Abstract:
CONTEXT:Strabismus surgery is one of the most common ophthalmic surgical procedures in children and is associated with significant postoperative nausea and vomiting (PONV). OBJECTIVE:We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery. DESIGN:Prospective, placebo-controlled, randomised double-blind study. SETTING:University hospital. PATIENTS:Ninety children, between 2 and 14 years scheduled for strabismus surgery, were recruited. Eighty-six completed the study. INTERVENTIONS:After induction of anaesthesia, intravenous dexamethasone 0.1 mg kg was administered to all. The patients were enrolled to receive either intravenous physiological saline (group S) or paracetamol 15 mg kg (group P). MAIN OUTCOME MEASURE:Incidence of PONV in the first 24 h postoperatively. RESULTS:General and clinical characteristics of the children were similar in both groups. PONV during the first 24 h was significantly higher in group S in comparison with group P (group S vs. group P, 33 vs. 14.6%, respectively, P = 0.038 for nausea; 24.4 vs. 7.3%, respectively, P = 0.030 for vomiting). The number of analgesic administrations during the first 24 h was higher in group S compared with group P (1.31 ± 0.85 and 0.73 ± 0.6, respectively, P = 0.001). The repeat number of postoperative analgesic administrations was significantly different between groups during the first 24 h (P = 0.005), but during 24-48 h was not significant. CONCLUSION:Intraoperative administration of intravenous paracetamol decreases the incidence of PONV during the first 24 h in children after strabismus surgery.
journal_name
Eur J Anaesthesioljournal_title
European journal of anaesthesiologyauthors
Cok OY,Eker HE,Pelit A,Canturk S,Akin S,Aribogan A,Arslan Gdoi
10.1097/EJA.0b013e32834c580bsubject
Has Abstractpub_date
2011-12-01 00:00:00pages
836-41issue
12eissn
0265-0215issn
1365-2346journal_volume
28pub_type
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journal_title:European journal of anaesthesiology
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