Abstract:
:To investigate the role of CD4(+) T cells in neurotrophin production following toluene exposure, male C3H mice were exposed to filtered air (control) or 9 ppm of toluene in a nose-only exposure chamber for 30 min on 3 consecutive days followed by weekly sessions for 4 weeks. All the mice were immunized with ovalbumin and some groups of mice were treated with anti-CD4 antibody. BDNF content in BAL fluid and NGF content in plasma were significantly increased in toluene-exposed mice. However, treatment with anti-CD4 mAb completely abrogated these effects. These findings suggest that the CD4(+) T cells may be involved in the toluene-induced modulation of neurotrophin production.
journal_name
Immunopharmacol Immunotoxicoljournal_title
Immunopharmacology and immunotoxicologyauthors
Fujimaki H,Win-Shwe TT,Yamamoto S,Nakajima D,Goto Sdoi
10.1080/08923970802504762subject
Has Abstractpub_date
2009-01-01 00:00:00pages
146-9issue
1eissn
0892-3973issn
1532-2513pii
908660406journal_volume
31pub_type
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