Elimination of alfentanil delivered by infusion is not altered by the chronic administration of atorvastatin.

Abstract:

BACKGROUND AND OBJECTIVE:Statins are prescribed for patients with hypercholesterolemia. Atorvastatin is metabolized by cytochrome P4503A4 and inhibits P4503A4 activity in vitro. Alfentanil is a potent opioid used in clinical anaesthetic practice and is also metabolized by P4503A4. This study tested the hypothesis that chronic atorvastatin administration inhibits the metabolism of alfentanil. METHODS:Sixteen patients undergoing elective surgery were studied as matched pairs. One member of each pair was maintained on standard doses of atorvastatin for at least 4 months. Each patient received an alfentanil bolus (80 microg kg(-1)) intravenously (i.v.), followed by an alfentanil infusion (0.67 microg kg(-1) min(-1)) for 90 min. Serial plasma alfentanil concentrations were measured using gas chromatography-nitrogen phosphorous detection. Pharmacokinetic parameters were calculated using two-compartment linear modelling. RESULTS:One patient and the corresponding match were excluded from the analysis. The elimination half-life of alfentanil was similar in the control and atorvastatin groups (98.8 +/- 12.4 versus 98.3 +/- 11.3 min, respectively). The clearance (Cl), volume of distribution at steady-state (Vdss) and area under the curve (AUC) were similar in the two groups (Cl = 0.20 (+/- 0.06) and 0.22 (+/- 0.04) L min(-1), Vdss = 0.38 (+/- 0.07) and 0.39 (+/- 0.07) L kg(-1), AUC = 0.05 (+/- 0.02) and 0.04 (+/- 0.01) mg min mL(-1)). CONCLUSIONS:Concurrent atorvastatin administration does not alter the pharmacokinetics of alfentanil in patients undergoing elective surgery.

journal_name

Eur J Anaesthesiol

authors

McDonnell CG,Malkan D,Van Pelt FD,Shorten GD

doi

10.1017/s0265021503001078

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

662-7

issue

8

eissn

0265-0215

issn

1365-2346

journal_volume

20

pub_type

临床试验,杂志文章
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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    authors: Vandermeulen EP,Van Aken H,Scholtes JL,Singelyn F,Buelens A,Haazen L

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    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1998-07-01 00:00:00

  • Intravenous ketamine attenuates arterial pressure changes during the induction of anaesthesia with propofol.

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:2001-02-01 00:00:00

  • The effect of paracetamol on postoperative nausea and vomiting during the first 24 h after strabismus surgery: a prospective, randomised, double-blind study.

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    journal_title:European journal of anaesthesiology

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  • The role of venodilators in the perioperative management of heart failure.

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    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

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    更新日期:2012-03-01 00:00:00

  • The effect of triple vs. double nonopioid therapy on postoperative pain and functional outcome after abdominal hysterectomy: a randomised double-blind control trial.

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    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000000190

    authors: Gilron I,Tu D,Dumerton-Shore D,Duggan S,Rooney R,McGrath M,Orr E

    更新日期:2015-04-01 00:00:00

  • Antiplatelet therapy preceding coronary artery surgery: implications for bleeding, transfusion requirements and outcome.

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    pub_type: 杂志文章

    doi:10.1017/S0265021506002262

    authors: Picker SM,Kaleta T,Hekmat K,Kampe S,Gathof BS

    更新日期:2007-04-01 00:00:00

  • Effects of nicardipine and diltiazem on the bispectral index and 95% spectral edge frequency.

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    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章

    doi:10.1017/s0265021503001303

    authors: Hirota K,Kabara S,Kushikata T,Kitayama M,Ishihara H,Matsuki A

    更新日期:2003-10-01 00:00:00

  • Physostigmine: going ... going ... gone? Two cases of central anticholinergic syndrome following anaesthesia and its treatment with physostigmine.

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    doi:10.1046/j.1365-2346.1997.00128.x

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    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000295

    authors: Chen Y,Cui J,Sun JJ,Wang E,Zhu Y,Li Y,Lu K

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  • Advantageous effects of dexmedetomidine on haemodynamic and recovery responses during extubation for intracranial surgery.

    abstract:BACKGROUND AND OBJECTIVE:The anaesthetic method for intracranial neurosurgery must provide haemodynamic stability on emergence and allow early evaluation of the neurological status. In this study, we examined the effects of the alpha-2 agonist dexmedetomidine given at the end of the procedure to prevent hyperdynamic re...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021508004201

    authors: Turan G,Ozgultekin A,Turan C,Dincer E,Yuksel G

    更新日期:2008-10-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1017/s0265021503000279

    authors: Lebuffe G,Onimus T,Vallet B

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  • Bilateral paravertebral somatic nerve block for ventral hernia repair.

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    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021502000352

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    更新日期:2002-03-01 00:00:00

  • Neuromuscular block by vecuronium: simulation with a flow-volume model.

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    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Nigrovic V

    更新日期:1994-03-01 00:00:00

  • Comparison of laryngeal tube with laryngeal mask airway in anaesthetized and paralysed patients.

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    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021507000129

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Boisson-Bertrand D,Taron F,Laxenaire MC

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    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021505001936

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