Effects of continuous epidural administration of bupivacaine through a catheter in pigs.

Abstract:

:We studied whether long-term epidural catheter (nylon) placement for bupivacaine administration (morphine in 2 pigs) would cause any pathological changes in the epidural space and spinal cord of pigs. There were similar kinds of slight inflammatory changes in ligamentum flavum and dura mater in bupivacaine-treated (4 ml 0.5% bupivacaine, twice daily for 7 days, n = 8; 16 ml 0.25% bupivacaine infusion in 12 h, n = 3) and morphine-treated (2 mg preservative-free morphine, twice daily for 7 days, n = 2) pigs compared with corresponding control pigs (saline, n = 8) 24 h after treatment. There were minimal inflammatory changes in one of the two bupivacaine-treated pigs recovering for 3 weeks. In one of the bupivacaine pigs there was a bacterial infection (Staphylococcus aureus) all along the epidural catheter. In this pig the overall level of bupivacaine plasma concentrations after an injection decreased stepwise during the 7-day period (sampling at 2-day intervals). In the other pigs treated for 7 days, the level of bupivacaine concentrations did not change markedly from first sampling to later samplings. It is probable that inflammatory changes in the epidural space, following prolonged administration of bupivacaine and morphine, are largely due to catheter irritation.

journal_name

Eur J Anaesthesiol

authors

Kyttä J,Rosenberg PH,Wahlström TR

subject

Has Abstract

pub_date

1986-11-01 00:00:00

pages

473-80

issue

6

eissn

0265-0215

issn

1365-2346

journal_volume

3

pub_type

杂志文章
  • Effect of midazolam on in vitro cerebral endothelial ICAM-1 expression induced by astrocyte-conditioned medium.

    abstract:BACKGROUND AND OBJECTIVE:Astrocytes exposed to hypoxia produce pro-inflammatory cytokines and upregulate intercellular adhesion molecule-1 on cerebral endothelium. This study investigated the effects of midazolam on this response. METHODS:Mouse astrocytes were exposed to 4 h of hypoxia and 24 h of reoxygenation. Astro...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021506000652

    authors: Ghori K,Harmon D,Walsh F,Shorten G

    更新日期:2006-09-01 00:00:00

  • Dexmedetomidine and meperidine prevent postanaesthetic shivering.

    abstract:BACKGROUND AND OBJECTIVE:This placebo-controlled study was performed to evaluate the efficacy of dexmedetomidine compared with meperidine and placebo in preventing postanaesthetic shivering. METHODS:We studied 120 patients (ASA I-II) scheduled for elective abdominal or orthopaedic surgery of about 1-3 h duration. Fort...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021505002061

    authors: Bicer C,Esmaoglu A,Akin A,Boyaci A

    更新日期:2006-02-01 00:00:00

  • Complications associated with 27 031 ultrasound-guided axillary brachial plexus blocks: a web-based survey of 36 French centres.

    abstract:BACKGROUND:Ultrasound guidance improves the efficacy of peripheral nerve blocks, reducing performance time and local anaesthetic doses. It should also reduce the risk of systemic toxicity of local anaesthetic and nerve injuries. OBJECTIVE:The primary objective of this prospective study was to estimate the incidence of...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/EJA.0000000000000063

    authors: Ecoffey C,Oger E,Marchand-Maillet F,Cimino Y,Rannou JJ,Beloeil H,SOS French Regional Anaesthesia Hotline.

    更新日期:2014-11-01 00:00:00

  • A prospective evaluation of the failure rate of spinal anaesthesia for transurethral prostatic resection.

    abstract::The rate of failed spinal anaesthesia, defined as the need for unplanned general anaesthesia, was evaluated in a prospective study involving 137 patients undergoing transurethral resection of the prostate (TURP). The incidence of sensations at the operative site which did not require general anaesthesia was also evalu...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Guinard JP,Carpenter RL,Smith HS

    更新日期:1992-01-01 00:00:00

  • Elimination of alfentanil delivered by infusion is not altered by the chronic administration of atorvastatin.

    abstract:BACKGROUND AND OBJECTIVE:Statins are prescribed for patients with hypercholesterolemia. Atorvastatin is metabolized by cytochrome P4503A4 and inhibits P4503A4 activity in vitro. Alfentanil is a potent opioid used in clinical anaesthetic practice and is also metabolized by P4503A4. This study tested the hypothesis that ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章

    doi:10.1017/s0265021503001078

    authors: McDonnell CG,Malkan D,Van Pelt FD,Shorten GD

    更新日期:2003-08-01 00:00:00

  • A comparison of the effects of codeine and tramadol on laryngeal reactivity.

