Responsiveness to inhaled NO in isolated-perfused lungs from endotoxin-challenged rats is dependent on endogenous nitrite/nitrate synthesis.

Abstract:

BACKGROUND AND OBJECTIVES:In isolated-perfused lungs of lipopolysaccharide (LPS)-challenged rats, vasodilatation to inhaled nitric oxide (NO) is impaired. Inhibition of nitric oxide synthase 2 (NOS2) by aminoguanidine (AG) prevented hyporesponsiveness to inhaled NO. Here, we investigated whether NOS2-mediated nitrite/nitrate synthesis modulates responsiveness to inhaled NO. METHODS:Sprague-Dawley rats received intraperitoneally 0.5 mg kg(-1) LPS. Four hours later, LPS-treated rats received 3, 10 or 30 mg kg(-1) AG or 0.01, 0.1 or 1 mg kg(-1) S-methylisothiourea (SMT) by intraperitoneal injection. Sixteen to eighteen hours later, lungs were isolated and perfused, and pulmonary artery pressure (PAP) was elevated by 6-8 mmHg using the thromboxane analogue U46619. The decrease of PAP in response to inhaled NO and nitrate/nitrite levels in serum and perfusate was measured. RESULTS:In rats treated with LPS alone or 0.01 or 0.1 mg kg(-1) SMT, 40 ppm NO decreased PAP less than in rats treated with AG and 1 mg kg(-1) SMT (-1.8 mmHg (95% confidence interval: -1.5 to -2.1) vs. -6.0 mmHg (-5.7 to -6.3), P < 0.01). Improved NO responsiveness was associated with lower serum and perfusate nitrite/nitrate levels than in rats with hyporesponsiveness to inhaled NO (102 micromol (82-122) vs. 282 micromol (261-303) and 8.1 micromol (6.9-9.3) vs. 19.8 micromol (17.2-22.4), respectively, P < 0.01). CONCLUSIONS:These observations demonstrate that in isolated-perfused lungs of LPS-treated rats, NOS2 inhibition improved responsiveness to inhaled NO. Here, responsiveness to inhaled NO is dependent on the ability of NOS2 inhibitors to reduce nitrite and nitrate levels in serum and released in the lung.

journal_name

Eur J Anaesthesiol

authors

Bopp Ch,Gust R,Taut F,Gries A,Martin E,Klein A

doi

10.1017/S0265021506001463

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

362-9

issue

4

eissn

0265-0215

issn

1365-2346

pii

S0265021506001463

journal_volume

24

pub_type

杂志文章
  • Duration of fluid fasting and choice of analgesic are modifiable factors for early postoperative delirium.

    abstract:BACKGROUND AND OBJECTIVE:Most therapeutic options for postoperative delirium are only symptom oriented; therefore, the best approach remains prevention. The aim of this study was to identify predisposing and precipitating factors for early postoperative delirium. METHODS:A total of 1002 patients were screened for deli...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0b013e3283335cee

    authors: Radtke FM,Franck M,MacGuill M,Seeling M,Lütz A,Westhoff S,Neumann U,Wernecke KD,Spies CD

    更新日期:2010-05-01 00:00:00

  • Platelet function assessed by whole-blood aggregometry in patients undergoing non-cardiac surgery.

    abstract:BACKGROUND:The risk/benefit of continuing low-dose acetylsalicylic acid (aspirin) for secondary prevention in the perioperative period is still debated. The primary aim of this study was to determine the effect of acetylsalicylic acid compared with placebo on platelet function in the perioperative period. METHODS:This...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/EJA.0b013e32834448ed

    authors: Oscarsson A,Öster S,Fredrikson M,Lindahl TL,Eintrei C

    更新日期:2011-05-01 00:00:00

  • Molecular sites of general anaesthetic action on acetylcholine receptors.

