Aqueous extract of Rhodiola imbricata rhizome stimulates proinflammatory mediators via phosphorylated IkappaB and transcription factor nuclear factor-kappaB.

abstract：:Heat shock protein 90 (Hsp90) is a ubiquitously expressed ATP-dependent molecular chaperone across all species that helps to the correct the folding of many proteins related to important signaling pathways. Tumor cells expressing Hsp90 have more ATP-binding affinity than normal cells. Many correlative inhibitors have ...

journal_title：Immunopharmacology and immunotoxicology

authors： Huyan T,Li Q,Dong DD,Yang H,Zhang J,Huang QS,Yin DC,Shang P

更新日期：2016-01-01 00:00:00

abstract：:Snakebites in rural areas of tropical and subtropical regions are commonly treated with medicinal plants. In this report, we have studied the ability of Anacardium occidentale bark extract to neutralize enzymatic as well as pharmacological effects induced by Vipera russelii venom. The extract neutralized the viper ven...

journal_title：Immunopharmacology and immunotoxicology

authors： Ushanandini S,Nagaraju S,Nayaka SC,Kumar KH,Kemparaju K,Girish KS

更新日期：2009-01-01 00:00:00

abstract：CONTEXT:Disease Modifying Anti-Rheumatic Drugs (DMARDs) are aimed to interfere with rheumatoid arthritis (RA) progression and reduce the joint damage; however, not all patients respond alike. Killer-cell immunoglobulin-like receptors (KIR) and their ligands, human leucocyte antigen class I (HLA-I), have been associated...

journal_title：Immunopharmacology and immunotoxicology

authors： Velarde-de la Cruz EE,Sánchez-Hernández PE,Muñoz-Valle JF,Palafox-Sánchez CA,Ramírez-de Los Santos S,Graciano-Machuca O,García-Iglesias T,Montoya-Buelna M,Ramírez-Dueñas MG

更新日期：2016-08-01 00:00:00

abstract：:The Scrophularia buergeriana (SB) has long been used to treat various diseases an account of its antimicrobial and anti-virus activity. However, it is unclear how SB regulates the immune responses. This study investigated the effect of SB on the production of cytokines in a human T-cell line, MOLT-4 cells, and mouse p...

journal_title：Immunopharmacology and immunotoxicology

authors： Kim SJ,Park JS,Myung NY,Moon PD,Choi IY,An HJ,Kim NH,Na HJ,Kim DH,Kim MC,An NH,Kim IK,Lee JY,Jeong HJ,Um JY,Kim HM,Hong SH

更新日期：2009-06-01 00:00:00

abstract：CONTEXT:Neutrophils are the primary effector cells in the pathogenesis of transfusion-related acute lung injury or multiple organ failure after blood transfusion. OBJECTIVE:We aimed to investigate the effect of fresh (1 day preparation) and aged (42 day preparation) PRBC-derived plasma on neutrophil morphology, migrat...

journal_title：Immunopharmacology and immunotoxicology

authors： Yu C,Xu L,Chen LF,Guan YJ,Kim M,Biffl WL,Chin YE

更新日期：2013-02-01 00:00:00

abstract：AIM:To determine the steady state concentration and the pharmacokinetics of Cyclosporine A (CsA) in heart transplant recipients. METHODS:A single dose of 100 mg CsA capsules twice daily was given to five heart transplant recipients of steady state. The concentrations of CsA in plasma were determined by streptavidin pe...

journal_title：Immunopharmacology and immunotoxicology

authors： Jin R,Duan H,Zhao C,Wang Z,Qu F

更新日期：2012-06-01 00:00:00

abstract：:Objective: Acne is a chronic skin disease that involves four key pathogenic factors: excess sebum production, ductal epidermal hyperproliferation, Propionibacterium acnes (P. acnes) colonization, and skin inflammation. Mangostins are well-known for their anti-bacterial and anti-inflammatory effects, suggesting that ma...

