Time course and train-of-four fade of mivacurium block during sevoflurane and intravenous anaesthesia.

Abstract:

BACKGROUND AND OBJECTIVE:Volatile anaesthetics inhibit nicotinic acetylcholine receptors at clinically relevant concentrations with higher affinity for the neuronal nicotinic receptor. The inhibitory effects of propofol on nicotinic receptors have only been documented at supraclinical concentrations. The aim of this study was to determine recovery properties and train-of-four (TOF) fade of mivacurium during sevoflurane and propofol anaesthesia, in order to examine any differences both in the enhancement of the neuromuscular block (postjunctional effects) and in TOF fade (prejunctional effects). METHODS:Twenty ASA I-II adult patients were randomly allocated to maintenance of anaesthesia with sevoflurane (end-tidal concentration 2%) or propofol. Neuromuscular block was assessed by acceleromyography and a single dose of mivacurium (0.15 mg kg(-1)) was administered (in the sevoflurane group after 30 min of exposure to sevoflurane). We measured time for recovery of the first twitch of the TOF (T1) from 25-75%, time from 25% recovery of T1 to achieving a TOF ratio (TOFR) of 0.8, TOFR at 50%, 75% and 90% recovery of T1, and height of T1 at TOFR of 0.7 and 0.9. Data were tested using t-test for independent samples. RESULTS:Recovery times (mean (95% confidence interval, CI)) of mivacurium in the sevoflurane group (T1 25-75%, 11.3 (8.1-14.5) min; T1 25%-TOFR0.8, 19.1 (15.7-22.5) min) were significantly longer (P < 0.05) than in the propofol group (T1 25-75%, 6.5 (5.2-7.7) min; T1 25%-TOFR0.8, 11.3 (7.8-10.3) min). No differences were found in the relations between TOFR and T1 or vice versa, between the groups. CONCLUSIONS:Recovery times after a single dose of mivacurium were prolonged by sevoflurane compared with propofol but no differences in TOF fade were observed between the two anaesthetics.

journal_name

Eur J Anaesthesiol

authors

Barrio J,SanMiguel G,Asensio I,Molina I,López F,García V

doi

10.1017/s0265021505000517

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

303-6

issue

4

eissn

0265-0215

issn

1365-2346

journal_volume

22

pub_type

临床试验,杂志文章,随机对照试验
  • Molecular sites of general anaesthetic action on acetylcholine receptors.

    abstract::Mechanisms of anaesthetics still remain unclear. However, various attempts have been made to elucidate the effects of anaesthetics at the molecular level. The nicotinic acetylcholine receptor has proved to be a good model of membrane-bound ligand-gated ion channels. It is available in abundance from Torpedo electropla...

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    doi:

    authors: Tonner PH,Miller KW

    更新日期:1995-01-01 00:00:00

  • The relation between left ventricular wall stress shortening and preload changes in ventilated patients.

    abstract::The relation between left ventricular end-systolic wall stress (ESWS) and the velocity of circumferential fibre shortening (Vcfs) was examined in four non-random groups with 12 patients each. In group A, preload was increased by the administration of hydroxyethylstarch 30 mL min-1. In group B, preload was reduced by a...

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    更新日期:1997-11-01 00:00:00

  • Neurotoxicity with single dose intrathecal midazolam administration.

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    更新日期:2005-12-01 00:00:00

  • Early postoperative neuropathic pain assessed by the DN4 score predicts an increased risk of persistent postsurgical neuropathic pain.

    abstract:BACKGROUND:Acute neuropathic pain can occur in the postoperative period but any link with persistent post-surgical neuropathic pain remains unclear. OBJECTIVES:The objectives of this study were to prospectively describe the incidence of acute post-surgical neuropathic pain in a large population using the DN4 (clinicia...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/EJA.0000000000000634

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  • Effects of a single subanaesthetic dose of ketamine on pain and mood after laparoscopic bariatric surgery: A randomised double-blind placebo controlled study.

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    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000000860

    authors: Wang J,Echevarria GC,Doan L,Ekasumara N,Calvino S,Chae F,Martinez E,Robinson E,Cuff G,Franco L,Muntyan I,Kurian M,Schwack BF,Bedrosian AS,Fielding GA,Ren-Fielding CJ

    更新日期:2019-01-01 00:00:00

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    更新日期:2018-04-01 00:00:00

  • The ProSeal laryngeal mask airway and the laryngeal tube Suction for ventilation in gynaecological patients undergoing laparoscopic surgery.

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    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0265021505000220

    authors: Roth H,Genzwuerker HV,Rothhaas A,Finteis T,Schmeck J

    更新日期:2005-02-01 00:00:00

  • Level of agreement between heart rate variability and pulse rate variability in healthy individuals.

