Growth-inhibitory effects of a Bulnesia sarmienti aqueous extract on A549 cells in vitro and S180 cells in vivo.

Abstract:

:The effects of Bulnesia sarmienti (BS) aqueous extract on the cell growth of A549 cell lines were investigated. BS has strong cytotoxic activity on the A549 cell lines (IC(50); less than 100 microg/mL) in MTT assay. HPLC confirmed that BS contains catechins as major compound. Cell cycle analysis by flow cytometry indicated that BS arrested the cell cycle in the sub-G(1) phase. BS induced DNA fragmentation, and increased the expression of the p53 protein in immunoblot analysis. These results indicated that the anticancer effect of BS was mediated via the process of apoptosis and growth-inhibition.

authors

Mollah ML,Kim JO,Lee GD,Park CH,Hong JH,Kim HY,Kim KS

doi

10.1080/08923970902810432

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

492-8

issue

3

eissn

0892-3973

issn

1532-2513

journal_volume

31

pub_type

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