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Effect of parecoxib sodium on postoperative shivering: a randomised, double-blind clinical trial.

Abstract：

BACKGROUND:Postoperative shivering is one of the most common complications in patients recovering from general anaesthesia. Although a variety of pharmacological therapies have been used to control postoperative shivering, no ideal drug has been found to date. OBJECTIVES:The aim of this study was to compare the efficacy and accompanying side-effects of prophylactic parecoxib sodium with that of tramadol or placebo for the prevention of postoperative shivering. DESIGN:A randomised, double-blind clinical study. SETTING:Mianyang Central Hospital, Sichuan, China, from December 2011 to November 2012. PATIENTS:One hundred and twenty adult patients, ASA 1 or 2, aged 20 to 60 years and scheduled for elective abdominal surgery under general anaesthesia. Reasons for noninclusion included allergy to any of the medications used; severe cardiovascular disease; kidney or liver dysfunction; peptic ulcer; muscle disease; intraoperative blood or blood products transfusion; or a history of convulsions or fever. INTERVENTIONS:The patients were allocated randomly to receive parecoxib sodium 40 mg (Group P, n = 40), tramadol 2 mg kg (Group T, n = 40) or isotonic saline (Group S, n = 40) 30 min before the end of surgery. MAIN OUTCOME MEASURES:The primary outcome measure was the incidence of postoperative shivering. Secondary outcomes were scores for postoperative pain and sedation, and the incidence of postoperative nausea and vomiting. RESULTS:The incidence and severity of postoperative shivering were significantly lower in Groups P and T than in Group S (P < 0.001). The sedation scores were higher in Group T than in Groups P and S (P < 0.05). The incidence of postoperative nausea and vomiting was also significantly higher in Group T than in Groups P and S (P = 0.016). CONCLUSION:Intravenous injection of parecoxib sodium 40 mg before the end of surgery effectively reduces the occurrence and severity of postoperative shivering after general anaesthesia without significant side effects. TRIAL REGISTRATION:ChiCTR-TRC-12002870.

journal_name

Eur J Anaesthesiol

journal_title

European journal of anaesthesiology

authors

Li X,Zhou M,Xia Q,Li W,Zhang Y

doi

10.1097/01.EJA.0000436684.94403.1e

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

225-30

issue

eissn

0265-0215

issn

1365-2346

journal_volume

pub_type

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Effect of parecoxib sodium on postoperative shivering: a randomised, double-blind clinical trial.