Intravenous immunoglobulin use in patients with toxic epidermal necrolysis and Stevens-Johnson syndrome.

Abstract:

:Intravenous immunoglobulin (IVIg) has been proposed as a treatment for toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS). A comprehensive search of the literature was conducted to examine the efficacy and safety of IVIg in TEN and SJS patients. Seventeen relevant articles (14 TEN, 3 SJS) were identified. Only three of the TEN studies and one of the SJS studies were prospective; retrospective studies were the most common study design published. Information regarding disease severity, IVIg use, response, and hospitalization were recorded and cumulated. Aggregate level statistics were calculated. The average IVIg doses used were 0.8 +/- 0.4 g/kg/day for a mean duration of 4.0 +/- 1.0 days in TEN patients and 0.8 +/- 0.2 g/kg/day for 3.4 +/- 1.0 days in SJS patients. The clinical experience of IVIg use in TEN and SJS patients was positive in most cases. However, more studies need to be conducted to confirm the benefit of IVIg use in patients with TEN or SJS.

journal_name

Am J Clin Dermatol

authors

Mittmann N,Chan B,Knowles S,Cosentino L,Shear N

doi

10.2165/00128071-200607060-00004

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

359-68

issue

6

eissn

1175-0561

issn

1179-1888

pii

764

journal_volume

7

pub_type

杂志文章,评审
  • Nontuberculous mycobacterial skin infections: recognition and management.

    abstract::Mycobacterial organisms have re-emerged as an important cause of infectious disease worldwide. Both tuberculosis and nontuberculous mycobacterial infections remain endemic in many parts of the world and are becoming more common in patients with iatrogenic immunosuppression and HIV infection. The nontuberculous mycobac...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200910050-00001

    authors: Elston D

    更新日期:2009-01-01 00:00:00

  • The Emerging Zika Virus Threat: A Guide for Dermatologists.

    abstract::We provide a guide for dermatologists to follow if they encounter patients with a rash and clinical history suspicious of Zika virus infection, including diagnostic testing and management options. We also provide an illustrative case report of a patient from Brazil who was diagnosed with Zika virus infection after pre...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-016-0243-z

    authors: He A,Brasil P,Siqueira AM,Calvet GA,Kwatra SG

    更新日期:2017-04-01 00:00:00

  • Topical metronidazole. A review of its use in rosacea.

    abstract:UNLABELLED:Topical application of the antibacterial agent metronidazole is effective in the treatment of moderate to severe rosacea, although its mechanism of action has yet to be clearly established. Metronidazole preparations (0.75 and 1% cream, 0.75% gel and 0.75% lotion) were significantly more effective than place...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200001030-00007

    authors: McClellan KJ,Noble S

    更新日期:2000-05-01 00:00:00

  • Topical use of dexpanthenol in skin disorders.

    abstract::Pantothenic acid is essential to normal epithelial function. It is a component of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions that are important in the metabolism of carbohydrates, fatty acids, proteins, gluconeogenesis, sterols, steroid hormones, and porphyrins. The topical use ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200203060-00005

    authors: Ebner F,Heller A,Rippke F,Tausch I

    更新日期:2002-01-01 00:00:00

  • Efficacy and tolerability of a cosmetically acceptable coal tar solution in the treatment of moderate plaque psoriasis: a controlled comparison with calcipotriene (calcipotriol) cream.

    abstract:BACKGROUND:Topical coal tar is a well known and effective treatment for psoriasis, but the messiness, staining, odor, and inconvenience associated with its use make patient satisfaction and compliance a challenge. OBJECTIVE:To determine the efficacy, patient tolerability, and cosmetic acceptability of a new topical li...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.2165/11530380-000000000-00000

    authors: Alora-Palli MB,Perkins AC,Van Cott A,Kimball AB

    更新日期:2010-01-01 00:00:00

  • The Future of Molecular Analysis in Melanoma: Diagnostics to Direct Molecularly Targeted Therapy.

