Chlorphentermine suppresses the phosphatidylinositol pathway in concanavalin A-activated mouse splenic lymphocytes.

abstract：:Several abnormalities of the immune system have been reported in association with clinical and experimental iron overload. To dissect further such abnormalities, changes in lymphocyte subsets were evaluated in iron-loaded male Sprague-Dawley rats. The iron-loading protocol consisted of a total dose of irondextran (1.5...

journal_title：Immunopharmacology and immunotoxicology

authors： Cardier JE,Romano E,Soyano A

更新日期：1997-02-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs), one of the major orchestrators of immunosuppressive network are present in the tumor microenvironment suppress antitumor immunity by subverting Th1 response in tumor site and considered as a great obstacle for advancement of different cancer immunotherapeutic protocols. Till d...

journal_title：Immunopharmacology and immunotoxicology

authors： Chakraborty P,Das S,Banerjee K,Sinha A,Roy S,Chatterjee M,Choudhuri SK

更新日期：2014-04-01 00:00:00

abstract：:The application of heat shock to different types of cells is known to cause multiple biochemical and metabolic changes. The predominant event though is an increased synthesis and expression of a family of proteins, the heat-shock proteins (Hsp). Some of these proteins are currently considered to be involved in the sig...

journal_title：Immunopharmacology and immunotoxicology

authors： Liossis SN,Tsokos GC

更新日期：1997-11-01 00:00:00

abstract：:Swiss Webster mice were exposed to excess dietary aluminum (Al) (1000 micrograms Al/g diet, Al as Al lactate) from conception to 6 months of age. Splenic lymphocytes (10(6) per culture) were incubated for 24 hrs with concanavalin A (5 micrograms/ml). Concentrations of interleukin-2, interferon-gamma and tumor necrosis...

journal_title：Immunopharmacology and immunotoxicology

authors： Golub MS,Takeuchi PT,Gershwin ME,Yoshida SH

更新日期：1993-11-01 00:00:00

abstract：:Sexual assault was a ubiquitous and serious problem in our society. The world's care centers and forensic associations, which were at the forefront of scientific research in sexual assaults, discussed the role of the Forensic Nursing in their early diagnosis and their prevention, but little has been written in literat...

journal_title：Immunopharmacology and immunotoxicology

authors： Vitale E

更新日期：2012-04-01 00:00:00

abstract：:Purple bamboo salt is a specially processed salt according to the traditional recipe using normal salt and bamboo. It has been used for the purpose of prevention and treatment of various diseases in Korea. We investigated the anti-inflammatory activity of purple bamboo salt by using human mast cell line (HMC-1). Purpl...

journal_title：Immunopharmacology and immunotoxicology

authors： Shin HY,Lee EH,Kim CY,Shin TY,Kim SD,Song YS,Lee KN,Hong SH,Kim HM

更新日期：2003-08-01 00:00:00

abstract：:Ponesimod, a novel selective sphingosine-1-phosphate 1 receptor modulator in the development for the treatment of autoimmune diseases, dose-dependently reduced lymphocyte counts in peripheral blood of healthy subjects. It rapidly and transiently reduced the number of circulating T and B cells, but not natural killer c...

journal_title：Immunopharmacology and immunotoxicology

authors： D'Ambrosio D,Steinmann J,Brossard P,Dingemanse J

更新日期：2015-02-01 00:00:00

abstract：:The aim of the present study was to investigate putative mechanisms implicated in the impaired phagocytic response of spontaneously hypertensive rats (SHR)1. The effect of in vitro treatment with isoproterenol (ISO), a beta-adrenergic drug, on phagocytosis and respiratory burst by splenic macrophages (SpMø) from normo...

journal_title：Immunopharmacology and immunotoxicology

authors： Serio M,Potenza MA,Montagnani M,Mansi G,Mitolo-Chieppa D,Jirillo E

更新日期：1996-05-01 00:00:00

abstract：:We have previously found that NK cell activity is present in rat lung lavage and inhibited by lidocaine. The purpose of this report is to characterize further the inhibition by lidocaine on NK activity. Peripheral blood lymphocytes from normal human volunteers were assayed in a four-hour 51chromium release assay in th...

journal_title：Immunopharmacology and immunotoxicology

authors： Renzi PM,Ginns LC

更新日期：1990-01-01 00:00:00

abstract：:A polymerase chain reaction was devised to simultaneously detect repeated insertion sequences and the pertussis toxin promoter gene for the diagnostic identification of Bordetella pertussis, B. parapertussis, and B. bronchiseptica. The sensitivity of this method was sufficient to detect one B. pertussis organism using...

