Apigenin inhibits release of inflammatory mediators by blocking the NF-κB activation pathways in the HMC-1 cells.

abstract：CONTEXT:Multiple organ dysfunction syndrome (MODS) is a major cause of death in critically patients. It has been hypothesized that inactivation or removal of pro-inflammatory molecules may prevent or reverse MODS. OBJECTIVE:The purpose of this paper was to investigate the efficacy of continuous veno-venous hemodiafilt...

journal_title：Immunopharmacology and immunotoxicology

authors： Chen J,Liu J,Yu C,Wen H

更新日期：2012-12-01 00:00:00

abstract：:Plasma levels of human polymorphonuclear elastase (PMN-E) are considered a marker of granulocyte activation and can potentially complement the peripheral neutrophil count in laboratory and pathophysiological settings. Neutrophilic leukocytosis is a well known effect of lithium therapy, but there is no information abou...

journal_title：Immunopharmacology and immunotoxicology

authors： Capodicasa E,Russano AM,Ciurnella E,De Bellis F,Rossi R,Scuteri A,Biondi R

更新日期：2000-11-01 00:00:00

abstract：:Plant medications have been used as treatment in various kinds of systemic inflammatory disorder such as Behçet's disease (BD). We investigated the roles of On-Chung-Eum (OCE), a traditional plant medicine, in cytokine regulation of BD. The effects of OCE on cytokine production from phytohaemagglutinin (PHA)-stimulate...

journal_title：Immunopharmacology and immunotoxicology

authors： Kim MS,Kim SO,Lim WK,Lee JM,Hwang CY,Cho KH,Kim HM

更新日期：2003-02-01 00:00:00

abstract：:Reynoutria elliptica has been used in traditional Korean medicine to promote blood circulation, relieve pain, increase dieresis, and alleviate respiratory problems, through as yet undefined mechanisms. We set out to determine whether the anti-inflammatory effects of this plant are linked with its ability to suppress m...

journal_title：Immunopharmacology and immunotoxicology

authors： Lee G,Choi TW,Kim C,Nam D,Lee SG,Jang HJ,Lee JH,Um JY,Jung SH,Shim BS,Ahn KS,Ahn KS

更新日期：2012-06-01 00:00:00

abstract：:This study is to explore the inner anti-inflammatory mechanism of the ethanol extract of Rungia pectinata (Linn.) Nees. As a result, the ethanol extract of Rungia pectinata (Linn.) Nees could not only strongly reduce production of pro-inflammatory cytokines and mediators via blocking NF-kappaB activation but slightly ...

journal_title：Immunopharmacology and immunotoxicology

authors： Zhao L,Tao JY,Zhang SL,Jin F,Pang R,Dong JH,Guo YJ,Ye P

更新日期：2008-01-01 00:00:00

abstract：:CD69, also known as activation inducer molecule, very early activation antigen, MLR-3 and Leu-23, is a member of the natural killer (NK) cell gene complex family of signal transducing receptors. CD69 is as a type II transmembrane glycoprotein with a C-type lectin binding domain in the extracellular portion of the mole...

journal_title：Immunopharmacology and immunotoxicology

authors： Marzio R,Mauël J,Betz-Corradin S

更新日期：1999-08-01 00:00:00

abstract：:Chief part of hemopoietic stromal cells in mediating hemopoiesis-stimulating effects of adamantylamide dipeptide (AdDP), a synthetic immunomodulatory compound, has been determined in a series of combined in vivo/in vitro studies. Indirect stimulatory effect of AdDP on proliferation of hemopoietic progenitor cells for ...

journal_title：Immunopharmacology and immunotoxicology

authors： Vacek A,Hofer M,Weiterová L,Hoferová Z,Pipalová I,Masek K

更新日期：2001-11-01 00:00:00

abstract：CONTEXT:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by autoreactive antibodies. Recent findings revealed the importance of innate immune responses, especially Toll-like receptors (TLRs) in the pathogenesis of SLE. OBJECTIVE:In this study, the level of TLR9 expression on peripheral...

journal_title：Immunopharmacology and immunotoxicology

authors： Mortezagholi S,Babaloo Z,Rahimzadeh P,Namdari H,Ghaedi M,Gharibdoost F,Mirzaei R,Bidad K,Salehi E

更新日期：2017-02-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a ubiquitously expressed ATP-dependent molecular chaperone across all species that helps to the correct the folding of many proteins related to important signaling pathways. Tumor cells expressing Hsp90 have more ATP-binding affinity than normal cells. Many correlative inhibitors have ...

journal_title：Immunopharmacology and immunotoxicology

authors： Huyan T,Li Q,Dong DD,Yang H,Zhang J,Huang QS,Yin DC,Shang P

更新日期：2016-01-01 00:00:00

abstract：:The protective effects of baicalin (BA), a major flavone from Scutellaria radix, on acetaminophen (AP)-induced hepatotoxicity and the possible mechanism(s) of its protective action were investigated in mice. Treatment with BA (300 mg/kg, p.o.) 0.5 h after AP administration significantly prevented an increase in plasma...

