Fentanyl pre-treatment does not affect the pharmacokinetic profile of an induction dose of propofol in adults.

Abstract:

:The initial disposition of propofol was reported to change when the administration was preceded by fentanyl. The pharmacokinetic profile of the induction dose of propofol (2 mg kg-1 body weight) was studied in 20 ASA I patients randomly allocated to receive fentanyl 1.5 microgram kg-1 (n = 12) or not (n = 8). Anaesthesia was maintained with isoflurane in N2O/O2. Venous blood drawn from the contralateral arm was used to determine whole blood propofol concentrations. The mean propofol blood concentrations were comparable in the two groups and were best fitted by a three exponential equation in all the patients, conforming to a three-compartment open mammillary model. Distributions (T1/2 alpha) redistribution (T1/2(7)) and elimination (T1/2 beta half-lives were comparable in the groups, without significant differences in the total body clearance in the area under the time-concentration curve (zero-infinity) in the volume of distribution at steady-state, in the volume of distribution during the elimination phase or in the mean resident time. Our data support the conclusion that pretreatment with fentanyl does not affect the pharmacokinetic profile of the induction dose of propofol in ASA I patients.

journal_name

Eur J Anaesthesiol

authors

De Gasperi A,Cristalli A,Noé L,Sabbadini D,Mazza E,Prosperi M,Fantini G,Crespi AM,Rezzani S

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

89-93

issue

2

eissn

0265-0215

issn

1365-2346

journal_volume

11

pub_type

临床试验,杂志文章,随机对照试验
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    abstract::The time-course of the neuromuscular effects of vecuronium (n = 25) and atracurium (n = 25) has been compared at three different levels of maintenance dose in anaesthetized patients. Following intubation with vecuronium 0.1 mg kg-1 or atracurium 0.5 mg kg-1, surgical muscle relaxation was maintained by using increment...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Khuenl-Brady KS,Scharz S,Richardson FJ,Mitterschiffthaler G

    更新日期:1991-01-01 00:00:00

  • Effects of volume and concentration of lidocaine on epidural anaesthesia in pregnant females.

    abstract:BACKGROUND AND OBJECTIVE:The effects of altering the concentration of a local anaesthetic on the development of epidural anaesthesia in pregnant females are unclear. We compared the anaesthetic effects of a constant dose of two different concentrations of epidural lidocaine for Caesarean section. METHODS:After Institu...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0265021502001308

    authors: Nakayama M,Yamamoto J,Ichinose H,Yamamoto S,Kanaya N,Namiki A

    更新日期:2002-11-01 00:00:00

  • Comparison of inhalation induction with isoflurane or halothane in children.

    abstract::Thirty-six children (mean age 2.4 years) premedicated with oral chloral hydrate 70 mg kg-1 and atropine 0.03 mg kg-1 were anaesthetized with either 3.75% isoflurane or 2.5% halothane in 70% nitrous oxide in oxygen. The eyelash reflex disappeared in 39 +/- 7 s (mean +/- SD) with isoflurane and in 56 +/- 16 s with halot...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Lindgren L,Randell T,Saarnivaara L

    更新日期:1991-01-01 00:00:00

  • Comparison of laryngeal tube with laryngeal mask airway in anaesthetized and paralysed patients.

    abstract:BACKGROUND AND OBJECTIVE:The laryngeal mask has become a widely accepted alternative to endotracheal intubation and mask ventilation. The laryngeal tube is a relatively new supraglottic airway device for airway management. We compared the new version of the laryngeal tube with the laryngeal mask. METHODS:In a randomiz...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021507000129

    authors: Yildiz TS,Solak M,Toker K

    更新日期:2007-07-01 00:00:00

  • Repeat autoclaving does not remove protein deposits from the classic laryngeal mask airway.

    abstract:INTRODUCTION:We tested the hypothesis that repeated autoclaving removes protein deposits from the classic laryngeal mask airway (LMA). METHODS:Twenty previously used LMAs were hand washed, machine washed, dried, autoclaved and randomly allocated into four equal-sized groups for repeat autoclaving on 0 (control), 1, 2 ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021505000888

    authors: Bannon L,Brimacombe J,Nixon T,Keller C

    更新日期:2005-07-01 00:00:00

  • Dynamic hyperinflation and intrinsic PEEP during mechanical ventilation.

    abstract::Dynamic hyperinflation, also called intrinsic PEEP (PEEPi,) occurs particularly when high tidal volumes or high respiratory rates are used during mechanical ventilation, although the phenomenon does occur at normal tidal volumes. It is not identified using existing monitoring such as the airway pressure but can be ide...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:

    authors: Romand JA,Suter PM

    更新日期:1994-01-01 00:00:00

  • Randomised comparison of hyperbaric articaine and hyperbaric low-dose bupivacaine along with fentanyl in spinal anaesthesia for day-case inguinal herniorrhaphy.

