Abstract：
:Mechanisms of anaesthetics still remain unclear. However, various attempts have been made to elucidate the effects of anaesthetics at the molecular level. The nicotinic acetylcholine receptor has proved to be a good model of membrane-bound ligand-gated ion channels. It is available in abundance from Torpedo electroplaques, thus enabling multiple experimental approaches. The receptor exists in different states: the resting state, the open state and the desensitized state, amongst others. For each of these states, effects of general anaesthetics at the receptor molecule have been shown. Displacement studies show barbiturates to bind to a site on the resting state of the nicotinic acetylcholine receptor; cation flux studies suggest barbiturates may also bind to the same, or a similar, site on the open state of the receptor when inhibiting its function. Long-chain alcohols inhibit the open receptor, perhaps by binding to such a site or sites. However, short-chain alcohols do not inhibit and do not share this long-chain alcohol binding site; instead they nonspecifically enhance the agonist's apparent affinity. All the alcohols also cause desensitization by a non-specific mechanism possibly involving perturbation of the lipid bilayer. Thus, general anaesthetics exert both specific and non-specific actions on the acetylcholine receptor.
journal_name
Eur J Anaesthesioljournal_title
European journal of anaesthesiologyauthors
Tonner PH,Miller KWsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
21-30issue
1eissn
0265-0215issn
1365-2346journal_volume
12pub_type
杂志文章,评审abstract：:A 72-year-old woman had a minitracheostomy inserted for sputum retention. This was undertaken by a relatively junior resident who opted to use an early model minitracheostomy kit Minitrach II. The following day the patients condition deteriorated and intubation was warranted, at which time it was apparent to senior st...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1046/j.1365-2346.1999.00530.x
更新日期：1999-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Isoflurane has been shown experimentally to protect the myocardium against infarction but the clinical relevance of these findings is not yet well established. We therefore evaluated the effects of isoflurane administration before cardiopulmonary bypass (CPB) on postoperative cardiac troponin I...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1017/s0265021504009044
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Transtracheal or transcricothyroid placement of a cannula is a practice used in a number of aspects of airway management in anaesthesia and intensive care. In this study, we aimed to investigate whether the use of ultrasound will facilitate cannula placement in a time-critical situation in pati...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1097/EJA.0b013e328344b4e1
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Low-dose mixture of hyperbaric bupivacaine and fentanyl is commonly used in day-case spinal anaesthesia. Using hyperbaric articaine, the onset may be faster and duration more predictable than with bupivacaine-fentanyl. We compared these two spinal anaesthetics for inguinal herniorrhaphy. METHO...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1097/EJA.0b013e32834a11be
更新日期：2012-01-01 00:00:00
abstract：:Haemodynamic alterations elicited by iced injectate during thermodilution cardiac output measurements were evaluated in the presence of metabolic acidosis or hypoxic hypoxia in 14 instrumented anaesthetized dogs. The alterations in some haemodynamic variables during slowing of the heart rate following injection of 3 m...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:The objective of this study was to determine the intracranial, cardiovascular and respiratory changes induced by conversion to high-frequency oscillator ventilation from conventional mechanical ventilation at increasing airway pressures. METHODS:In this study, 11 anaesthetized sheep had invasive cardiovascu...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1017/S0265021506002006
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND:Epidural analgesia (EDA) is known to be an independent risk factor for perioperative hypothermia and its many known adverse effects. Combined general and epidural anaesthesia decreases intraoperative core temperature more rapidly than general anaesthesia alone. Hence, adequate warming procedures are needed f...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1097/EJA.0000000000000369
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Post-anaesthetic shivering is one of the most common complications, occurring in 5-65% of patients recovering from general anaesthesia and 33% of patients receiving epidural anaesthesia. Our objective was to investigate the efficacy of intraoperative dexmedetomidine infusion on postoperative shivering. METH...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1017/S0265021507003110
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:The dorsalis pedis artery (DPA) is a good alternative to the radial artery (RA) for invasive blood pressure monitoring when the upper limb is burned or injured, or if the RA is not available. Understanding the pattern of pressure difference between DPA and the commonly used RA during inhalational anaesthesia...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0000000000000295
更新日期：2016-02-01 00:00:00
abstract：:The time profile of the neuromuscular block produced by a single bolus administration of vecuronium was simulated by a new model for the access of the relaxant to the receptors on the motor end plates. The receptors were assumed to be kinetically a part of the interstitial space of the muscle. The time course of the n...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:In a prospective randomized study in children, we compared caudal bupivacaine-clonidine with bupivacaine-morphine to evaluate whether clonidine can be used as an alternative to morphine in caudal anaesthesia. Caudal anaesthesia was administered in 36 children undergoing orchidopexy, hernia repair or circumcision, usin...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2346.1999.00430.x
更新日期：1999-01-01 00:00:00
abstract：:Sixty patients were randomly assigned to two equal groups. Group I received epidural morphine 1 mg after surgery and used a patient-controlled analgesia device programmed to deliver morphine 0. 2 mg h-1, 0.2 mg per bolus. Group II received an epidural loading dose of morphine 1 mg plus ketamine 5 mg and used a patient...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2346.1999.00592.x
更新日期：1999-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Acute renal failure is a serious complication of cardiac surgery. We studied the long-term survival and quality of life of patients requiring renal replacement therapy after cardiac surgery, since they represent a heavy burden on hospital resources and their outcome has never been adequately ev...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章
doi：10.1017/S0265021505001705
