Hypoxemic fetoplacental vasoconstriction: a graduated response to reduced oxygen conditions in the human placenta.

Abstract:

:We investigated the characteristics of hypoxemic fetoplacental vasoconstriction (HFPV) in the dual perfused, single isolated human placental cotyledon. Fetal arterial blood pressures (FAP) were measured in four cotyledons (Group 1) equilibrated with 21% oxygen (O2), 5% carbon dioxide (CO2), and nitrogen (N2) [control] followed by 5% CO2 in N2 for 30 min. FAP (mean +/- sd) increased from 69.8 (+/- 6.4) to 105 (+/- 3.0) mm Hg (P < 0.05), confirming the utility of HFPV in the human placenta. Eight more cotyledons (Group 2) were exposed sequentially and alternately at 15-min intervals to the control gases and to gas blends containing 15%, 12%, 5%, and 0% O2 with 5% CO2 and N2. FAP increased significantly (P < 0.05) in a stepwise fashion from 68.7 (+/- 3.7) to 70.5 (+/- 3.3) mm Hg with 15% O2; from 69.3 (+/- 3.8) to 72.4 (+/- 4.3) mm Hg with 12% O2; from 67.8 (+/- 3.2) to 74.5 (+/- 3.4) mm Hg with 5% O2; and from 69.7 (+/- 3.4) to 77.9 (+/- 5.9) mm Hg with 0% O2, suggesting that HFPV is a graduated response to reduced O2 conditions in the human placenta.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Ramasubramanian R,Johnson RF,Downing JW,Minzter BH,Paschall RL

doi

10.1213/01.ane.0000222468.76942.d8

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

439-42, table of contents

issue

2

eissn

0003-2999

issn

1526-7598

pii

103/2/439

journal_volume

103

pub_type

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