Unusual presentation of carpal tunnel syndrome with cutaneous signs: a case report and review of the literature.


:Carpal tunnel syndrome (CTS) is a neurological impairment caused by compression of the median nerve throughout the carpal tunnel, which consequently induces ischemia and mechanical disruption, dysfunctional axonal transport, and epidural blood flow. Most common symptoms include numbness, rather than pain, with a typical night exacerbation, weakness, paresthesia, and loss of sensitive discrimination. In rare cases, such syndrome may present with cutaneous manifestations localized on the distal phalanges of the hands, even without the above mentioned neurological symptoms. We describe a case of a woman who came to our attention complaining of the appearance of recurrent bullous eruptions involving the distal phalanges innervated by the median nerve. She did not report any neurological signs whatsoever. After excluding a bullous disease, we further investigated through additional analysis that revealed a CTS. Hence, physicians should consider CTS as a differential diagnosis when assessing cutaneous lesions of the first three fingers of the hands.


Foti C,Romita P,Vestita M




Has Abstract


2011-12-01 00:00:00












  • Immunomodulatory and antiviral activities of 2',3'-dideoxy-beta-L-cytidine and 2',3'-dideoxy-beta-L-5-fluorocytidine.

    abstract::Two dideoxynucleosides, 2',3'-dideoxy-beta-L-cytidine and 2',3'-dideoxy-beta-L-5-flurocytidine, containing unnatural L-configuration in their sugar moieties, were synthesized and assayed for antiviral activities. Both compounds were shown to possess potent anti-human immunodeficiency virus type 1 and antihepatitis B v...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Gagnon L,Nordstrom PA,Duchaine J,Jutras D,Hamel M,Barbeau D,Hooker E,Ashman C,Cammack N,Tse A

    更新日期:1995-02-01 00:00:00

  • PRBC-derived plasma induces non-muscle myosin type IIA-mediated neutrophil migration and morphologic change.

    abstract:CONTEXT:Neutrophils are the primary effector cells in the pathogenesis of transfusion-related acute lung injury or multiple organ failure after blood transfusion. OBJECTIVE:We aimed to investigate the effect of fresh (1 day preparation) and aged (42 day preparation) PRBC-derived plasma on neutrophil morphology, migrat...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Yu C,Xu L,Chen LF,Guan YJ,Kim M,Biffl WL,Chin YE

    更新日期:2013-02-01 00:00:00

  • Influence of dietary aluminum on cytokine production by mitogen-stimulated spleen cells from Swiss Webster mice.

    abstract::Swiss Webster mice were exposed to excess dietary aluminum (Al) (1000 micrograms Al/g diet, Al as Al lactate) from conception to 6 months of age. Splenic lymphocytes (10(6) per culture) were incubated for 24 hrs with concanavalin A (5 micrograms/ml). Concentrations of interleukin-2, interferon-gamma and tumor necrosis...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Golub MS,Takeuchi PT,Gershwin ME,Yoshida SH

    更新日期:1993-11-01 00:00:00

  • Capsaicin attenuates liver fibrosis by targeting Notch signaling to inhibit TNF-α secretion from M1 macrophages.

    abstract:BACKGROUND:Capsaicin is a chili pepper extract with multiple therapeutic properties including anti-liver fibrosis. However, the paucity of its underlying mechanisms limited its widely clinical application. METHODS:In the present study, carbon tetrachloride (CCl4) was used to induce liver fibrosis in mice, and transfor...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Sheng J,Zhang B,Chen Y,Yu F

    更新日期:2020-12-01 00:00:00

  • Protection of C3H/HE J mice from development of Candida albicans infection by oral administration of Juzen-taiho-to and its component, Ginseng radix: possible roles of macrophages in the host defense mechanisms.

    abstract::Protective effect of a Japanese traditional herbal medicine, Juzen-taiho-to (TJ-48), which was recently reported to augment host-mediated antifungal actions, in Candida albicans-infected mice was further studied. TJ-48, given orally once daily for 5 consecutive days in a dose of 2 g/kg after intravenous infection of C...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Akagawa G,Abe S,Tansho S,Uchida K,Yamaguchi H

    更新日期:1996-02-01 00:00:00

  • Polyclonal stimulation of lymphocytes induced by beta blockers in the mouse: influences of age, sex and strain.

    abstract::The immune effects of acebutolol, a beta-blocker, are investigated in various strains of mice. In 6-12 weeks old C57Bl/6 female mice, an increase in the number of immunoglobulin secreting cells is observed only at the age of 9 weeks. At that age, such an effect is seen neither in C57Bl/6 male mice nor in female mice f...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: In S,Lulé J,Fournié GJ

