Scrophularia buergeriana regulates cytokine production in vitro.

abstract：:Objective: Apigenin is a natural flavonoid compound extracted from Matricaria chamomilla. We evaluated the anti-inflammatory effects of apigenin in this study using the Lipopolysaccharide (LPS)-stimulated BV2 microglia.Methods: BV2 cells were treated with apigenin for 1 h and then treated with LPS. The inflammatory cy...

journal_title：Immunopharmacology and immunotoxicology

authors： Chen P,Huo X,Liu W,Li K,Sun Z,Tian J

更新日期：2020-02-01 00:00:00

abstract：:We have previously obtained and elucidated the precise structure of a highly branched 1,3-β-D-glucan (with 6-monoglucopyranosyl side chains), Aureobasidium pullulans-fermented β-D-glucan (AP-FBG), from the fungus A. pullulans. However, the mechanism(s) of the effects of AP-FBG on in vitro mouse primary cells have not ...

journal_title：Immunopharmacology and immunotoxicology

authors： Tada R,Yoshikawa M,Kuge T,Tanioka A,Ishibashi K,Adachi Y,Tsubaki K,Ohno N

更新日期：2011-06-01 00:00:00

abstract：CONTEXT:β-d-Mannuronic acid (M2000) has shown its therapeutic effects with the greatest tolerability and efficacy in various experimental models such as experimental autoimmune encephalomyelitis (EAE), adjuvant induced arthritis (AIA), nephrotic syndrome, and acute glomerulonephritis. Despite pharmacological effects of...

journal_title：Immunopharmacology and immunotoxicology

authors： Fattahi MJ,Abdollahi M,Agha Mohammadi A,Rastkari N,Khorasani R,Ahmadi H,Tofighi Zavareh F,Sedaghat R,Tabrizian N,Mirshafiey A

更新日期：2015-01-01 00:00:00

abstract：:T-2 toxin, a fungal metabolite shown previously to exert potent immunosuppressive effects, was examined for its effects on activation and interleukin 2 (IL 2) production by murine and rat splenocytes. Splenocytes (1 X 10(6) cells/well) were incubated with 1 microgram Concanavalin A (Con A) for 48 h at which time cellu...

journal_title：Immunopharmacology and immunotoxicology

authors： Holt PS,Corrier DE,DeLoach JR

更新日期：1988-01-01 00:00:00

abstract：:Contribution of cytotoxic T lymphocytes (CTL) to experimental autoimmune thyroiditis (EAT) was well defined (Speidel et al., Eur. J. Immunol. 1997, 27, 2391-2399, Ref. 7). The native porcine thyroglobulin (pTg) showed high sensitivity to endo-o-N-acetylglucosaminidase F (Endo F) and its molecular weights, correspondin...

journal_title：Immunopharmacology and immunotoxicology

authors： Kang BS,Chung TW,Moon JY,Lim JK,Shon YH,Nam KS,Kim DS,Jeon BH,Kim CH

更新日期：2004-08-01 00:00:00

abstract：:Chief part of hemopoietic stromal cells in mediating hemopoiesis-stimulating effects of adamantylamide dipeptide (AdDP), a synthetic immunomodulatory compound, has been determined in a series of combined in vivo/in vitro studies. Indirect stimulatory effect of AdDP on proliferation of hemopoietic progenitor cells for ...

journal_title：Immunopharmacology and immunotoxicology

authors： Vacek A,Hofer M,Weiterová L,Hoferová Z,Pipalová I,Masek K

更新日期：2001-11-01 00:00:00

abstract：:We hypothesized that immunosuppression in birds that is caused by exposure to antiandrogenic chemicals occurs mainly through disruption of the development of the androgen-sensitive avian lymphoid organ, the bursa of Fabricius. Injections of 20.0 or 40.0 mug of p,p'-DDE [ethylene, 1,1-dichloro-2,2-bis(p-chlorophenyl)],...

journal_title：Immunopharmacology and immunotoxicology

authors： Quinn MJ,Summitt CL,Ottinger MA

更新日期：2006-01-01 00:00:00

abstract：:Recently, a number of studies have focused on the secondary effects of rifampicin. In the present study, we assessed whether rifampicin influences the rapamycin-induced autophagy of RAW 264.7 cells. Here, we demonstrate that the rapamycin-induced autophagy is dependent on protein phosphatase (PP) 2A activity and rifam...

journal_title：Immunopharmacology and immunotoxicology

authors： Park IH,Yeum CE,Chae GT,Lee SB

更新日期：2008-01-01 00:00:00

abstract：:Abstract Alpinetin, a flavonoid compound extracted from the seeds of Alpinia katsumadai Hayata, has been known to possess antibacterial, anti-inflammatory and other important therapeutic activities. In the current study, we investigated alpinetin for its immunosuppressive effect on activation and cytokines secretion o...

journal_title：Immunopharmacology and immunotoxicology

authors： Guan S,Fang B,Song B,Xiong Y,Lu J

更新日期：2014-08-01 00:00:00

abstract：:Although the development of atopy in the newborn is determined by a multitude of factors, an intense Th1 stimulus early in life could be protective by facilitating a switch away from Th2. Aimed to determine the effect of single Mycobacterium vaccae (M. vaccae) immunization to OVA-sensitized pregnant mice on IL-5 and I...

