Immunomodulatory and antitumor activity of Aerva lanata ethanolic extract.

abstract：:Two dideoxynucleosides, 2',3'-dideoxy-beta-L-cytidine and 2',3'-dideoxy-beta-L-5-flurocytidine, containing unnatural L-configuration in their sugar moieties, were synthesized and assayed for antiviral activities. Both compounds were shown to possess potent anti-human immunodeficiency virus type 1 and antihepatitis B v...

journal_title：Immunopharmacology and immunotoxicology

authors： Gagnon L,Nordstrom PA,Duchaine J,Jutras D,Hamel M,Barbeau D,Hooker E,Ashman C,Cammack N,Tse A

更新日期：1995-02-01 00:00:00

abstract：:Lymphocyte proliferation assays are commonly used to quantify the effects of immunosuppressive drugs in animal models, but the influence of anesthetic agents on those assays is not well understood. We used a whole blood proliferation assay to compare lymphocyte proliferation in blood drawn from normal male Lewis rats ...

journal_title：Immunopharmacology and immunotoxicology

authors： Gummert JF,Otto G,Barten MJ,Morris RE

更新日期：1999-05-01 00:00:00

abstract：:Objective: Little is known about the exact underlying molecular mechanisms of the hepatoprotective effect of carvacrol against liver fibrosis. In the current study, we aimed to investigate the effect of carvacrol on the suppression of liver fibrosis progression via regulation of yes-associated protein (YAP) and transc...

journal_title：Immunopharmacology and immunotoxicology

authors： Mohseni R,Karimi J,Tavilani H,Khodadadi I,Hashemnia M

更新日期：2019-02-01 00:00:00

abstract：:Taraxasterol, a pentacyclic-triterpene, was isolated from the Chinese medicinal herb Taraxacum officinale. In the present study, we investigated the protective effect of taraxasterol on murine model of endotoxic shock and the mechanism of its action. Mice were treated with 2.5, 5 and 10 mg/kg of taraxasterol prior to ...

journal_title：Immunopharmacology and immunotoxicology

authors： Zhang X,Xiong H,Li H,Cheng Y

更新日期：2014-02-01 00:00:00

abstract：:Density of nerve fibers, axonal growth, calcitonin gene-related peptide (CGRP), and substance P, and serotonin immunoreactivity as well as concentration were all determined in a murine model of contact allergy. Female Balb/c mice were sensitized on the back with oxazolone and 6 days later challenged with the same anti...

journal_title：Immunopharmacology and immunotoxicology

authors： El-Nour H,Lundeberg L,Boman A,Beck O,Harvima IT,Theodorsson E,Nordlind K

更新日期：2005-01-01 00:00:00

abstract：:Several abnormalities of the immune system have been reported in association with clinical and experimental iron overload. To dissect further such abnormalities, changes in lymphocyte subsets were evaluated in iron-loaded male Sprague-Dawley rats. The iron-loading protocol consisted of a total dose of irondextran (1.5...

journal_title：Immunopharmacology and immunotoxicology

authors： Cardier JE,Romano E,Soyano A

更新日期：1997-02-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a ubiquitously expressed ATP-dependent molecular chaperone across all species that helps to the correct the folding of many proteins related to important signaling pathways. Tumor cells expressing Hsp90 have more ATP-binding affinity than normal cells. Many correlative inhibitors have ...

journal_title：Immunopharmacology and immunotoxicology

authors： Huyan T,Li Q,Dong DD,Yang H,Zhang J,Huang QS,Yin DC,Shang P

更新日期：2016-01-01 00:00:00

abstract：:We have previously demonstrated that the chlorphentermine (CP)1-induced impairment in lymphocyte blastogenesis involves drug-induced inhibition of an event which occurs very early during lymphocyte activation. An early event, which is associated with mitogen-induced lymphocyte activation, involves the hydrolysis of ph...

journal_title：Immunopharmacology and immunotoxicology

authors： Sauers LJ,Wierda D,Reasor MJ

更新日期：1988-01-01 00:00:00

abstract：:Ponesimod, a novel selective sphingosine-1-phosphate 1 receptor modulator in the development for the treatment of autoimmune diseases, dose-dependently reduced lymphocyte counts in peripheral blood of healthy subjects. It rapidly and transiently reduced the number of circulating T and B cells, but not natural killer c...

journal_title：Immunopharmacology and immunotoxicology

authors： D'Ambrosio D,Steinmann J,Brossard P,Dingemanse J

更新日期：2015-02-01 00:00:00

abstract：:The immunological effects of interferon (IFN)-alpha administration were evaluated in 15 patients with cHCV infection. Individuals were treated with 6 MU of lymphoblastoid IFN-alpha three times a week for 6 months and with 3 MU three times a week for an additional 6 months. Patients were divided into responders (12 sub...