    abstract:BACKGROUND AND OBJECTIVE:Low-dose mixture of hyperbaric bupivacaine and fentanyl is commonly used in day-case spinal anaesthesia. Using hyperbaric articaine, the onset may be faster and duration more predictable than with bupivacaine-fentanyl. We compared these two spinal anaesthetics for inguinal herniorrhaphy. METHO...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e32834a11be

    authors: Bachmann M,Pere P,Kairaluoma P,Rosenberg PH,Kallio H

    更新日期:2012-01-01 00:00:00

  • Five oxygen-nitrous oxide proportioning systems compared.

    abstract::The majority of contemporary gas delivery modules, on anaesthetic workstations, are equipped with oxygen-nitrous oxide proportioning systems which should prevent the delivery of hypoxic gas mixtures. We investigated five modules, of two different types, using fresh gas flows ranging from 50 mL min-1 to 20 L min-1 with...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/00003643-199601000-00013

    authors: Feigenwinter P,Pohle TH,Zbinden AM

    更新日期:1996-01-01 00:00:00

  • S100B protein and neuron-specific enolase as predictors of cognitive dysfunction after coronary artery bypass graft surgery: A prospective observational study.

    abstract:BACKGROUND:Postoperative cognitive dysfunction (POCD) may be related to the systemic inflammatory response and an increase in serum markers of brain injury such as S100B protein and neuron-specific enolase (NSE). OBJECTIVE:The study aims to evaluate the association between POCD and serum levels of S100B and NSE after ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000450

    authors: Silva FP,Schmidt AP,Valentin LS,Pinto KO,Zeferino SP,Oses JP,Wiener CD,Otsuki DA,Tort AB,Portela LV,Souza DO,Auler JO Jr,Carmona MJ

    更新日期:2016-09-01 00:00:00

  • A comparison of the effects of codeine and tramadol on laryngeal reactivity.

    abstract::The effect of tramadol on laryngeal reflex activity was assessed in a double-blind cross-over study in six volunteers receiving single oral doses of either codeine 50 mg, tramadol 50 mg or tramadol 100 mg. Laryngeal reactivity was measured by the response to the inhalation of dilute ammonia vapour. The minimum ammonia...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Szekely SM,Vickers MD

    更新日期:1992-03-01 00:00:00

  • Pharmacokinetic-based total intravenous anaesthesia using remifentanil and propofol for surgical myocardial revascularization.

    abstract:BACKGROUND AND OBJECTIVE:We investigated the following aspects of pharmacokinetic-guided total intravenous anaesthesia with remifentanil and propofol in patients undergoing surgical myocardial revascularization: anaesthetic efficacy, haemodynamic effects, impact on extubation of the trachea and analgesia after operatio...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021503000589

    authors: Guarracino F,Penzo D,De Cosmo D,Vardanega A,De Stefani R

    更新日期:2003-05-01 00:00:00

  • Total hip arthroplasty and perioperative oral carbohydrate treatment: a randomised, double-blind, controlled trial.

    abstract:CONTEXT:Perioperative oral carbohydrate intake is beneficial to general surgery patients. Total hip arthroplasty is a common surgical procedure, and even a moderate improvement in patient outcome could have a significant effect on the resources needed for these patients. However, few studies have focused on the effects...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e3283525ba9

    authors: Harsten A,Hjartarson H,Toksvig-Larsen S

    更新日期:2012-06-01 00:00:00

  • Multimodal analgesia with gabapentin, ketamine and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: a preliminary study.

    abstract:BACKGROUND AND OBJECTIVE:It has been hypothesized that combinations of analgesics with different mechanisms of action may reduce or even prevent postoperative pain. We, therefore, investigated the analgesic effect of gabapentin, dexamethasone and low-dose ketamine in combination with paracetamol and ketorolac as compar...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328331c71d

    authors: Rasmussen ML,Mathiesen O,Dierking G,Christensen BV,Hilsted KL,Larsen TK,Dahl JB

    更新日期:2010-04-01 00:00:00

  • Learning curves of the Glidescope, the McGrath and the Airtraq laryngoscopes: a manikin study.

    abstract:BACKGROUND AND OBJECTIVE:Several video and optical laryngoscopes have been developed but few have been compared in terms of their learning curves and efficacy. Using a manikin with normal airways we compared the Glidescope, the McGrath, the Airtraq and the Macintosh laryngoscopes. METHODS:Sixty anaesthetists (20 staff...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/eja.0b013e3283269ff4

    authors: Savoldelli GL,Schiffer E,Abegg C,Baeriswyl V,Clergue F,Waeber JL

    更新日期:2009-07-01 00:00:00

  • The effect of a standardised source of divided attention in airway management: A randomised, crossover, interventional manikin study.