journal_title：Immunopharmacology and immunotoxicology

authors： Akkoc T,Eifan AO,Ozdemir C,Yazi D,Yesil O,Bahceciler NN,Barlan IB

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Parsley (Petroselinum crispum) has been traditionally used for the treatment of allergy, autoimmune and chronic inflammatory disorders. The present study aims to investigate the suppressive effects of parsley essential oil on mouse splenocytes and macrophages cells. METHODS AND MATERIALS:Parsley essential...

journal_title：Immunopharmacology and immunotoxicology

authors： Yousofi A,Daneshmandi S,Soleimani N,Bagheri K,Karimi MH

更新日期：2012-04-01 00:00:00

abstract：:Taraxasterol, a pentacyclic-triterpene, was isolated from the Chinese medicinal herb Taraxacum officinale. In the present study, we investigated the protective effect of taraxasterol on murine model of endotoxic shock and the mechanism of its action. Mice were treated with 2.5, 5 and 10 mg/kg of taraxasterol prior to ...

journal_title：Immunopharmacology and immunotoxicology

authors： Zhang X,Xiong H,Li H,Cheng Y

更新日期：2014-02-01 00:00:00

abstract：:Two dideoxynucleosides, 2',3'-dideoxy-beta-L-cytidine and 2',3'-dideoxy-beta-L-5-flurocytidine, containing unnatural L-configuration in their sugar moieties, were synthesized and assayed for antiviral activities. Both compounds were shown to possess potent anti-human immunodeficiency virus type 1 and antihepatitis B v...

journal_title：Immunopharmacology and immunotoxicology

authors： Gagnon L,Nordstrom PA,Duchaine J,Jutras D,Hamel M,Barbeau D,Hooker E,Ashman C,Cammack N,Tse A

更新日期：1995-02-01 00:00:00

abstract：:CD69, also known as activation inducer molecule, very early activation antigen, MLR-3 and Leu-23, is a member of the natural killer (NK) cell gene complex family of signal transducing receptors. CD69 is as a type II transmembrane glycoprotein with a C-type lectin binding domain in the extracellular portion of the mole...

journal_title：Immunopharmacology and immunotoxicology

authors： Marzio R,Mauël J,Betz-Corradin S

更新日期：1999-08-01 00:00:00

abstract：:In the present study, we introduce a new class of organometallic compound, the Biphosphinic Palladacycle Complex [Pd (C2, N-S(-)(dmpa)(dppf)] Cl (BPC), as an angiotensin-I converting-enzyme inhibitor (ACEI) with hematological regulation properties. When BPC was assayed as a competitive inhibitor over the hydrolysis of...

journal_title：Immunopharmacology and immunotoxicology

authors： Caires AC,Oliveira CR,Smith MC,Hemerly JP,Juliano MA,Bincoletto C

更新日期：2004-01-01 00:00:00

abstract：:Hematopoietic cytokines such as interleukin (IL)-3, IL-5, and granulocyte macrophage colony-stimulating factor (GM-CSF) play a fundamental role in eosinophil functions in allergic asthma. The intracellular signal transduction mechanisms of these cytokines regulating the activation of eosinophils have been potential th...

journal_title：Immunopharmacology and immunotoxicology

authors： Ip WK,Wong CK,Wang CB,Tian YP,Lam CW

更新日期：2005-01-01 00:00:00

abstract：:A polymerase chain reaction was devised to simultaneously detect repeated insertion sequences and the pertussis toxin promoter gene for the diagnostic identification of Bordetella pertussis, B. parapertussis, and B. bronchiseptica. The sensitivity of this method was sufficient to detect one B. pertussis organism using...

journal_title：Immunopharmacology and immunotoxicology

authors： Furuya D,Yagihashi A,Endoh T,Uehara N,Fujii N,Chiba S,Watanabe N

更新日期：1999-02-01 00:00:00

abstract：:The aim of the present study was to investigate putative mechanisms implicated in the impaired phagocytic response of spontaneously hypertensive rats (SHR)1. The effect of in vitro treatment with isoproterenol (ISO), a beta-adrenergic drug, on phagocytosis and respiratory burst by splenic macrophages (SpMø) from normo...

journal_title：Immunopharmacology and immunotoxicology

authors： Serio M,Potenza MA,Montagnani M,Mansi G,Mitolo-Chieppa D,Jirillo E

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Capsaicin is a chili pepper extract with multiple therapeutic properties including anti-liver fibrosis. However, the paucity of its underlying mechanisms limited its widely clinical application. METHODS:In the present study, carbon tetrachloride (CCl4) was used to induce liver fibrosis in mice, and transfor...

journal_title：Immunopharmacology and immunotoxicology

authors： Sheng J,Zhang B,Chen Y,Yu F

更新日期：2020-12-01 00:00:00

abstract：:Heavy metals administered to animals, at doses which appear relatively innoxious by themselves, enhance susceptibility to endotoxin. The mechanisms which underly this phenomenon are not yet fully understood. In this study we investigated the role of the cytokine Tumour Necrosis Factor (TNF), an important mediator of t...

