Dolasetron for the prevention of postoperative nausea and vomiting following outpatient surgery with general anaesthesia: a randomized, placebo-controlled study. The Dolasetron PONV Prevention Study Group.

Abstract:

:In a multicentre, randomized, double-blind, placebo-controlled dose-ranging study, 1030 patients undergoing outpatient surgery with general anaesthesia received i.v. dolasetron mesylate (12.5, 25, 50, or 100 mg) or placebo. The principal outcome measure was the proportion of patients who were free of emesis or rescue medication for the 24-h period after the study drug was given; the subsidiary outcome measure was survival time without rescue medication. Effects on nausea were quantified using a visual analogue scale. Compared with placebo, a complete response was significantly higher when all four dolasetron doses were combined (49% vs. 58%, P =0.025). In females, dolasetron, 12.5-mg, dolasetron provided maximum clinical benefit (effectiveness compared with adverse events), with no additional benefit in complete response rates or nausea visual analogue scale scores at higher doses. No significant differences were observed in complete response for any dolasetron dose in males compared with placebo. The majority of adverse events reported were mild or moderate. Dolasetron provided well-tolerated, safe, and effective prophylaxis for post-operative nausea and vomiting with maximum effectiveness observed at a dose of 12.5 mg.

journal_name

Eur J Anaesthesiol

authors

Philip BK,Pearman MH,Kovac AL,Chelly JE,Wetchler BV,McKenzie R,Monk TG,Dershwitz M,Mingus M,Sung YF,Hahne WF,Brown RA

doi

10.1046/j.1365-2346.2000.00594.x

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

23-32

issue

1

eissn

0265-0215

issn

1365-2346

pii

eja594

journal_volume

17

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Respiratory effects of the kneeling prone position for low back surgery.

    abstract:BACKGROUND AND OBJECTIVE:The kneeling prone position is often used for low back surgery in order to decrease intraoperative bleeding and increase the surgical exposure of the vertebral canal. The aim of this study was to assess effects of the kneeling prone position on respiratory gas exchange focusing on oxygen consum...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021504004053

    authors: Radstrom M,Loswick AC,Bengtsson JP

    更新日期:2004-04-01 00:00:00

  • Use of EEG spectral edge as index of equipotency in a comparison of propofol and isoflurane for maintenance of general anaesthesia.

    abstract::Propofol and isoflurane were compared for haemodynamic stability and recovery time as main anaesthetic agents for maintenance in a total of 43 ASA I and II patients in uncomplicated operations lasting at least 30 min. The premedication (oral diazepam), induction (thiopentone-fentanyl-suxamethonium) and maintenance pro...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Gurman GM,Fajer S,Porat A,Schily M,Pearlman A

    更新日期:1994-11-01 00:00:00

  • Bilateral phaeochromocytomas in pregnancy: anaesthetic management of combined caesarean section and tumour removal.

    abstract::A 25-year-old primigravida with bilateral phaeochromocytomas was managed from 6 weeks' gestation until 2.5 years following combined Caesarean section and removal of adrenal tumours. Pre-operative alpha-blockade was achieved by oral prazosin without deleterious effects. Intra-operative management comprised neuroleptana...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Pinaud M,Souron R,Le Neel JC,Lopes P,Murat A,L'hoste F

    更新日期:1985-12-01 00:00:00

  • Anaesthetic implications of osteo-odonto-keratoprosthesis surgery.

    abstract::Patients with bilateral corneal blindness in whom corneal transplantation has either been unsuccessful or inappropriate may be considered for osteo-odonto-keratoprosthesis surgery. During a two-stage procedure the surface of the cornea is removed and covered with a graft of buccal mucosa. An optical cylinder, supporte...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2346.2000.00698.x

    authors: Skelton VA,Henderson K,Liu C

    更新日期:2000-06-01 00:00:00

  • Cardiovascular responses and airway complications following awake nasal intubation with blind intubation device and fibreoptic bronchoscope: a randomized controlled study.

    abstract:BACKGROUND AND OBJECTIVE:The blind intubation device (BID) was introduced for awake nasotracheal intubation recently. The aim of this study was to compare the cardiovascular responses and associated airway complications of fibreoptic bronchoscope (FOB) with those of BID. The intubation attempts and intubation time were...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328332845a

    authors: Sun Y,Liu JX,Jiang H,Zhu YS,Xu H,Huang Y

    更新日期:2010-05-01 00:00:00

  • Post-operative course after conventional or laparoscopic gastroplasty in morbidly obese patients.

