Tramadol suppositories are less suitable for post-operative pain relief than rectal acetaminophen/codeine.

Abstract:

:The suitability of tramadol suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated. In an open randomized trial, rectal tramadol was compared with our standard treatment acetaminophen/codeine suppositories. We expected tramadol to be equally effective as our current standard but with fewer side effects. Forty patients were treated with either tramadol suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds. Patients were comparable with regard to demographic data and type of surgery and anaesthesia. Post-operative pain was scored with the aid of a Visual Analogue Scale before each drug administration, at rest and during movement. Side effects, notably nausea and vomiting, were recorded by interviewing the patients and by inspecting the nursing report. There was no difference in pain scores between the two groups. The incidence of nausea and vomiting was significantly higher in the tramadol-treated (84%) than in the acetaminophen/codeine treated group (31%). The relative risk of experiencing an episode of nausea under treatment with tramadol was 2.7 (95% confidence interval: 1.3-5.3; P = 0.0001) as compared with acetaminophen/codeine. We conclude that for acute treatment of mild to moderate post-operative pain frequent nausea and vomiting makes tramadol suppositories less suitable than acetaminophen/codeine.

journal_name

Eur J Anaesthesiol

authors

Pluim MA,Wegener JT,Rupreht J,Vulto AG

doi

10.1046/j.1365-2346.1999.00520.x

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

473-8

issue

7

eissn

0265-0215

issn

1365-2346

journal_volume

16

pub_type

临床试验,杂志文章,随机对照试验
  • Intrathecal hydromorphone added to hyperbaric bupivacaine for postoperative pain relief after knee arthroscopic surgery: a prospective, randomised, controlled trial.

    abstract:BACKGROUND AND OBJECTIVE:Adding opioid to spinal anaesthetic provides additional analgesia during the postoperative period. The purpose of this study was to determine the dose of intrathecal hydromorphone necessary to achieve postoperative pain relief after arthroscopic knee surgery. METHODS:In a prospective, double-b...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e3283476055

    authors: Lee YS,Park YC,Kim JH,Kim WY,Yoon SZ,Moon MG,Min TJ

    更新日期:2012-01-01 00:00:00

  • Anaesthesia for Sturge-Weber syndrome.

    abstract::A 6-month-old boy with Sturge-Weber syndrome was scheduled for congenital glaucoma and left buphthalmus surgery. Physical examination revealed haemangioma throughout the right trigeminal nerve, congenital glaucoma, left megalocornea and bilateral buphthalmus. Examination of the eye was performed under general anaesthe...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.1999.00472.x

    authors: Ceyhan A,Cakan T,Başar H,Bababalim M,Unal N

    更新日期:1999-05-01 00:00:00

  • Safety and efficacy of sugammadex for the reversal of rocuronium-induced neuromuscular blockade in cardiac patients undergoing noncardiac surgery.

    abstract:BACKGROUND AND OBJECTIVE:The present randomized, safety-assessor blinded, placebo-controlled trial was designed to assess safety and efficacy of sugammadex, a novel selective relaxant-binding agent, in patients with underlying cardiovascular disease undergoing noncardiac surgery. METHODS:Overall, 116 patients (New Yor...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/EJA.0b013e32832c605b

    authors: Dahl V,Pendeville PE,Hollmann MW,Heier T,Abels EA,Blobner M

    更新日期:2009-10-01 00:00:00

  • Incidence and risk factors for adverse events during monitored anaesthesia care for gastrointestinal endoscopy in children: A prospective observational study.

    abstract:BACKGROUND:Better understanding of risk factors for adverse events during monitored anaesthesia care (MAC) for paediatric gastrointestinal endoscopy may improve outcome in children. OBJECTIVES:To identify the prevalence and predictors of adverse events during MAC for paediatric endoscopy. DESIGN:An observational stud...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000995

    authors: Najafi N,Veyckemans F,Vanhonacker D,Legrand C,Van de Velde A,Vandenplas Y,Poelaert J

    更新日期:2019-06-01 00:00:00

  • Metabolic and subjective responses to oral diazepam and midazolam.

    abstract::Diazepam premedication decreases the overall metabolic rate and oxygen consumption. Whether its properties are shared by midazolam is not known. In this study, eight healthy male volunteers were given oral diazepam (10 mg), midazolam (15 mg) and placebo in a random double-blind cross-over fashion. Metabolic responses ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kirvelä O,Katila A,Aantaa R,Kanto J,Himberg JJ

    更新日期:1994-09-01 00:00:00

  • The LAS VEGAS risk score for prediction of postoperative pulmonary complications: An observational study.

    abstract:BACKGROUND:Currently used pre-operative prediction scores for postoperative pulmonary complications (PPCs) use patient data and expected surgery characteristics exclusively. However, intra-operative events are also associated with the development of PPCs. OBJECTIVE:We aimed to develop a new prediction score for PPCs t...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/EJA.0000000000000845

    authors: Neto AS,da Costa LGV,Hemmes SNT,Canet J,Hedenstierna G,Jaber S,Hiesmayr M,Hollmann MW,Mills GH,Vidal Melo MF,Pearse R,Putensen C,Schmid W,Severgnini P,Wrigge H,Gama de Abreu M,Pelosi P,Schultz MJ,LAS VEGAS.

