Abstract:
BACKGROUND AND OBJECTIVE:To determine if there is any significant difference between the effects of desflurane, isoflurane and sevoflurane on the QT interval, QT dispersion, heart rate corrected QT interval and QTc dispersion of the electrocardiogram. METHODS:The study was conducted in a prospective, double blind and randomized manner in a teaching hospital. Ninety ASA I patients, aged 16-50 yr, undergoing general anaesthesia for noncardiac surgery were studied. RESULTS:There was no significant change in QT intervals during the study in any group (P > 0.05). QT dispersion in the sevoflurane group 49+/-14 ms vs. 37+/-10 ms; in the desflurane group 55+/-16 and 62+/-21 ms vs. 35+/-14 ms and in the isoflurane group 54+/-26 and 59+/-24 ms vs. 42+/-19 ms were significantly increased at 3 and 10 min after 1 MAC of steady end-tidal anaesthetic concentration compared with baseline values (P < 0.05). QTc values in the sevoflurane group were 444+/-24 and 435+/-2 1ms vs. 413+/-19 ms (P < 0.05), in the isoflurane group were 450+/-26 and 455+/-34 ms vs. 416+/-34 ms (P < 0.05), in the desflurane group were 450+/-26 and 455+/-34 ms vs. 416+/-34 ms (P < 0.05) at 3 and 10 min after reaching 1 MAC of anaesthetic concentration and significantly increased compared with baseline values. QTc dispersion increased significantly with sevoflurane 62+/-14 ms vs. 45+/-16 ms (P < 0.05); isoflurane 70+/-36 ms at 3 min and 75+/-36 ms at 10 min after reaching 1 MAC of anaesthetic concentration vs. 50+/-24 ms (P < 0.05); desflurane 67+/-25 ms at 3 min and 74+/-27 ms at 10 min after 1 MAC concentration vs. 41+/-22 ms (P < 0.05). CONCLUSION:Sevoflurane, isoflurane and desflurane all prolonged QTd, QTc and QTcd but there were no significant intergroup differences.
journal_name
Eur J Anaesthesioljournal_title
European journal of anaesthesiologyauthors
Yildirim H,Adanir T,Atay A,Katircioğlu K,Savaci Sdoi
10.1017/s0265021504007112subject
Has Abstractpub_date
2004-07-01 00:00:00pages
566-70issue
7eissn
0265-0215issn
1365-2346journal_volume
21pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND AND OBJECTIVE:Low-dose mixture of hyperbaric bupivacaine and fentanyl is commonly used in day-case spinal anaesthesia. Using hyperbaric articaine, the onset may be faster and duration more predictable than with bupivacaine-fentanyl. We compared these two spinal anaesthetics for inguinal herniorrhaphy. METHO...
journal_title:European journal of anaesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/EJA.0b013e32834a11be
更新日期:2012-01-01 00:00:00
abstract::Ringer's solution expands blood volume by between 20% and 25% in awake volunteers, but little is known about its volume effect during general anaesthesia. In 35 men with a mean age of 70 years, the power of various intra-operative factors to change blood volume as estimated by the haemoglobin dilution method were anal...
journal_title:European journal of anaesthesiology
pub_type: 杂志文章
doi:10.1046/j.1365-2346.1998.00313.x
更新日期:1998-07-01 00:00:00
abstract::A 6-month-old boy with Sturge-Weber syndrome was scheduled for congenital glaucoma and left buphthalmus surgery. Physical examination revealed haemangioma throughout the right trigeminal nerve, congenital glaucoma, left megalocornea and bilateral buphthalmus. Examination of the eye was performed under general anaesthe...
journal_title:European journal of anaesthesiology
pub_type: 杂志文章
doi:10.1046/j.1365-2346.1999.00472.x
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:We compared the effects of sub-Tenon's local anaesthetic block and placebo on peri-operative opioid requirement and cardiovascular stability and on postoperative pain, nausea and vomiting in patients undergoing vitreo-retinal surgery under general anaesthesia. METHODS:We studied 43 patients un...
