Pharmacokinetics of zidovudine and concomitant inosine-pranobex in AIDS patients.

abstract：:Multiple Drug Allergy Syndrome (MDAS) is a frequent clinical condition characterized by reactions to more than one different class of antibiotics. Even if some studies have previously reported an increased rate of allergic reactions to drugs in patients with a history of antimicrobials and NSAIDs allergy, risk factors...

journal_title：Immunopharmacology and immunotoxicology

authors： Nettis E,Colanardi MC,Paola RD,Ferrannini A,Tursi A

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:Abnormal microglia secrete neuroinflammatory factors that play a pivotal role in neurodegenerative-disorder development. Thus, regulating abnormal microglia-activation could be a promising therapeutic strategy. The purposes of this study included investigating the effect of Petatewalide B on lipopolysacchari...

journal_title：Immunopharmacology and immunotoxicology

authors： Park SY,Choi MH,Li M,Li K,Park G,Choi YW

更新日期：2018-06-01 00:00:00

abstract：:During the last few years, several observations outline that the impaired T lymphocyte proliferative capacity in the elderly is due to a reduced interleukin 2 (IL-2) release. To further investigate the activation process during lectin stimulation, aged peripheral blood mononuclear cells (PBMC) were stimulated with phy...

journal_title：Immunopharmacology and immunotoxicology

authors： Antonaci S,Tortorella C,Polignano A,Ottolenghi A,Jirillo E,Bonomo L

更新日期：1991-01-01 00:00:00

abstract：:The effect that MnCl2 has on murine splenic natural killer (NK) cell activity was investigated in infant (10 days old), pre-weanling (18 days old) and weanling (24 days old) C57BL/6J mice. A single intraperitoneal injection of 10, 20 or 40 micrograms MnCl2/g body weight caused a significant enhancement in NK activity,...

journal_title：Immunopharmacology and immunotoxicology

authors： Smialowicz RJ,Riddle MM,Rogers RR,Luebke RW,Burleson GR

更新日期：1988-01-01 00:00:00

abstract：:Objective: Apigenin is a natural flavonoid compound extracted from Matricaria chamomilla. We evaluated the anti-inflammatory effects of apigenin in this study using the Lipopolysaccharide (LPS)-stimulated BV2 microglia.Methods: BV2 cells were treated with apigenin for 1 h and then treated with LPS. The inflammatory cy...

journal_title：Immunopharmacology and immunotoxicology

authors： Chen P,Huo X,Liu W,Li K,Sun Z,Tian J

更新日期：2020-02-01 00:00:00

abstract：:Several studies outline the imbalance of phagocyte functions in chronic obstructive pulmonary disease (COPD). In this regard, here, we have assessed either monocyte- and polymorphonuclear cell (PMN)-mediated chemotactic, phagocytic and killing capacities or PMN-triggered metabolic pathway in a group of COPD patients b...

journal_title：Immunopharmacology and immunotoxicology

authors： Tortorella C,Ottolenghi A,Moretti AM,Jirillo E,Antonaci S

更新日期：1992-01-01 00:00:00

abstract：:Apigenin is a plant flavonoid and a pharmacologically active agent that has been isolated from several plant species. However, the molecular mechanism of apigenin-mediated immune modulation has not been fully understood. One of the possible mechanisms of its protective effects is the down-regulation of inflammatory re...

journal_title：Immunopharmacology and immunotoxicology

authors： Kang OH,Lee JH,Kwon DY

更新日期：2011-09-01 00:00:00

abstract：INTRODUCTION:Parsley (Petroselinum crispum) has been traditionally used for the treatment of allergy, autoimmune and chronic inflammatory disorders. The present study aims to investigate the suppressive effects of parsley essential oil on mouse splenocytes and macrophages cells. METHODS AND MATERIALS:Parsley essential...

journal_title：Immunopharmacology and immunotoxicology

authors： Yousofi A,Daneshmandi S,Soleimani N,Bagheri K,Karimi MH

更新日期：2012-04-01 00:00:00

abstract：:Hematopoietic cytokines such as interleukin (IL)-3, IL-5, and granulocyte macrophage colony-stimulating factor (GM-CSF) play a fundamental role in eosinophil functions in allergic asthma. The intracellular signal transduction mechanisms of these cytokines regulating the activation of eosinophils have been potential th...

journal_title：Immunopharmacology and immunotoxicology

authors： Ip WK,Wong CK,Wang CB,Tian YP,Lam CW

更新日期：2005-01-01 00:00:00

abstract：:Association between Crohn's disease (CD) and lupus nephritis is very rare and, to the best of our knowledge, it has been described only once. We report here a clinical case of CD occurred in a young woman 8 years after a diagnosis of lupus nephritis according to clinical, laboratory and histological criteria. CD was u...

journal_title：Immunopharmacology and immunotoxicology

authors： Principi M,Di Leo A,Ingrosso M,Pisani A,Marangi S,Amoruso A,Panella C,Francavilla A,Ierardi E

