Serum tumor necrosis factor activity in inflammatory bowel disease.

Abstract:

:Serum tumor necrosis factor (TNF) levels in 33 patients with inflammatory bowel disease (IBD) were measured by using a sensitive enzyme immunoassay. Four of five Crohn's diseases (CD) and nine of twenty eight ulcerative colitis (UC) had elevated levels of serum TNF. In active CD or UC, a greater fraction of patients studied had significantly increased serum TNF levels (3/3 for CD and 8/11 for UC). Production of TNF by peripheral blood monocytes when stimulated by lipopolysaccharide was also increased in these patients and correlated with their serum TNF levels. These results suggest that TNF may have some pathoetiological meaning in IBD.

authors

Maeda M,Watanabe N,Neda H,Yamauchi N,Okamoto T,Sasaki H,Tsuji Y,Akiyama S,Tsuji N,Niitsu Y

doi

10.3109/08923979209005404

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

451-61

issue

3

eissn

0892-3973

issn

1532-2513

journal_volume

14

pub_type

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