    abstract::Melanoma is a malignancy of pigment-producing cells that is driven by a variety of genetic mutations and aberrations. In most cases, this leads to upregulation of the mitogen-activated protein kinase (MAPK) pathway through activating mutations of upstream mediators of the pathway including BRAF and NRAS. With the adve...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-015-0159-z

    authors: Akabane H,Sullivan RJ

    更新日期:2016-02-01 00:00:00

  • Itch associated with skin disease: advances in pathophysiology and emerging therapies.

    abstract::Itch, also known as pruritus, is the major symptom in skin diseases with a variety of etiologies and pathophysiologies. Significant progress has been achieved in understanding the pathophysiology of itch in the last 5 years. Neurophysiological experiments in humans and animals have revealed that itch is carried by spe...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200304090-00004

    authors: Yosipovitch G,Fleischer A

    更新日期:2003-01-01 00:00:00

  • Clinicopathological and diagnostic characterization of confluent and reticulate papillomatosis of Gougerot and Carteaud: a retrospective study in a South-East Asian population.

    abstract:BACKGROUND:Confluent and reticulate papillomatosis of Gougerot and Carteaud (CRP) is a rare dermatological condition, which has not been reported widely in Asian populations. AIM:To characterize the clinicopathological and diagnostic features of CRP in a South-East Asian population. METHODS:The medical records of 29 ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.1007/s40257-014-0110-8

    authors: Huang W,Ong G,Chong WS

    更新日期:2015-04-01 00:00:00

  • Association Between Psoriasis and Vitiligo: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:The relationship between psoriasis and vitiligo has not been previously confirmed, and we therefore aimed to investigate this association. METHODS:We conducted a search of the MEDLINE and EMBASE electronic databases on 22 January 2018 for case-control, cross-sectional, and cohort studies examining the assoc...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s40257-018-0394-1

    authors: Yen H,Chi CC

    更新日期:2019-02-01 00:00:00

  • Erythroid disturbances before and after treatment of Portuguese psoriasis vulgaris patients: a cross-sectional and longitudinal study.

    abstract:BACKGROUND:A few studies in psoriasis vulgaris patients have reported changes suggesting red blood cell (RBC) damage is linked to neutrophil activation, oxidative stress, and psoriasis worsening. OBJECTIVE:The aim of this study was to evaluate erythroid disturbances in Portuguese psoriasis vulgaris patients, before, d...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.2165/11592110-000000000-00000

    authors: Coimbra S,Oliveira H,Reis F,Belo L,Rocha S,Quintanilha A,Figueiredo A,Teixeira F,Castro E,Rocha-Pereira P,Santos-Silva A

    更新日期:2012-02-01 00:00:00

  • Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review.

    abstract:BACKGROUND:The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required. OBJECTIVE:Our aim was to conduct a hybrid systematic review of t...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-016-0245-x

    authors: Layton AM,Eady EA,Whitehouse H,Del Rosso JQ,Fedorowicz Z,van Zuuren EJ

    更新日期:2017-04-01 00:00:00

  • The role of toll-like receptors in host defenses and their relevance to dermatologic diseases.

    abstract::The family of toll-like receptors (TLRs) plays a central role in the cutaneous immune defense system. To date, different TLRs have been found on several major cell populations of the skin, such as keratinocytes, fibroblasts, antigen-presenting cells, and melanocytes. Activation of TLRs leads, via different intracellul...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/11311110-000000000-00000

    authors: Terhorst D,Kalali BN,Ollert M,Ring J,Mempel M

    更新日期:2010-01-01 00:00:00

  • Disorders of keratinization: diagnosis and management.

    abstract::Disorders of cornification are a group of diseases that share abnormalities in the manufacture or desquamation of corneocytes. This paper reviews the major and a few of the rarer ones with a concentration on their therapy. Ichthyosis vulgaris is probably a post-translational defect in pro-filaggrin expression. It show...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200405010-00004

    authors: Shwayder T

    更新日期:2004-01-01 00:00:00

  • Cutaneous drug reaction case reports: from the world literature.

    abstract::Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200304070-00007

    authors:

    更新日期:2003-01-01 00:00:00

  • Photoaging: prevention and topical treatments.