journal_title：Immunopharmacology and immunotoxicology

authors： Furuya D,Yagihashi A,Endoh T,Uehara N,Fujii N,Chiba S,Watanabe N

更新日期：1999-02-01 00:00:00

abstract：CONTEXT:Serum IgA suppresses immune responses when exposed to antigens recognized by the antibody; however, the underlying mechanism remains unclear. OBJECTIVE:We herein clarified the relationships between changes in antigen distribution and antigen-dependent B cell activation in the presence or absence of IgA against...

journal_title：Immunopharmacology and immunotoxicology

authors： Yamaki K,Yoshino S

更新日期：2016-01-01 00:00:00

abstract：:Both pregnancy and cyclosporin A (CsA) are known to inhibit T-cell mediated immune response and to activate phagocytes against microbial infections as a compensatory mechanism. Pregnant women, either with organ transplantation or suffering from autoimmune diseases, are commonly managed with CsA therapy. This investiga...

journal_title：Immunopharmacology and immunotoxicology

authors： Khan HA

更新日期：2007-01-01 00:00:00

abstract：:Objective: Little is known about the exact underlying molecular mechanisms of the hepatoprotective effect of carvacrol against liver fibrosis. In the current study, we aimed to investigate the effect of carvacrol on the suppression of liver fibrosis progression via regulation of yes-associated protein (YAP) and transc...

journal_title：Immunopharmacology and immunotoxicology

authors： Mohseni R,Karimi J,Tavilani H,Khodadadi I,Hashemnia M

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of ginsenoside metabolite compound K (CK) on adjuvant-induced arthritis (AA) rats and the partial mechanisms focused on the function of immunocyte (B cell and macrophage) and effectors' cell (fibroblast-like synoviocyte, FLS). METHODS:Animals were divided randomly into nine groups ...

journal_title：Immunopharmacology and immunotoxicology

authors： Wu H,Chen J,Wang Q,Jia X,Song S,Yuan P,Liu K,Liu L,Zhang Y,Zhou A,Wei W

更新日期：2014-04-01 00:00:00

abstract：:Inflammatory bowel diseases are characterized by disabilities in gastrointestinal system and defects in mucosal immune system. Statins are 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitor and are used to treat hypercholesterolemia in patients with coronary artery and atherosclerotic diseases. Recent studies ...

journal_title：Immunopharmacology and immunotoxicology

authors： Aktunc E,Kayhan B,Arasli M,Gun BD,Barut F

更新日期：2011-12-01 00:00:00

abstract：:Naloxone at concentrations 10(-6) M to 10(-10) M modulated endogenous NK-activity in 11 of 14 samples of human peripheral blood lymphocytes after 18-hour incubation. The dose response usually showed two peaks, which varied with the donor. Enhancement was obtained in 6, suppression in 4, and both effects (depending on ...

journal_title：Immunopharmacology and immunotoxicology

authors： Martin-Kleiner I,Gabrilovac J

更新日期：1993-03-01 00:00:00

abstract：:Modulation of immune response to alleviate diseases has long since been of interest. Plant extracts have been widely investigated for their possible immunomodulatory properties. We have evaluated the immunomodulatory activity of aqueous extract of Rhodiola rhizome in human peripheral blood mononuclear cells (PBMCs) an...

journal_title：Immunopharmacology and immunotoxicology

authors： Mishra KP,Padwad YS,Jain M,Karan D,Ganju L,Sawhney RC

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Capsaicin is a chili pepper extract with multiple therapeutic properties including anti-liver fibrosis. However, the paucity of its underlying mechanisms limited its widely clinical application. METHODS:In the present study, carbon tetrachloride (CCl4) was used to induce liver fibrosis in mice, and transfor...

journal_title：Immunopharmacology and immunotoxicology

authors： Sheng J,Zhang B,Chen Y,Yu F

更新日期：2020-12-01 00:00:00

abstract：:N-nitrozodimethyloamine (NDMA) is a carcinogenic compound that can be formed in vivo. NDMA is synthesized from precursors-amines and nitrosating agents. Nitrosating agents are formed through the reaction of oxide, reactive oxygen species and nitric oxide (NO). Human neutrophils (PMN) are an important source of the mos...

journal_title：Immunopharmacology and immunotoxicology

authors： Jabłoński J,Jabłońska E,Iwanowska J,Marcińczyk M,Moniuszko-Jakoniuk J

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To establish the clearance of cervical human papillomavirus (HPV) infection following postoperative immunotherapy with inosine pranobex in women receiving surgical treatment of established high-grade squamous intraepithelial lesion (HSIL) of the uterine cervix. MATERIALS AND METHODS:Over the six-year study p...

journal_title：Immunopharmacology and immunotoxicology

authors： Kovachev SM

更新日期：2020-08-01 00:00:00

abstract：:The guidelines for the management of urticaria in adults and children have been published in outstanding position papers. By contrast, the onset of urticaria in the elderly has not yet had a clear definition. In order to approach diagnosis and treatment in a population of elderly patients, we have performed an epidemi...

