Abstract:
AIM:To determine the steady state concentration and the pharmacokinetics of Cyclosporine A (CsA) in heart transplant recipients. METHODS:A single dose of 100 mg CsA capsules twice daily was given to five heart transplant recipients of steady state. The concentrations of CsA in plasma were determined by streptavidin peroxidase fluorescent polarization immunoassay. RESULTS:The main pharmacokinetic parameters of CsA were as follows: t(max) (1.60 ± 0.55) h, ρmax(951.60 ± 229.20) μg.L-1, t1/2(6.53 ± 2.40) h, and AUC0 -t(5162.10 ± 1355.01) μg.h.L-1. CONCLUSION:The study obtained the steady state pharmacokinetic parameters of CsA in Chinese heart transplant recipients.
journal_name
Immunopharmacol Immunotoxicoljournal_title
Immunopharmacology and immunotoxicologyauthors
Jin R,Duan H,Zhao C,Wang Z,Qu Fdoi
10.3109/08923973.2011.613400subject
Has Abstractpub_date
2012-06-01 00:00:00pages
519-22issue
3eissn
0892-3973issn
1532-2513journal_volume
34pub_type
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journal_title:Immunopharmacology and immunotoxicology
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