journal_title：Immunopharmacology and immunotoxicology

authors： Jirillo E,Greco B,Caradonna L,Satalino R,Amati L,Cozzolongo R,Cuppone R,Manghisi OG

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:Abnormal microglia secrete neuroinflammatory factors that play a pivotal role in neurodegenerative-disorder development. Thus, regulating abnormal microglia-activation could be a promising therapeutic strategy. The purposes of this study included investigating the effect of Petatewalide B on lipopolysacchari...

journal_title：Immunopharmacology and immunotoxicology

authors： Park SY,Choi MH,Li M,Li K,Park G,Choi YW

更新日期：2018-06-01 00:00:00

abstract：:T-2 toxin, a fungal metabolite shown previously to exert potent immunosuppressive effects, was examined for its effects on activation and interleukin 2 (IL 2) production by murine and rat splenocytes. Splenocytes (1 X 10(6) cells/well) were incubated with 1 microgram Concanavalin A (Con A) for 48 h at which time cellu...

journal_title：Immunopharmacology and immunotoxicology

authors： Holt PS,Corrier DE,DeLoach JR

更新日期：1988-01-01 00:00:00

abstract：:Sexual assault was a ubiquitous and serious problem in our society. The world's care centers and forensic associations, which were at the forefront of scientific research in sexual assaults, discussed the role of the Forensic Nursing in their early diagnosis and their prevention, but little has been written in literat...

journal_title：Immunopharmacology and immunotoxicology

authors： Vitale E

更新日期：2012-04-01 00:00:00

abstract：:To determine how estrogen exacerbates allergies, the effects of 17beta-estradiol (E2) on lymphocyte proliferation were investigated. BALB/c mice were ovariectomized, administered 3.2 microg E2, and sensitized with 50 microL 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one. After 7 days, their spleens were excised and flow ...

journal_title：Immunopharmacology and immunotoxicology

authors： Sakazaki F,Ueno H,Nakamuro K

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Sorafenib is an orally active multikinase inhibitor licensed for the treatment of patients with unresectable hepatocellular carcinoma (HCC). PATIENTS AND METHODS:The web-based registry, used for appraisal on new drugs, allows developing the observational prospective analysis of innovative drug therapies. To...

journal_title：Immunopharmacology and immunotoxicology

authors： Trojniak MP,Palozzo AC,Mazurek M,Jirillo A

更新日期：2012-06-01 00:00:00

abstract：:Formyl peptides are oligopeptides released by Gram-negative bacteria. So far, specific formyl peptide receptors (FPRs) have been described in mammals only. FPRs are seven-transmembrane G-coupled molecules and make up a relatively homogeneous group, although exhibiting different levels of affinity for the ligands. We e...

journal_title：Immunopharmacology and immunotoxicology

authors： Panaro MA,Acquafredda A,Sisto M,Lisi S,Calvello R,Mitolo CI,Cianciulli A,Mitolo V

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To establish the clearance of cervical human papillomavirus (HPV) infection following postoperative immunotherapy with inosine pranobex in women receiving surgical treatment of established high-grade squamous intraepithelial lesion (HSIL) of the uterine cervix. MATERIALS AND METHODS:Over the six-year study p...

journal_title：Immunopharmacology and immunotoxicology

authors： Kovachev SM

更新日期：2020-08-01 00:00:00

abstract：:Luminol-enhanced chemiluminescence assay was used to detect the surface expression and the consequent activation of receptors (FcRI and FcRII) of murine macrophages (M phi s). When murine IgG2a was used for the specific detection of FcRI and IgG2b for FcRII, a newly established procedure enabled us to detect the activ...

journal_title：Immunopharmacology and immunotoxicology

authors： Majima T,Itoh K,Yatsu J,Yoshie O,Ishida N

更新日期：1989-01-01 00:00:00

abstract：:Arecoline, a major alkaloid of arecanut was screened to explore its modulatory influence on cell-mediated immune response in a murine model system. The in vivo and in vitro effects were evaluated at subtoxic concentrations of arecoline. Delayed type hypersensitivity (DTH) reactions to sheep red blood cells (SRBC) were...

journal_title：Immunopharmacology and immunotoxicology

authors： Selvan RS,Selvakumaran M,Rao AR

更新日期：1991-01-01 00:00:00

abstract：:We describe the case of a 42-years-old non-atopic man who developed a severe eczematous reaction in the genital area some hours after the use of a condom (Settebello-Hatù Durex) containing a retarding cream. Patch test revealed a strong allergic reaction to the retarding cream and to benzocaine and paraben mix contain...

