Abstract：
BACKGROUND AND OBJECTIVE:Administration of calcium safely and effectively reverses many of the electrophysiological actions of hyperkalaemia, but it has not been studied for pretreatment. Based on cellular studies, magnesium also has been suggested to prevent the effects of potassium on the heart. As their mechanisms of action differ, a combination of these drugs might have a synergistic protective action. Both compounds are inexpensive and can be administered safely in modest doses. We investigated whether magnesium, calcium or their combination could protect against hyperkalaemic cardiac arrest. METHODS:Twenty-four adult rats were anaesthetized with halothane and randomly pretreated with CaCl2 15 mg kg(-1), MgSO4 30 mg kg(-1), CaCl2 7.5 mg kg(-1) + MgSO4 15 mg kg(-1) or physiological saline. Potassium (0.01 mmol kg(-1) h(-1)) was infused. The times to the first dysrhythmia, mean arterial pressure decrease to <40% of baseline and cardiovascular collapse were measured. RESULTS:Serum potassium concentrations increased to similar values in all groups (to 12.0 +/- 0.2 mmol L(-1) at the time of collapse). No differences in survival times were observed between groups. There was a trend for respiratory values to be better in the group receiving magnesium. CONCLUSIONS:Pretreatment with magnesium, calcium or a combination of both did not influence the time to cardiovascular collapse, and is therefore--at least in our model--not of any benefit in preventing hyperkalaemic cardiac arrest.
journal_name
Eur J Anaesthesioljournal_title
European journal of anaesthesiologyauthors
Hollmann MW,Strümper D,Salmons VA,Washington JM,Durieux MEdoi
10.1017/s0265021503000978subject
Has Abstractpub_date
2003-08-01 00:00:00pages
606-11issue
8eissn
0265-0215issn
1365-2346journal_volume
20pub_type
杂志文章abstract：BACKGROUND:Transoesophageal echocardiography (TOE) probe insertion in anaesthetised patients can cause pharyngeal and oesophageal injuries. Kim et al. have shown that insertion assisted by a Macintosh laryngoscope can reduce such complications but it may sometimes be difficult to observe the passage of a TOE probe. The...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
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更新日期：2016-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Infraclavicular plexus block has many advantages of particular interest in the emergency setting. However, the number of nerve stimulations needed to optimize the technique remains unclear. We evaluated both the local anaesthetic requirement and the success rate of Sim's derived infraclavicula...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of anaesthesiology
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journal_title：European journal of anaesthesiology
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journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0000000000001021
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journal_title：European journal of anaesthesiology
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journal_title：European journal of anaesthesiology
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journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of anaesthesiology
pub_type： 杂志文章,多中心研究
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journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of anaesthesiology
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journal_title：European journal of anaesthesiology
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更新日期：1991-05-01 00:00:00
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journal_title：European journal of anaesthesiology
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更新日期：2007-04-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of anaesthesiology
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journal_title：European journal of anaesthesiology
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journal_title：European journal of anaesthesiology
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journal_title：European journal of anaesthesiology
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journal_title：European journal of anaesthesiology
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journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章
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更新日期：1997-07-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,多中心研究
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journal_title：European journal of anaesthesiology
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journal_title：European journal of anaesthesiology
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