Abstract:
:To allow selection of embryos for transfer after in vitro fertilization, ovarian stimulation is usually carried out with exogenous gonadotropins. To compensate for changes induced by stimulation, GnRH analog cotreatment, oral contraceptive pretreatment, late follicular phase human chorionic gonadotropin, and luteal phase progesterone supplementation are usually added. These approaches render ovarian stimulation complex and costly. The stimulation of multiple follicular development disrupts the physiology of follicular development, with consequences for the oocyte, embryo, and endometrium. In recent years, recombinant gonadotropin preparations have become available, and novel stimulation protocols with less detrimental effects have been developed. In this article, the scientific background to current approaches to ovarian stimulation for in vitro fertilization is reviewed. After a brief discussion of the relevant aspect of ovarian physiology, the development, application, and consequences of ovarian stimulation strategies are reviewed in detail.
journal_name
Endocr Revjournal_title
Endocrine reviewsauthors
Macklon NS,Stouffer RL,Giudice LC,Fauser BCdoi
10.1210/er.2005-0015subject
Has Abstractpub_date
2006-04-01 00:00:00pages
170-207issue
2eissn
0163-769Xissn
1945-7189pii
er.2005-0015journal_volume
27pub_type
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