Duration of stabilization of control responses affects the onset and duration of action of rocuronium but not suxamethonium.

Abstract:

:The effect of the duration of stabilization of control responses on the onset and duration of clinical relaxation of suxamethonium 1 mg kg-1 and rocuronium 0.6 mg kg-1 were investigated in 90 patients. The control responses were allowed to stabilize for 1, 5, 10, 15 or 20 min prior to administration of rocuronium and for 1, 5, 10 or 15 min prior to suxamethonium. The mean onset time for rocuronium decreased from 150 to 46 s as the duration of stabilization increased from 1 to 20 min (P < 0.001) although the maximal effect was observed within the first 5 min. The average duration of clinical relaxation also increased from 25 to 40 min (P < 0.001). No effect was observed for either variable in the case of suxamethonium.

journal_name

Eur J Anaesthesiol

authors

Symington MJ,McCoy EP,Mirakhur RK,Kumar N

doi

10.1046/j.1365-2346.1996.d01-379.x

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

377-80

issue

4

eissn

0265-0215

issn

1365-2346

journal_volume

13

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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    doi:

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    pub_type: 杂志文章,随机对照试验

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