    更新日期:1990-01-01 00:00:00

  • Inhibitory effect of interleukin-1alpha-induced apoptosis by Polygala tenuifolia in Hep G2 cells.

    abstract::A human hepatoma cell line, Hep G2 cells are reliable for the study of alcohol-induced hepatotoxicity. In this study, we investigated the effect of an aqueous extract of Polygala tenuifolia WILLDENOW (Polygalaceae) roots (PTAE) on ethanol (EtOH)-induced cytotoxicity in Hep G2 cells. PTAE (0.01-1 microg/ml) dose-depend...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Koo HN,Jeong HJ,Kim KR,Kim JC,Kim KS,Kang BK,Kim HM,Kim JJ

    更新日期:2000-08-01 00:00:00

  • Hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity in rats.

    abstract::Objectives: Several studies demonstrated the antioxidant and anti-inflammatory role of melatonin and celecoxib. This study is designed to explore the underlying mechanism of hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity by morphological, and biochemical approaches.Materials...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Ullah U,Badshah H,Malik Z,Uddin Z,Alam M,Sarwar S,Aman A,Khan AU,Shah FA

    更新日期:2020-06-01 00:00:00

  • Artemether: a new therapeutic strategy in experimental rheumatoid arthritis.

    abstract::The current research was designed to determine the effect of artemether in treatment of experimental rheumatoid arthritis. Collagen-induced arthritis was induced in Lewis rats. The intramusculary administration of artemether (ART) and intraperitoneally injection of methotrexate (MTX) were started on day 25 postimmuniz...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Cuzzocrea S,Saadat F,Di Paola R,Mirshafiey A

    更新日期:2005-01-01 00:00:00

  • Sorafenib in hepatocellular carcinoma - a post marketing evaluation.

    abstract:BACKGROUND:Sorafenib is an orally active multikinase inhibitor licensed for the treatment of patients with unresectable hepatocellular carcinoma (HCC). PATIENTS AND METHODS:The web-based registry, used for appraisal on new drugs, allows developing the observational prospective analysis of innovative drug therapies. To...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Trojniak MP,Palozzo AC,Mazurek M,Jirillo A

    更新日期:2012-06-01 00:00:00

  • The antagonistic effect of tamoxifen against d-galactosamine/lipopolysaccharide-induced acute liver failure is associated with reactivation of hepatic nuclear factor-κB.

    abstract::Context: Tamoxifen (TAM) ameliorates D-galactosamine/lipopolysaccharide (Gal/LPS)-induced acute liver failure (ALF) through its antioxidative effect; thus, this study was designed to determine whether the effectiveness of TAM is related to nuclear factor-κB (NF-κB) reactivation. Materials and methods: Experimental mic...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Liu L,Zhao Y,Lin Y,Zhang R,Luo S,Ye P,Luo M

    更新日期:2019-04-01 00:00:00

  • Decrease of phagocytic functions in hypertensive rats.

    abstract::The present investigation was aimed to examine non-specific immunologic capabilities of spontaneously hypertensive rats (SHR) during the development of hypertension. In vitro phagocytosis and oxidative killing exerted by monocytes, polymorphonuclear cells (PMN) and splenic macrophages (SpM0) were evaluated in SHR at 5...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Serio M,Potenza MA,Vulpis V,Pirrelli A,Mitolo-Chieppa D,Jirillo E

    更新日期:1994-05-01 00:00:00

  • Neuropeptides modulate a murine monocyte/macrophage cell line capacity for phagocytosis and killing of Leishmania major parasites.

    abstract::Host-parasite interactions and their outcome constitute a critical and challenging step in disease establishment in cutaneous leishmaniasis. In the present in vitro study we investigated the possible modulating effects of both sensory and autonomic neuropeptides that normally exist in human and mouse skin, on the upta...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Ahmed AA,Wahbi AH,Nordlin K

    更新日期:2001-08-01 00:00:00

  • The effects of cadmium exposure in the induction of inflammation.

    abstract::Inflammation is a physiological process essential for maintaining homeostatic mechanisms in human, but however, exaggerated inflammatory responses are closely related to many chronic diseases. Cadmium (Cd) is a heavy metal with high toxicity when present in food, water and air has the potential of eliciting inflammato...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章,评审


    authors: Hossein-Khannazer N,Azizi G,Eslami S,Alhassan Mohammed H,Fayyaz F,Hosseinzadeh R,Usman AB,Kamali AN,Mohammadi H,Jadidi-Niaragh F,Dehghanifard E,Noorisepehr M

    更新日期:2020-02-01 00:00:00

  • Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor induce adhesion and chemotaxis of human eosinophils via p38 mitogen-activated protein kinase and nuclear factor kappaB.