更新日期：2004-05-01 00:00:00

abstract：:Ponesimod, a novel selective sphingosine-1-phosphate 1 receptor modulator in the development for the treatment of autoimmune diseases, dose-dependently reduced lymphocyte counts in peripheral blood of healthy subjects. It rapidly and transiently reduced the number of circulating T and B cells, but not natural killer c...

journal_title：Immunopharmacology and immunotoxicology

authors： D'Ambrosio D,Steinmann J,Brossard P,Dingemanse J

更新日期：2015-02-01 00:00:00

abstract：:We examined the effect of sulfapyridine on mast cell-mediated immediate-type allergic reactions. Sulfapyridine (1 and 10 microg/kg) significantly inhibited systemic allergic reaction induced by compound 48/80 in rats. Sulfapyridine (1 and 10 microg/kg) also inhibited significantly local mast cell-mediated immediate-ty...

journal_title：Immunopharmacology and immunotoxicology

authors： Kim HM,An NH,Yi BH,Chae HJ,Kim HR,Moon SJ,Kim JJ,Park ST,Baek SH

更新日期：2000-05-01 00:00:00

abstract：:Ethanol has been recognized as an immunosuppressive agent for many years. Effects of high levels of ethanol consumption on immune functions have been extensively studied, but little is known about the effects of low levels (scuh as 5% ethanol) of ethanol consumption. Herein we report that exposure of mice to 5% ethano...

journal_title：Immunopharmacology and immunotoxicology

authors： Guo TL,Zhang LX,Chen JP,Nguyen VA,White KL Jr,Gao B

更新日期：2002-02-01 00:00:00

abstract：:Tubeimoside-1 (TBMS1) is one of the important components in Bolbostemma paniculatum (Maxim.) Franque. In the study, its immunosuppressive effects on murine T lymphocyte responses were evaluated in vitro and in vivo. The data showed that TBMS1 inhibited ConA-induced T lymphocyte proliferation, decreased the ratio of CD...

journal_title：Immunopharmacology and immunotoxicology

authors： Huang Y,Ren M,Xiong Y,Wang T,Chen H,Deng X,Lu J

更新日期：2015-01-01 00:00:00

abstract：:We conducted a comparative study of NK1.1+ cells in spleen and bone marrow and the effects of administration of M-CSF on them. Administration of M-CSF to mice increased the number of NK1.1+ cells in spleen but not in bone marrow. The NK1.1+ cells in spleen (Spl-NK1.1) and bone marrow (BM-NK1.1) were purified by magnet...

journal_title：Immunopharmacology and immunotoxicology

authors： Sakurai T,Misawa E,Yamada M,Hayasawa H,Motoyoshi K

更新日期：2002-11-01 00:00:00

abstract：:The objective of the current study was to assess the effects of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) along with their simultaneous application on proliferation and pluripotency genes of murine adipose tissue-derived mesenchymal stem cells (AT-MSCs). The proliferation, doubling time (DT), colony-for...

journal_title：Immunopharmacology and immunotoxicology

authors： Mohammadpour H,Pourfathollah AA,Nikougoftar Zarif M,Hashemi SM

更新日期：2016-01-01 00:00:00

abstract：:A competitive enzyme-linked immunosorbent assay (ELISA) with generated mouse anti-consensus interferon (CIFN) antibody was developed for quantitative determination of pegylated consensus interferon (PEG-CIFN) in rhesus monkey serum. The operational concentrations of the original assay were determined using the chessbo...

journal_title：Immunopharmacology and immunotoxicology

authors： Cao J,Du Y,Tian H,Gao XD,Yao WB

更新日期：2009-01-01 00:00:00

abstract：:The effect of rapamycin (RAPA) on kidney function and histopathology was assessed in two strains of mice. Male C3H/HeJ mice were treated with RAPA for 4 days at doses of 25, 50, 75, and 100 mg/kg, ip and male C3H/HeJ or female Balb/cJ mice were both treated for 7 days at doses of 75, 150 and 200 mg/kg. Cyclosporine (C...

journal_title：Immunopharmacology and immunotoxicology

authors： Di Joseph JF,Sehgal SN

更新日期：1993-01-01 00:00:00

abstract：:Host-parasite interactions and their outcome constitute a critical and challenging step in disease establishment in cutaneous leishmaniasis. In the present in vitro study we investigated the possible modulating effects of both sensory and autonomic neuropeptides that normally exist in human and mouse skin, on the upta...

journal_title：Immunopharmacology and immunotoxicology

authors： Ahmed AA,Wahbi AH,Nordlin K

更新日期：2001-08-01 00:00:00

abstract：:Traditionally venoms are used from thousands of years to treat pain, inflammation, and arthritis. In Ayurveda "Suchika Voron" and "Shodhona" were practiced against pain. In the present study, venom composition of the Indian honeybee Apis florea (AF), Apis dorsata (AD), and Apis cerana indica (AC) were analyzed using e...

journal_title：Immunopharmacology and immunotoxicology

authors： Nipate SS,Hurali PB,Ghaisas MM

更新日期：2015-04-01 00:00:00

abstract：CONTEXT:T regulatory (Treg) cells play an important role in the modulation of the immune response, and are implicated in the pathogenesis of autoimmune diseases. Many people is exposed to fluoride (F), mainly through drinking water. OBJECTIVE:The aim of this work was to assess the possible effect of F exposure on diff...

