Abstract：
:Disruption of the GH receptor (GHR) gene eliminates GH-induced intracellular signaling and, thus, its biological actions. Therefore, the GHR gene disrupted mouse (GHR-/-) has been and is a valuable tool for helping to define various parameters of GH physiology. Since its creation in 1995, this mouse strain has been used by our laboratory and others for numerous studies ranging from growth to aging. Some of the most notable discoveries are their extreme insulin sensitivity in the presence of obesity. Also, the animals have an extended lifespan, which has generated a large number of investigations into the roles of GH and IGF-I in the aging process. This review summarizes the many results derived from the GHR-/- mice. We have attempted to present the findings in the context of current knowledge regarding GH action and, where applicable, to discuss how these mice compare to GH insensitivity syndrome in humans.
journal_name
Endocr Revjournal_title
Endocrine reviewsauthors
List EO,Sackmann-Sala L,Berryman DE,Funk K,Kelder B,Gosney ES,Okada S,Ding J,Cruz-Topete D,Kopchick JJdoi
10.1210/er.2010-0009subject
Has Abstractpub_date
2011-06-01 00:00:00pages
356-86issue
3eissn
0163-769Xissn
1945-7189pii
er.2010-0009journal_volume
32pub_type
杂志文章,评审abstract：:The secretion of glucocorticoids (GCs) is a classic endocrine response to stress. Despite that, it remains controversial as to what purpose GCs serve at such times. One view, stretching back to the time of Hans Selye, posits that GCs help mediate the ongoing or pending stress response, either via basal levels of GCs p...
journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/edrv.21.1.0389
更新日期：2000-02-01 00:00:00
abstract：:Loss of estrogens or androgens increases the rate of bone remodeling by removing restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal imbalance between resorption and formation by prolonging the lifespan of osteoclasts and shortening the lifespan of osteoblasts. Conversely, androge...
journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/er.2003-0003
更新日期：2004-06-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/edrv-15-4-421
更新日期：1994-08-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/er.2002-0023
更新日期：2003-04-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2018-10-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/er.2002-0003
更新日期：2002-12-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2008-10-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2008-04-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/er.2007-0004
更新日期：2008-02-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2014-04-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/er.2005-0018
更新日期：2006-06-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/er.2017-00220
更新日期：2018-06-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2019-10-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/er.2006-0019
更新日期：2007-12-01 00:00:00
abstract：:The endocrine functions of the adipose organ are widely studied at this stage. The adipose organ, and in particular adipocytes, communicate with almost all other organs. Although some adipose tissue pads assume the functions as distinct "miniorgans," adipocytes can also be present in smaller numbers interspersed with ...
journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/er.2006-0033
更新日期：2006-12-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 历史文章,杂志文章,评审
doi：10.1210/er.2005-0015
更新日期：2006-04-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2019-02-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章
doi：10.1210/endrev/bnaa020
更新日期：2020-12-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2002-08-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2005-05-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：1993-10-01 00:00:00
abstract：:In recent years, much interest has been devoted to defining the role of the IGF system in the nervous system. The ubiquitous IGFs, their cell membrane receptors, and their carrier binding proteins, the IGFBPs, are expressed early in the development of the nervous system and are therefore considered to play a key role ...
journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/er.2004-0024
更新日期：2005-12-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2019-08-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/er.2003-0029
更新日期：2004-08-01 00:00:00
abstract：:Natriuretic peptides are a family of structurally related but genetically distinct hormones/paracrine factors that regulate blood volume, blood pressure, ventricular hypertrophy, pulmonary hypertension, fat metabolism, and long bone growth. The mammalian members are atrial natriuretic peptide, B-type natriuretic pepti...
journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2006-02-01 00:00:00
abstract：:It is well established that the organ damage that complicates human diabetes is caused by prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels of glucose cause tissue damage in humans are still not fully understood. The prevalent hypothesis explaining the mechanisms that may underlie...
journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2015-06-01 00:00:00
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journal_title：Endocrine reviews
pub_type： 杂志文章,评审
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更新日期：2008-06-01 00:00:00
abstract：:PRL and GH are hormones with a wide spectrum of actions. Specific receptors are widely distributed in a number of classical target organs, but other tissues that are not known targets also contain measurable binding sites or receptor mRNA. The most likely explanation is that PRL and GH cause effects that have not yet ...
journal_title：Endocrine reviews
pub_type： 杂志文章,评审
doi：10.1210/edrv-12-3-235
更新日期：1991-08-01 00:00:00
