The effects of sevoflurane, isoflurane and desflurane on QT interval of the ECG.

Abstract:

BACKGROUND AND OBJECTIVE:To determine if there is any significant difference between the effects of desflurane, isoflurane and sevoflurane on the QT interval, QT dispersion, heart rate corrected QT interval and QTc dispersion of the electrocardiogram. METHODS:The study was conducted in a prospective, double blind and randomized manner in a teaching hospital. Ninety ASA I patients, aged 16-50 yr, undergoing general anaesthesia for noncardiac surgery were studied. RESULTS:There was no significant change in QT intervals during the study in any group (P > 0.05). QT dispersion in the sevoflurane group 49+/-14 ms vs. 37+/-10 ms; in the desflurane group 55+/-16 and 62+/-21 ms vs. 35+/-14 ms and in the isoflurane group 54+/-26 and 59+/-24 ms vs. 42+/-19 ms were significantly increased at 3 and 10 min after 1 MAC of steady end-tidal anaesthetic concentration compared with baseline values (P < 0.05). QTc values in the sevoflurane group were 444+/-24 and 435+/-2 1ms vs. 413+/-19 ms (P < 0.05), in the isoflurane group were 450+/-26 and 455+/-34 ms vs. 416+/-34 ms (P < 0.05), in the desflurane group were 450+/-26 and 455+/-34 ms vs. 416+/-34 ms (P < 0.05) at 3 and 10 min after reaching 1 MAC of anaesthetic concentration and significantly increased compared with baseline values. QTc dispersion increased significantly with sevoflurane 62+/-14 ms vs. 45+/-16 ms (P < 0.05); isoflurane 70+/-36 ms at 3 min and 75+/-36 ms at 10 min after reaching 1 MAC of anaesthetic concentration vs. 50+/-24 ms (P < 0.05); desflurane 67+/-25 ms at 3 min and 74+/-27 ms at 10 min after 1 MAC concentration vs. 41+/-22 ms (P < 0.05). CONCLUSION:Sevoflurane, isoflurane and desflurane all prolonged QTd, QTc and QTcd but there were no significant intergroup differences.

journal_name

Eur J Anaesthesiol

authors

Yildirim H,Adanir T,Atay A,Katircioğlu K,Savaci S

doi

10.1017/s0265021504007112

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

566-70

issue

7

eissn

0265-0215

issn

1365-2346

journal_volume

21

pub_type

临床试验,杂志文章,随机对照试验
  • Randomised comparison of hyperbaric articaine and hyperbaric low-dose bupivacaine along with fentanyl in spinal anaesthesia for day-case inguinal herniorrhaphy.

    abstract:BACKGROUND AND OBJECTIVE:Low-dose mixture of hyperbaric bupivacaine and fentanyl is commonly used in day-case spinal anaesthesia. Using hyperbaric articaine, the onset may be faster and duration more predictable than with bupivacaine-fentanyl. We compared these two spinal anaesthetics for inguinal herniorrhaphy. METHO...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e32834a11be

    authors: Bachmann M,Pere P,Kairaluoma P,Rosenberg PH,Kallio H

    更新日期:2012-01-01 00:00:00

  • Volume effect of Ringer's solution in the blood during general anaesthesia.

    abstract::Ringer's solution expands blood volume by between 20% and 25% in awake volunteers, but little is known about its volume effect during general anaesthesia. In 35 men with a mean age of 70 years, the power of various intra-operative factors to change blood volume as estimated by the haemoglobin dilution method were anal...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.1998.00313.x

    authors: Hahn RG

    更新日期:1998-07-01 00:00:00

  • Anaesthesia for Sturge-Weber syndrome.