journal_title：Immunopharmacology and immunotoxicology

authors： Ventura MT,Napolitano S,Buquicchio R,Cecere R,Arsieni A

更新日期：2012-06-01 00:00:00

abstract：:A human hepatoma cell line, Hep G2 cells are reliable for the study of alcohol-induced hepatotoxicity. In this study, we investigated the effect of an aqueous extract of Polygala tenuifolia WILLDENOW (Polygalaceae) roots (PTAE) on ethanol (EtOH)-induced cytotoxicity in Hep G2 cells. PTAE (0.01-1 microg/ml) dose-depend...

journal_title：Immunopharmacology and immunotoxicology

authors： Koo HN,Jeong HJ,Kim KR,Kim JC,Kim KS,Kang BK,Kim HM,Kim JJ

更新日期：2000-08-01 00:00:00

abstract：:The current research was designed to determine the effect of artemether in treatment of experimental rheumatoid arthritis. Collagen-induced arthritis was induced in Lewis rats. The intramusculary administration of artemether (ART) and intraperitoneally injection of methotrexate (MTX) were started on day 25 postimmuniz...

journal_title：Immunopharmacology and immunotoxicology

authors： Cuzzocrea S,Saadat F,Di Paola R,Mirshafiey A

更新日期：2005-01-01 00:00:00

abstract：:Various cells are associated with the integrated stress response (ISR) that leads to translation arrest via phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Pathogenic insults or nutritional imbalance in the mucosal tissues including the intestinal, airway, and genitourinary epitheli...

journal_title：Immunopharmacology and immunotoxicology

authors： Park SH,Moon Y

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To explore the effect and mechanism of artesunate on γδ T cell-mediated antitumor immune responses against hepatoma carcinoma cells (HepG2) in vitro. METHODS:Human γδ T cells or HepG2 were respectively treated with artesunate, subjected to co-culture as appropriate, and the following assays were subsequently...

journal_title：Immunopharmacology and immunotoxicology

authors： Qian P,Zhang YW,Zhou ZH,Liu JQ,Yue SY,Guo XL,Sun LQ,Lv XT,Chen JQ

更新日期：2018-04-01 00:00:00

abstract：:Apigenin is a plant flavonoid and a pharmacologically active agent that has been isolated from several plant species. However, the molecular mechanism of apigenin-mediated immune modulation has not been fully understood. One of the possible mechanisms of its protective effects is the down-regulation of inflammatory re...

journal_title：Immunopharmacology and immunotoxicology

authors： Kang OH,Lee JH,Kwon DY

更新日期：2011-09-01 00:00:00

abstract：:Two dideoxynucleosides, 2',3'-dideoxy-beta-L-cytidine and 2',3'-dideoxy-beta-L-5-flurocytidine, containing unnatural L-configuration in their sugar moieties, were synthesized and assayed for antiviral activities. Both compounds were shown to possess potent anti-human immunodeficiency virus type 1 and antihepatitis B v...

journal_title：Immunopharmacology and immunotoxicology

authors： Gagnon L,Nordstrom PA,Duchaine J,Jutras D,Hamel M,Barbeau D,Hooker E,Ashman C,Cammack N,Tse A

更新日期：1995-02-01 00:00:00

abstract：:Luminol-enhanced chemiluminescence assay was used to detect the surface expression and the consequent activation of receptors (FcRI and FcRII) of murine macrophages (M phi s). When murine IgG2a was used for the specific detection of FcRI and IgG2b for FcRII, a newly established procedure enabled us to detect the activ...

journal_title：Immunopharmacology and immunotoxicology

authors： Majima T,Itoh K,Yatsu J,Yoshie O,Ishida N

更新日期：1989-01-01 00:00:00

abstract：:The purpose of our study was to compare the effectiveness of immunosuppressive drugs on the prevention of allograft rejection in a murine model of low-risk and high-risk keratoplasty. The therapy included FK 506 (tacrolimus; 0.2 mg/kg), mycophenolate mofetil (30 mg/kg), aminoguanidine (0.1 g/kg), and combination of FK...

journal_title：Immunopharmacology and immunotoxicology

authors： Svozílková P,Bysterská P,Masek K,Valenta Z,Zvárová J,Farghali H

更新日期：2006-01-01 00:00:00

abstract：:Engystol-N at the doses of 10(-4) and 10(-8) in isolated human leukocytes stimulates the superoxide anion generation by neutrophils and the cytokine(s) production by T lymphocytes. In whole blood the same concentrations of the drug produce the decrease of the superoxide anion generation of neutrophils, this inhibiting...

journal_title：Immunopharmacology and immunotoxicology

authors： Fimiani V,Cavallaro A,Ainis O,Bottari C

更新日期：2000-02-01 00:00:00