Pharmacokinetics of Cyclosporine A in Chinese heart transplant recipients.

Abstract:

AIM:To determine the steady state concentration and the pharmacokinetics of Cyclosporine A (CsA) in heart transplant recipients. METHODS:A single dose of 100 mg CsA capsules twice daily was given to five heart transplant recipients of steady state. The concentrations of CsA in plasma were determined by streptavidin peroxidase fluorescent polarization immunoassay. RESULTS:The main pharmacokinetic parameters of CsA were as follows: t(max) (1.60 ± 0.55) h, ρmax(951.60 ± 229.20) μg.L-1, t1/2(6.53 ± 2.40) h, and AUC0 -t(5162.10 ± 1355.01) μg.h.L-1. CONCLUSION:The study obtained the steady state pharmacokinetic parameters of CsA in Chinese heart transplant recipients.

authors

Jin R,Duan H,Zhao C,Wang Z,Qu F

doi

10.3109/08923973.2011.613400

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

519-22

issue

3

eissn

0892-3973

issn

1532-2513

journal_volume

34

pub_type

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