    更新日期:2018-09-01 00:00:00

  • Continuous epidural anaesthesia for major abdominal surgery in young children.

    abstract::The benefits of epidural anaesthesia combined with general anaesthesia were studied in young children scheduled for major abdominal surgical procedure (pull-through for Hirschsprung's disease). Two groups of nine children were studied receiving, respectively, general anaesthesia or general anaesthesia plus epidural an...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Murat I,Delleur MM,Levy J,Esteve C,Saint-Maurice C

    更新日期:1987-09-01 00:00:00

  • Effects of continuous epidural administration of bupivacaine through a catheter in pigs.

    abstract::We studied whether long-term epidural catheter (nylon) placement for bupivacaine administration (morphine in 2 pigs) would cause any pathological changes in the epidural space and spinal cord of pigs. There were similar kinds of slight inflammatory changes in ligamentum flavum and dura mater in bupivacaine-treated (4 ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Kyttä J,Rosenberg PH,Wahlström TR

    更新日期:1986-11-01 00:00:00

  • Ketamine does not affect suxamethonium-induced neuromuscular blockade in man.

    abstract::The effect of ketamine on the onset time, the duration of action and the recovery characteristics of suxamethonium-induced neuromuscular blockade was examined in a double-blind randomized study comprising 30 patients anaesthetized with thiopentone, fentanyl, midazolam and nitrous oxide. The ulnar nerve was stimulated ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Helbo-Hansen HS,Toft P,Nielsen HK

    更新日期:1989-11-01 00:00:00

  • Preoperative oral dextromethorphan vs. clonidine to prevent tourniquet-induced cardiovascular responses in orthopaedic patients under general anaesthesia.

    abstract:BACKGROUND AND OBJECTIVE:Preoperative oral dextromethorphan and intravenous clonidine attenuate arterial pressure and heart rate increases during tourniquet inflation under general anaesthesia. The effect of preoperative oral clonidine on these variables has not been investigated. METHODS:We designed this study to com...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021506002055

    authors: Honarmand A,Safavi MR

    更新日期:2007-06-01 00:00:00

  • Arterial pressure waveform analysis versus thermodilution cardiac output measurement during open abdominal aortic aneurysm repair: a prospective observational study.

    abstract:BACKGROUND:Arterial pressure waveform analysis enables continuous, minimally invasive measurement of cardiac output. Haemodynamic instability compromises the reliability of the technique and a means of maintaining accurate measurement in this circumstance would be useful. OBJECTIVES:To investigate the accuracy, precis...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000160

    authors: Montenij LJ,Buhre WF,de Jong SA,Harms JH,van Herwaarden JA,Kruitwagen CL,de Waal EE

    更新日期:2015-01-01 00:00:00

  • Transoesophageal echocardiography accurately detects cardiac output variation: a prospective comparison with thermodilution in cardiac surgery.

    abstract:BACKGROUND AND OBJECTIVE:Intraoperative Doppler ultrasound can be used to measure cardiac output by transoesophageal echocardiography. Recently, its reliability, when compared to the thermodilution technique, has been questioned. The purpose of this study was to compare intraoperative changes in cardiac output measured...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021507001354

    authors: Parra V,Fita G,Rovira I,Matute P,Gomar C,Paré C

    更新日期:2008-02-01 00:00:00

  • The effect of triple vs. double nonopioid therapy on postoperative pain and functional outcome after abdominal hysterectomy: a randomised double-blind control trial.

    abstract:BACKGROUND:Movement-evoked pain is more severe than pain at rest and is likely to interfere more with functional recovery after surgery. OBJECTIVE:To compare triple vs. double nonopioid perioperative analgesic regimens in women undergoing abdominal hysterectomy. DESIGN:A randomised, parallel design, double-blind cont...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000000190

    authors: Gilron I,Tu D,Dumerton-Shore D,Duggan S,Rooney R,McGrath M,Orr E

    更新日期:2015-04-01 00:00:00

  • The influence of etomidate upon cerebral metabolites after complete brain ischaemia in the rat.

    abstract::The influence of etomidate on post-ischaemic cerebral metabolism was examined in 1-year-old male Wistar rats. Ten rats were randomly allocated to each of three groups. Group 1 animals received etomidate for 60 min without undergoing cerebral ischaemia. In Group 2, there was a 60-min recovery period following 15 min of...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Böhrer H,Hoyer S,Krier C

