Isoflurane reduces synaptic glutamate release without changing cytosolic free calcium in isolated nerve terminals.

abstract：:Two patients presented with very different signs of central anticholinergic syndrome following general anaesthesia for which they had received premedication with hyoscine. Both responded dramatically to 1 mg of intravenous (i.v.) physostigmine, which produced a rapid return to a normal level of consciousness. The aeti...

journal_title：European journal of anaesthesiology

authors： Martin B,Howell PR

更新日期：1997-07-01 00:00:00

abstract：:Morbidly obese patients present with excess fatty tissue externally on the breast, neck, thoracic wall and abdomen and internally in the mouth, pharynx and abdomen. This excess tissue tends to make access (intubation, tracheostomy) to and patency (during sedation or mask ventilation) of the upper airway and the functi...

journal_title：European journal of anaesthesiology

authors： Kristensen MS

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Proinflammatory cytokines as well as nitric oxide (NO) play a major role in mediating the response to lipopolysaccharide (LPS). The present study tested the hypothesis that LPS induces proinflammatory cytokines in the lung via the Toll-like receptor 4 (TLR4)/CD14 signalling cascade. METHODS:Co...

journal_title：European journal of anaesthesiology

authors： Baumgarten G,Knuefermann P,Wrigge H,Putensen C,Stapel H,Fink K,Meyer R,Hoeft A,Grohé C

更新日期：2006-12-01 00:00:00

abstract：:Haemodynamic alterations elicited by iced injectate during thermodilution cardiac output measurements were evaluated in the presence of metabolic acidosis or hypoxic hypoxia in 14 instrumented anaesthetized dogs. The alterations in some haemodynamic variables during slowing of the heart rate following injection of 3 m...

journal_title：European journal of anaesthesiology

authors： Nishikawa T,Dohi S

更新日期：1993-09-01 00:00:00

abstract：:The effects of 5% and 8% glucose in 0.5% tetracaine or bupivacaine on the anaesthetic spread were investigated in 80 urological patients requiring spinal anaesthesia for trans-urethral resection of the prostate. The local anaesthetic solutions were randomly administered, the patients being divided into four groups of ...

journal_title：European journal of anaesthesiology

authors： Janik R,Dick W,Stanton-Hicks MD

更新日期：1989-05-01 00:00:00

abstract：:This study was designed to evaluate the metabolic effects of intrathecal morphine in patients undergoing coronary artery surgery. Ten patients received 4 mg preservative-free morphine in 6 ml saline intrathecally before surgery and were compared with 10 patients anaesthetised in a similar manner, though without intrat...

journal_title：European journal of anaesthesiology

authors： Sebel PS,Aun C,Fiolet J,Noonan K,Savege TM,Colvin MP

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Neuromuscular blockade (NMB) monitoring is essential to avoid residual NMB. While the adductor pollicis is the recommended site for monitoring recovery, it is not always accessible. The flexor hallucis brevis could be an interesting alternative. OBJECTIVE:The aim of our study was to compare NMB onset and re...

journal_title：European journal of anaesthesiology

authors： Le Merrer M,Frasca D,Dupuis M,Debaene B,Boisson M

更新日期：2020-01-01 00:00:00

abstract：:Many adults are distressed by painful investigations or treatment, including venepuncture. The early effects of Eutectic Mixture of Local Anaesthetics (EMLA) 5%, on relief of pinprick pain in the antecubital area was investigated and compared with EMLA plus glyceryl trinitrate and with a placebo cream in 100 patients....

journal_title：European journal of anaesthesiology

authors： Nott MR,Clemson CJ,Peacock JL

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We compared the effects of sub-Tenon's local anaesthetic block and placebo on peri-operative opioid requirement and cardiovascular stability and on postoperative pain, nausea and vomiting in patients undergoing vitreo-retinal surgery under general anaesthesia. METHODS:We studied 43 patients un...

journal_title：European journal of anaesthesiology

authors： Farmery AD,Shlugman D,Rahman R,Rosen P

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The effect of anaesthesia induced by intrathecal injection of 6.3% MgSO4 or 4% lidocaine on intracellular electrolyte homeostasis in spinal cord neurones of a rat model was investigated. METHODS:Intracellular Ca2+, Mg2+, Na+ and K+ concentrations were determined at different times after intrat...

journal_title：European journal of anaesthesiology

authors： Bahar M,Berman S,Chanimov M,Weissgarten J,Averbukh Z,Cohen ML,Grinshpon Y