    abstract::Mechanisms of anaesthetics still remain unclear. However, various attempts have been made to elucidate the effects of anaesthetics at the molecular level. The nicotinic acetylcholine receptor has proved to be a good model of membrane-bound ligand-gated ion channels. It is available in abundance from Torpedo electropla...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:

    authors: Tonner PH,Miller KW

    更新日期:1995-01-01 00:00:00

  • Pressure-regulated volume control vs. volume control ventilation in healthy and injured rabbit lung: An experimental study.

    abstract:BACKGROUND:It is not well understood how different ventilation modes affect the regional distribution of ventilation, particularly within the injured lung. OBJECTIVES:We compared respiratory mechanics, lung aeration and regional specific ventilation ((Equation is included in full-text article.)) distributions in healt...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000485

    authors: Porra L,Bayat S,Malaspinas I,Albu G,Doras C,Broche L,Strengell S,Peták F,Habre W

    更新日期:2016-10-01 00:00:00

  • The effect of lidocaine on neutrophil CD11b/CD18 and endothelial ICAM-1 expression and IL-1beta concentrations induced by hypoxia-reoxygenation.

    abstract:BACKGROUND:Lidocaine has actions potentially of benefit during ischaemia-reperfusion. Neutrophils and endothelial cells have an important role in ischaemia-reperfusion injury. METHODS:Isolated human neutrophil CD11b and CD18, and human umbilical vein endothelial cell (HUVEC) ICAM-1 expression and supernatant IL-1beta ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021504000353

    authors: Lan W,Harmon D,Wang JH,Shorten G,Redmond P

    更新日期:2004-12-01 00:00:00

  • Predicted end-tidal sevoflurane concentration for insertion of a Laryngeal Mask Supreme: a prospective observational study.

    abstract:CONTEXT:The single-use Laryngeal Mask Airway (LMA) Supreme is a new supraglottic airway device. It has been reported to be reliable and easy-to-use in clinical practice; however, the anaesthetic techniques for its insertion are not standardised. OBJECTIVES:The purpose of this study was to determine the ED50 of end-tid...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0b013e32835c5512

    authors: Zaballos M,Bastida E,Jiménez C,Agustí S,López-Gil MT

    更新日期:2013-04-01 00:00:00

  • Incidence of gastric insufflation at high compared with low laryngeal mask cuff pressure: A randomised controlled cross-over trial.

    abstract:BACKGROUND:The success of ventilation with a laryngeal mask depends crucially on the seal between the mask and the periglottic tissue. Increasing the laryngeal mask's cuff volume is known to reduce oral air leakage but may lead to gastric insufflation. OBJECTIVE:We hypothesised that a lower cuff pressure would result ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000001269

    authors: Hell J,Pohl H,Spaeth J,Baar W,Buerkle H,Schumann S,Schmutz A

    更新日期:2021-02-01 00:00:00

  • Dexmedetomidine and meperidine prevent postanaesthetic shivering.

    abstract:BACKGROUND AND OBJECTIVE:This placebo-controlled study was performed to evaluate the efficacy of dexmedetomidine compared with meperidine and placebo in preventing postanaesthetic shivering. METHODS:We studied 120 patients (ASA I-II) scheduled for elective abdominal or orthopaedic surgery of about 1-3 h duration. Fort...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021505002061

    authors: Bicer C,Esmaoglu A,Akin A,Boyaci A

    更新日期:2006-02-01 00:00:00

  • Pharmacological study of BRS, a new bicarbonated Ringer's solution, in partially hepatectomized rabbits.

    abstract:BACKGROUND AND OBJECTIVE:The effects of bicarbonated Ringer's solution were evaluated and compared with those of acetated Ringer's, lactated Ringer's and Ringer's solutions in partially hepatectomized rabbits. METHOD:Animals were randomly divided into six groups (n = 6 in each group): a sham-operated group, an operate...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021505001043

    authors: Satoh K,Ohtawa M,Okamura E,Satoh T,Matsuura A

    更新日期:2005-08-01 00:00:00

  • Lorazepam fast-dissolving drug formulation (FDDF) and intravenous administrations as anaesthetic premedicants: a pharmacokinetic analysis.