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Hypoventilation is a major cause of morbidity and mortality in patients having procedures under sedation. Few clinical strategies have been evaluated to reduce intraoperative hypoventilation during surgical procedures under deep sedation. OBJECTIVE:The primary objective of this investigation was to examine ...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1097/EJA.0000000000000025
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Infraclavicular plexus block has many advantages of particular interest in the emergency setting. However, the number of nerve stimulations needed to optimize the technique remains unclear. We evaluated both the local anaesthetic requirement and the success rate of Sim's derived infraclavicula...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1017/S0265021506000329
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In polymorphonuclear leucocytes, phagocytosis and respiratory burst activity are mainly responsible for bacterial killing. We aimed to investigate the effects of anaesthesia with desflurane, sevoflurane and propofol on these functional activities of polymorphonuclear leucocytes in bronchoalveol...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1097/EJA.0b013e328319bfeb
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Hyperlactataemia represents oxygen imbalance in the tissues and its occurrence during cardiac surgery is associated with adverse outcomes. Glucose-insulin-potassium (GIK) infusion confers myocardial protection against ischaemia-reperfusion injury and has the potential to reduce lactate release while improvin...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1097/EJA.0000000000000250
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Pre-operative anaemia is associated with adverse outcomes of noncardiac surgery, but its association with myocardial injury after noncardiac surgery (MINS) has not been fully investigated. OBJECTIVE:The association between pre-operative anaemia and MINS. DESIGN:A single-centre retrospective cohort study. ...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0000000000001421
更新日期：2021-01-04 00:00:00
abstract：BACKGROUND:Many trauma centres have adopted the administration of fixed ratios of packed red blood cells (PRBCs), platelet concentrates and fresh frozen plasma (FFP) for bleeding patients. However, the haemostatic efficacy of this concept is not well proven. OBJECTIVE:Our objective was to characterise the haemostatic ...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0000000000001202
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:The C-MAC D-blade is a new, highly angulated, videolaryngoscope blade designed for use in patients with difficult airways. Directing a tracheal tube into the trachea with any indirect viewing laryngoscope can be difficult, even with a good view of the laryngeal inlet. OBJECTIVE:To determine which introducin...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0000000000000070
更新日期：2015-06-01 00:00:00
abstract：:Two groups of 25 patients were sedated during neuroradiological investigation. The first group was sedated with fentanyl and midazolam while the other was given fentanyl and a two-stage infusion of propofol in a subanaesthetic dose. Both techniques resulted in satisfactory sedation and recovery, although those who rec...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1989-09-01 00:00:00
abstract：:The effects of anaesthetic techniques and drugs on 18 neonates born after elective Caesarean section were studied, employing computerized EEG. Three different groups, epidural, spinal and general anaesthesia, were compared with each other and with a control group after normal vaginal delivery. A new computerized EEG m...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The perception of a looming manpower shortage led the French College of Anaesthesiologists (CFAR) and the French Society of Anaesthesia and Intensive Care (SFAR), with assistance from the National Institute for Demographic Studies (INED), to conduct a national survey of French anaesthesiologist...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1017/s0265021504005095
更新日期：2004-05-01 00:00:00
abstract：INTRODUCTION:We tested the hypothesis that repeated autoclaving removes protein deposits from the classic laryngeal mask airway (LMA). METHODS:Twenty previously used LMAs were hand washed, machine washed, dried, autoclaved and randomly allocated into four equal-sized groups for repeat autoclaving on 0 (control), 1, 2 ...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1017/s0265021505000888
更新日期：2005-07-01 00:00:00
abstract：:Anaesthetic agents for day-case surgery ideally should have a short duration of action. This study was designed to compare the efficacy and safety of mivacurium and vecuronium for healthy adults undergoing dental day-case surgery. Thirty fit healthy adult patients (ASA I or II) randomly received either mivacurium 0.15...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2346.1994.00207.x
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Previous studies have shown that general anaesthetic agents modulate the production of hypothalamic prostaglandins (PG) D2 and E2, which are mediators of sleep and wakefulness respectively. Although flurbiprofen, a cyclo-oxygenase inhibitor, is used clinically as a non-steroidal anti-inflammato...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1017/s0265021502000790
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:For cannulation of the internal jugular vein (IJV), ultrasound increases the number of first pass successes and reduces the rate of mechanical complications. A frequent complication of IJV access is the accidental injury of the common carotid artery (CCA), which can be dangerous in some circums...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0b013e328341a492
更新日期：2011-05-01 00:00:00
abstract：:A prospective observational study of 101 women having breast surgery under general anaesthesia was performed to assess the extent of postoperative nausea and vomiting in this group of women. The overall rate of postoperative nausea and vomiting was high, 56% and 41%, respectively, and was significantly associated with...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2346.2000.00637.x
更新日期：2000-04-01 00:00:00
abstract：:Morbidly obese patients present with excess fatty tissue externally on the breast, neck, thoracic wall and abdomen and internally in the mouth, pharynx and abdomen. This excess tissue tends to make access (intubation, tracheostomy) to and patency (during sedation or mask ventilation) of the upper airway and the functi...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,评审
doi：10.1097/EJA.0b013e32833d91aa
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Recent evidence indicates that platelet function may recover more rapidly after cessation of aspirin therapy than previously thought. The present study evaluated the effect of aspirin on platelet function using platelet aggregometry in healthy individuals and in aspirin-treated patients schedul...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0b013e328335b354
更新日期：2010-07-01 00:00:00
