Abstract:
:The Signal Recognition Particle (SRP) plays a critical role in the sorting of nascent secretory and membrane proteins. Remarkably, this function has been conserved from bacteria, where SRP delivers proteins to the inner membrane, through to eukaryotes, where SRP is required for targeting of proteins to the endoplasmic reticulum. This review focuses on present understanding of SRP structure and function and the relationship between the two. Furthermore, the similarities and differences in the structure, function and cellular role of SRP in bacteria, chloroplasts, fungi and mammals will be stressed.
journal_name
Mol Membr Bioljournal_title
Molecular membrane biologyauthors
Pool MRdoi
10.1080/09687860400026348subject
Has Abstractpub_date
2005-01-01 00:00:00pages
3-15issue
1-2eissn
0968-7688issn
1464-5203journal_volume
22pub_type
杂志文章,评审abstract::Modification of proteins with the lipid palmitate, a process called palmitoylation, is important for the normal function of neuronal cells. However, most attention has focused on how palmitoylation regulates the targeting and trafficking of neurotransmitter receptors and non-enzymatic scaffold proteins. In this review...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/09687688.2016.1182652
更新日期:2015-08-01 00:00:00
abstract::Caveolae are approximately 50-100 nm membrane micro-invaginations associated with the plasma membrane of a wide variety of cells. Although they were first identified in transmission electron micrographs approximately 40 years ago, their exact function(s) has remained controversial. Two well-established functions inclu...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687689509038506
更新日期:1995-01-01 00:00:00
abstract::The present review introduces the concept of 'non-permanent membrane proteins', to encompass the wide variety of proteins that are not found in a stable membrane-bound form under physiological conditions, yet they interact with the membrane at some stage of their specific course of action. Non-permanent membrane prote...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/0968768021000035078
更新日期:2002-10-01 00:00:00
abstract::Glu-269, which is located on the hydrophilic face of putative helix VIII in the lactose permease of Escherichia coli, has been replaced with Asp, Gln or Cys by oligonucleotide-directed, site specific mutagenesis. Cells expressing Asp-269 permease exhibit no lactose accumulation or lactose-induced H+ translocation, but...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687689409161024
更新日期:1994-01-01 00:00:00
abstract::Notch receptor signalling plays a central role in development and its misfunction has been linked to a number of diseases. In the cannonical Notch signalling pathway, ligand binding to Notch activates a series of proteolytic cleavages that release the Notch intracellular domain for trafficking to the nucleus, where it...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/09687860500129778
更新日期:2005-07-01 00:00:00
abstract::Organellar and cytosolic pH homeostasis is central to most cellular processes, including vesicular trafficking, post-translational modification/processing of proteins, and receptor-ligand interactions. SLC9A7 (NHE7) was identified as a unique (Na+, K+)/H+ exchanger that dynamically cycles between the trans-Golgi netwo...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687680802263046
更新日期:2008-08-01 00:00:00
abstract::The eukaryotic endomembrane system (ES) is served by hundreds of dedicated proteins. Experimental characterization of the ES-associated molecular machinery in several model eukaryotes complemented by a recent progress in phylogenomics and comparative genomics have revealed a conserved complex core of the machinery tha...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687688.2010.521201
更新日期:2010-11-01 00:00:00
abstract::2B is a 99 amino acid membrane protein encoded by enteroviruses such as polio and coxsackie viruses with two transmembrane domains. The protein is found to make membranes of infected cells permeable. Using a computational approach which positions the models and assesses stability by molecular dynamics (MD) simulations...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687680903164101
更新日期:2009-08-01 00:00:00
abstract::The Amt/Mep/Rh family of integral membrane proteins comprises ammonium transporters of bacteria, archaea and eukarya, as well as the Rhesus proteins found in animals. They play a central role in the uptake of reduced nitrogen for biosynthetic purposes, in energy metabolism, or in renal excretion. Recent structural inf...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/09687680701388423
更新日期:2007-09-01 00:00:00
abstract::Membrane microdomains enriched in cholesterol, sphingolipids (rafts), and specific proteins are involved in important physiological functions. However their structure, size and stability are still controversial. Given that detergent-resistant membranes (DRMs) are in the liquid-ordered state and are rich in raft-like c...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2014.949319
更新日期:2014-09-01 00:00:00
abstract::The number of Signal Peptidase I (SPasel) molecules per E. coli cell was determined using western blot techniques. Different strains were found to contain approximately 1000 SPasel molecules per cell during exponential growth. Based on the activity of SPasel in vitro it could be estimated that this amount is sufficien...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687689509072437
更新日期:1995-10-01 00:00:00
abstract::Glycosyl-phosphatidylinositol (GPI)-anchored proteins are enriched in cholesterol- and sphingolipid-rich lipid rafts within the membrane. Rafts are known to have roles in cellular organization and function, but little is understood about the factors controlling the distribution of proteins in rafts. We have used atomi...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687860601127770
更新日期:2007-05-01 00:00:00
abstract::Time and distance scales in membranes are discussed in relation to the inference of domain structure from spectroscopic measurements. Each type of spectroscopy has a natural time scale set by the magnitude of the interactions that determine the spectral width. For fluid membranes, the lateral diffusion of the lipid mo...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687689509038489
更新日期:1995-01-01 00:00:00
abstract::In Saccharomyces cerevisiae Jen1p is a lactate/proton symporter belonging to the lactate/pyruvate:H(+) symporter subfamily (TC#2.A.1.12.2) of the Major Facilitator Superfamily. We investigated structure-function relationships of Jen1p using a rational mutational analysis based on the identification of conserved amino ...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687680701342669
更新日期:2007-09-01 00:00:00