    abstract::The pharmacokinetics of lorazepam premedication were studied in 16 patients using two different formulations (intravenous and FDDF oral administrations). Arterial blood samples were taken at intervals for up to 600 min after administration of 4 mg of each formulation, and plasma lorazepam concentrations were determine...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Camu F,Maes V,Van de Velde A,Sevens C

    更新日期:1988-07-01 00:00:00

  • Effects of clonidine and midazolam premedication on bispectral index and recovery after elective surgery.

    abstract:BACKGROUND AND OBJECTIVES:Alpha-2 agonists offer useful effects that make these drugs an interesting alternative for pharmacological premedication. METHODS:In a randomized, double-blind study, effects of clonidine (150 microg orally), midazolam (7.5 mg orally) and placebo administered 60-90 min prior to estimated anae...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e32832a0c7c

    authors: Paris A,Kaufmann M,Tonner PH,Renz P,Lemke T,Ledowski T,Scholz J,Bein B

    更新日期:2009-07-01 00:00:00

  • Effect of pre-operative oral carbohydrate loading on recovery after day-case cholecystectomy: A randomised controlled trial.

    abstract:BACKGROUND:Pre-operative carbohydrate loading has been shown to reduce pre-operative discomfort and postoperative nausea and vomiting in general surgical patients. Few studies have considered day-case surgery. OBJECTIVE:The aim of this prospective randomised study was to determine whether pre-operative carbohydrate lo...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000001002

    authors: Helminen H,Branders H,Ohtonen P,Saarnio J

    更新日期:2019-08-01 00:00:00

  • Intravenous ketamine attenuates arterial pressure changes during the induction of anaesthesia with propofol.

    abstract:BACKGROUND AND OBJECTIVE:To investigate whether the administration of ketamine before induction with propofol produces a smaller decrease in arterial pressure. METHODS:Twenty-two patients were assigned to one of two groups to receive either propofol with ketamine (n = 11) or propofol alone (n = 11, control). Anaesthes...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.0265-0215.2000.00784.x

    authors: Furuya A,Matsukawa T,Ozaki M,Nishiyama T,Kume M,Kumazawa T

    更新日期:2001-02-01 00:00:00

  • Cardiovascular responses and airway complications following awake nasal intubation with blind intubation device and fibreoptic bronchoscope: a randomized controlled study.

    abstract:BACKGROUND AND OBJECTIVE:The blind intubation device (BID) was introduced for awake nasotracheal intubation recently. The aim of this study was to compare the cardiovascular responses and associated airway complications of fibreoptic bronchoscope (FOB) with those of BID. The intubation attempts and intubation time were...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328332845a

    authors: Sun Y,Liu JX,Jiang H,Zhu YS,Xu H,Huang Y

    更新日期:2010-05-01 00:00:00

  • Drotrecogin alfa (activated): diffusion from clinical trials to clinical practice.

    abstract:BACKGROUND AND OBJECTIVE:Although the PROWESS trial demonstrated a mortality benefit, subsequent studies in different patient populations have not reproduced the effect. As a result, concerns have been expressed about the clinical effectiveness of drotrecogin alfa (activated). Therefore the aim of this audit was to rev...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021507002992

    authors: Ridley S,Lwin A,Wyncoll D,Lippett S,Watson D,Gunning K,Higgins D

    更新日期:2008-03-01 00:00:00

  • The relative potencies of thiopentone and propofol.

    abstract::The relative potencies of the intravenous anaesthetics propofol and thiopentone have been investigated by finding the dose necessary to produce unconsciousness in approximately 30%, 50% and 80% of patients. The estimated potency of propofol to thiopentone was 1:1.604 as obtained by the probit method of analysis which ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Grounds RM,Moore M,Morgan M

    更新日期:1986-01-01 00:00:00

  • Comparison of a simplified nasal continuous positive airways pressure device with nasal cannula in obese patients undergoing colonoscopy during deep sedation: A randomised clinical trial.