journal_title：Immunopharmacology and immunotoxicology

authors： Jang SI,Kim HJ,Hwang KM,Jekal SJ,Pae HO,Choi BM,Yun YG,Kwon TO,Chung HT,Kim YC

更新日期：2003-11-01 00:00:00

abstract：:We previously showed that formation of pulmonary granulomas in mice in response to a mycobacterial glycolipid, trehalose 6,6'-dimycolate (TDM) is due to the action of TNF-α and not of IFN-γ. However, the mechanisms of formation and maintenance of pulmonary granulomas are not yet clear. The purpose of the present study...

journal_title：Immunopharmacology and immunotoxicology

authors： Saitoh T,Yano I,Kumazawa Y,Takimoto H

更新日期：2012-10-01 00:00:00

abstract：:In the present study, we investigated the possibility that the WNT/β-catenin pathway plays a role in inflammatory responses both in an human inflammatory condition and in an in vitro inflammation model. First, we analyzed gene expression patterns of the peripheral blood cells from asthma patients compared with those f...

journal_title：Immunopharmacology and immunotoxicology

authors： Lee H,Bae S,Choi BW,Yoon Y

更新日期：2012-02-01 00:00:00

abstract：:Lung cancer continues to be the leading cause of cancer deaths and more than one million lung cancer patients will die every year worldwide. Radiotherapy (RT) plays an important role in lung cancer treatment, but the side effects of RT are pneumonitis and pulmonary fibrosis. RT-induced lung injury causes damage to alv...

journal_title：Immunopharmacology and immunotoxicology

authors： S N SG,Raviraj R,Nagarajan D,Zhao W

更新日期：2019-06-01 00:00:00

abstract：:The etiology of inflammatory bowel diseases which include ulcerative colitis (UC) and Crohn disease has not yet been clarified. Several hypotheses suggest a change in composition of gut microflora along with an impaired mucosal barrier that lead to excessive mucosal immunologic responses. Increased production of nitri...

journal_title：Immunopharmacology and immunotoxicology

authors： Toumi R,Abdelouhab K,Rafa H,Soufli I,Raissi-Kerboua D,Djeraba Z,Touil-Boukoffa C

更新日期：2013-06-01 00:00:00

abstract：:The effect of aqueous extract of Stachys riederi var. japonica Miq. (Labiatae) (SRAE) on the mast cell-mediated allergic and inflammatory reactions were investigated. SRAE inhibited systemic allergic reaction induced by compound 48/80. SRAE dose-dependently inhibited passive cutaneous anaphylaxis (PCA) activated by an...

journal_title：Immunopharmacology and immunotoxicology

authors： Shin TY

更新日期：2004-01-01 00:00:00

abstract：:Sexual assault was a ubiquitous and serious problem in our society. The world's care centers and forensic associations, which were at the forefront of scientific research in sexual assaults, discussed the role of the Forensic Nursing in their early diagnosis and their prevention, but little has been written in literat...

journal_title：Immunopharmacology and immunotoxicology

authors： Vitale E

更新日期：2012-04-01 00:00:00

abstract：:Protective effect of a Japanese traditional herbal medicine, Juzen-taiho-to (TJ-48), which was recently reported to augment host-mediated antifungal actions, in Candida albicans-infected mice was further studied. TJ-48, given orally once daily for 5 consecutive days in a dose of 2 g/kg after intravenous infection of C...

journal_title：Immunopharmacology and immunotoxicology

authors： Akagawa G,Abe S,Tansho S,Uchida K,Yamaguchi H

更新日期：1996-02-01 00:00:00

abstract：:Antidepressants are reported to display anti-inflammatory effects. Nitric oxide (NO), in turn, has a key role in inflammation. The objective of the present study was to evaluate the effect of amitriptyline co-administered with L-NAME (a NO synthase inhibitor) on certain parameters of acute inflammatory response in rat...

journal_title：Immunopharmacology and immunotoxicology

authors： Vismari L,Alves GJ,Muscará MN,Palermo-Neto J

更新日期：2012-08-01 00:00:00

abstract：:Neuroinflammation plays a critical role in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease (AD). Microglial cells after activated play critical roles in development of neuroinflammation, and may accelerate the progression of AD. Andrographolide (ANDRO), a potent naturally extracte...

journal_title：Immunopharmacology and immunotoxicology

authors： Yang R,Liu S,Zhou J,Bu S,Zhang J

更新日期：2017-10-01 00:00:00

abstract：:Multiple Drug Allergy Syndrome (MDAS) is a frequent clinical condition characterized by reactions to more than one different class of antibiotics. Even if some studies have previously reported an increased rate of allergic reactions to drugs in patients with a history of antimicrobials and NSAIDs allergy, risk factors...

