Peri-operative administration of rectal diclofenac sodium. The effect on renal function in patients undergoing minor orthopaedic surgery.

Abstract:

:In a randomized, double-blind study, we administered placebo and diclofenac sodium 100 mg suppositories 1 h pre-operatively and on the first post-operative morning to 22 adult patients undergoing minor orthopaedic surgery. A standardized post-operative intravenous fluid regimen was instituted until oral fluids were tolerated. Renal function was assessed pre-operatively, and on the first and second post-operative days by the measurement of urine output, creatinine, urea, sodium, potassium and NAG (N-acetyl-b-D-glucosaminidase) levels and serum creatinine, urea, sodium and potassium concentrations. On the first post-operative day, the diclofenac group demonstrated a reduced urinary sodium excretion. On the second post-operative day, a reduced urinary NAG/creatinine ratio was observed in the diclofenac group when compared to placebo. We conclude that peri-operative administration of diclofenac causes changes in renal function consistent with prostaglandin inhibition on the first post-operative day but had no lasting adverse effects in this group of patients. Our results reinforce the need for caution when administering this drug in the context of pre-existing renal impairment.

journal_name

Eur J Anaesthesiol

authors

Irwin MG,Roulson CJ,Jones RD,Cheng IK,Visram AR,Chan YM

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

403-6

issue

4

eissn

0265-0215

issn

1365-2346

journal_volume

12

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    pub_type: 评论,杂志文章

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1984-09-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1017/s0265021505000888

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    更新日期:2005-07-01 00:00:00

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    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0265021503001133

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