    更新日期:1991-05-01 00:00:00

  • Influence of microcatheter length on flow rates of disposable infusion kits.

    abstract:BACKGROUND AND OBJECTIVE:Continuous spinal analgesia (CSA) offers considerable pain relief, and has been used in various procedures such as for surgery and cancer pain control. In Japan, portable and disposable infusion kits are increasingly employed for continuous epidural analgesia and CSA. In CSA, the use of a micro...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021504000183

    authors: Kasai T,Hirose M,Yaegashi K,Fujita T,Hirai Y,Tanaka Y

    更新日期:2004-11-01 00:00:00

  • Comparison of Bullard and Airtraq laryngoscopes with conventional laryngoscopy in a manikin study of simulated difficult intubation.

    abstract:BACKGROUND:When airway management is difficult, various measures can be taken to facilitate tracheal intubation. The Bullard and Airtraq laryngoscopes were developed for this purpose. We hypothesised that the Bullard and Airtraq laryngoscopes would perform better than a conventional laryngoscope in the management of a ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328354b22c

    authors: Legrand MA,Steinmann D,Priebe HJ,Mols G

    更新日期:2012-07-01 00:00:00

  • Crystalloid versus red blood cell-containing medium in the Langendorff-perfused isolated heart preparation.

    abstract:BACKGROUND:The isolated heart model is widely used for the assessment of coronary vascular response under various experimental conditions. As medium perfusate influences oxygenation conditions, coronary vascular response and myocardial consumption performance may differ between isolated hearts perfused with from with K...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0b013e328337cc0d

    authors: Mouren S,Vicaut E,Lamhaut L,Riou B,Ouattara A

    更新日期:2010-09-01 00:00:00

  • Systemic and alveolar inflammatory response in the dependent and nondependent lung in patients undergoing lung resection surgery: A prospective observational study.

    abstract:BACKGROUND:Measurement of inflammatory mediators in bronchoalveolar lavage (BAL) during lung resection surgery with periods of one-lung ventilation (OLV) has revealed an intense local pulmonary response. The role of each lung in the inflammation that occurs during this procedure has never been investigated. OBJECTIVE(...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000233

    authors: de la Gala F,Piñeiro P,Garutti I,Reyes A,Olmedilla L,Cruz P,Duque P,Casanova J,Rancan L,Benito P,Vara E

    更新日期:2015-12-01 00:00:00

  • Laparoscopically assisted vaginal and abdominal hysterectomy: comparison of postoperative pain, fatigue and systemic response. A case-control study.

    abstract:BACKGROUND AND OBJECTIVE:Laparoscopic and open surgery have been compared with conflicting results regarding their systemic responses. The sensitivity of biochemical markers that are used to discriminate between the stress responses to different types of surgery varies from study to study. We wanted to evaluate the str...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.2001.00889.x

    authors: Rorarius MG,Kujansuu E,Baer GA,Suominen P,Teisala K,Miettinen A,Ylitalo P,Laippala P

    更新日期:2001-08-01 00:00:00

  • Malignant hyperthermia.

    abstract::Malignant hyperthermia is an autosomal-dominant inherited disorder of the skeletal muscle cell characterized by a hypermetabolic response to all commonly used inhalational anaesthetics and depolarizing muscle relaxants. The clinical syndrome includes muscle rigidity, hypercapnia, tachycardia and myoglobinuria as resul...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2346.2001.00888.x

    authors: Wappler F

    更新日期:2001-10-01 00:00:00

  • Vasorelaxant effect of opioid analgesics on the isolated human radial artery.

    abstract:BACKGROUND AND OBJECTIVE:Arterial grafts are prone to vasospasm. Opioid analgesics are commonly used in the perioperative course of cardiac surgical procedures. Therefore, we investigated the direct effects of morphine, meperidine, fentanyl and remifentanil on the human radial artery. METHODS:Radial artery segments, o...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021506000172

    authors: Gursoy S,Bagcivan I,Yildirim MK,Berkan O,Kaya T

    更新日期:2006-06-01 00:00:00

  • Dolasetron for the prevention of postoperative nausea and vomiting following outpatient surgery with general anaesthesia: a randomized, placebo-controlled study. The Dolasetron PONV Prevention Study Group.

    abstract::In a multicentre, randomized, double-blind, placebo-controlled dose-ranging study, 1030 patients undergoing outpatient surgery with general anaesthesia received i.v. dolasetron mesylate (12.5, 25, 50, or 100 mg) or placebo. The principal outcome measure was the proportion of patients who were free of emesis or rescue ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1046/j.1365-2346.2000.00594.x

    authors: Philip BK,Pearman MH,Kovac AL,Chelly JE,Wetchler BV,McKenzie R,Monk TG,Dershwitz M,Mingus M,Sung YF,Hahne WF,Brown RA

