Abstract:
BACKGROUND AND AIM:Tanshione IIA (TSN) is the major active component of Salvia miltiorrhiza, a traditional Chinese Medicine. TSN protects against antioxidant-induced liver injury, although the exact mechanism is not well understood. MATERIALS AND METHODS:In this study, the protective effects of TSN was examined by enzyme-linked immunosorbent assay (ELISA) and histochemistry of several cytokines. RESULTS:TSN is found to significantly reduce plasma alanin aminotransferase and aspartate amino transferase levels in mice with concanavalin A-induced immune-mediated liver injury. TSN increases T lymphocyte subset CD3+, CD4+ and CD8+ ratios.Also, TSN significantly reduces inflammatory cytokines, including interleukin-2, interleukin-4, interferon-gamma and tumor necrosis factor alpha, while elevates anti-inflammatory cytokine, interleukin-10. CONCLUSIONS:TSN may provide a potential drug candidate for liver injury therapeutics.
journal_name
Immunopharmacol Immunotoxicoljournal_title
Immunopharmacology and immunotoxicologyauthors
Qin XY,Li T,Yan L,Liu QS,Tian Ydoi
10.1080/08923970903120997subject
Has Abstractpub_date
2010-03-01 00:00:00pages
51-5issue
1eissn
0892-3973issn
1532-2513journal_volume
32pub_type
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