Abstract:
:The effect of the opioid peptide dynorphin (DYN) on PHA-induced lymphocyte proliferation has been evaluated in the present study. A significant increase in PHA-induced lymphocyte activation was observed when DYN was added to cultures 48 hr after the mitogenic stimulation. This effect occurred at suboptimal (3.12 and 6.25 micrograms/ml) PHA concentrations and at DYN doses ranging from 10(-9) to 10(-12) M. Conversely, DYN did not affect the lymphocyte blastogenic process either when added before, or simultaneously or after intense PHA (12.5 micrograms/ml) stimulation. Naloxone preincubation did not modify the above described effects. Results suggest that DYN might play a role in neuroendocrine regulation of the lymphocyte blastogenic process.
journal_name
Immunopharmacol Immunotoxicoljournal_title
Immunopharmacology and immunotoxicologyauthors
Barreca T,Di Benedetto G,Corsini G,Lenzi G,Puppo Fdoi
10.3109/08923978709035226subject
Has Abstractpub_date
1987-01-01 00:00:00pages
467-75issue
4eissn
0892-3973issn
1532-2513journal_volume
9pub_type
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