    abstract::A rapidly increasing number of people visit dermatologists for the prevention and treatment of aging skin. Sun avoidance and sunscreen use are widely accepted strategies of primary prevention against photoaging. Convincing evidence shows that topical application of retinoids has an effect on reversing, at least partia...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/11530210-000000000-00000

    authors: Antoniou C,Kosmadaki MG,Stratigos AJ,Katsambas AD

    更新日期:2010-01-01 00:00:00

  • The Role of the Microbiome and Microbiome-Derived Metabolites in Atopic Dermatitis and Non-Histaminergic Itch.

    abstract::Recent advances in our understanding of the pathophysiology of atopic dermatitis (AD) have revealed that skin microbiome dysbiosis plays an important role in the disease. In this review, we describe how changes in the structure and function of the microbiome are involved in the pathogenesis of AD. We highlight recent ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-020-00538-8

    authors: Li W,Yosipovitch G

    更新日期:2020-09-01 00:00:00

  • Impact of Clinical Specialty Setting and Geographic Regions on Disease Management in Patients with Psoriatic Arthritis in the United States: A Multicenter Observational Study.

    abstract:BACKGROUND:Information on the factors that influence treatment management decisions for psoriatic arthritis (PsA) is limited. OBJECTIVE:Our objective was to evaluate the impact of clinical specialty setting and geographic region on the management of patients with PsA in the USA. METHODS:LOOP was a multicenter, cross-...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s40257-019-00470-6

    authors: Mease PJ,Liu C,Siegel E,Richmond H,Wu M,Chen L,Douglas K,Lockshin B

    更新日期:2019-12-01 00:00:00

  • Efficacy of 5% minoxidil versus combined 5% minoxidil and 0.01% tretinoin for male pattern hair loss: a randomized, double-blind, comparative clinical trial.

    abstract:BACKGROUND:5% topical minoxidil solution has been widely used to stimulate new hair growth and help stop hair loss in men with androgenetic alopecia (AGA). However, it is not convenient for patients to continue applying the solution twice daily on a regular basis. Tretinoin is known to increase the percutaneous absorpt...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.2165/00128071-200708050-00003

    authors: Shin HS,Won CH,Lee SH,Kwon OS,Kim KH,Eun HC

    更新日期:2007-01-01 00:00:00

  • Anti-IL-17 Medications Used in the Treatment of Plaque Psoriasis and Psoriatic Arthritis: A Comprehensive Review.

    abstract::Our ability to successfully treat patients with moderate to severe psoriasis has improved significantly over the last several years with the development of more targeted therapies. IL-17A, a member of the IL-17 family of interleukins, is involved in regulating the innate and adaptive immune systems and has been identi...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-015-0162-4

    authors: Canavan TN,Elmets CA,Cantrell WL,Evans JM,Elewski BE

    更新日期:2016-02-01 00:00:00

  • Comparing the effectiveness of automated online counseling to standard web-based education on improving acne knowledge: a randomized controlled trial.

    abstract:BACKGROUND:Evidence regarding what comprises effective education for acne vulgaris patients is lacking. Internet-based education may improve patient knowledge of this condition. OBJECTIVES:Our objective was to compare the effectiveness of standard web-based education and an automated counseling website in improving ac...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s40257-014-0104-6

    authors: Tuong W,Wang AS,Armstrong AW

    更新日期:2015-02-01 00:00:00

  • The Safety and Efficacy of Narrow Band Ultraviolet B Treatment in Dermatology: A Review.

    abstract::Narrow-band ultraviolet B (NBUVB) phototherapy is an important treatment modality in dermatology. The most common dermatological indications for NBUVB include psoriasis, atopic dermatitis and vitiligo; however, it has been found to be an effective and well-tolerated treatment option in various other dermatoses. The ef...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-015-0151-7

    authors: Sokolova A,Lee A,D Smith S

    更新日期:2015-12-01 00:00:00

  • Treatment of systemic sclerosis.

    abstract::Systemic sclerosis is an extremely variable disease in its manifestations and consequently, treatment needs to be individualized depending on the specific problems that each patient has. Limited scleroderma patients have a prolonged duration of Raynaud's phenomenon and puffy fingers before they develop any skin thicke...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200102050-00006

    authors: Steen VD

    更新日期:2001-01-01 00:00:00

  • Role of lasers and photodynamic therapy in the treatment of cutaneous malignancy.