    abstract:BACKGROUND:Dual-tasking, the need to divide attention between concurrent tasks, causes a severe increase in workload in emergency situations and yet there is no standardised training simulation scenario for this key difficulty. OBJECTIVES:We introduced and validated a quantifiable source of divided attention and inves...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000000315

    authors: Prottengeier J,Petzoldt M,Jess N,Moritz A,Gall C,Schmidt J,Breuer G

    更新日期:2016-03-01 00:00:00

  • Urinary neprilysin for early detection of acute kidney injury after cardiac surgery: A prospective observational study.

    abstract:BACKGROUND:Acute kidney injury (AKI) predicts adverse outcomes after cardiac surgery. The accuracy of using changes in serum creatinine for diagnosis and grading of AKI is limited in the peri-operative cardiac surgical setting and AKI may be underdiagnosed due to haemodilution from cardiopulmonary bypass priming and th...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000001321

    authors: Bernardi MH,Wagner L,Ryz S,Puchinger J,Nixdorf L,Edlinger-Stanger M,Geilen J,Kainz M,Hiesmayr MJ,Lassnigg A

    更新日期:2021-01-01 00:00:00

  • Antagonism of midazolam sedation by flumazenil: a placebo-controlled study in patients recovering from intravenous anaesthesia with high doses of midazolam.

    abstract::Twenty adult surgical patients were anaesthetized with high-dose midazolam and alfentanil by infusion, vecuronium, and intubated and ventilated with 50% N2O in O2. The midazolam and alfentanil infusions were stopped at the end of surgery. Residual neuromuscular blockade and ventilatory depression were antagonized and ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Hennis PJ,van Haastert FA,Mulder AJ,Spierdijk J

    更新日期:1988-11-01 00:00:00

  • Landiolol, a new ultra-short-acting beta1-blocker, reduces anaesthetic requirement during sevoflurane/N(2)O/fentanyl anaesthesia in surgical patients.

    abstract:BACKGROUND AND OBJECTIVE:It is known that esmolol, a short-acting beta1-blocker, reduces anaesthetic requirement. In this study, we evaluated whether a low dose of landiolol, a new ultra-short-acting beta1-blocker, can reduce the sevoflurane requirement. METHODS:Twenty-five patients undergoing hip surgery were randoml...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328318c6a9

    authors: Tanabe T,Fukusaki M,Fujinaga A,Ando Y,Yamashita K,Terao Y,Sumikawa K

    更新日期:2009-01-01 00:00:00

  • Aetiology of convulsions due to stellate ganglion block: a review and report of two cases.

    abstract::Stellate ganglion block is a selective sympathetic block that affects the ipsilateral head, neck, upper extremity and upper part of the thorax. Convulsions are a recognized complication of intra-arterial injection during stellate ganglion block. As central nervous system toxicity depends ultimately on the concentratio...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:10.1017/s0265021502000613

    authors: Mahli A,Coskun D,Akcali DT

    更新日期:2002-05-01 00:00:00

  • Biphasic cardiac output changes during onset of spinal anaesthesia in elderly patients.

    abstract:BACKGROUND AND OBJECTIVE:In most studies of cardiac output changes after spinal anaesthesia, the time-resolution is limited. The aim of this study was to demonstrate cardiac output changes with high time-resolution during onset of spinal anaesthesia in elderly patients. METHODS:We investigated 32 patients aged 60 yr s...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021507000427

    authors: Meyhoff CS,Hesselbjerg L,Koscielniak-Nielsen Z,Rasmussen LS

    更新日期:2007-09-01 00:00:00

  • Arterial pressure waveform analysis versus thermodilution cardiac output measurement during open abdominal aortic aneurysm repair: a prospective observational study.

    abstract:BACKGROUND:Arterial pressure waveform analysis enables continuous, minimally invasive measurement of cardiac output. Haemodynamic instability compromises the reliability of the technique and a means of maintaining accurate measurement in this circumstance would be useful. OBJECTIVES:To investigate the accuracy, precis...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000160

    authors: Montenij LJ,Buhre WF,de Jong SA,Harms JH,van Herwaarden JA,Kruitwagen CL,de Waal EE

    更新日期:2015-01-01 00:00:00

  • Platelet function assessed by whole-blood aggregometry in patients undergoing non-cardiac surgery.