更新日期：2001-04-01 00:00:00

abstract：:Irrigation of the bladder after transurethral resection of the prostate is often distressing because of pain arising from detrusor muscle spasm. The effect of post-operative oral diazepam was compared with sacral epidural (caudal) block at the time of surgery, both treatments together and a control group, assessed by ...

journal_title：European journal of anaesthesiology

authors： Nott MR,Jameson PM,Julious SA

更新日期：1997-03-01 00:00:00

abstract：:Patients with bilateral corneal blindness in whom corneal transplantation has either been unsuccessful or inappropriate may be considered for osteo-odonto-keratoprosthesis surgery. During a two-stage procedure the surface of the cornea is removed and covered with a graft of buccal mucosa. An optical cylinder, supporte...

journal_title：European journal of anaesthesiology

authors： Skelton VA,Henderson K,Liu C

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Statins are prescribed for patients with hypercholesterolemia. Atorvastatin is metabolized by cytochrome P4503A4 and inhibits P4503A4 activity in vitro. Alfentanil is a potent opioid used in clinical anaesthetic practice and is also metabolized by P4503A4. This study tested the hypothesis that ...

journal_title：European journal of anaesthesiology

authors： McDonnell CG,Malkan D,Van Pelt FD,Shorten GD

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Neostigmine is widely used to antagonise residual paralysis. Over the last decades, the benchmark of acceptable neuromuscular recovery has increased progressively to a train-of-four (TOF) ratio of at least 0.9. Raising this benchmark may impact on the efficacy of neostigmine. OBJECTIVE(S):The systematic rev...

journal_title：European journal of anaesthesiology

authors： Tajaate N,Schreiber JU,Fuchs-Buder T,Jelting Y,Kranke P

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Robot-assisted prostatectomy requires pneumoperitoneum in a steep Trendelenburg position, which may induce endobronchial intubation or accidental extubation. The aim of the study was to evaluate the effect of pneumoperitoneum in 30 degrees Trendelenburg position on the displacement of the trach...

journal_title：European journal of anaesthesiology

authors： Chang CH,Lee HK,Nam SH

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Astrocytes exposed to hypoxia produce pro-inflammatory cytokines and upregulate intercellular adhesion molecule-1 on cerebral endothelium. This study investigated the effects of midazolam on this response. METHODS:Mouse astrocytes were exposed to 4 h of hypoxia and 24 h of reoxygenation. Astro...

journal_title：European journal of anaesthesiology

authors： Ghori K,Harmon D,Walsh F,Shorten G

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hypotension, the commonest side-effect of spinal anaesthesia, results from sympathetic denervation. This study compared patient positioning (supine vs. decubitus) on haemodynamic variables during spinal anaesthesia. METHODS:After intravenous crystalloid preloading with 5 mL kg(-1), hyperbaric ...

journal_title：European journal of anaesthesiology

authors： Kelly JD,McCoy D,Rosenbaum SH,Brull SJ

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:To compare the inotropic and lusitropic effect of lidocaine and mepivacaine on rat papillary muscle. METHODS:Effects of lidocaine and mepivacaine (10-8-10-3 M) were studied in rat left ventricular papillary muscles in vitro at a calcium concentration of 1 mmol, under low (isotony) and high (is...

journal_title：European journal of anaesthesiology

authors： David JS,Amour J,Duracher C,Ferretti C,Precloux P,Petit P,Riou B,Gueugniaud PY

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Previous studies have shown that general anaesthetic agents modulate the production of hypothalamic prostaglandins (PG) D2 and E2, which are mediators of sleep and wakefulness respectively. Although flurbiprofen, a cyclo-oxygenase inhibitor, is used clinically as a non-steroidal anti-inflammato...

journal_title：European journal of anaesthesiology

authors： Hirota K,Fukushi S,Baba S,Matsuki A

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We assessed the analgesic efficacy of postoperative epidural infusions of ropivacaine 0.1 and 0.2% combined with sufentanil 1 microg mL(-1) in a prospective, randomized, double-blinded study. METHODS:Twenty-two ASA I-III patients undergoing elective total-knee replacement were included. Lumbar...

journal_title：European journal of anaesthesiology

authors： Kampe S,Diefenbach C,Kanis B,Auweiler M,Kiencke P,Cranfield K

更新日期：2002-09-01 00:00:00

abstract：:The analgesic, respiratory and haemodynamic effects of epidural sufentanil 75 micrograms (Group 1) or sufentanil 75 micrograms with adrenaline 75 micrograms (Group 2) were studied in 20 patients following abdominal surgery in a double-blind randomized trial. Pain relief, assessed on a linear analogue scale, sedation, ...