journal_title：Immunopharmacology and immunotoxicology

authors： Dentener MA,Greve JW,Maessen JG,Buurman WA

更新日期：1989-01-01 00:00:00

abstract：:We have developed an in vitro system to model the interactions of drugs used to treat transplant rejection. This system consists of stimulation of human lymphocytes with a primary mitogen (anti-T-cell receptor complex antibodies (OKT3 or wt31)) and treatment with a primary immunosuppressive drug (ISD) (Cyclosporine A ...

journal_title：Immunopharmacology and immunotoxicology

authors： Weaver JL,Pine PS,Aszalos A

更新日期：1994-05-01 00:00:00

abstract：:The effect of the opioid peptide dynorphin (DYN) on PHA-induced lymphocyte proliferation has been evaluated in the present study. A significant increase in PHA-induced lymphocyte activation was observed when DYN was added to cultures 48 hr after the mitogenic stimulation. This effect occurred at suboptimal (3.12 and 6...

journal_title：Immunopharmacology and immunotoxicology

authors： Barreca T,Di Benedetto G,Corsini G,Lenzi G,Puppo F

更新日期：1987-01-01 00:00:00

abstract：:Experiments were performed to analyze the possible effect of the immunomodulating agent Pidotimod (3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid) on mouse Natural Killer (NK) cell activity and glucocorticoid hormone(GCH)-induced thymocyte apoptosis. The results indicate that in vivo treatment with Pidotimod (200 m...

journal_title：Immunopharmacology and immunotoxicology

authors： Migliorati G,D'Adamio L,Coppi G,Nicoletti I,Riccardi C

更新日期：1992-01-01 00:00:00

abstract：:The effect of rapamycin (RAPA) on kidney function and histopathology was assessed in two strains of mice. Male C3H/HeJ mice were treated with RAPA for 4 days at doses of 25, 50, 75, and 100 mg/kg, ip and male C3H/HeJ or female Balb/cJ mice were both treated for 7 days at doses of 75, 150 and 200 mg/kg. Cyclosporine (C...

journal_title：Immunopharmacology and immunotoxicology

authors： Di Joseph JF,Sehgal SN

更新日期：1993-01-01 00:00:00

abstract：:Sexual assault was a ubiquitous and serious problem in our society. The world's care centers and forensic associations, which were at the forefront of scientific research in sexual assaults, discussed the role of the Forensic Nursing in their early diagnosis and their prevention, but little has been written in literat...

journal_title：Immunopharmacology and immunotoxicology

authors： Vitale E

更新日期：2012-04-01 00:00:00

abstract：:We previously showed that formation of pulmonary granulomas in mice in response to a mycobacterial glycolipid, trehalose 6,6'-dimycolate (TDM) is due to the action of TNF-α and not of IFN-γ. However, the mechanisms of formation and maintenance of pulmonary granulomas are not yet clear. The purpose of the present study...

journal_title：Immunopharmacology and immunotoxicology

authors： Saitoh T,Yano I,Kumazawa Y,Takimoto H

更新日期：2012-10-01 00:00:00

abstract：:The popular murine macrophage cell line, RAW 264.7, is often used to initially screen natural products for bioactivity and to predict their potential effect in vivo or on primary cells. The cell line response is considered to reflect the potential human de novo response, and is used to evaluate the effective bioactivi...

journal_title：Immunopharmacology and immunotoxicology

authors： Merly L,Smith SL

更新日期：2017-04-01 00:00:00

abstract：:Traditionally venoms are used from thousands of years to treat pain, inflammation, and arthritis. In Ayurveda "Suchika Voron" and "Shodhona" were practiced against pain. In the present study, venom composition of the Indian honeybee Apis florea (AF), Apis dorsata (AD), and Apis cerana indica (AC) were analyzed using e...

journal_title：Immunopharmacology and immunotoxicology

authors： Nipate SS,Hurali PB,Ghaisas MM

更新日期：2015-04-01 00:00:00

abstract：:Myricetin, a common dietary flavonoid, is widely distributed in fruits and vegetables. It is known to be a food supplement contributing to human health because of its immune modulatory function, and its antioxidation, antitumor, and anti-inflammatory properties. In the present study, myricetin was shown to directly in...

journal_title：Immunopharmacology and immunotoxicology

authors： Yuan X,Liu Y,Hua X,Deng X,Sun P,Yu C,Chen L,Yu S,Liu S,Pang H

更新日期：2015-01-01 00:00:00

abstract：:In this study we investigated the ability of GM-1/P, a calcium mediated processed form of monosialoganglioside GM-1, of in vivo augmenting mouse T and B-lymphocyte blastogenesis induced by mitogens. We have also determined its effect on IL-2 responsiveness by analyzing the induction of the expression of IL-2 receptor ...

journal_title：Immunopharmacology and immunotoxicology

authors： Giuffrida A,Morrone S,Gismondi A,Santoni G,Punturieri A,Velotti F,Cavallo G,Tubaro E,Piccoli M,Frati L

更新日期：1990-01-01 00:00:00