    abstract::The post-operative period is particularly dangerous for obese patients. The aim of this study was to compare the immediate post-operative course after either laparoscopic or open gastroplasty. We studied retrospectively 20 and 14 consecutive patients who underwent laparoscopic or open adjustable silicone gastric bandi...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.1999.00510.x

    authors: Juvin P,Marmuse JP,Delerme S,Lecomte P,Mantz J,Demetriou M,Desmonts JM

    更新日期:1999-06-01 00:00:00

  • The ProSeal laryngeal mask airway and the laryngeal tube Suction for ventilation in gynaecological patients undergoing laparoscopic surgery.

    abstract:BACKGROUND AND OBJECTIVE:ProSeal Laryngeal Mask Airway (PLMA) and Laryngeal Tube Suction (LTS), supraglottic airway devices allowing gastric drainage, were compared in this prospective, randomized study for airway management under conditions with elevated intra-abdominal pressure induced by capnoperitoneum. METHODS:Fi...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0265021505000220

    authors: Roth H,Genzwuerker HV,Rothhaas A,Finteis T,Schmeck J

    更新日期:2005-02-01 00:00:00

  • The effect of propofol and thiopentone on impairment by reactive oxygen species of endothelium-dependent relaxation in rat aortic rings.

    abstract::The effect in isolated rat aorta of propofol, thiopentone, midazolam, etomidate and fentanyl on the impairment of endothelium-dependent relaxation by reactive oxygen species is reported. Aortic rings were exposed to reactive oxygen species by the electrolysis of the bathing physiological buffer, and endothelium-depend...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.1997.00110.x

    authors: Kelicen P,Ismailoglu UB,Erdemli O,Sahin-Erdemli I

    更新日期:1997-05-01 00:00:00

  • The preventive effect of diphenhydramine on bacterial growth in propofol: a laboratory study.

    abstract:BACKGROUND AND OBJECTIVE:Diphenhydramine has local anaesthetic and antimicrobial activity and may be used to prevent intravenous propofol injection pain. We studied the effect of adding diphenhydramine to propofol emulsions for preventing bacterial growth. METHODS:Staphylococcus aureus, Pseudomonas aeruginosa, Escheri...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021508004377

    authors: Güzelant A,Apiliogullari S,Kara I,Turhan V,Apiliogullari B,Yilmaz H,Balasar M,Duman A

    更新日期:2008-09-01 00:00:00

  • Comparison of fresh frozen plasma vs. coagulation factor concentrates for reconstitution of blood: An in vitro study.

    abstract:BACKGROUND:Many trauma centres have adopted the administration of fixed ratios of packed red blood cells (PRBCs), platelet concentrates and fresh frozen plasma (FFP) for bleeding patients. However, the haemostatic efficacy of this concept is not well proven. OBJECTIVE:Our objective was to characterise the haemostatic ...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000001202

    authors: Gratz J,Ponschab M,Iapichino GE,Schlimp CJ,Cadamuro J,Grottke O,Zipperle J,Oberladstätter D,Gabriel C,Ziegler B,Schöchl H

    更新日期:2020-10-01 00:00:00

  • The role of venodilators in the perioperative management of heart failure.

    abstract::A unifying hypothesis which satisfactorily explains the clinical syndrome of heart failure has proved elusive. A deeper understanding of the underlying pathophysiology has led to the development of more complex models and, as a result, the evolution of new treatment strategies. In patients undergoing non-cardiac surge...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:10.1097/EJA.0b013e32835016be

    authors: Valchanov KP,Arrowsmith JE

    更新日期:2012-03-01 00:00:00

  • A survey of anaesthetic practice in predicting difficult intubation in UK and Europe.

    abstract:CONTEXT:Unexpected difficulty in tracheal intubation is an intermittent and often terrifying problem for all practising anaesthetists. There are many preoperative assessment tests to predict a difficult laryngeal view or a difficult intubation, but we found no published evidence of how frequently these predictive tests...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0b013e32835103e6

    authors: McPherson D,Vaughan RS,Wilkes AR,Mapleson WW,Hodzovic I

    更新日期:2012-05-01 00:00:00

  • The effect of paracetamol on postoperative nausea and vomiting during the first 24 h after strabismus surgery: a prospective, randomised, double-blind study.

    abstract:CONTEXT:Strabismus surgery is one of the most common ophthalmic surgical procedures in children and is associated with significant postoperative nausea and vomiting (PONV). OBJECTIVE:We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery. DESIGN:Prospective, placebo-controlled...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e32834c580b

    authors: Cok OY,Eker HE,Pelit A,Canturk S,Akin S,Aribogan A,Arslan G

    更新日期:2011-12-01 00:00:00

  • The use of cuffed tracheal tubes for paediatric tracheal intubation, a survey of specialist practice in the United Kingdom.