    abstract::A 6-month-old boy with Sturge-Weber syndrome was scheduled for congenital glaucoma and left buphthalmus surgery. Physical examination revealed haemangioma throughout the right trigeminal nerve, congenital glaucoma, left megalocornea and bilateral buphthalmus. Examination of the eye was performed under general anaesthe...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.1999.00472.x

    authors: Ceyhan A,Cakan T,Başar H,Bababalim M,Unal N

    更新日期:1999-05-01 00:00:00

  • Sub-Tenon's block reduces both intraoperative and postoperative analgesia requirement in vitreo-retinal surgery under general anaesthesia.

    abstract:BACKGROUND AND OBJECTIVE:We compared the effects of sub-Tenon's local anaesthetic block and placebo on peri-operative opioid requirement and cardiovascular stability and on postoperative pain, nausea and vomiting in patients undergoing vitreo-retinal surgery under general anaesthesia. METHODS:We studied 43 patients un...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0265021503001571

    authors: Farmery AD,Shlugman D,Rahman R,Rosen P

    更新日期:2003-12-01 00:00:00

  • Cerebral state index vs. bispectral index during sevoflurane-nitrous oxide anaesthesia.

    abstract:BACKGROUND AND OBJECTIVE:The cerebral state index (CSI) is a low-cost and compact electroencephalographic monitor alternative to the bispectral index (BIS). Although both indices are shown as the number between 0 and 100, owing to the different calculation algorithms, both indices might be different during anaesthesia....

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0b013e328324e946

    authors: Nishiyama T

    更新日期:2009-08-01 00:00:00

  • Sensory blockade after thoracic paravertebral injection of ropivacaine or bupivacaine.

    abstract:BACKGROUND AND OBJECTIVE:No clinical trials comparing the characteristics of sensory blockade caused by various local anaesthetics in thoracic paravertebral blockade have been published. The aim of this prospective study was a clinical assessment of sensory blockade after paravertebral injection of ropivacaine or bupiv...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021506000561

    authors: Hura G,Knapik P,Misiołek H,Krakus A,Karpe J

    更新日期:2006-08-01 00:00:00

  • Cognitive decline after carotid endarterectomy: Systematic review and meta-analysis.

    abstract:BACKGROUND:Postoperative cognitive decline (pCD) occurs frequently (6 to 30%) after carotid endarterectomy (CEA), although there are no exact estimates and risk factors are still unclear. OBJECTIVE:The objective of this study was to determine pCD incidence and risk factors in CEA patients. DESIGN:We performed a syste...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000001130

    authors: Aceto P,Lai C,De Crescenzo F,Crea MA,Di Franco V,Pellicano GR,Perilli V,Lai S,Papanice D,Sollazzi L

    更新日期:2020-11-01 00:00:00

  • A comparison of propofol and isoflurane anaesthesia: the need for ephedrine and glycopyrrolate.

    abstract::Sixty patients, ASA I-III, presenting for elective colonic surgery were studied to assess the stability of blood pressure and heart rate during anaesthesia with three equally potent anaesthetic techniques. Patients in group I (n = 20) received thiopentone induction, isoflurane and nitrous oxide; patients in group II (...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Jensen AG,Granfeldt H,Kalman SH,Nyström PO,Eintrei C

    更新日期:1995-05-01 00:00:00

  • Ketamine does not affect suxamethonium-induced neuromuscular blockade in man.

    abstract::The effect of ketamine on the onset time, the duration of action and the recovery characteristics of suxamethonium-induced neuromuscular blockade was examined in a double-blind randomized study comprising 30 patients anaesthetized with thiopentone, fentanyl, midazolam and nitrous oxide. The ulnar nerve was stimulated ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Helbo-Hansen HS,Toft P,Nielsen HK

    更新日期:1989-11-01 00:00:00

  • Quadratus lumborum block for postoperative pain after caesarean section: A randomised controlled trial.