journal_title：Immunopharmacology and immunotoxicology

authors： Nettis E,Colanardi MC,Paola RD,Ferrannini A,Tursi A

更新日期：2001-11-01 00:00:00

abstract：:We hypothesized that immunosuppression in birds that is caused by exposure to antiandrogenic chemicals occurs mainly through disruption of the development of the androgen-sensitive avian lymphoid organ, the bursa of Fabricius. Injections of 20.0 or 40.0 mug of p,p'-DDE [ethylene, 1,1-dichloro-2,2-bis(p-chlorophenyl)],...

journal_title：Immunopharmacology and immunotoxicology

authors： Quinn MJ,Summitt CL,Ottinger MA

更新日期：2006-01-01 00:00:00

abstract：:The rate of collagen deposition in implanted polytetrafluoroethylene (PTFE) tubing in non-diabetic and streptozotocin-induced (STZ) diabetic mice was measured during 14 days post-wounding. At the time of implantation, test groups received injections of either Quadrol [N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine...

journal_title：Immunopharmacology and immunotoxicology

authors： Bhide MV,Dunphy MJ,Mirkopulos N,Smith DJ

更新日期：1988-01-01 00:00:00

abstract：:The application of heat shock to different types of cells is known to cause multiple biochemical and metabolic changes. The predominant event though is an increased synthesis and expression of a family of proteins, the heat-shock proteins (Hsp). Some of these proteins are currently considered to be involved in the sig...

journal_title：Immunopharmacology and immunotoxicology

authors： Liossis SN,Tsokos GC

更新日期：1997-11-01 00:00:00

abstract：:Immunostimulants known to initiate cytokine production were found to inhibit processes of microsomal drug oxidation but to activate arylamine N-acetylation. The present study investigated the effects of immunstimulating doses of rat interferon-gamma (IFN gamma, 670,000 units ip) and streptolysin O (SLO, 100 HU/kg iv f...

journal_title：Immunopharmacology and immunotoxicology

authors： Walter R,Siegmund W,Scheuch E

更新日期：1996-11-01 00:00:00

abstract：:We have previously obtained and elucidated the precise structure of a highly branched 1,3-β-D-glucan (with 6-monoglucopyranosyl side chains), Aureobasidium pullulans-fermented β-D-glucan (AP-FBG), from the fungus A. pullulans. However, the mechanism(s) of the effects of AP-FBG on in vitro mouse primary cells have not ...

journal_title：Immunopharmacology and immunotoxicology

authors： Tada R,Yoshikawa M,Kuge T,Tanioka A,Ishibashi K,Adachi Y,Tsubaki K,Ohno N

更新日期：2011-06-01 00:00:00

abstract：:The immunological status of lead acid battery workers with blood lead levels and urinary delta-aminolevulinic acid (ALA-U) concentrations ranging from safe to toxic levels has been examined and compared with those of non-exposed, age and sex matched controls. No differences in the serum concentrations of IgG, IgA and ...

journal_title：Immunopharmacology and immunotoxicology

authors： Queiroz ML,Perlingeiro RC,Bincoletto C,Almeida M,Cardoso MP,Dantas DC

更新日期：1994-02-01 00:00:00

abstract：:The aim of the present investigation was to evaluate the efficacy of Withania somnifera on tricarboxylic acid (TCA) cycle enzymes and electron transport chain in azoxymethane-induced experimental colon cancer in mice. Azoxymethane at the dose of 15 mg/kg body weight was induced intraperitoneally once in a week for 28 ...

journal_title：Immunopharmacology and immunotoxicology

authors： Muralikrishnan G,Amanullah S,Basha MI,Dinda AK,Shakeel F

更新日期：2010-09-01 00:00:00

abstract：:Myasthenia gravis is an autoimmune disease in which antibodies are produced against one's acetylcholine receptors, resulting in complement-mediated membrane destruction and internalization of antibody-receptor complexes. Symptoms range from weakening of extraocular muscles to severe impairment of movement and breathin...

journal_title：Immunopharmacology and immunotoxicology

authors： Hinman CL,Stevens-Truss R

更新日期：1998-05-01 00:00:00

abstract：:The present investigation was aimed to examine non-specific immunologic capabilities of spontaneously hypertensive rats (SHR) during the development of hypertension. In vitro phagocytosis and oxidative killing exerted by monocytes, polymorphonuclear cells (PMN) and splenic macrophages (SpM0) were evaluated in SHR at 5...

journal_title：Immunopharmacology and immunotoxicology

authors： Serio M,Potenza MA,Vulpis V,Pirrelli A,Mitolo-Chieppa D,Jirillo E

更新日期：1994-05-01 00:00:00

abstract：AIM:To assess the immunogenicity of Peginterferon alpha-2 b(Pegberon) and its effect on the efficacy and safety in phase III clinical trial, by comparing it with the control drug Pegasys. METHODS:770 patients were recruited in total. 509 were treated with Pegberon plus ribavirin and 261 were treated with Pegasys plus ...

journal_title：Immunopharmacology and immunotoxicology

authors： Zhou W,Lu D,Liao X,Zhuang L,Sun L

更新日期：2018-02-01 00:00:00