journal_title：Immunopharmacology and immunotoxicology

authors： Foti C,Bonamonte D,Antelmi A,Conserva A,Angelini G

更新日期：2004-08-01 00:00:00

abstract：:Apigenin is a plant flavonoid and a pharmacologically active agent that has been isolated from several plant species. However, the molecular mechanism of apigenin-mediated immune modulation has not been fully understood. One of the possible mechanisms of its protective effects is the down-regulation of inflammatory re...

journal_title：Immunopharmacology and immunotoxicology

authors： Kang OH,Lee JH,Kwon DY

更新日期：2011-09-01 00:00:00

abstract：:Myricetin, a common dietary flavonoid, is widely distributed in fruits and vegetables. It is known to be a food supplement contributing to human health because of its immune modulatory function, and its antioxidation, antitumor, and anti-inflammatory properties. In the present study, myricetin was shown to directly in...

journal_title：Immunopharmacology and immunotoxicology

authors： Yuan X,Liu Y,Hua X,Deng X,Sun P,Yu C,Chen L,Yu S,Liu S,Pang H

更新日期：2015-01-01 00:00:00

abstract：:Tubeimoside-1 (TBMS1) is one of the important components in Bolbostemma paniculatum (Maxim.) Franque. In the study, its immunosuppressive effects on murine T lymphocyte responses were evaluated in vitro and in vivo. The data showed that TBMS1 inhibited ConA-induced T lymphocyte proliferation, decreased the ratio of CD...

journal_title：Immunopharmacology and immunotoxicology

authors： Huang Y,Ren M,Xiong Y,Wang T,Chen H,Deng X,Lu J

更新日期：2015-01-01 00:00:00

abstract：:The application of heat shock to different types of cells is known to cause multiple biochemical and metabolic changes. The predominant event though is an increased synthesis and expression of a family of proteins, the heat-shock proteins (Hsp). Some of these proteins are currently considered to be involved in the sig...

journal_title：Immunopharmacology and immunotoxicology

authors： Liossis SN,Tsokos GC

更新日期：1997-11-01 00:00:00

abstract：CONTEXT:β-d-Mannuronic acid (M2000) has shown its therapeutic effects with the greatest tolerability and efficacy in various experimental models such as experimental autoimmune encephalomyelitis (EAE), adjuvant induced arthritis (AIA), nephrotic syndrome, and acute glomerulonephritis. Despite pharmacological effects of...

journal_title：Immunopharmacology and immunotoxicology

authors： Fattahi MJ,Abdollahi M,Agha Mohammadi A,Rastkari N,Khorasani R,Ahmadi H,Tofighi Zavareh F,Sedaghat R,Tabrizian N,Mirshafiey A

更新日期：2015-01-01 00:00:00

abstract：:The effect of rapamycin (RAPA) on kidney function and histopathology was assessed in two strains of mice. Male C3H/HeJ mice were treated with RAPA for 4 days at doses of 25, 50, 75, and 100 mg/kg, ip and male C3H/HeJ or female Balb/cJ mice were both treated for 7 days at doses of 75, 150 and 200 mg/kg. Cyclosporine (C...

journal_title：Immunopharmacology and immunotoxicology

authors： Di Joseph JF,Sehgal SN

更新日期：1993-01-01 00:00:00

abstract：:Thalidomide causes congenital anomalies and it is immunomodulatory. These properties could be explained by an ability to alter the orderly process of programmed cell death during embryogenesis and modulation of apoptosis of lymphoid and/or myeloid cells in the immune response. Apoptosis of lymphoid and myeloid cells w...

journal_title：Immunopharmacology and immunotoxicology

authors： Aseffa A,Dietrich MA,Shannon EJ

更新日期：1997-08-01 00:00:00

abstract：:CD69, also known as activation inducer molecule, very early activation antigen, MLR-3 and Leu-23, is a member of the natural killer (NK) cell gene complex family of signal transducing receptors. CD69 is as a type II transmembrane glycoprotein with a C-type lectin binding domain in the extracellular portion of the mole...

journal_title：Immunopharmacology and immunotoxicology

authors： Marzio R,Mauël J,Betz-Corradin S

更新日期：1999-08-01 00:00:00

abstract：:The popular murine macrophage cell line, RAW 264.7, is often used to initially screen natural products for bioactivity and to predict their potential effect in vivo or on primary cells. The cell line response is considered to reflect the potential human de novo response, and is used to evaluate the effective bioactivi...

journal_title：Immunopharmacology and immunotoxicology

authors： Merly L,Smith SL

更新日期：2017-04-01 00:00:00

abstract：:We have previously found that NK cell activity is present in rat lung lavage and inhibited by lidocaine. The purpose of this report is to characterize further the inhibition by lidocaine on NK activity. Peripheral blood lymphocytes from normal human volunteers were assayed in a four-hour 51chromium release assay in th...

journal_title：Immunopharmacology and immunotoxicology

authors： Renzi PM,Ginns LC

更新日期：1990-01-01 00:00:00