    更新日期:2000-01-01 00:00:00

  • Myocardial infarction and death after caesarean section in a woman with protein S deficiency and undiagnosed phaeochromocytoma.

    abstract::We describe the case of a 36-year-old woman, with a previous history of recurrent abortion due to protein S deficiency, undergoing an elective Caesarean section at 39-weeks gestation. During pregnancy no signs of hypertension or cardiovascular disease were reported, but at the end of the surgical procedure, the patien...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2346.1999.00474.x

    authors: Zangrillo A,Valentini G,Casati A,Torri G

    更新日期:1999-04-01 00:00:00

  • Comparison of the modified Airway Management Device with the Proseal laryngeal mask airway in patients undergoing gynaecological procedures.

    abstract:BACKGROUND AND OBJECTIVE:The modified Airway Management Device (AMD) and the Proseal laryngeal mask airway (PLMA) are both supraglottic airway devices designed to maintain airway patency and allow ventilation during anaesthesia. In this prospective, randomized trial, we compared the two devices in patients undergoing m...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021505001808

    authors: Pay LL,Lim Y

    更新日期:2006-01-01 00:00:00

  • Implementation of patient blood management remains extremely variable in Europe and Canada: the NATA benchmark project: An observational study.

    abstract:BACKGROUND:Preoperative anaemia is associated with increased postoperative morbidity and mortality. Patient blood management (PBM) is advocated to improve patient outcomes. OBJECTIVES:NATA, the 'Network for the advancement of patient blood management, haemostasis and thrombosis', initiated a benchmark project with the...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/EJA.0000000000000519

    authors: Van der Linden P,Hardy JF

    更新日期:2016-12-01 00:00:00

  • Effects of hyperbaric spinal ropivacaine for caesarean section: with or without fentanyl.

    abstract:BACKGROUND AND OBJECTIVE:Adding various opioids to the local anaesthetic solution administrated intrathecally improves the analgesic potency of spinal analgesia. The purpose of this study was to evaluate the efficacy and safety of intrathecal fentanyl 10 microg added to 15 mg hyperbaric ropivacaine in patients undergoi...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0265021505000785

    authors: Sanli S,Yegin A,Kayacan N,Yilmaz M,Coskunfirat N,Karsli B

    更新日期:2005-06-01 00:00:00

  • Sevoflurane potentiates and blocks GABA-induced currents through recombinant alpha1beta2gamma2 GABAA receptors: implications for an enhanced GABAergic transmission.

    abstract:BACKGROUND AND OBJECTIVE:The gamma-aminobutyric acidA receptor (GABAAR) is a target for anaesthetic agents. We investigated the interactions of sevoflurane with a recombinant GABAAR. Emphasis was on the mechanism of block, as relevant open-channel block by a volatile anaesthetic would possibly explain prolonged GABAerg...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.0265-0215.2001.00848.x

    authors: Hapfelmeier G,Schneck H,Kochs E

    更新日期:2001-06-01 00:00:00

  • Gradient between dorsalis pedis and radial arterial blood pressures during sevoflurane anaesthesia: A self-control study in patients undergoing neurosurgery.

    abstract:BACKGROUND:The dorsalis pedis artery (DPA) is a good alternative to the radial artery (RA) for invasive blood pressure monitoring when the upper limb is burned or injured, or if the RA is not available. Understanding the pattern of pressure difference between DPA and the commonly used RA during inhalational anaesthesia...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000295

    authors: Chen Y,Cui J,Sun JJ,Wang E,Zhu Y,Li Y,Lu K

    更新日期:2016-02-01 00:00:00

  • Effects of intra-operative positive end-expiratory pressure setting guided by oesophageal pressure measurement on oxygenation and respiratory mechanics during laparoscopic gynaecological surgery: A randomised controlled trial.

    abstract:BACKGROUND:The creation of pneumoperitoneum during laparoscopic surgery can lead to adverse effects on the respiratory system. Positive end-expiratory pressure (PEEP) plays an important role in mechanical ventilation during laparoscopic surgery. OBJECTIVE:To evaluate whether PEEP setting guided by oesophageal pressure...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000001204

    authors: Piriyapatsom A,Phetkampang S

    更新日期:2020-11-01 00:00:00

  • Bilateral paravertebral somatic nerve block for ventral hernia repair.

    abstract:BACKGROUND AND OBJECTIVE:Unilateral paravertebral nerve blockade has been reported to produce excellent afferent nerve block, reduce the incidence of postoperative nausea and vomiting, and reduce hospital stay following inguinal hernia repair. The aim was to compare the use of bilateral paravertebral blocks to regular ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021502000352

    authors: Naja Z,Ziade MF,Lönnqvist PA

    更新日期:2002-03-01 00:00:00