    abstract::Hematopoietic cytokines such as interleukin (IL)-3, IL-5, and granulocyte macrophage colony-stimulating factor (GM-CSF) play a fundamental role in eosinophil functions in allergic asthma. The intracellular signal transduction mechanisms of these cytokines regulating the activation of eosinophils have been potential th...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Ip WK,Wong CK,Wang CB,Tian YP,Lam CW

    更新日期:2005-01-01 00:00:00

  • Immunohistochemical analysis of protective effects of maternal fingolimod on the placenta and fetal lung and brain in chorioamnionitis-induced preterm birth rat model.

    abstract:OBJECTIVES:Fingolimod (FIN) is used for multiple sclerosis treatment and has potential antiapoptotic and anti-inflammatory effects. We aimed at expanding our knowledge on various immunohistochemical markers for elucidating the possible mechanisms of action of fingolimod in the placenta and fetal lung and brain. METHOD...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Yavuz A,Sezik M,Eris Yalcin S,Asci H,Ozmen O

    更新日期:2020-12-01 00:00:00

  • Continuous veno-venous hemodiafiltration alleviates multiple organ dysfunction syndrome in dogs.

    abstract:CONTEXT:Multiple organ dysfunction syndrome (MODS) is a major cause of death in critically patients. It has been hypothesized that inactivation or removal of pro-inflammatory molecules may prevent or reverse MODS. OBJECTIVE:The purpose of this paper was to investigate the efficacy of continuous veno-venous hemodiafilt...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Chen J,Liu J,Yu C,Wen H

    更新日期:2012-12-01 00:00:00

  • Insertion/deletion polymorphism of the angiotensin-converting enzyme gene in lupus nephritis among Mexicans.

    abstract:UNLABELLED:The angiotensin (Ang)-converting enzyme (ACE) insertion/deletion (I/D) polymorphism determines Ang II levels, but its relationship with lupus nephritis (LN) in different populations is controversial. OBJECTIVE:To describe the allelic and genotypic distribution of the I/D polymorphism in Mexican mestizos wit...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Topete-Reyes JF,Soto-Vargas J,Morán-Moguel MC,Dávalos-Rodríguez IP,Chávez-González EL,García-de la Torre I,Parra-Michel R,Medina-Pérez M,Jalomo-Martínez B,Salazar-Páramo M

    更新日期:2013-02-01 00:00:00

  • Bleomycin and FK 565 enhance the release of GM-CSF from LPS-stimulated BALB/c peritoneal macrophages.

    abstract::The anti-tumour antibiotic Bleomycin, the experimental immunostimulatory tripeptide FK 565, and the immunosuppressive agent Cyclosporin A were examined for their in vitro effects on the release of the haemopoietic cytokine Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) from LPS stimulated BALB/c adherent pe...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Blaney BA,Turk JL

    更新日期:1995-08-01 00:00:00

  • Ginsenoside metabolite compound K attenuates inflammatory responses of adjuvant-induced arthritis rats.

    abstract:OBJECTIVE:To investigate the effects of ginsenoside metabolite compound K (CK) on adjuvant-induced arthritis (AA) rats and the partial mechanisms focused on the function of immunocyte (B cell and macrophage) and effectors' cell (fibroblast-like synoviocyte, FLS). METHODS:Animals were divided randomly into nine groups ...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Wu H,Chen J,Wang Q,Jia X,Song S,Yuan P,Liu K,Liu L,Zhang Y,Zhou A,Wei W

    更新日期:2014-04-01 00:00:00

  • Effects of interferon-gamma and streptolysin O on hepatic procainamide N-acetyltransferase and various microsomal cytochrome P450-dependent monooxygenases in rats.

    abstract::Immunostimulants known to initiate cytokine production were found to inhibit processes of microsomal drug oxidation but to activate arylamine N-acetylation. The present study investigated the effects of immunstimulating doses of rat interferon-gamma (IFN gamma, 670,000 units ip) and streptolysin O (SLO, 100 HU/kg iv f...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Walter R,Siegmund W,Scheuch E

    更新日期:1996-11-01 00:00:00

  • WNT/β-catenin pathway is modulated in asthma patients and LPS-stimulated RAW264.7 macrophage cell line.

    abstract::In the present study, we investigated the possibility that the WNT/β-catenin pathway plays a role in inflammatory responses both in an human inflammatory condition and in an in vitro inflammation model. First, we analyzed gene expression patterns of the peripheral blood cells from asthma patients compared with those f...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 临床试验,杂志文章


    authors: Lee H,Bae S,Choi BW,Yoon Y

    更新日期:2012-02-01 00:00:00

  • A new sight for paraquat poisoning from immunology.