    abstract::Tumor therapy is not a common indication for the use of lasers, as it is in the treatment of benign vascular skin lesions, since many alternative treatment modalities exist. However, certain patients may benefit from laser therapy of premalignant and malignant skin tumors. Skin tumors can be treated by laser excision,...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200102040-00004

    authors: Karrer S,Szeimies RM,Hohenleutner U,Landthaler M

    更新日期:2001-01-01 00:00:00

  • Stevens-Johnson Syndrome and toxic epidermal necrolysis overlap due to oral temozolomide and cranial radiotherapy.

    abstract::A 46-year-old man developed Stevens-Johnson syndrome and toxic epidermal necrolysis overlap, with severe localized denudation of the skin on the head and neck, following radiotherapy and oral temozolomide therapy for cranial glioblastoma multiforme. He also had a primary malignant fibrous histiocytoma of the thigh tha...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.2165/00128071-200910040-00007

    authors: Sarma N

    更新日期:2009-01-01 00:00:00

  • Corticosteroid-induced osteoporosis: an update for dermatologists.

    abstract::Long-term corticosteroid treatment is the most common secondary cause of bone loss. Patients treated with long-term corticosteroid therapy may develop osteopenia or osteoporosis, and many have fractures. It is difficult to predict which corticosteroid-treated patients will develop significant skeletal complications be...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/11594250-000000000-00000

    authors: Clarke BL

    更新日期:2012-06-01 00:00:00

  • Granular Parakeratosis: A Comprehensive Review and a Critical Reappraisal.

    abstract::Granular parakeratosis (GP) is a rare, idiopathic, and benign skin condition that presents classically as erythematous to brown hyperkeratotic papules that can coalesce into plaques. Axillary GP was initially observed by Northcutt and colleagues and has since been described in various other areas of the body including...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-015-0148-2

    authors: Ding CY,Liu H,Khachemoune A

    更新日期:2015-12-01 00:00:00

  • Managing pediatric patients with psoriasis.

    abstract::Childhood-onset psoriasis affects approximately one-third of the psoriatic population. Among many potential treatments of childhood psoriasis, biological agents are emerging as a valuable option in the management of this disease. In Europe, etanercept has recently been approved for children aged 8 years and over. Data...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/1153415-S0-000000000-00000

    authors: Bard S,Torchia D,Schachner LA

    更新日期:2010-01-01 00:00:00

  • Comparative study of 2% sertaconazole solution and cream formulations in patients with tinea corporis, tinea pedis interdigitalis, or a corresponding candidosis.

    abstract:BACKGROUND:Based on the results of numerous preclinical and clinical studies, sertaconazole can be considered a safe and effective drug for the treatment of fungal skin infections. OBJECTIVE:The objective of the study was to compare the efficacy of a solution containing 2% sertaconazole with the well established 2% se...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2165/00128071-200708060-00007

    authors: Borelli C,Klövekorn G,Ernst TM,Bödeker RH,Korting HC,Neumeister C

    更新日期:2007-01-01 00:00:00

  • Optimal management of acne to prevent scarring and psychological sequelae.

    abstract::Acne vulgaris is one of the most common inflammatory dermatoses and is seen in both the hospital setting and in general practice. Multiple factors are involved in the pathophysiology of acne, including: an alteration in the pattern of keratinization within the pilosebaceous follicles resulting in comedone formation; a...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200102030-00002

    authors: Layton AM

    更新日期:2001-01-01 00:00:00

  • Effects of airbag deployment: lesions, epidemiology, and management.

    abstract::Airbags are restraining safety devices, but their activation may sometimes induce injuries during road accidents. Rapid deceleration due to an impact causes the ignition of a sodium azide cartridge, which releases nitrogen gas to inflate the nylon rubber bag. Numerous high-temperature gases, sodium hydroxide, carbon d...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200405050-00002

    authors: Corazza M,Trincone S,Virgili A

    更新日期:2004-01-01 00:00:00