Abstract:
:Of all the psychotropic medications currently available, the mood-stabilizing agents have the highest incidence of severe and life-threatening adverse cutaneous drug reactions (ACDRs). An exanthematous eruption in a patient treated with a mood-stabilizing agent should be viewed as possibly being the initial symptom of a severe and life-threatening ACDR, such as a hypersensitivity reaction, Stevens-Johnson syndrome, or toxic epidermal necrolysis. The combination of mood-stabilizing agents may increase the risk of such reactions. The mood-stabilizing agents addressed in this article are carbamazepine, lithium carbonate, valproic acid, topiramate, lamotrigine, gabapentin, and oxcarbazepine. Prior to the initiation of a mood stabilizer, the potential benefits, risks, and adverse effects should be communicated to the patient. If possible, slow dose escalation should be attempted by the physician. Patients should also be advised to seek medical attention if they suspect a drug-induced skin reaction. If the physician suspects a severe ACDR, the offending agent should be removed immediately.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Warnock JK,Morris DWdoi
10.2165/00128071-200304010-00003subject
Has Abstractpub_date
2003-01-01 00:00:00pages
21-30issue
1eissn
1175-0561issn
1179-1888pii
040103journal_volume
4pub_type
杂志文章,评审abstract::Viral skin infections are common findings in organ transplant recipients. The most important etiological agents are the group of human herpesviruses (HHV), human papillomaviruses (HPV), and molluscum contagiosum virus. HHV that are important in this group of patients are herpes simplex virus (HSV) types 1 and 2, varic...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200607010-00003
更新日期:2006-01-01 00:00:00
abstract::Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous tumor with a predilection for the head and neck of elderly Caucasian patients. Although much less common than melanoma, MCC has higher rates of sentinel lymph node involvement, local and regional recurrences, and mortality. The majority of MCC cases have b...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Methotrexate (MTX) is an effective treatment for psoriasis but its use is limited by its toxicity. Folate supplementation can be used to reduce the adverse effects of MTX, though this may impact efficacy. The frequency of folic acid supplementation is not well characterized. PURPOSE:The objective of this st...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-013-0017-9
更新日期:2013-06-01 00:00:00
abstract::The treatment of cutaneous T cell lymphoma (CTCL), which includes mycosis fungoides and Sezary syndrome, has been in a state of continual change over recent decades, as new therapies are constantly emerging in the search for more effective treatments for the disease. However, prognosis and survival of patients with CT...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200203030-00006
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis (AD) is an allergic disorder caused by both immunological dysregulation and epidermal barrier defect. Several studies have investigated the association between AD and mental health disorders. Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental conditions characte...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-015-0145-5
更新日期:2015-10-01 00:00:00
abstract::Aggressive digital papillary adenocarcinoma (ADPAC) is a rare cutaneous malignant tumor. We report on a 42-year-old man presenting with a nontender firm nodule on his right thumb that had been present for 3 years. The lesion clinically resembled an acquired digital fibrokeratoma, but was found to be an ADPAC after pat...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200708040-00007
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/11530210-000000000-00000
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abstract::At least 20 clinically relevant factors affect percutaneous absorption of drugs and chemicals: relevant physico-chemical properties, vehicle/formulation, drug exposure conditions (dose, duration, surface area, exposure frequency), skin appendages (hair follicles, glands) as sub-anatomical pathways, skin application si...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-019-00480-4
更新日期:2020-02-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Scalp psoriasis is commonly the initial presentation of psoriasis, and almost 80 % of patients with psoriasis will eventually experience it. OBJECTIVE:Although several systematic reviews and guidelines exist, an up-to-date evidence-based review including more recent progress on the use of biologics and new ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-016-0222-4
更新日期:2017-02-01 00:00:00
abstract::Pantothenic acid is essential to normal epithelial function. It is a component of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions that are important in the metabolism of carbohydrates, fatty acids, proteins, gluconeogenesis, sterols, steroid hormones, and porphyrins. The topical use ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200203060-00005
更新日期:2002-01-01 00:00:00
abstract::Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304070-00007
更新日期:2003-01-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-014-0107-3
更新日期:2015-02-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200506010-00006
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Botulinum toxin (BTX) is a potent neurotoxin with a long history of therapeutic application in neurological and dermatological conditions, with a strong efficacy and safety profile. OBJECTIVE:Our aim was to assess whether intradermal injection with BTX-B is an effective treatment for hidradenitis suppurativ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.1007/s40257-020-00537-9
更新日期:2020-10-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200102040-00004
更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200203050-00006
更新日期:2002-01-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Topical coal tar is a well known and effective treatment for psoriasis, but the messiness, staining, odor, and inconvenience associated with its use make patient satisfaction and compliance a challenge. OBJECTIVE:To determine the efficacy, patient tolerability, and cosmetic acceptability of a new topical li...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,随机对照试验
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200809050-00009
更新日期:2008-01-01 00:00:00
abstract::Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200304050-00006
更新日期:2003-01-01 00:00:00
abstract::Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Mult...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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abstract::Acne vulgaris is one of the most common inflammatory dermatoses and is seen in both the hospital setting and in general practice. Multiple factors are involved in the pathophysiology of acne, including: an alteration in the pattern of keratinization within the pilosebaceous follicles resulting in comedone formation; a...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200102030-00002
更新日期:2001-01-01 00:00:00
abstract::Our ability to successfully treat patients with moderate to severe psoriasis has improved significantly over the last several years with the development of more targeted therapies. IL-17A, a member of the IL-17 family of interleukins, is involved in regulating the innate and adaptive immune systems and has been identi...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-015-0162-4
更新日期:2016-02-01 00:00:00
abstract::Ocular diseases associated with atopic dermatitis (AD) may be sight-threatening. A general understanding of the pathophysiology, diagnosis, and treatment of atopic eye disease may assist dermatologists in knowing when to refer to ophthalmology and in co-managing these diseases with ophthalmologists. Ocular diseases as...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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更新日期:2019-12-01 00:00:00