    abstract:BACKGROUND:Continuous positive airways pressure (CPAP) with a CPAP machine and mask has been shown to be more effective at minimising hypoxaemia than other devices under deep sedation. However, the efficacy of a new and simple CPAP device for spontaneously breathing obese patients during colonoscopy is unknown. OBJECT...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000001052

    authors: Bai Y,Xu Z,Chandrashekar M,St Jacques PJ,Liang Y,Jiang Y,Kla K

    更新日期:2019-09-01 00:00:00

  • Has the quality of abstracts for randomised controlled trials improved since the release of Consolidated Standards of Reporting Trial guideline for abstract reporting? A survey of four high-profile anaesthesia journals.

    abstract:BACKGROUND AND OBJECTIVE:Randomised controlled trial (RCT) abstracts published in journal articles have traditionally been deficient of crucial information. To improve the quality of RCT abstracts, in January 2008, the Consolidated Standards of Reporting Trial (CONSORT) group published a checklist of essential informat...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0b013e32833fb96f

    authors: Can OS,Yilmaz AA,Hasdogan M,Alkaya F,Turhan SC,Can MF,Alanoglu Z

    更新日期:2011-07-01 00:00:00

  • S100B protein and neuron-specific enolase as predictors of cognitive dysfunction after coronary artery bypass graft surgery: A prospective observational study.

    abstract:BACKGROUND:Postoperative cognitive dysfunction (POCD) may be related to the systemic inflammatory response and an increase in serum markers of brain injury such as S100B protein and neuron-specific enolase (NSE). OBJECTIVE:The study aims to evaluate the association between POCD and serum levels of S100B and NSE after ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000450

    authors: Silva FP,Schmidt AP,Valentin LS,Pinto KO,Zeferino SP,Oses JP,Wiener CD,Otsuki DA,Tort AB,Portela LV,Souza DO,Auler JO Jr,Carmona MJ

    更新日期:2016-09-01 00:00:00

  • Comparison of Bullard and Airtraq laryngoscopes with conventional laryngoscopy in a manikin study of simulated difficult intubation.

    abstract:BACKGROUND:When airway management is difficult, various measures can be taken to facilitate tracheal intubation. The Bullard and Airtraq laryngoscopes were developed for this purpose. We hypothesised that the Bullard and Airtraq laryngoscopes would perform better than a conventional laryngoscope in the management of a ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328354b22c

    authors: Legrand MA,Steinmann D,Priebe HJ,Mols G

    更新日期:2012-07-01 00:00:00

  • Monitoring depth of anaesthesia: is it worth the effort?

    abstract::In this review paper, the authors critically analyse the use of a number of depth of anaesthesia monitors in light of the most recent literature and their own clinical experience. There appears to be increasing evidence that anaesthesia depth monitors reduce the incidence of unexpected intraoperative awareness and als...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:10.1017/s0265021504006027

    authors: Bonhomme V,Hans P

    更新日期:2004-06-01 00:00:00

  • Duration of stabilization of control responses affects the onset and duration of action of rocuronium but not suxamethonium.

    abstract::The effect of the duration of stabilization of control responses on the onset and duration of clinical relaxation of suxamethonium 1 mg kg-1 and rocuronium 0.6 mg kg-1 were investigated in 90 patients. The control responses were allowed to stabilize for 1, 5, 10, 15 or 20 min prior to administration of rocuronium and ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2346.1996.d01-379.x

    authors: Symington MJ,McCoy EP,Mirakhur RK,Kumar N

    更新日期:1996-07-01 00:00:00

  • Hemiplegia following general anaesthesia: an unusual presentation of migraine.