journal_title：Immunopharmacology and immunotoxicology

authors： Hernández-Castro B,Vigna-Pérez M,Doníz-Padilla L,Ortiz-Pérez MD,Jiménez-Capdeville E,González-Amaro R,Baranda L

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Capsaicin is a chili pepper extract with multiple therapeutic properties including anti-liver fibrosis. However, the paucity of its underlying mechanisms limited its widely clinical application. METHODS:In the present study, carbon tetrachloride (CCl4) was used to induce liver fibrosis in mice, and transfor...

journal_title：Immunopharmacology and immunotoxicology

authors： Sheng J,Zhang B,Chen Y,Yu F

更新日期：2020-12-01 00:00:00

abstract：:The beta-subunits of thyroid stimulating hormone (TSH) and human chorionic gonadotropin (hCG) share a high homology, just like the ectodomains of their receptors, do. As a consequence, hCG was shown to exert a thyrotropic action in humans and hamsters. This study aimed to investigate whether hCG, used to induce ovulat...

journal_title：Immunopharmacology and immunotoxicology

authors： Rizzo A,Mutinati M,Spedicato M,Minoia G,Trisolini C,Punzi S,Roscino MT,Jirillo F,Sciorsci R

更新日期：2009-06-01 00:00:00

abstract：:A human THP-1 monocyte cell line culture system has been utilized to observe the effect of granulocyte macrophage colony stimulating factor (GM-CSF) supplementation with lipopolysaccharide (LPS) of oral microorganisms to stimulate monocyte/macrophage functional activity. LPS of oral microorganisms, Fusobacterium nucle...

journal_title：Immunopharmacology and immunotoxicology

authors： Baqui AA,Meiller TF,Turng BF,Kelley JI,Falkler WA Jr

更新日期：1998-11-01 00:00:00

abstract：:The aim of the present study was to investigate putative mechanisms implicated in the impaired phagocytic response of spontaneously hypertensive rats (SHR)1. The effect of in vitro treatment with isoproterenol (ISO), a beta-adrenergic drug, on phagocytosis and respiratory burst by splenic macrophages (SpMø) from normo...

journal_title：Immunopharmacology and immunotoxicology

authors： Serio M,Potenza MA,Montagnani M,Mansi G,Mitolo-Chieppa D,Jirillo E

更新日期：1996-05-01 00:00:00

abstract：:CD69, also known as activation inducer molecule, very early activation antigen, MLR-3 and Leu-23, is a member of the natural killer (NK) cell gene complex family of signal transducing receptors. CD69 is as a type II transmembrane glycoprotein with a C-type lectin binding domain in the extracellular portion of the mole...

journal_title：Immunopharmacology and immunotoxicology

authors： Marzio R,Mauël J,Betz-Corradin S

更新日期：1999-08-01 00:00:00

abstract：:Present inventory evaluates the anti-atherogenic potential of C. glandulosum.Coleb leaf extract (CG) using in vivo and in vitro experimental models. Serum markers of low density lipoprotein (LDL-C) oxidation, cholesterol, triglycerides, lipoproteins, auto-antibody titer, ex vivo LDL-C oxidation, LDL-C aggregation, aor...

journal_title：Immunopharmacology and immunotoxicology

authors： Jadeja RN,Thounaojam MC,Jain M,Devkar RV,Ramachandran AV

更新日期：2012-06-01 00:00:00

abstract：:Antidepressants are reported to display anti-inflammatory effects. Nitric oxide (NO), in turn, has a key role in inflammation. The objective of the present study was to evaluate the effect of amitriptyline co-administered with L-NAME (a NO synthase inhibitor) on certain parameters of acute inflammatory response in rat...

journal_title：Immunopharmacology and immunotoxicology

authors： Vismari L,Alves GJ,Muscará MN,Palermo-Neto J

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of ginsenoside metabolite compound K (CK) on adjuvant-induced arthritis (AA) rats and the partial mechanisms focused on the function of immunocyte (B cell and macrophage) and effectors' cell (fibroblast-like synoviocyte, FLS). METHODS:Animals were divided randomly into nine groups ...

journal_title：Immunopharmacology and immunotoxicology

authors： Wu H,Chen J,Wang Q,Jia X,Song S,Yuan P,Liu K,Liu L,Zhang Y,Zhou A,Wei W

更新日期：2014-04-01 00:00:00

abstract：AIM:To assess the immunogenicity of Peginterferon alpha-2 b(Pegberon) and its effect on the efficacy and safety in phase III clinical trial, by comparing it with the control drug Pegasys. METHODS:770 patients were recruited in total. 509 were treated with Pegberon plus ribavirin and 261 were treated with Pegasys plus ...

journal_title：Immunopharmacology and immunotoxicology

authors： Zhou W,Lu D,Liao X,Zhuang L,Sun L

更新日期：2018-02-01 00:00:00