abstract::The mitochondrial ADP/ATP carrier imports ADP from the cytosol into the mitochondrial matrix for its conversion to ATP by ATP synthase and exports ATP out of the mitochondrion to replenish the eukaryotic cell with chemical energy. Here the substrate specificity of the human mitochondrial ADP/ATP carrier AAC1 was deter...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2012.745175
更新日期:2013-03-01 00:00:00
abstract::Palmitoylation is required for the activities of several cancer-associated proteins, making the palmitoyl acyltransferase (PAT) enzymes that catalyze these reactions potential targets for anticancer therapeutics. In this study, we sought to identify and characterize a human PAT with activity toward N-terminally myrist...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687681003616854
更新日期:2010-04-01 00:00:00
abstract::A structural characterization of a synthetic peptide corresponding to the fourth transmembrane domain (M4-TMD) of the gamma-subunit of the nicotinic acetylcholine receptor from Torpedo californica has been undertaken. Solid-state NMR and CD spectroscopy studies indicate that upon reconstitution into lipid vesicles or ...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687860500370653
更新日期:2005-11-01 00:00:00
abstract::Intracellular pH was measured with the pH-sensitive fluorescent probe BCECF in spinal cord neurones cultured from rat embryos. At an external pH of 7.3, the average steady-state pHi was 7.18 +/- 0.03 (SEM, n = 97) and 7.02 +/- 0.01 (n = 221) in HEPES-buffered and in bicarbonate-buffered medium, respectively. In both e...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687680050117129
更新日期:2000-04-01 00:00:00
abstract::Nedd4 family ubiquitin ligases regulate trafficking and degradation of numerous target substrates in different cellular compartments, including at the plasma membrane, in endosomes, in the secretory pathway and in the nucleus. WWP1 is a Nedd4 family protein closely related to mouse Itch and Drosophila Su(dx), both of ...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687860600665010
更新日期:2006-05-01 00:00:00
abstract::Radiation-based therapies aided by nanoparticles have been developed for decades, and can be primarily categorized into two main platforms. First, delivery of payload of photo-reactive drugs (photosensitizers) using the conventional nanoparticles, and second, design and development of photo-triggerable nanoparticles (...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687688.2010.507788
更新日期:2010-10-01 00:00:00
abstract::Elucidating the detailed mechanism of activation of membrane protein receptors and their ligand binding is essential for structure-based drug design. Membrane protein crystal structure analysis successfully aids in understanding these fundamental molecular interactions. However, protein crystal structure analysis of t...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2014.923588
更新日期:2014-08-01 00:00:00
abstract::Homotypic fusion between early endosomes can be reconstituted in vitro. By using wortmannin and LY294002, inhibitors of phosphatidylinositol (Pl) 3-kinase, a requirement for this activity has been established in order for fusion to proceed efficiently. It has been shown that Pl 3-kinase activity is required downstream...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/096876899294788
更新日期:1999-01-01 00:00:00
abstract::Recent advances have revealed much about the signaling events and molecular components associated with autophagy. Although it is clear that there are multiple points of intersection and connection between autophagy and known vesicular membrane transport processes between membrane compartments, autophagy is modulated b...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2013.850178
更新日期:2013-12-01 00:00:00
abstract::At least four different types of interaction between protein transmembrane helices have been described to date. These include the use of charge-pair interactions that can play a positive or negative role in the assembly of multi-subunit complexes such as the T cell receptor, or recruit signal transducing accessory mol...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687689609160579
更新日期:1996-04-01 00:00:00
abstract::Temperature-composition phase diagrams of binary lipid mixtures under conditions of constant pressure and excess water show that component immiscibility is the rule rather than the exception in these systems. Phase immiscibility is particularly noted in the solid phase but several cases are known where immiscibility i...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687689509038493
更新日期:1995-01-01 00:00:00
abstract::Constitutive secretion is used to deliver newly synthesized proteins to the cell surface and to the extracellular milieu. The trans-Golgi network is a key station along this route that mediates sorting of proteins into distinct transport pathways, aided in part by clathrin and adaptor proteins. Subsequent movement of ...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/0968768031000084172
更新日期:2003-04-01 00:00:00
abstract::That some membranes restrict certain lipid species to one side of the bilayer and others to the opposite side has been known for two decades. However, how this asymmetric transbilayer distribution is generated and controlled, how many and what type of membranes are so structured, and even the reason for its existence ...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687689409160430
更新日期:1994-10-01 00:00:00
abstract::Loss of epithelial cell polarity, which can arise following disruption of tight junctions (TJs), is a precursor to the care-fully orchestrated removal of moribund cells from epithelia in apoptosis. Ordinarily, this cycle of events has minimally disruptive effects on the function of the epithelial barrier, but some age...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/0968768021000061150
更新日期:2003-01-01 00:00:00
abstract::ADP-ribosylation factor related protein 1 (ARFRP1) is a member of the ARF-family of GTPases which operate as molecular switches in the regulation of intracellular protein traffic. Deletion of the mouse Arfrp1 gene leads to embryonic lethality during early gastrulation, suggesting that ARFRP1 is required for cell adhes...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687860600840100
更新日期:2006-11-01 00:00:00
abstract::Membrane proteins are intrinsically involved in both human and pathogen physiology, and are the target of 60% of all marketed drugs. During the past decade, advances in the studies of membrane proteins using X-ray crystallography, electron microscopy and NMR-based techniques led to the elucidation of over 250 unique m...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2012.710341
更新日期:2013-03-01 00:00:00