    abstract::The effect of tramadol on laryngeal reflex activity was assessed in a double-blind cross-over study in six volunteers receiving single oral doses of either codeine 50 mg, tramadol 50 mg or tramadol 100 mg. Laryngeal reactivity was measured by the response to the inhalation of dilute ammonia vapour. The minimum ammonia...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Szekely SM,Vickers MD

    更新日期:1992-03-01 00:00:00

  • Effects of hyperbaric spinal ropivacaine for caesarean section: with or without fentanyl.

    abstract:BACKGROUND AND OBJECTIVE:Adding various opioids to the local anaesthetic solution administrated intrathecally improves the analgesic potency of spinal analgesia. The purpose of this study was to evaluate the efficacy and safety of intrathecal fentanyl 10 microg added to 15 mg hyperbaric ropivacaine in patients undergoi...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0265021505000785

    authors: Sanli S,Yegin A,Kayacan N,Yilmaz M,Coskunfirat N,Karsli B

    更新日期:2005-06-01 00:00:00

  • Perioperative care of diabetic patients.

    abstract::Diabetes mellitus is the most common metabolic disease and its incidence is increasing. New classifications have been recently proposed based upon a better knowledge of pathogenesis, mechanisms of glucose transport and insulin resistance. The perioperative care of diabetic patients is less dependent on blood-glucose c...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.0265-0215.2001.00876.x

    authors: Scherpereel PA,Tavernier B

    更新日期:2001-05-01 00:00:00

  • Airway management and morbid obesity.

    abstract::Morbidly obese patients present with excess fatty tissue externally on the breast, neck, thoracic wall and abdomen and internally in the mouth, pharynx and abdomen. This excess tissue tends to make access (intubation, tracheostomy) to and patency (during sedation or mask ventilation) of the upper airway and the functi...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:10.1097/EJA.0b013e32833d91aa

    authors: Kristensen MS

    更新日期:2010-11-01 00:00:00

  • Cerebral blood flow velocity and carbon dioxide vasoreactivity during gamma-hydroxybutyrate/fentanyl anaesthesia in non-neurosurgical patients.

    abstract::In this study the effects of gamma-hydroxybutyrate/fentanyl on cerebral blood flow velocity (CBFV) (as measured in the middle cerebral artery by transcranial Doppler ultrasonography) and on cerebrovascular carbon dioxide reactivity were investigated. Mean CBFV (Vmean) and haemodynamic responses were recorded in 12 non...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2346.1999.00452.x

    authors: Detsch O,Erkens U,Schneck H,Denker T,Kochs E,Hempelmann G

    更新日期:1999-03-01 00:00:00

  • Etomidate for critically ill patients. Con: do you really want to weaken the frail?

    abstract::Etomidate is an imidazole-derived hypnotic agent preferentially used for rapid sequence induction of anaesthesia because of its favourable haemodynamic profile. However, 11β-hydroxylase inhibition causes adrenal insufficiency with potentially fatal consequences in specific populations. We review the arguments against ...

    journal_title:European journal of anaesthesiology

    pub_type: 评论,杂志文章

    doi:10.1097/EJA.0b013e32835819ca

    authors: de la Grandville B,Arroyo D,Walder B

    更新日期:2012-11-01 00:00:00

  • Double- vs. single-injection infraclavicular plexus block in the emergency setting: higher success rate with lower volume of local anaesthetic.

    abstract:BACKGROUND AND OBJECTIVES:Infraclavicular plexus block has many advantages of particular interest in the emergency setting. However, the number of nerve stimulations needed to optimize the technique remains unclear. We evaluated both the local anaesthetic requirement and the success rate of Sim's derived infraclavicula...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0265021506000329

    authors: Fuzier R,Fourcade O,Fuzier V,Albert N,Samii K,Olivier M

    更新日期:2006-04-01 00:00:00

  • Learning curves of the Glidescope, the McGrath and the Airtraq laryngoscopes: a manikin study.

    abstract:BACKGROUND AND OBJECTIVE:Several video and optical laryngoscopes have been developed but few have been compared in terms of their learning curves and efficacy. Using a manikin with normal airways we compared the Glidescope, the McGrath, the Airtraq and the Macintosh laryngoscopes. METHODS:Sixty anaesthetists (20 staff...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/eja.0b013e3283269ff4

    authors: Savoldelli GL,Schiffer E,Abegg C,Baeriswyl V,Clergue F,Waeber JL

    更新日期:2009-07-01 00:00:00

  • A comparison between the flexor hallucis brevis and adductor pollicis muscles in atracurium-induced neuromuscular blockade using acceleromyography: A prospective observational study.