    abstract:BACKGROUND AND OBJECTIVE:For more than 50 yr, uncuffed tracheal tubes have been the gold standard for intubation in children under the age of 8 yr. However, recently there has been interest in the use of cuffed tubes in paediatric practice. This survey aimed to benchmark UK practice with regard to tracheal intubation w...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021508003839

    authors: Flynn PE,Black AE,Mitchell V

    更新日期:2008-08-01 00:00:00

  • Epidural combination of ropivacaine with sufentanil for postoperative analgesia after total knee replacement: a pilot study.

    abstract:BACKGROUND AND OBJECTIVE:We assessed the analgesic efficacy of postoperative epidural infusions of ropivacaine 0.1 and 0.2% combined with sufentanil 1 microg mL(-1) in a prospective, randomized, double-blinded study. METHODS:Twenty-two ASA I-III patients undergoing elective total-knee replacement were included. Lumbar...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0265021502001096

    authors: Kampe S,Diefenbach C,Kanis B,Auweiler M,Kiencke P,Cranfield K

    更新日期:2002-09-01 00:00:00

  • Cerebral aneurysm surgery in a patient with phaeochromocytoma.

    abstract::This case report describes the peri-operative management of a 48-year-old woman with three cerebral aneurysms and phaeochromocytoma. The pharmacological and anaesthetic management of such patients is complex, and needs to be managed carefully by titrating anaesthetic agents and vasoactive drugs. The primary concern is...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.1998.00285.x

    authors: Sahin A,Erçelen O,Aypar U,Erbengi A

    更新日期:1998-05-01 00:00:00

  • Incidence and risk factors for adverse events during monitored anaesthesia care for gastrointestinal endoscopy in children: A prospective observational study.

    abstract:BACKGROUND:Better understanding of risk factors for adverse events during monitored anaesthesia care (MAC) for paediatric gastrointestinal endoscopy may improve outcome in children. OBJECTIVES:To identify the prevalence and predictors of adverse events during MAC for paediatric endoscopy. DESIGN:An observational stud...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000995

    authors: Najafi N,Veyckemans F,Vanhonacker D,Legrand C,Van de Velde A,Vandenplas Y,Poelaert J

    更新日期:2019-06-01 00:00:00

  • Intrathecal anaesthesia alters intracellular Ca2+/Mg2+ homeostasis in the spinal cord neurones of experimental rats.

    abstract:BACKGROUND AND OBJECTIVE:The effect of anaesthesia induced by intrathecal injection of 6.3% MgSO4 or 4% lidocaine on intracellular electrolyte homeostasis in spinal cord neurones of a rat model was investigated. METHODS:Intracellular Ca2+, Mg2+, Na+ and K+ concentrations were determined at different times after intrat...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.0265-0215.2000.00808.x

    authors: Bahar M,Berman S,Chanimov M,Weissgarten J,Averbukh Z,Cohen ML,Grinshpon Y

    更新日期:2001-04-01 00:00:00

  • The orthogonal two-needle technique: a new axillary approach to the brachial plexus.

    abstract::Ninety-eight patients scheduled for elbow, forearm, wrist or hand surgery were allocated randomly to one of two different techniques of brachial plexus block, both using the axillary approach. The blocks were all performed at the level of the insertion of the lateral margin of the pectoralis major muscle on the humeru...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Rucci FS,Boccaccini A,Doni L,Pippa P

    更新日期:1995-07-01 00:00:00

  • Molecular sites of general anaesthetic action on acetylcholine receptors.

    abstract::Mechanisms of anaesthetics still remain unclear. However, various attempts have been made to elucidate the effects of anaesthetics at the molecular level. The nicotinic acetylcholine receptor has proved to be a good model of membrane-bound ligand-gated ion channels. It is available in abundance from Torpedo electropla...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,评审

    doi:

    authors: Tonner PH,Miller KW

    更新日期:1995-01-01 00:00:00

  • Nasotracheal intubation using the Blind Intubation Device in anaesthetised adults with Mallampati class 3: a comparison with the Macintosh laryngoscope.

    abstract:CONTEXT:We hypothesised that the Blind Intubation Device (BID) would be effective for nasotracheal intubation (NTI) in anaesthetised adults with Mallampati class 3. We also hypothesised that BID may cause less haemodynamic changes due to the avoidance of direct stimulation induced by the Macintosh blade. OBJECTIVE:The...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328349a9f9

    authors: Sun Y,Liu JX,Zhu YS,Xu H,Huang Y,Jiang H

    更新日期:2011-11-01 00:00:00

  • The effect of a standardised source of divided attention in airway management: A randomised, crossover, interventional manikin study.

    abstract:BACKGROUND:Dual-tasking, the need to divide attention between concurrent tasks, causes a severe increase in workload in emergency situations and yet there is no standardised training simulation scenario for this key difficulty. OBJECTIVES:We introduced and validated a quantifiable source of divided attention and inves...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000000315

    authors: Prottengeier J,Petzoldt M,Jess N,Moritz A,Gall C,Schmidt J,Breuer G

    更新日期:2016-03-01 00:00:00

  • Effect of midazolam on in vitro cerebral endothelial ICAM-1 expression induced by astrocyte-conditioned medium.

