Intravenous ketamine attenuates arterial pressure changes during the induction of anaesthesia with propofol.

Abstract:

BACKGROUND AND OBJECTIVE:To investigate whether the administration of ketamine before induction with propofol produces a smaller decrease in arterial pressure. METHODS:Twenty-two patients were assigned to one of two groups to receive either propofol with ketamine (n = 11) or propofol alone (n = 11, control). Anaesthesia was induced with 2 mg kg-1 propofol and 0.5 mg kg-1 ketamine or 2 mg kg-1 propofol alone. Ketamine was administered 1 min prior to induction with propofol. Immediately after induction with propofol, vecuronium (0.15 mg kg-1) was administered. Four minutes after administration of vecuronium, tracheal intubation was performed. Anaesthesia was maintained using sevoflurane (0.5%) in 66% nitrous oxide until 3 min after intubation. Systolic, diastolic and mean arterial pressure and heart rate were recorded on arrival, directly before induction with propofol, prior to tracheal intubation, immediately after intubation and at 3 min after intubation. RESULTS AND CONCLUSIONS:Administration of ketamine before induction with propofol preserved haemodynamic stability compared with induction with propofol alone.

journal_name

Eur J Anaesthesiol

authors

Furuya A,Matsukawa T,Ozaki M,Nishiyama T,Kume M,Kumazawa T

doi

10.1046/j.0265-0215.2000.00784.x

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

88-92

issue

2

eissn

0265-0215

issn

1365-2346

journal_volume

18

pub_type

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