    abstract:BACKGROUND:Effective postoperative analgesia after caesarean section is important because it enables early ambulation and facilitates breast-feeding. Several case reports have shown that local anaesthetic injection around the quadratus lumborum muscle is effective in providing pain relief after various abdominal operat...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000000299

    authors: Blanco R,Ansari T,Girgis E

    更新日期:2015-11-01 00:00:00

  • Intracranial meningioma with progesterone positive receptors presenting in late pregnancy.

    abstract::A 36-year-old female presented with seizures and transient dysphasia in her 31 week of pregnancy. Neuroradiological investigations revealed a large falx meningioma. A decision was taken to deliver the infant and excise the tumor before term because of the risk of an increase in the size of the tumour and the risk of s...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.1998.00225.x

    authors: Ismail K,Coakham HB,Walters FJ

    更新日期:1998-01-01 00:00:00

  • Advantageous effects of dexmedetomidine on haemodynamic and recovery responses during extubation for intracranial surgery.

    abstract:BACKGROUND AND OBJECTIVE:The anaesthetic method for intracranial neurosurgery must provide haemodynamic stability on emergence and allow early evaluation of the neurological status. In this study, we examined the effects of the alpha-2 agonist dexmedetomidine given at the end of the procedure to prevent hyperdynamic re...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021508004201

    authors: Turan G,Ozgultekin A,Turan C,Dincer E,Yuksel G

    更新日期:2008-10-01 00:00:00

  • Myocardial infarction and death after caesarean section in a woman with protein S deficiency and undiagnosed phaeochromocytoma.

    abstract::We describe the case of a 36-year-old woman, with a previous history of recurrent abortion due to protein S deficiency, undergoing an elective Caesarean section at 39-weeks gestation. During pregnancy no signs of hypertension or cardiovascular disease were reported, but at the end of the surgical procedure, the patien...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2346.1999.00474.x

    authors: Zangrillo A,Valentini G,Casati A,Torri G

    更新日期:1999-04-01 00:00:00

  • A survey of anaesthetic practice in predicting difficult intubation in UK and Europe.

    abstract:CONTEXT:Unexpected difficulty in tracheal intubation is an intermittent and often terrifying problem for all practising anaesthetists. There are many preoperative assessment tests to predict a difficult laryngeal view or a difficult intubation, but we found no published evidence of how frequently these predictive tests...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0b013e32835103e6

    authors: McPherson D,Vaughan RS,Wilkes AR,Mapleson WW,Hodzovic I

    更新日期:2012-05-01 00:00:00

  • Low-dose fentanyl analgesia modified by calcium channel blockers in cardiac surgery.

    abstract::The hypothesis that calcium channel blockers can potentiate and prolong the anti-nociceptive effects of opioids was tested. Forty-five men scheduled for aorto-coronary bypass operation received fentanyl according to their individual demands (haemodynamics, clinical parameters). The patients were allocated at random in...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Boldt J,von Bormann B,Kling D,Russ W,Ratthey K,Hempelmann G

    更新日期:1987-11-01 00:00:00

  • Gradient between dorsalis pedis and radial arterial blood pressures during sevoflurane anaesthesia: A self-control study in patients undergoing neurosurgery.

    abstract:BACKGROUND:The dorsalis pedis artery (DPA) is a good alternative to the radial artery (RA) for invasive blood pressure monitoring when the upper limb is burned or injured, or if the RA is not available. Understanding the pattern of pressure difference between DPA and the commonly used RA during inhalational anaesthesia...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000295

    authors: Chen Y,Cui J,Sun JJ,Wang E,Zhu Y,Li Y,Lu K

    更新日期:2016-02-01 00:00:00

  • Physostigmine: going ... going ... gone? Two cases of central anticholinergic syndrome following anaesthesia and its treatment with physostigmine.

    abstract::Two patients presented with very different signs of central anticholinergic syndrome following general anaesthesia for which they had received premedication with hyoscine. Both responded dramatically to 1 mg of intravenous (i.v.) physostigmine, which produced a rapid return to a normal level of consciousness. The aeti...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.1997.00128.x

    authors: Martin B,Howell PR

    更新日期:1997-07-01 00:00:00

  • Flurbiprofen does not change the bispectral index and 95% spectral edge frequency during total intravenous anaesthesia with propofol and fentanyl.

