00:00

  • Bleomycin and FK 565 enhance the release of GM-CSF from LPS-stimulated BALB/c peritoneal macrophages.

    abstract::The anti-tumour antibiotic Bleomycin, the experimental immunostimulatory tripeptide FK 565, and the immunosuppressive agent Cyclosporin A were examined for their in vitro effects on the release of the haemopoietic cytokine Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) from LPS stimulated BALB/c adherent pe...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979509016381

    authors: Blaney BA,Turk JL

    更新日期:1995-08-01 00:00:00

  • Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma.

    abstract::Many flavonoids were demonstrated to possess the antiallergic effect. Here we detected whether apigenin, a flavonoid, can attenuate allergen-induced airway inflammation and what is the possible mechanism in a murine model of asthma. Apigenin decreased the degree of the inflammatory cell infiltration, airway hyperrespo...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923970903420566

    authors: Li RR,Pang LL,Du Q,Shi Y,Dai WJ,Yin KS

    更新日期:2010-09-01 00:00:00

  • HP-NAP ameliorates OXA-induced atopic dermatitis symptoms in mice.

    abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic skin inflammatory disease characterized by disequilibrium between Th1/Th2 lymphocytes. Helicobacter pylori neutrophil-activating protein (HP-NAP) has been reported that it has the potential immunomodulatory effect able to regulate the Th1/Th2 balance. OBJECTIVE:This study...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923973.2020.1806869

    authors: Guo X,Ding C,Lu J,Zhou T,Liang T,Ji Z,Xie P,Liu X,Kang Q

    更新日期:2020-10-01 00:00:00

  • IFN-β, IFN-γ, and TNF-α decrease erythrophagocytosis by human monocytes independent of SIRP-α or SHP-1 expression.

    abstract:BACKGROUND:Many cases of autoimmune hemolytic anemia have been reported after viral infection. Phagocyte activation and accompanying erythrophagocytosis are thought to result from proinflammatory cytokines released during viral infection. SIRP-α (signal regulatory protein-α), a receptor expressed on phagocytes, inhibit...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2012.697470

    authors: de Almeida AC,Barbosa SM,de Lourdes Rios Barjas-Castro M,Olalla-Saad ST,Condino-Neto A

    更新日期:2012-12-01 00:00:00

  • Beta-adrenoceptor responsiveness of splenic macrophages in normotensive and hypertensive rats.

    abstract::The aim of the present study was to investigate putative mechanisms implicated in the impaired phagocytic response of spontaneously hypertensive rats (SHR)1. The effect of in vitro treatment with isoproterenol (ISO), a beta-adrenergic drug, on phagocytosis and respiratory burst by splenic macrophages (SpMø) from normo...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979609052735

    authors: Serio M,Potenza MA,Montagnani M,Mansi G,Mitolo-Chieppa D,Jirillo E

    更新日期:1996-05-01 00:00:00

  • Integrated stress response-altered pro-inflammatory signals in mucosal immune-related cells.

    abstract::Various cells are associated with the integrated stress response (ISR) that leads to translation arrest via phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Pathogenic insults or nutritional imbalance in the mucosal tissues including the intestinal, airway, and genitourinary epitheli...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章,评审

    doi:10.3109/08923973.2012.742535

    authors: Park SH,Moon Y

    更新日期:2013-04-01 00:00:00

  • Andrographolide attenuates microglia-mediated Aβ neurotoxicity partially through inhibiting NF-κB and JNK MAPK signaling pathway.

    abstract::Neuroinflammation plays a critical role in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease (AD). Microglial cells after activated play critical roles in development of neuroinflammation, and may accelerate the progression of AD. Andrographolide (ANDRO), a potent naturally extracte...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923973.2017.1344989

    authors: Yang R,Liu S,Zhou J,Bu S,Zhang J

    更新日期:2017-10-01 00:00:00

  • Continuous veno-venous hemodiafiltration alleviates multiple organ dysfunction syndrome in dogs.

    abstract:CONTEXT:Multiple organ dysfunction syndrome (MODS) is a major cause of death in critically patients. It has been hypothesized that inactivation or removal of pro-inflammatory molecules may prevent or reverse MODS. OBJECTIVE:The purpose of this paper was to investigate the efficacy of continuous veno-venous hemodiafilt...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2012.685630

    authors: Chen J,Liu J,Yu C,Wen H

    更新日期:2012-12-01 00:00:00

  • WNT/β-catenin pathway is modulated in asthma patients and LPS-stimulated RAW264.7 macrophage cell line.

    abstract::In the present study, we investigated the possibility that the WNT/β-catenin pathway plays a role in inflammatory responses both in an human inflammatory condition and in an in vitro inflammation model. First, we analyzed gene expression patterns of the peripheral blood cells from asthma patients compared with those f...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 临床试验,杂志文章

    doi:10.3109/08923973.2011.574704

    authors: Lee H,Bae S,Choi BW,Yoon Y

    更新日期:2012-02-01 00:00:00

  • Unusual presentation of carpal tunnel syndrome with cutaneous signs: a case report and review of the literature.