journal_title:European journal of anaesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The cerebral state index (CSI) is a low-cost and compact electroencephalographic monitor alternative to the bispectral index (BIS). Although both indices are shown as the number between 0 and 100, owing to the different calculation algorithms, both indices might be different during anaesthesia....
journal_title:European journal of anaesthesiology
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journal_title:European journal of anaesthesiology
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of anaesthesiology
pub_type: 杂志文章
doi:10.1097/EJA.0000000000001130
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journal_title:European journal of anaesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::The effect of ketamine on the onset time, the duration of action and the recovery characteristics of suxamethonium-induced neuromuscular blockade was examined in a double-blind randomized study comprising 30 patients anaesthetized with thiopentone, fentanyl, midazolam and nitrous oxide. The ulnar nerve was stimulated ...
journal_title:European journal of anaesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1989-11-01 00:00:00
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journal_title:European journal of anaesthesiology
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of anaesthesiology
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abstract:BACKGROUND AND OBJECTIVE:The anaesthetic method for intracranial neurosurgery must provide haemodynamic stability on emergence and allow early evaluation of the neurological status. In this study, we examined the effects of the alpha-2 agonist dexmedetomidine given at the end of the procedure to prevent hyperdynamic re...
journal_title:European journal of anaesthesiology
pub_type: 杂志文章,随机对照试验
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更新日期:2008-10-01 00:00:00
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journal_title:European journal of anaesthesiology
pub_type: 杂志文章,评审
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更新日期:1999-04-01 00:00:00
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journal_title:European journal of anaesthesiology
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
abstract::The hypothesis that calcium channel blockers can potentiate and prolong the anti-nociceptive effects of opioids was tested. Forty-five men scheduled for aorto-coronary bypass operation received fentanyl according to their individual demands (haemodynamics, clinical parameters). The patients were allocated at random in...
journal_title:European journal of anaesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-11-01 00:00:00
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journal_title:European journal of anaesthesiology
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journal_title:European journal of anaesthesiology
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journal_title:European journal of anaesthesiology
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journal_title:European journal of anaesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of anaesthesiology
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of anaesthesiology
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of anaesthesiology
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journal_title:European journal of anaesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:General anaesthesia may contribute to postoperative cognitive decline in the elderly. The aim was to determine the effects of repeated pentobarbital anaesthesia throughout life on central cholinergic function in the rat. METHODS:Young Lewis rats were randomly allocated to two groups. The anaes...
journal_title:European journal of anaesthesiology
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journal_title:European journal of anaesthesiology
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abstract:BACKGROUND AND OBJECTIVE:Sedation is commonly used to facilitate diagnostic procedures in children. The aim of our study was to investigate sedation in children using propofol alone or combined with fentanyl or midazolam with regard to efficacy, adverse reactions or side-effects related to the drugs, ease of operation ...
journal_title:European journal of anaesthesiology
pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND:The respiratory exchange ratio (RER), defined as the ratio of CO2 production (VCO2) to O2 consumption (VO2), is reported to be a noninvasive marker of anaerobic metabolism. The intubated, ventilated patient's inspired and expired fractions of O2 and CO2 (FiO2, FeO2, FiCO2 and FeCO2) are monitored in the oper...
journal_title:European journal of anaesthesiology
pub_type: 杂志文章
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abstract:BACKGROUND AND OBJECTIVE:The aim of the present study was to determine the dosage of remifentanil that must be added to thiopental 5 mg kg(-1) to provide excellent intubating conditions in 95% of patients. METHODS:Sixty-eight premedicated female American Society of Anesthesiologists class 1 and 2 patients were randoml...
journal_title:European journal of anaesthesiology
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更新日期:2010-07-01 00:00:00
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journal_title:European journal of anaesthesiology
pub_type: 杂志文章,评审
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更新日期:2005-09-01 00:00:00