    abstract:BACKGROUND AND OBJECTIVE:Previous studies have shown that general anaesthetic agents modulate the production of hypothalamic prostaglandins (PG) D2 and E2, which are mediators of sleep and wakefulness respectively. Although flurbiprofen, a cyclo-oxygenase inhibitor, is used clinically as a non-steroidal anti-inflammato...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021502000790

    authors: Hirota K,Fukushi S,Baba S,Matsuki A

    更新日期:2002-07-01 00:00:00

  • Factors independently associated with increased risk of pain development after ophthalmic surgery.

    abstract:BACKGROUND AND OBJECTIVE:Little has been documented about the development of pain after ophthalmic surgery. This study was designed to assess the incidence and severity of postoperative pain following ophthalmic surgery, and to identify key factors independently associated with development of such pain. METHODS:In a p...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021504002042

    authors: Henzler D,Kramer R,Steinhorst UH,Piepenbrock S,Rossaint R,Kuhlen R

    更新日期:2004-02-01 00:00:00

  • Propofol as a continuous infusion during cardiopulmonary bypass does not affect changes in serum free fatty acids.

    abstract::Perioperative myocardial infarction or ischaemia is a potential consequence of cardiac surgery and elevated free fatty acids can increase the severity of myocardial ischaemic damage. We investigated perioperative changes in serum free fatty acids, and other serum lipids, as a consequence of using propofol infusions fo...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.0265-0215.2000.00789.x

    authors: Inoue S,Takauchi Y,Kayamori Y,Kuro M,Furuya H

    更新日期:2001-02-01 00:00:00

  • McGRATH MAC video laryngoscope for insertion of a transoesophageal echocardiography probe: A randomised controlled trial.

    abstract:BACKGROUND:Transoesophageal echocardiography (TOE) probe insertion in anaesthetised patients can cause pharyngeal and oesophageal injuries. Kim et al. have shown that insertion assisted by a Macintosh laryngoscope can reduce such complications but it may sometimes be difficult to observe the passage of a TOE probe. The...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000000367

    authors: Ishida T,Kiuchi C,Sekiguchi T,Tsujimoto T,Kawamata M

    更新日期:2016-04-01 00:00:00

  • Preoperative oral dextromethorphan vs. clonidine to prevent tourniquet-induced cardiovascular responses in orthopaedic patients under general anaesthesia.

    abstract:BACKGROUND AND OBJECTIVE:Preoperative oral dextromethorphan and intravenous clonidine attenuate arterial pressure and heart rate increases during tourniquet inflation under general anaesthesia. The effect of preoperative oral clonidine on these variables has not been investigated. METHODS:We designed this study to com...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021506002055

    authors: Honarmand A,Safavi MR

    更新日期:2007-06-01 00:00:00

  • Acute desflurane or sevoflurane exposure on a previously stabilized atracurium-induced neuromuscular block.

    abstract:BACKGROUND AND OBJECTIVE:The aim of this prospective study was to compare the effect of the administration of desflurane or sevoflurane to a fixed neuromuscular block. METHODS:After written consent, 12 patients were anaesthetized with propofol and sufentanil. Atracurium was administered via a continuous infusion in or...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021506000706

    authors: Beaussier M,Boughaba A,Schiffer E,Debaene B,Lienhart A,d'Hollander A

    更新日期:2006-09-01 00:00:00

  • Epidural analgesia for labour using a continuous infusion of bupivacaine and alfentanil.