    abstract::Carpal tunnel syndrome (CTS) is a neurological impairment caused by compression of the median nerve throughout the carpal tunnel, which consequently induces ischemia and mechanical disruption, dysfunctional axonal transport, and epidural blood flow. Most common symptoms include numbness, rather than pain, with a typic...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章,评审

    doi:10.3109/08923973.2010.551214

    authors: Foti C,Romita P,Vestita M

    更新日期:2011-12-01 00:00:00

  • Feasibility study of personalized peptide vaccination for recurrent ovarian cancer patients.

    abstract:CONTEXT:To develop a personalized peptide vaccine (PPV) for recurrent ovarian cancer patients and evaluate its efficacy from the point of view of overall survival (OS), Phase II study of PPV was performed. PATIENTS AND METHODS:Forty-two patients, 17 with platinum-sensitive and 25 with platinum-resistant recurrent ovar...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2014.913617

    authors: Kawano K,Tsuda N,Matsueda S,Sasada T,Watanabe N,Ushijima K,Yamaguchi T,Yokomine M,Itoh K,Yamada A,Kamura T

    更新日期:2014-06-01 00:00:00

  • Radiation-induced lung injury: impact on macrophage dysregulation and lipid alteration - a review.

    abstract::Lung cancer continues to be the leading cause of cancer deaths and more than one million lung cancer patients will die every year worldwide. Radiotherapy (RT) plays an important role in lung cancer treatment, but the side effects of RT are pneumonitis and pulmonary fibrosis. RT-induced lung injury causes damage to alv...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923973.2018.1533025

    authors: S N SG,Raviraj R,Nagarajan D,Zhao W

    更新日期:2019-06-01 00:00:00

  • Anti-inflammatory mechanism of Rungia pectinata (Linn.) Nees.

    abstract::This study is to explore the inner anti-inflammatory mechanism of the ethanol extract of Rungia pectinata (Linn.) Nees. As a result, the ethanol extract of Rungia pectinata (Linn.) Nees could not only strongly reduce production of pro-inflammatory cytokines and mediators via blocking NF-kappaB activation but slightly ...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923970701812704

    authors: Zhao L,Tao JY,Zhang SL,Jin F,Pang R,Dong JH,Guo YJ,Ye P

    更新日期:2008-01-01 00:00:00

  • Immunohistochemical analysis of protective effects of maternal fingolimod on the placenta and fetal lung and brain in chorioamnionitis-induced preterm birth rat model.

    abstract:OBJECTIVES:Fingolimod (FIN) is used for multiple sclerosis treatment and has potential antiapoptotic and anti-inflammatory effects. We aimed at expanding our knowledge on various immunohistochemical markers for elucidating the possible mechanisms of action of fingolimod in the placenta and fetal lung and brain. METHOD...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923973.2020.1818771

    authors: Yavuz A,Sezik M,Eris Yalcin S,Asci H,Ozmen O

    更新日期:2020-12-01 00:00:00

  • Insertion/deletion polymorphism of the angiotensin-converting enzyme gene in lupus nephritis among Mexicans.

    abstract:UNLABELLED:The angiotensin (Ang)-converting enzyme (ACE) insertion/deletion (I/D) polymorphism determines Ang II levels, but its relationship with lupus nephritis (LN) in different populations is controversial. OBJECTIVE:To describe the allelic and genotypic distribution of the I/D polymorphism in Mexican mestizos wit...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2012.739175

    authors: Topete-Reyes JF,Soto-Vargas J,Morán-Moguel MC,Dávalos-Rodríguez IP,Chávez-González EL,García-de la Torre I,Parra-Michel R,Medina-Pérez M,Jalomo-Martínez B,Salazar-Páramo M

    更新日期:2013-02-01 00:00:00

  • Apigenin exhibits anti-inflammatory effects in LPS-stimulated BV2 microglia through activating GSK3β/Nrf2 signaling pathway.

    abstract::Objective: Apigenin is a natural flavonoid compound extracted from Matricaria chamomilla. We evaluated the anti-inflammatory effects of apigenin in this study using the Lipopolysaccharide (LPS)-stimulated BV2 microglia.Methods: BV2 cells were treated with apigenin for 1 h and then treated with LPS. The inflammatory cy...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923973.2019.1688345

    authors: Chen P,Huo X,Liu W,Li K,Sun Z,Tian J

    更新日期:2020-02-01 00:00:00

  • Siglec-8 and Siglec-F, the new therapeutic targets in asthma.

    abstract::The recruitment of eosinophils from the circulation into the airway is a prominent feature of allergic asthma. Persistent inflammatory responses may arise from inefficient mechanisms for resolution of inflammation, including delayed apoptosis. Several studies suggest that eosinophil apoptosis is delayed in asthma. Sia...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章,评审

    doi:10.3109/08923973.2011.589453

    authors: Farid SSh,Mirshafiey A,Razavi A

    更新日期:2012-10-01 00:00:00

  • Quantitative determination of pegylated consensus interferon in rhesus monkey serum using a competitive enzyme-linked immunosorbent assay.