    abstract::Paraquat (methyl viologen, PQ) is highly toxic to humans. Pulmonary fibrosis is the most common cause of death after PQ poisoning. However, no effective therapy is available. The current treatment dilemma and pathology suggest that we should reconsider how to treat the poisoning using other methods, such as immunizati...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Wu Q,Xu Q,Jian X,Wang H,He X,Gao B,Wang K,Kan B

    更新日期:2018-08-01 00:00:00

  • Artesunate enhances γδ T-cell-mediated antitumor activity through augmenting γδ T-cell function and reversing immune escape of HepG2 cells.

    abstract:OBJECTIVE:To explore the effect and mechanism of artesunate on γδ T cell-mediated antitumor immune responses against hepatoma carcinoma cells (HepG2) in vitro. METHODS:Human γδ T cells or HepG2 were respectively treated with artesunate, subjected to co-culture as appropriate, and the following assays were subsequently...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Qian P,Zhang YW,Zhou ZH,Liu JQ,Yue SY,Guo XL,Sun LQ,Lv XT,Chen JQ

    更新日期:2018-04-01 00:00:00

  • Pharmacokinetics of Cyclosporine A in Chinese heart transplant recipients.

    abstract:AIM:To determine the steady state concentration and the pharmacokinetics of Cyclosporine A (CsA) in heart transplant recipients. METHODS:A single dose of 100 mg CsA capsules twice daily was given to five heart transplant recipients of steady state. The concentrations of CsA in plasma were determined by streptavidin pe...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 临床试验,杂志文章


    authors: Jin R,Duan H,Zhao C,Wang Z,Qu F

    更新日期:2012-06-01 00:00:00

  • Functional changes in THP-1 human monocytic cells after stimulation with lipopolysaccharide of oral microorganisms and granulocyte macrophage colony stimulating factor.

    abstract::A human THP-1 monocyte cell line culture system has been utilized to observe the effect of granulocyte macrophage colony stimulating factor (GM-CSF) supplementation with lipopolysaccharide (LPS) of oral microorganisms to stimulate monocyte/macrophage functional activity. LPS of oral microorganisms, Fusobacterium nucle...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Baqui AA,Meiller TF,Turng BF,Kelley JI,Falkler WA Jr

    更新日期:1998-11-01 00:00:00

  • Immunological effects following administration of interferon-alpha in patients with chronic hepatitis C virus (cHCV) infection.

    abstract::The immunological effects of interferon (IFN)-alpha administration were evaluated in 15 patients with cHCV infection. Individuals were treated with 6 MU of lymphoblastoid IFN-alpha three times a week for 6 months and with 3 MU three times a week for an additional 6 months. Patients were divided into responders (12 sub...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Jirillo E,Greco B,Caradonna L,Satalino R,Amati L,Cozzolongo R,Cuppone R,Manghisi OG

    更新日期:1996-08-01 00:00:00

  • Apigenin inhibits release of inflammatory mediators by blocking the NF-κB activation pathways in the HMC-1 cells.

    abstract::Apigenin is a plant flavonoid and a pharmacologically active agent that has been isolated from several plant species. However, the molecular mechanism of apigenin-mediated immune modulation has not been fully understood. One of the possible mechanisms of its protective effects is the down-regulation of inflammatory re...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Kang OH,Lee JH,Kwon DY

    更新日期:2011-09-01 00:00:00

  • A copper chelate selectively triggers apoptosis in myeloid-derived suppressor cells in a drug-resistant tumor model and enhances antitumor immune response.

    abstract::Myeloid-derived suppressor cells (MDSCs), one of the major orchestrators of immunosuppressive network are present in the tumor microenvironment suppress antitumor immunity by subverting Th1 response in tumor site and considered as a great obstacle for advancement of different cancer immunotherapeutic protocols. Till d...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Chakraborty P,Das S,Banerjee K,Sinha A,Roy S,Chatterjee M,Choudhuri SK

    更新日期:2014-04-01 00:00:00

  • Anti-inflammatory activity of Korean folk medicine purple bamboo salt.

    abstract::Purple bamboo salt is a specially processed salt according to the traditional recipe using normal salt and bamboo. It has been used for the purpose of prevention and treatment of various diseases in Korea. We investigated the anti-inflammatory activity of purple bamboo salt by using human mast cell line (HMC-1). Purpl...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章


    authors: Shin HY,Lee EH,Kim CY,Shin TY,Kim SD,Song YS,Lee KN,Hong SH,Kim HM

    更新日期:2003-08-01 00:00:00