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    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021506000329

    authors: Fuzier R,Fourcade O,Fuzier V,Albert N,Samii K,Olivier M

    更新日期:2006-04-01 00:00:00

  • Measuring depth of sedation in intensive care patients with the electroencephalographic Narcotrend Index.

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    pub_type: 杂志文章

    doi:10.1017/S0265021507001329

    authors: Weber F,Steinberger M,Ritzka M,Prasser C,Bein T

    更新日期:2008-02-01 00:00:00

  • Ventilatory response to progressive curarization in patients during light halothane, N2O in O2 anaesthesia.

    abstract::The effects of progressive curarization on spontaneous ventilation were studied in 23 patients during light halothane-nitrous oxide-oxygen anaesthesia. In 11 patients, in whom the end-expiratory CO2 concentration and evoked mechanical response were recorded, increasing curarization caused first a slow CO2 accumulation...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Linko K,Wirtavuori K,Tammisto T

    更新日期:1984-06-01 00:00:00

  • Factors independently associated with increased risk of pain development after ophthalmic surgery.

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    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021503000279

    authors: Lebuffe G,Onimus T,Vallet B

    更新日期:2003-02-01 00:00:00

  • Effects of desflurane, sevoflurane and propofol on phagocytosis and respiratory burst activity of human polymorphonuclear leucocytes in bronchoalveolar lavage.

    abstract:BACKGROUND AND OBJECTIVE:In polymorphonuclear leucocytes, phagocytosis and respiratory burst activity are mainly responsible for bacterial killing. We aimed to investigate the effects of anaesthesia with desflurane, sevoflurane and propofol on these functional activities of polymorphonuclear leucocytes in bronchoalveol...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328319bfeb

    authors: Erol A,Reisli R,Reisli I,Kara R,Otelcioglu S

    更新日期:2009-02-01 00:00:00

  • Bilateral phaeochromocytomas in pregnancy: anaesthetic management of combined caesarean section and tumour removal.

    abstract::A 25-year-old primigravida with bilateral phaeochromocytomas was managed from 6 weeks' gestation until 2.5 years following combined Caesarean section and removal of adrenal tumours. Pre-operative alpha-blockade was achieved by oral prazosin without deleterious effects. Intra-operative management comprised neuroleptana...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Pinaud M,Souron R,Le Neel JC,Lopes P,Murat A,L'hoste F

    更新日期:1985-12-01 00:00:00

  • Intravenous administration of tenoxicam 40 mg for post-operative analgesia: a double-blind, placebo-controlled multicentre study.

    abstract::The analgesic efficacy of tenoxicam, a newer injectable non-steroidal anti-inflammatory drug, for post-operative analgesia after abdominal or orthopaedic surgery in ASA Grade I/II patients is reported. Two hundred and fifty-six patients received a single dose of tenoxicam 40 mg intravenous (i.v.) at the end of surgery...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1046/j.1365-2346.1997.00061.x

    authors: Vandermeulen EP,Van Aken H,Scholtes JL,Singelyn F,Buelens A,Haazen L

    更新日期:1997-05-01 00:00:00

  • Responsiveness to inhaled NO in isolated-perfused lungs from endotoxin-challenged rats is dependent on endogenous nitrite/nitrate synthesis.

    abstract:BACKGROUND AND OBJECTIVES:In isolated-perfused lungs of lipopolysaccharide (LPS)-challenged rats, vasodilatation to inhaled nitric oxide (NO) is impaired. Inhibition of nitric oxide synthase 2 (NOS2) by aminoguanidine (AG) prevented hyporesponsiveness to inhaled NO. Here, we investigated whether NOS2-mediated nitrite/n...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021506001463

    authors: Bopp Ch,Gust R,Taut F,Gries A,Martin E,Klein A

    更新日期:2007-04-01 00:00:00

  • Implementation of patient blood management remains extremely variable in Europe and Canada: the NATA benchmark project: An observational study.

    abstract:BACKGROUND:Preoperative anaemia is associated with increased postoperative morbidity and mortality. Patient blood management (PBM) is advocated to improve patient outcomes. OBJECTIVES:NATA, the 'Network for the advancement of patient blood management, haemostasis and thrombosis', initiated a benchmark project with the...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/EJA.0000000000000519

    authors: Van der Linden P,Hardy JF

    更新日期:2016-12-01 00:00:00

  • The effect of anaesthesia on renal function.

    abstract::Anaesthesia and surgical stress can affect renal function and body fluid regulation indirectly as well as directly. The indirect effects, through influences on haemodynamics, sympathetic activity and humoral regulation, are more pronounced than the direct ones. Inhalational anaesthetics generally reduce glomerular fil...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:

    authors: Burchardi H,Kaczmarczyk G

    更新日期:1994-05-01 00:00:00

  • CobraPLUS and Cookgas air-Q versus Fastrach for blind endotracheal intubation: a randomised controlled trial.