    abstract::A competitive enzyme-linked immunosorbent assay (ELISA) with generated mouse anti-consensus interferon (CIFN) antibody was developed for quantitative determination of pegylated consensus interferon (PEG-CIFN) in rhesus monkey serum. The operational concentrations of the original assay were determined using the chessbo...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923970902814111

    authors: Cao J,Du Y,Tian H,Gao XD,Yao WB

    更新日期:2009-01-01 00:00:00

  • Allergic reactions to henna-based temporary tattoos and their components.

    abstract::Temporary henna-based tattoos, particularly popular among western tourists holidaying in exotic places, can expose to the risk to develop allergic reactions. Although hypersensitivity to henna is extremely rare, para-phenylenediamine, which is sometimes added to henna to obtain a dark, blackish color, is a frequent co...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章,评审

    doi:10.3109/08923971003685942

    authors: Calogiuri G,Foti C,Bonamonte D,Nettis E,Muratore L,Angelini G

    更新日期:2010-12-01 00:00:00

  • Neutrophil peripheral count and human leukocyte elastase during chronic lithium carbonate therapy.

    abstract::Plasma levels of human polymorphonuclear elastase (PMN-E) are considered a marker of granulocyte activation and can potentially complement the peripheral neutrophil count in laboratory and pathophysiological settings. Neutrophilic leukocytosis is a well known effect of lithium therapy, but there is no information abou...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923970009016431

    authors: Capodicasa E,Russano AM,Ciurnella E,De Bellis F,Rossi R,Scuteri A,Biondi R

    更新日期:2000-11-01 00:00:00

  • Pidotimod stimulates natural killer cell activity and inhibits thymocyte cell death.

    abstract::Experiments were performed to analyze the possible effect of the immunomodulating agent Pidotimod (3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid) on mouse Natural Killer (NK) cell activity and glucocorticoid hormone(GCH)-induced thymocyte apoptosis. The results indicate that in vivo treatment with Pidotimod (200 m...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979209009231

    authors: Migliorati G,D'Adamio L,Coppi G,Nicoletti I,Riccardi C

    更新日期:1992-01-01 00:00:00

  • An approach to urticaria in the elderly patients.

    abstract::The guidelines for the management of urticaria in adults and children have been published in outstanding position papers. By contrast, the onset of urticaria in the elderly has not yet had a clear definition. In order to approach diagnosis and treatment in a population of elderly patients, we have performed an epidemi...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2011.631549

    authors: Ventura MT,Napolitano S,Buquicchio R,Cecere R,Arsieni A

    更新日期:2012-06-01 00:00:00

  • Functional changes in THP-1 human monocytic cells after stimulation with lipopolysaccharide of oral microorganisms and granulocyte macrophage colony stimulating factor.

    abstract::A human THP-1 monocyte cell line culture system has been utilized to observe the effect of granulocyte macrophage colony stimulating factor (GM-CSF) supplementation with lipopolysaccharide (LPS) of oral microorganisms to stimulate monocyte/macrophage functional activity. LPS of oral microorganisms, Fusobacterium nucle...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979809031512

    authors: Baqui AA,Meiller TF,Turng BF,Kelley JI,Falkler WA Jr

    更新日期:1998-11-01 00:00:00

  • PRBC-derived plasma induces non-muscle myosin type IIA-mediated neutrophil migration and morphologic change.

    abstract:CONTEXT:Neutrophils are the primary effector cells in the pathogenesis of transfusion-related acute lung injury or multiple organ failure after blood transfusion. OBJECTIVE:We aimed to investigate the effect of fresh (1 day preparation) and aged (42 day preparation) PRBC-derived plasma on neutrophil morphology, migrat...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2012.677046

    authors: Yu C,Xu L,Chen LF,Guan YJ,Kim M,Biffl WL,Chin YE

    更新日期:2013-02-01 00:00:00

  • Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine.

    abstract::We examined the effect of sulfapyridine on mast cell-mediated immediate-type allergic reactions. Sulfapyridine (1 and 10 microg/kg) significantly inhibited systemic allergic reaction induced by compound 48/80 in rats. Sulfapyridine (1 and 10 microg/kg) also inhibited significantly local mast cell-mediated immediate-ty...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923970009016419

    authors: Kim HM,An NH,Yi BH,Chae HJ,Kim HR,Moon SJ,Kim JJ,Park ST,Baek SH

    更新日期:2000-05-01 00:00:00

  • Influence of dietary aluminum on cytokine production by mitogen-stimulated spleen cells from Swiss Webster mice.

    abstract::Swiss Webster mice were exposed to excess dietary aluminum (Al) (1000 micrograms Al/g diet, Al as Al lactate) from conception to 6 months of age. Splenic lymphocytes (10(6) per culture) were incubated for 24 hrs with concanavalin A (5 micrograms/ml). Concentrations of interleukin-2, interferon-gamma and tumor necrosis...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979309019733

    authors: Golub MS,Takeuchi PT,Gershwin ME,Yoshida SH

    更新日期:1993-11-01 00:00:00