    abstract:BACKGROUND:Neuromuscular blockade (NMB) monitoring is essential to avoid residual NMB. While the adductor pollicis is the recommended site for monitoring recovery, it is not always accessible. The flexor hallucis brevis could be an interesting alternative. OBJECTIVE:The aim of our study was to compare NMB onset and re...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000001090

    authors: Le Merrer M,Frasca D,Dupuis M,Debaene B,Boisson M

    更新日期:2020-01-01 00:00:00

  • Emergency intubation with the Combitube in two cases of difficult airway management.

    abstract::The airway was managed successfully in two cases of difficult intubation using the Combitube, a new device for emergency intubation, which combines the functions of an oesophageal obturator airway and a conventional endotracheal airway. One patient could not be intubated due to lockjaw; in the other patient, the vocal...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Staudinger T,Tesinsky P,Klappacher G,Brugger S,Rintelen C,Locker G,Weiss K,Frass M

    更新日期:1995-03-01 00:00:00

  • The impact of continuous non-invasive arterial blood pressure monitoring on blood pressure stability during general anaesthesia in orthopaedic patients: A randomised trial.

    abstract:BACKGROUND:In patients undergoing general anaesthesia, intraoperative hypotension occurs frequently and is associated with adverse outcomes such as postoperative acute kidney failure, myocardial infarction or stroke. A history of chronic hypertension renders patients more susceptible to a decrease in blood pressure (BP...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000000690

    authors: Meidert AS,Nold JS,Hornung R,Paulus AC,Zwißler B,Czerner S

    更新日期:2017-11-01 00:00:00

  • Peri-operative administration of rectal diclofenac sodium. The effect on renal function in patients undergoing minor orthopaedic surgery.

    abstract::In a randomized, double-blind study, we administered placebo and diclofenac sodium 100 mg suppositories 1 h pre-operatively and on the first post-operative morning to 22 adult patients undergoing minor orthopaedic surgery. A standardized post-operative intravenous fluid regimen was instituted until oral fluids were to...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Irwin MG,Roulson CJ,Jones RD,Cheng IK,Visram AR,Chan YM

    更新日期:1995-07-01 00:00:00

  • Diastolic function: the influence of pneumoperitoneum and Trendelenburg positioning during laparoscopic hysterectomy.

    abstract:BACKGROUND AND OBJECTIVE:Several reports concerning the haemodynamic changes during gynaecologic laparoscopy have been published so far, and the effects of head-down tilt and pneumoperitoneum have not been clearly separated. However, its main effect seems to be an increase in systemic vascular resistance. We investigat...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0b013e32832cb3c9

    authors: Russo A,Marana E,Viviani D,Polidori L,Colicci S,Mettimano M,Proietti R,Di Stasio E

    更新日期:2009-11-01 00:00:00

  • Implementation of patient blood management remains extremely variable in Europe and Canada: the NATA benchmark project: An observational study.

    abstract:BACKGROUND:Preoperative anaemia is associated with increased postoperative morbidity and mortality. Patient blood management (PBM) is advocated to improve patient outcomes. OBJECTIVES:NATA, the 'Network for the advancement of patient blood management, haemostasis and thrombosis', initiated a benchmark project with the...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/EJA.0000000000000519

    authors: Van der Linden P,Hardy JF

    更新日期:2016-12-01 00:00:00

  • The influence of etomidate upon cerebral metabolites after complete brain ischaemia in the rat.

    abstract::The influence of etomidate on post-ischaemic cerebral metabolism was examined in 1-year-old male Wistar rats. Ten rats were randomly allocated to each of three groups. Group 1 animals received etomidate for 60 min without undergoing cerebral ischaemia. In Group 2, there was a 60-min recovery period following 15 min of...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Böhrer H,Hoyer S,Krier C

    更新日期:1991-05-01 00:00:00

  • The relative potencies of thiopentone and propofol.

    abstract::The relative potencies of the intravenous anaesthetics propofol and thiopentone have been investigated by finding the dose necessary to produce unconsciousness in approximately 30%, 50% and 80% of patients. The estimated potency of propofol to thiopentone was 1:1.604 as obtained by the probit method of analysis which ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Grounds RM,Moore M,Morgan M

    更新日期:1986-01-01 00:00:00

  • Does left molar approach to laryngoscopy make difficult intubation easier than the conventional midline approach?

    abstract:BACKGROUND AND OBJECTIVE:It has been reported that the left molar approach of laryngoscopy can make difficult intubation easier. The aim of this study was to investigate whether left molar approach to laryngoscopy provided a better laryngeal view in cases of unexpected difficult intubation. METHODS:Following the appro...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021508004110

    authors: Bozdogan N,Sener M,Bilen A,Turkoz A,Donmez A,Arslan G

    更新日期:2008-08-01 00:00:00

  • Fentanyl pre-treatment does not affect the pharmacokinetic profile of an induction dose of propofol in adults.