journal_title：European journal of anaesthesiology

authors： Verborgh C,Van der Auwera D,Noorduin H,Camu F

更新日期：1988-05-01 00:00:00

abstract：:The aim of this study was to elucidate the influence of four neuromuscular blocking substances on coronary vascular tone using the model of isolated porcine coronary artery segments. We studied the effects of four muscle relaxants, atracurium, pancuronium, rocuronium, and vecuronium (0.1, 1, and 10 microg mL-1 each), ...

journal_title：European journal of anaesthesiology

authors： Klockgether-Radke AP,Haemmerle A,Kettler D,Hellige G

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Several approaches have been proposed for ultrasound-guided thoracic paravertebral block, but the best approach remains unclear. OBJECTIVE:We compared two ultrasound-guided in-plane approaches using a microconvex probe, transverse and parasagittal. We assessed whether either approach would facilitate succes...

journal_title：European journal of anaesthesiology

authors： Fujii T,Shibata Y,Shinya S,Nishiwaki K

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Pressure-based dynamic variables are poor predictors of fluid responsiveness in children, and their predictability is expected to reduce further during lung-protective ventilation with a low tidal volume. OBJECTIVE:We hypothesised that lung recruitment manoeuvre (LRM)-induced changes in dynamic variables im...

journal_title：European journal of anaesthesiology

authors： Kim EH,Lee JH,Jang YE,Ji SH,Kim HS,Cho SA,Kim JT

更新日期：2020-11-11 00:00:00

abstract：CONTEXT:Previous research has shown that most patients are satisfied with their anaesthetic care. For those who are not the causes may be multifactorial including dissatisfaction with surgical outcomes. OBJECTIVES:We aimed to identify whether quality of recovery after anaesthesia and surgery measured in multiple domai...

journal_title：European journal of anaesthesiology

authors： Royse CF,Chung F,Newman S,Stygall J,Wilkinson DJ

更新日期：2013-03-01 00:00:00

abstract：:In order to compare the neuromuscular effects following rocuronium 0.6 mg kg-1 and atracurium 0.5 mg kg-1 30 children aged from 18 to 67 months were studied under the same anaesthetic conditions. After induction of anaesthesia with etomidate and fentanyl, neuromuscular blockade was monitored by recording the electromy...

journal_title：European journal of anaesthesiology

authors： Ribeiro FC,Scheiber G,Marichal A

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Movement-evoked pain is more severe than pain at rest and is likely to interfere more with functional recovery after surgery. OBJECTIVE:To compare triple vs. double nonopioid perioperative analgesic regimens in women undergoing abdominal hysterectomy. DESIGN:A randomised, parallel design, double-blind cont...

journal_title：European journal of anaesthesiology

authors： Gilron I,Tu D,Dumerton-Shore D,Duggan S,Rooney R,McGrath M,Orr E

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Diphenhydramine has local anaesthetic and antimicrobial activity and may be used to prevent intravenous propofol injection pain. We studied the effect of adding diphenhydramine to propofol emulsions for preventing bacterial growth. METHODS:Staphylococcus aureus, Pseudomonas aeruginosa, Escheri...

journal_title：European journal of anaesthesiology

authors： Güzelant A,Apiliogullari S,Kara I,Turhan V,Apiliogullari B,Yilmaz H,Balasar M,Duman A

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:The success of ventilation with a laryngeal mask depends crucially on the seal between the mask and the periglottic tissue. Increasing the laryngeal mask's cuff volume is known to reduce oral air leakage but may lead to gastric insufflation. OBJECTIVE:We hypothesised that a lower cuff pressure would result ...

journal_title：European journal of anaesthesiology

authors： Hell J,Pohl H,Spaeth J,Baar W,Buerkle H,Schumann S,Schmutz A

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:the objective of this study was to assess whether antiemetic drugs metoclopramide and diphenhydramine, administered together as opposed to alone, can have better efficacy in preventing postoperative nausea and vomiting when added to patient-controlled morphine analgesia. PATIENTS AND METHODS:d...

journal_title：European journal of anaesthesiology

authors： Lu CW,Jean WH,Wu CC,Shieh JS,Lin TY

更新日期：2010-12-01 00:00:00