    abstract::Seventy women who requested epidural pain relief in labour received a continuous epidural infusion at 8 ml h-1, which contained either 0.25% bupivacaine (n = 29), or a mixture of 0.125% bupivacaine and 0.005% alfentanil (n = 31), assigned randomly. Increments of 4 ml 0.25% bupivacaine were given on demand to prevent r...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Cooper RA,Devlin E,Boyd TH,Bali IM

    更新日期:1993-05-01 00:00:00

  • Effects of repeated anaesthesia on central cholinergic function in the rat cerebral cortex.

    abstract:BACKGROUND AND OBJECTIVE:General anaesthesia may contribute to postoperative cognitive decline in the elderly. The aim was to determine the effects of repeated pentobarbital anaesthesia throughout life on central cholinergic function in the rat. METHODS:Young Lewis rats were randomly allocated to two groups. The anaes...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021503000176

    authors: Hanning CD,Blokland A,Johnson M,Perry EK

    更新日期:2003-02-01 00:00:00

  • Incidence and risk factors for adverse events during monitored anaesthesia care for gastrointestinal endoscopy in children: A prospective observational study.

    abstract:BACKGROUND:Better understanding of risk factors for adverse events during monitored anaesthesia care (MAC) for paediatric gastrointestinal endoscopy may improve outcome in children. OBJECTIVES:To identify the prevalence and predictors of adverse events during MAC for paediatric endoscopy. DESIGN:An observational stud...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000995

    authors: Najafi N,Veyckemans F,Vanhonacker D,Legrand C,Van de Velde A,Vandenplas Y,Poelaert J

    更新日期:2019-06-01 00:00:00

  • Propofol sedation with fentanyl or midazolam during oesophagogastroduodenoscopy in children.

    abstract:BACKGROUND AND OBJECTIVE:Sedation is commonly used to facilitate diagnostic procedures in children. The aim of our study was to investigate sedation in children using propofol alone or combined with fentanyl or midazolam with regard to efficacy, adverse reactions or side-effects related to the drugs, ease of operation ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021505001432

    authors: Disma N,Astuto M,Rizzo G,Rosano G,Naso P,Aprile G,Bonanno G,Russo A

    更新日期:2005-11-01 00:00:00

  • Predicting postoperative complications with the respiratory exchange ratio after high-risk noncardiac surgery: A prospective cohort study.

    abstract:BACKGROUND:The respiratory exchange ratio (RER), defined as the ratio of CO2 production (VCO2) to O2 consumption (VO2), is reported to be a noninvasive marker of anaerobic metabolism. The intubated, ventilated patient's inspired and expired fractions of O2 and CO2 (FiO2, FeO2, FiCO2 and FeCO2) are monitored in the oper...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000001111

    authors: Bar S,Grenez C,Nguyen M,de Broca B,Bernard E,Abou-Arab O,Bouhemad B,Lorne E,Guinot PG

    更新日期:2020-11-01 00:00:00

  • What is the optimal remifentanil dosage for providing excellent intubating conditions when coadministered with thiopental? A prospective randomized dose-response study.

    abstract:BACKGROUND AND OBJECTIVE:The aim of the present study was to determine the dosage of remifentanil that must be added to thiopental 5 mg kg(-1) to provide excellent intubating conditions in 95% of patients. METHODS:Sixty-eight premedicated female American Society of Anesthesiologists class 1 and 2 patients were randoml...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e3283396341

    authors: Bouvet L,Stoian A,Rousson D,Allaouchiche B,Chassard D,Boselli E

    更新日期:2010-07-01 00:00:00

  • The effect of anaesthetics on the myocardium--new insights into myocardial protection.

    abstract::A variety of laboratory and clinical studies clearly indicate that exposure to anaesthetic agents can lead to a pronounced protection of the myocardium against ischaemia-reperfusion injury. Several changes in the protein structure of the myocardium that may mediate this cardioprotection have been identified. Ischaemia...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:10.1017/s0265021505001080

    authors: Weber NC,Preckel B,Schlack W

    更新日期:2005-09-01 00:00:00