    abstract:BACKGROUND:The risk/benefit of continuing low-dose acetylsalicylic acid (aspirin) for secondary prevention in the perioperative period is still debated. The primary aim of this study was to determine the effect of acetylsalicylic acid compared with placebo on platelet function in the perioperative period. METHODS:This...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/EJA.0b013e32834448ed

    authors: Oscarsson A,Öster S,Fredrikson M,Lindahl TL,Eintrei C

    更新日期:2011-05-01 00:00:00

  • Lorazepam fast-dissolving drug formulation (FDDF) and intravenous administrations as anaesthetic premedicants: a pharmacokinetic analysis.

    abstract::The pharmacokinetics of lorazepam premedication were studied in 16 patients using two different formulations (intravenous and FDDF oral administrations). Arterial blood samples were taken at intervals for up to 600 min after administration of 4 mg of each formulation, and plasma lorazepam concentrations were determine...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Camu F,Maes V,Van de Velde A,Sevens C

    更新日期:1988-07-01 00:00:00

  • Drotrecogin alfa (activated): diffusion from clinical trials to clinical practice.

    abstract:BACKGROUND AND OBJECTIVE:Although the PROWESS trial demonstrated a mortality benefit, subsequent studies in different patient populations have not reproduced the effect. As a result, concerns have been expressed about the clinical effectiveness of drotrecogin alfa (activated). Therefore the aim of this audit was to rev...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021507002992

    authors: Ridley S,Lwin A,Wyncoll D,Lippett S,Watson D,Gunning K,Higgins D

    更新日期:2008-03-01 00:00:00

  • Duration of stabilization of control responses affects the onset and duration of action of rocuronium but not suxamethonium.

    abstract::The effect of the duration of stabilization of control responses on the onset and duration of clinical relaxation of suxamethonium 1 mg kg-1 and rocuronium 0.6 mg kg-1 were investigated in 90 patients. The control responses were allowed to stabilize for 1, 5, 10, 15 or 20 min prior to administration of rocuronium and ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2346.1996.d01-379.x

    authors: Symington MJ,McCoy EP,Mirakhur RK,Kumar N

    更新日期:1996-07-01 00:00:00

  • Pulmonary lipiodol embolism during transcatheter arterial chemoembolization for hepatoblastoma under general anaesthesia.

    abstract::We present a case of pulmonary embolism that occurred during the injection of lipiodol during transcatheter arterial chemoembolization under general anaesthesia. A 7-year-old child suffering from a large hepatoblastoma was admitted for arterial chemoembolization and carcinostatic administration. Pulmonary embolism due...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.2000.00759.x

    authors: Yamaura K,Higashi M,Akiyoshi K,Itonaga Y,Inoue H,Takahashi S

    更新日期:2000-11-01 00:00:00

  • Perioperative care of diabetic patients.

    abstract::Diabetes mellitus is the most common metabolic disease and its incidence is increasing. New classifications have been recently proposed based upon a better knowledge of pathogenesis, mechanisms of glucose transport and insulin resistance. The perioperative care of diabetic patients is less dependent on blood-glucose c...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.0265-0215.2001.00876.x

    authors: Scherpereel PA,Tavernier B

    更新日期:2001-05-01 00:00:00

  • Systemic and alveolar inflammatory response in the dependent and nondependent lung in patients undergoing lung resection surgery: A prospective observational study.

    abstract:BACKGROUND:Measurement of inflammatory mediators in bronchoalveolar lavage (BAL) during lung resection surgery with periods of one-lung ventilation (OLV) has revealed an intense local pulmonary response. The role of each lung in the inflammation that occurs during this procedure has never been investigated. OBJECTIVE(...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000233

    authors: de la Gala F,Piñeiro P,Garutti I,Reyes A,Olmedilla L,Cruz P,Duque P,Casanova J,Rancan L,Benito P,Vara E

    更新日期:2015-12-01 00:00:00

  • Do muscle relaxants influence vascular tone in isolated coronary artery segments?

    abstract::The aim of this study was to elucidate the influence of four neuromuscular blocking substances on coronary vascular tone using the model of isolated porcine coronary artery segments. We studied the effects of four muscle relaxants, atracurium, pancuronium, rocuronium, and vecuronium (0.1, 1, and 10 microg mL-1 each), ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.2000.00712.x

    authors: Klockgether-Radke AP,Haemmerle A,Kettler D,Hellige G

    更新日期:2000-08-01 00:00:00

  • Bilateral phaeochromocytomas in pregnancy: anaesthetic management of combined caesarean section and tumour removal.

    abstract::A 25-year-old primigravida with bilateral phaeochromocytomas was managed from 6 weeks' gestation until 2.5 years following combined Caesarean section and removal of adrenal tumours. Pre-operative alpha-blockade was achieved by oral prazosin without deleterious effects. Intra-operative management comprised neuroleptana...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Pinaud M,Souron R,Le Neel JC,Lopes P,Murat A,L'hoste F

    更新日期:1985-12-01 00:00:00