    abstract::The initial disposition of propofol was reported to change when the administration was preceded by fentanyl. The pharmacokinetic profile of the induction dose of propofol (2 mg kg-1 body weight) was studied in 20 ASA I patients randomly allocated to receive fentanyl 1.5 microgram kg-1 (n = 12) or not (n = 8). Anaesthe...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: De Gasperi A,Cristalli A,Noé L,Sabbadini D,Mazza E,Prosperi M,Fantini G,Crespi AM,Rezzani S

    更新日期:1994-03-01 00:00:00

  • Comparison of time course of neuromuscular blockade in young children following rocuronium and atracurium.

    abstract::In order to compare the neuromuscular effects following rocuronium 0.6 mg kg-1 and atracurium 0.5 mg kg-1 30 children aged from 18 to 67 months were studied under the same anaesthetic conditions. After induction of anaesthesia with etomidate and fentanyl, neuromuscular blockade was monitored by recording the electromy...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2346.1998.00294.x

    authors: Ribeiro FC,Scheiber G,Marichal A

    更新日期:1998-05-01 00:00:00

  • Monitoring of respiratory function before and after cardiopulmonary bypass using side-stream spirometry.

    abstract::Pulmonary impairment is more frequent after cardiac surgery than after other major surgical procedures. The present study investigates whether, by using standard respiratory monitoring, i.e. side-stream spirometry and blood gas analysis, it is possible to detect changes in pulmonary function secondary to cardiopulmona...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章

    doi:10.1017/s026502159800009x

    authors: Bund M,Seitz W,Uthoff K,Krieg P,Strüber M,Piepenbrock S

    更新日期:1998-01-01 00:00:00

  • Neostigmine-based reversal of intermediate acting neuromuscular blocking agents to prevent postoperative residual paralysis: A systematic review.

    abstract:BACKGROUND:Neostigmine is widely used to antagonise residual paralysis. Over the last decades, the benchmark of acceptable neuromuscular recovery has increased progressively to a train-of-four (TOF) ratio of at least 0.9. Raising this benchmark may impact on the efficacy of neostigmine. OBJECTIVE(S):The systematic rev...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000741

    authors: Tajaate N,Schreiber JU,Fuchs-Buder T,Jelting Y,Kranke P

    更新日期:2018-03-01 00:00:00

  • Effect of sevoflurane-based or propofol-based anaesthesia on the incidence of postoperative acute kidney injury: A retrospective propensity score-matched analysis.

    abstract:BACKGROUND:Propofol may help to protect against ischaemic acute kidney injury (AKI); however, research on this topic is sparse. OBJECTIVE:The current study aimed to investigate whether there were differences in the incidence of postoperative AKI after lung resection surgery between patients who received propofol-based...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000001020

    authors: Oh TK,Kim J,Han S,Kim K,Jheon S,Ji E

    更新日期:2019-09-01 00:00:00

  • Bispectral index-controlled postoperative sedation in cardiac surgery patients: a comparative trial between closed loop and manual administration of propofol.

    abstract:BACKGROUND AND OBJECTIVE:Postoperative cardiac surgery patients are usually sedated according to clinical sedation scores. Electrophysiological data derived from electroencephalography, such as the bispectral index (BIS), have been reported to assess and quantify the level of sedation, although experience in these pati...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328335b2d4

    authors: Solanki A,Puri GD,Mathew PJ

    更新日期:2010-08-01 00:00:00

  • The effect of anaesthetics on the myocardium--new insights into myocardial protection.

    abstract::A variety of laboratory and clinical studies clearly indicate that exposure to anaesthetic agents can lead to a pronounced protection of the myocardium against ischaemia-reperfusion injury. Several changes in the protein structure of the myocardium that may mediate this cardioprotection have been identified. Ischaemia...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:10.1017/s0265021505001080

    authors: Weber NC,Preckel B,Schlack W

    更新日期:2005-09-01 00:00:00

  • Assessment of ondansetron and droperidol for the prevention of post-operative nausea and vomiting after cholecystectomy and minor gynaecological surgery performed by laparoscopy.

    abstract::The anti-emetic effects of ondansetron and droperidol were evaluated in 134 ASA Grade I and II female patients, scheduled for laparoscopic cholecystectomy and minor gynaecological laparoscopic surgery, who were randomly assigned to receive ondansetron 4 mg or droperidol 75 micrograms kg-1 intravenously immediately aft...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2346.1999.00581.x

    authors: Swiatkowski J,Goral A,Dzieciuch JA,Przesmycki K

    更新日期:1999-11-01 00:00:00