    abstract:BACKGROUND AND OBJECTIVE:CobraPLUS and Cookgas air-Q are supraglottic airways expected to allow safe ventilation as well as reliable blind intubation. In a prospective, controlled trial, we hypothesised that quality of ventilation and success rate of blind endotracheal intubation of these new devices would be superior ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328340c352

    authors: Erlacher W,Tiefenbrunner H,Kästenbauer T,Schwarz S,Fitzgerald RD

    更新日期:2011-03-01 00:00:00

  • Comparison of Bullard and Airtraq laryngoscopes with conventional laryngoscopy in a manikin study of simulated difficult intubation.

    abstract:BACKGROUND:When airway management is difficult, various measures can be taken to facilitate tracheal intubation. The Bullard and Airtraq laryngoscopes were developed for this purpose. We hypothesised that the Bullard and Airtraq laryngoscopes would perform better than a conventional laryngoscope in the management of a ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328354b22c

    authors: Legrand MA,Steinmann D,Priebe HJ,Mols G

    更新日期:2012-07-01 00:00:00

  • Isoflurane reduces synaptic glutamate release without changing cytosolic free calcium in isolated nerve terminals.

    abstract::The molecular mechanism of volatile anaesthetic action on presynaptic glutamate release is not clear. An inhibitory effect on voltage-gated calcium channels has been proposed. The present study examines the effect of isoflurane on cytosolic free calcium and synaptic glutamate release from isolated nerve terminals. Syn...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Larsen M,Valø ET,Berg-Johnsen J,Langmoen IA

    更新日期:1998-03-01 00:00:00

  • Use of EEG spectral edge as index of equipotency in a comparison of propofol and isoflurane for maintenance of general anaesthesia.

    abstract::Propofol and isoflurane were compared for haemodynamic stability and recovery time as main anaesthetic agents for maintenance in a total of 43 ASA I and II patients in uncomplicated operations lasting at least 30 min. The premedication (oral diazepam), induction (thiopentone-fentanyl-suxamethonium) and maintenance pro...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Gurman GM,Fajer S,Porat A,Schily M,Pearlman A

    更新日期:1994-11-01 00:00:00

  • Ropivacaine 0.1% with fentanyl 2 microg mL(-1) by epidural infusion for labour analgesia.

    abstract:BACKGROUND AND OBJECTIVE:To evaluate the efficacy of 0.1% ropivacaine with fentanyl 2 microg mL(-1) via epidural for analgesia in labour. METHODS:In a randomized study, 80 nulliparous parturients in labour had epidural analgesia initiated with 0.2% ropivacaine and fentanyl and were then randomized to receive either 0....

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0265021504000031

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    更新日期:2004-10-01 00:00:00

  • The role of venodilators in the perioperative management of heart failure.

    abstract::A unifying hypothesis which satisfactorily explains the clinical syndrome of heart failure has proved elusive. A deeper understanding of the underlying pathophysiology has led to the development of more complex models and, as a result, the evolution of new treatment strategies. In patients undergoing non-cardiac surge...

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    更新日期:2012-03-01 00:00:00

  • First clinical experience with the rapid-, short-acting amiodarone derivative E 047/1 after cardiac surgery.

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    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0265021502000042

    authors: Gombotz H,Vicenzi M,Mahla E,Rehak P,Metzler H

    更新日期:2002-01-01 00:00:00

  • Cerebral blood flow velocity and carbon dioxide vasoreactivity during gamma-hydroxybutyrate/fentanyl anaesthesia in non-neurosurgical patients.

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    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2346.1999.00452.x

    authors: Detsch O,Erkens U,Schneck H,Denker T,Kochs E,Hempelmann G

    更新日期:1999-03-01 00:00:00

  • Effects of calcium and magnesium pretreatment on hyperkalaemic cardiac arrest in rats.

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    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021503000978

    authors: Hollmann MW,Strümper D,Salmons VA,Washington JM,Durieux ME

    更新日期:2003-08-01 00:00:00

  • Systemic and alveolar inflammatory response in the dependent and nondependent lung in patients undergoing lung resection surgery: A prospective observational study.

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    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000233

    authors: de la Gala F,Piñeiro P,Garutti I,Reyes A,Olmedilla L,Cruz P,Duque P,Casanova J,Rancan L,Benito P,Vara E

    更新日期:2015-12-01 00:00:00

  • Biphasic cardiac output changes during onset of spinal anaesthesia in elderly patients.

    abstract:BACKGROUND AND OBJECTIVE:In most studies of cardiac output changes after spinal anaesthesia, the time-resolution is limited. The aim of this study was to demonstrate cardiac output changes with high time-resolution during onset of spinal anaesthesia in elderly patients. METHODS:We investigated 32 patients aged 60 yr s...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021507000427

    authors: Meyhoff CS,Hesselbjerg L,Koscielniak-Nielsen Z,Rasmussen LS

    更新日期:2007-09-01 00:00:00