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Multidrug resistance protein 1 is not associated to detergent-resistant membranes.

Abstract：

:Multidrug resistance protein 1 (MRP1) is a member of the ATP-binding cassette superfamily. Using the energy provided by ATP hydrolysis, it transports a broad spectrum of substrates across the plasma membrane, including hormones, leukotriene C(4), bile salts, and anti-cancer drugs. Recent works have suggested that P-glycoprotein is associated to cholesterol and sphingolipid-rich membrane microdomains and that cholesterol upregulates its ATPase and drug transport activities. Confocal microscopy experiments and Triton X-100 extraction of detergent-resistant membranes provide evidence that MRP1 is not located in raft-like structures and that its activity is downregulated by cholesterol. The data are discussed in terms of cholesterol-protein interaction and topology.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cerf E,Gasper R,Belani JD,Rychnovsky S,Chang XB,Buyse F,Ruysschaert JM

doi

10.1016/j.bbrc.2007.02.075

subject

Has Abstract

pub_date

2007-04-20 00:00:00

pages

1025-30

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)00350-6

journal_volume

355

pub_type

杂志文章

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