    abstract::We report the case of a 33-year-old woman who developed a dense hemiplegia immediately after an uncomplicated general anaesthetic for diagnostic laparoscopy. She had a history of recurrent hemiplegic migraine with a strong family history. Her migraine was normally associated with visual disturbances and a unilateral h...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.1998.00368.x

    authors: Thurlow JA

    更新日期:1998-09-01 00:00:00

  • Sevoflurane potentiates and blocks GABA-induced currents through recombinant alpha1beta2gamma2 GABAA receptors: implications for an enhanced GABAergic transmission.

    abstract:BACKGROUND AND OBJECTIVE:The gamma-aminobutyric acidA receptor (GABAAR) is a target for anaesthetic agents. We investigated the interactions of sevoflurane with a recombinant GABAAR. Emphasis was on the mechanism of block, as relevant open-channel block by a volatile anaesthetic would possibly explain prolonged GABAerg...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.0265-0215.2001.00848.x

    authors: Hapfelmeier G,Schneck H,Kochs E

    更新日期:2001-06-01 00:00:00

  • Haemodynamic changes associated with thermodilution cardiac output determination during metabolic acidosis or hypoxic hypoxia in dogs.

    abstract::Haemodynamic alterations elicited by iced injectate during thermodilution cardiac output measurements were evaluated in the presence of metabolic acidosis or hypoxic hypoxia in 14 instrumented anaesthetized dogs. The alterations in some haemodynamic variables during slowing of the heart rate following injection of 3 m...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Nishikawa T,Dohi S

    更新日期:1993-09-01 00:00:00

  • The influence of etomidate upon cerebral metabolites after complete brain ischaemia in the rat.

    abstract::The influence of etomidate on post-ischaemic cerebral metabolism was examined in 1-year-old male Wistar rats. Ten rats were randomly allocated to each of three groups. Group 1 animals received etomidate for 60 min without undergoing cerebral ischaemia. In Group 2, there was a 60-min recovery period following 15 min of...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Böhrer H,Hoyer S,Krier C

    更新日期:1991-05-01 00:00:00

  • Impact of intra-operative fluid and noradrenaline administration on early postoperative renal function after cystectomy and urinary diversion: A retrospective observational cohort study.

    abstract:BACKGROUND:The use of noradrenaline to enable a restrictive approach to intra-operative fluid therapy to avoid salt and water overload has gained increasing acceptance. However, concerns have been raised about the impact of this approach on renal function. OBJECTIVES:To identify risk factors for acute kidney injury (A...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000808

    authors: Furrer MA,Schneider MP,Löffel LM,Burkhard FC,Wuethrich PY

    更新日期:2018-09-01 00:00:00

  • Factors independently associated with increased risk of pain development after ophthalmic surgery.

    abstract:BACKGROUND AND OBJECTIVE:Little has been documented about the development of pain after ophthalmic surgery. This study was designed to assess the incidence and severity of postoperative pain following ophthalmic surgery, and to identify key factors independently associated with development of such pain. METHODS:In a p...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021504002042

    authors: Henzler D,Kramer R,Steinhorst UH,Piepenbrock S,Rossaint R,Kuhlen R

    更新日期:2004-02-01 00:00:00

  • Isoflurane reduces synaptic glutamate release without changing cytosolic free calcium in isolated nerve terminals.

    abstract::The molecular mechanism of volatile anaesthetic action on presynaptic glutamate release is not clear. An inhibitory effect on voltage-gated calcium channels has been proposed. The present study examines the effect of isoflurane on cytosolic free calcium and synaptic glutamate release from isolated nerve terminals. Syn...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Larsen M,Valø ET,Berg-Johnsen J,Langmoen IA

    更新日期:1998-03-01 00:00:00

  • Quadratus lumborum block for postoperative pain after caesarean section: A randomised controlled trial.

    abstract:BACKGROUND:Effective postoperative analgesia after caesarean section is important because it enables early ambulation and facilitates breast-feeding. Several case reports have shown that local anaesthetic injection around the quadratus lumborum muscle is effective in providing pain relief after various abdominal operat...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000000299

    authors: Blanco R,Ansari T,Girgis E

    更新日期:2015-11-01 00:00:00