journal_title：Immunopharmacology and immunotoxicology

authors： Xu N,Deng W,He G,Gan X,Gao S,Chen Y,Gao Y,Xu K,Qi J,Lin H,Shen L,Li X,Hu Z

更新日期：2018-10-01 00:00:00

abstract：:Myricetin, a common dietary flavonoid, is widely distributed in fruits and vegetables. It is known to be a food supplement contributing to human health because of its immune modulatory function, and its antioxidation, antitumor, and anti-inflammatory properties. In the present study, myricetin was shown to directly in...

journal_title：Immunopharmacology and immunotoxicology

authors： Yuan X,Liu Y,Hua X,Deng X,Sun P,Yu C,Chen L,Yu S,Liu S,Pang H

更新日期：2015-01-01 00:00:00

abstract：:In the present study, we investigated the possibility that the WNT/β-catenin pathway plays a role in inflammatory responses both in an human inflammatory condition and in an in vitro inflammation model. First, we analyzed gene expression patterns of the peripheral blood cells from asthma patients compared with those f...

journal_title：Immunopharmacology and immunotoxicology

authors： Lee H,Bae S,Choi BW,Yoon Y

更新日期：2012-02-01 00:00:00

abstract：:Formyl peptides released by some bacteria are powerful chemoattractants and activators of mammalian granulocytes and monocytes, acting through 7-transmembrane specific formyl peptide receptors (FPRs). Three distinct segments of the formyl peptide receptor 1 (FPR1) mRNA of Man share probabilistically significant homolo...

journal_title：Immunopharmacology and immunotoxicology

authors： Panaro MA,Acquafredda A,Sisto M,Lisi S,Calvello R,Saccia M,Maffione AB,Mitolo V

更新日期：2005-01-01 00:00:00

abstract：:Increased numbers of myeloid-derived suppressor cells (MDSCs) are often observed in various pathological and physiological conditions. However, the interactions between neurotransmitters and MDSCs have not been elucidated. In this study, we studied whether norepinephrine (NE), a neurotransmitter, could affect the diff...

journal_title：Immunopharmacology and immunotoxicology

authors： Liu Y,Wei J,Guo G,Zhou J

更新日期：2015-01-01 00:00:00

abstract：:We have previously found that NK cell activity is present in rat lung lavage and inhibited by lidocaine. The purpose of this report is to characterize further the inhibition by lidocaine on NK activity. Peripheral blood lymphocytes from normal human volunteers were assayed in a four-hour 51chromium release assay in th...

journal_title：Immunopharmacology and immunotoxicology

authors： Renzi PM,Ginns LC

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:Ipomoea obscura (L.) Ker-Gawl, is a medicinal herb with indole alkaloids as an active constituent. In this study, we investigated the anti-angiogenic activity of I. obscura extract and one of its major compounds Ipobscurine-A (IPO-A). METHODS:In vivo angiogenesis was induced by injecting B16F10 melanoma cell...

journal_title：Immunopharmacology and immunotoxicology

authors： Hamsa TP,Kuttan G

更新日期：2011-09-01 00:00:00

abstract：:The current research was designed to determine the effect of artemether in treatment of experimental rheumatoid arthritis. Collagen-induced arthritis was induced in Lewis rats. The intramusculary administration of artemether (ART) and intraperitoneally injection of methotrexate (MTX) were started on day 25 postimmuniz...

journal_title：Immunopharmacology and immunotoxicology

authors： Cuzzocrea S,Saadat F,Di Paola R,Mirshafiey A

更新日期：2005-01-01 00:00:00

abstract：:Physalin E is a naturally occurring seco-steroid isolated from the stems and aerial parts of Physalis angulata L. (Solanaceae). This study was aimed to explore the anti-inflammatory effects of physalin E on RAW 264.7 mouse macrophages stimulated by lipopolysaccharide (LPS) and the potential underlying mechanisms. The ...