    abstract:BACKGROUND AND OBJECTIVE:Astrocytes exposed to hypoxia produce pro-inflammatory cytokines and upregulate intercellular adhesion molecule-1 on cerebral endothelium. This study investigated the effects of midazolam on this response. METHODS:Mouse astrocytes were exposed to 4 h of hypoxia and 24 h of reoxygenation. Astro...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021506000652

    authors: Ghori K,Harmon D,Walsh F,Shorten G

    更新日期:2006-09-01 00:00:00

  • Early experience with remote pressure sensor respiratory plethysmography monitoring sedation in the MR scanner.

    abstract:BACKGROUND AND OBJECTIVE:The importance of monitoring the breathing pattern during sedation of children undergoing magnetic resonance scans is indicated in guidelines, but no appropriate magnetic resonance-compatible devices are available. We report preliminary findings from a technique referred to as remote pressure s...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021507000312

    authors: Caldiroli D,Minati L

    更新日期:2007-09-01 00:00:00

  • Effects of desflurane, sevoflurane and propofol on phagocytosis and respiratory burst activity of human polymorphonuclear leucocytes in bronchoalveolar lavage.

    abstract:BACKGROUND AND OBJECTIVE:In polymorphonuclear leucocytes, phagocytosis and respiratory burst activity are mainly responsible for bacterial killing. We aimed to investigate the effects of anaesthesia with desflurane, sevoflurane and propofol on these functional activities of polymorphonuclear leucocytes in bronchoalveol...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328319bfeb

    authors: Erol A,Reisli R,Reisli I,Kara R,Otelcioglu S

    更新日期:2009-02-01 00:00:00

  • Thoracolumbar epidural anaesthesia and isoflurane to prevent hypertension and tachycardia in patients undergoing abdominal aortic surgery.

    abstract::Cardiovascular and hormonal responses to reconstructive abdominal aortic surgery were studied in 20 patients anaesthetized either with moderate-dose fentanyl (20 micrograms kg-1) combined with isoflurane, nitrous oxide and oxygen (n = 10), or with thoracolumbar epidural bupivacaine combined with isoflurane, nitrous ox...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kataja J

    更新日期:1991-11-01 00:00:00

  • Total hip arthroplasty and perioperative oral carbohydrate treatment: a randomised, double-blind, controlled trial.

    abstract:CONTEXT:Perioperative oral carbohydrate intake is beneficial to general surgery patients. Total hip arthroplasty is a common surgical procedure, and even a moderate improvement in patient outcome could have a significant effect on the resources needed for these patients. However, few studies have focused on the effects...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e3283525ba9

    authors: Harsten A,Hjartarson H,Toksvig-Larsen S

    更新日期:2012-06-01 00:00:00

  • Cerebral blood flow velocity and carbon dioxide vasoreactivity during gamma-hydroxybutyrate/fentanyl anaesthesia in non-neurosurgical patients.

    abstract::In this study the effects of gamma-hydroxybutyrate/fentanyl on cerebral blood flow velocity (CBFV) (as measured in the middle cerebral artery by transcranial Doppler ultrasonography) and on cerebrovascular carbon dioxide reactivity were investigated. Mean CBFV (Vmean) and haemodynamic responses were recorded in 12 non...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2346.1999.00452.x

    authors: Detsch O,Erkens U,Schneck H,Denker T,Kochs E,Hempelmann G

    更新日期:1999-03-01 00:00:00

  • Randomised comparison of hyperbaric articaine and hyperbaric low-dose bupivacaine along with fentanyl in spinal anaesthesia for day-case inguinal herniorrhaphy.

    abstract:BACKGROUND AND OBJECTIVE:Low-dose mixture of hyperbaric bupivacaine and fentanyl is commonly used in day-case spinal anaesthesia. Using hyperbaric articaine, the onset may be faster and duration more predictable than with bupivacaine-fentanyl. We compared these two spinal anaesthetics for inguinal herniorrhaphy. METHO...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e32834a11be

    authors: Bachmann M,Pere P,Kairaluoma P,Rosenberg PH,Kallio H

    更新日期:2012-01-01 00:00:00

  • Optimal regional anaesthesia for abdominal hysterectomy: combined subarachnoid and epidural block compared with other regional techniques.

    abstract::Regional anaesthesia for abdominal hysterectomy is commonly combined with heavy sedation or light general anaesthesia in order to avoid the occurrence of visceral pain. Our clinical experience has indicated that this pain can be controlled using regional anaesthesia techniques alone. In an effort to find the optimal t...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Mihic DN,Abram SE

    更新日期:1993-07-01 00:00:00