Propofol inhibits potassium chloride induced contractions of isolated human umbilical vessels.

Abstract:

BACKGROUND AND OBJECTIVE:We have evaluated the effects of propofol and its relationship with K+ channels on human isolated umbilical vessels. METHODS:Umbilical vessel rings were suspended in isolated organ baths containing Krebs-Ringer solution. In the first series of experiments the effect of propofol (10(-9)-10(-4) M) was examined in a concentration-dependent manner on umbilical vessels precontracted with KCl (60 mmol). In the second series, these effects were studied in the presence of tetraethylammonium. RESULTS:A mild contraction was produced by low dose propofol in both precontracted umbilical artery and umbilical vein segments. 10(-4) M propofol caused significant relaxation in both umbilical artery and umbilical vein. The relaxation response was significantly reduced by the addition of 10(-1) M tetraethylammonium. CONCLUSION:These results suggested that the responses of propofol on KCl-induced contractions of both umbilical artery and vein were dose dependent, and this effect involved Ca2+ activated K+ channels.

journal_name

Eur J Anaesthesiol

authors

Caliskan E,Kayhan Z,Tufan H

doi

10.1017/S0265021505001924

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

411-7

issue

5

eissn

0265-0215

issn

1365-2346

pii

S0265021505001924

journal_volume

23

pub_type

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