journal_title：Immunopharmacology and immunotoxicology

authors： Yang YJ,Yi L,Wang Q,Xie BB,Dong Y,Sha CW

更新日期：2017-04-01 00:00:00

abstract：:The induction of T-cell responses involves the recognition of extrinsic antigens in association with antigens of the major histocompatibility complex (MHC). The present results demonstrate that the lateralized control exerted by the brain neocortex on T-cell activities extends to the expression of MHC antigens, yet di...

journal_title：Immunopharmacology and immunotoxicology

authors： Renoux G,Renoux M,Bizière K

更新日期：1988-01-01 00:00:00

abstract：:Both pregnancy and cyclosporin A (CsA) are known to inhibit T-cell mediated immune response and to activate phagocytes against microbial infections as a compensatory mechanism. Pregnant women, either with organ transplantation or suffering from autoimmune diseases, are commonly managed with CsA therapy. This investiga...

journal_title：Immunopharmacology and immunotoxicology

authors： Khan HA

更新日期：2007-01-01 00:00:00

abstract：:Vasoactive intestinal polypeptide (VIP) has been shown to stimulate adenylate cyclase in a human lymphoblast cell line (MOLT 4). In the present study, we monitored fluorescence in cell suspensions and in single fura-2 loaded MOLT 4 lymphoblasts to determine if VIP modulates intracellular calcium concentrations ([Ca2+]...

journal_title：Immunopharmacology and immunotoxicology

authors： Anton PA,Shanahan F,Sun XP,Diehl D,Kodner A,Mayer EA

更新日期：1993-08-01 00:00:00

abstract：UNLABELLED:The angiotensin (Ang)-converting enzyme (ACE) insertion/deletion (I/D) polymorphism determines Ang II levels, but its relationship with lupus nephritis (LN) in different populations is controversial. OBJECTIVE:To describe the allelic and genotypic distribution of the I/D polymorphism in Mexican mestizos wit...

journal_title：Immunopharmacology and immunotoxicology

authors： Topete-Reyes JF,Soto-Vargas J,Morán-Moguel MC,Dávalos-Rodríguez IP,Chávez-González EL,García-de la Torre I,Parra-Michel R,Medina-Pérez M,Jalomo-Martínez B,Salazar-Páramo M

更新日期：2013-02-01 00:00:00

abstract：:Arecoline, a major alkaloid of arecanut was screened to explore its modulatory influence on cell-mediated immune response in a murine model system. The in vivo and in vitro effects were evaluated at subtoxic concentrations of arecoline. Delayed type hypersensitivity (DTH) reactions to sheep red blood cells (SRBC) were...

journal_title：Immunopharmacology and immunotoxicology

authors： Selvan RS,Selvakumaran M,Rao AR

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of ginsenoside metabolite compound K (CK) on adjuvant-induced arthritis (AA) rats and the partial mechanisms focused on the function of immunocyte (B cell and macrophage) and effectors' cell (fibroblast-like synoviocyte, FLS). METHODS:Animals were divided randomly into nine groups ...

journal_title：Immunopharmacology and immunotoxicology

authors： Wu H,Chen J,Wang Q,Jia X,Song S,Yuan P,Liu K,Liu L,Zhang Y,Zhou A,Wei W

更新日期：2014-04-01 00:00:00

abstract：:3'-azido-3'-deoxythymidine (AZT) was administered orally to 8 AIDS patients at a dose of 100 mg every 6 hours for 14 days. On days 8 - 14 the patients were also given 1 g inosine-pranobex (INPX) every 6 hours. On day 7, while the subjects were taking AZT alone and on day 14 while they were receiving AZT + INPX, blood ...

journal_title：Immunopharmacology and immunotoxicology

authors： De Simone C,Ferrazzi M,Bitonti F,Falciano M,Tzantzoglou S,Delia S,Sorice F

更新日期：1988-01-01 00:00:00

abstract：:Luminol-enhanced chemiluminescence assay was used to detect the surface expression and the consequent activation of receptors (FcRI and FcRII) of murine macrophages (M phi s). When murine IgG2a was used for the specific detection of FcRI and IgG2b for FcRII, a newly established procedure enabled us to detect the activ...

journal_title：Immunopharmacology and immunotoxicology

authors： Majima T,Itoh K,Yatsu J,Yoshie O,Ishida N

更新日期：1989-01-01 00:00:00

abstract：:We conducted a comparative study of NK1.1+ cells in spleen and bone marrow and the effects of administration of M-CSF on them. Administration of M-CSF to mice increased the number of NK1.1+ cells in spleen but not in bone marrow. The NK1.1+ cells in spleen (Spl-NK1.1) and bone marrow (BM-NK1.1) were purified by magnet...

journal_title：Immunopharmacology and immunotoxicology

authors： Sakurai T,Misawa E,Yamada M,Hayasawa H,Motoyoshi K

更新日期：2002-11-01 00:00:00

abstract：:The effects of Bulnesia sarmienti (BS) aqueous extract on the cell growth of A549 cell lines were investigated. BS has strong cytotoxic activity on the A549 cell lines (IC(50); less than 100 microg/mL) in MTT assay. HPLC confirmed that BS contains catechins as major compound. Cell cycle analysis by flow cytometry indi...

journal_title：Immunopharmacology and immunotoxicology

authors： Mollah ML,Kim JO,Lee GD,Park CH,Hong JH,Kim HY,Kim KS

更新日期：2009-01-01 00:00:00

abstract：:Antidepressants are reported to display anti-inflammatory effects. Nitric oxide (NO), in turn, has a key role in inflammation. The objective of the present study was to evaluate the effect of amitriptyline co-administered with L-NAME (a NO synthase inhibitor) on certain parameters of acute inflammatory response in rat...

journal_title：Immunopharmacology and immunotoxicology

authors： Vismari L,Alves GJ,Muscará MN,Palermo-Neto J

更新日期：2012-08-01 00:00:00

abstract：:Heavy metals administered to animals, at doses which appear relatively innoxious by themselves, enhance susceptibility to endotoxin. The mechanisms which underly this phenomenon are not yet fully understood. In this study we investigated the role of the cytokine Tumour Necrosis Factor (TNF), an important mediator of t...

journal_title：Immunopharmacology and immunotoxicology

authors： Dentener MA,Greve JW,Maessen JG,Buurman WA

更新日期：1989-01-01 00:00:00

abstract：:The anti-cancer activity of saponins and phenolic compounds present in green tea was previously reported. However, the immunomodulatory and adjuvanticity activity of tea saponin has never been studied. In this study, we investigated the immunomodulatory effect of tea saponin in T-lymphocytes and EL4 cells via regulati...

journal_title：Immunopharmacology and immunotoxicology

authors： Bhardwaj J,Chaudhary N,Seo HJ,Kim MY,Shin TS,Kim JD

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND AIM:Tanshione IIA (TSN) is the major active component of Salvia miltiorrhiza, a traditional Chinese Medicine. TSN protects against antioxidant-induced liver injury, although the exact mechanism is not well understood. MATERIALS AND METHODS:In this study, the protective effects of TSN was examined by enz...

journal_title：Immunopharmacology and immunotoxicology

authors： Qin XY,Li T,Yan L,Liu QS,Tian Y

更新日期：2010-03-01 00:00:00

abstract：:Context: Pyocyanin is a typical Pseudomonas aeruginosa virulence factor, a common Gram-negative rod responsible for a wide range of severe nosocomial infections. There is evidence indicating that pyocyanin has multiple biological activities, but little is known about anti-inflammatory properties. Objective: This study...

journal_title：Immunopharmacology and immunotoxicology

authors： Marreiro de Sales-Neto J,Lima ÉA,Cavalcante-Silva LHA,Vasconcelos U,Rodrigues-Mascarenhas S

更新日期：2019-02-01 00:00:00